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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Evaluation of invitro absorption,decontamination and desorption oforganophosphorous compounds from skin and syntheticmembranes显示文摘 | Mircioiu C Victor A V Ionescu M | 2013 | Toxicol Lett2013，219，2： | 1 |
| 3 | Liver Stiffness Measurement in Children Using FibroScan: Feasibility Study and Comparison With Fibrotest, Aspartate Transaminase to Platelets Ratio Index, and Liver Biopsy显示文摘 | Victor de Lédinghen Brigitte Le Bail Laurent Rebouissoux Céline Fournier Juliette Foucher Véronique Miette Laurent Castéra Laurent Sandrin Wassil Merrouche Frédéric Lavrand Thierry Lamireau | 2007 | Journal of Pediatric Gastroenterology and Nutrition2007，，4： | 1 |
| 4 | Hydromechanical characterization of CO2 injection sites显示文摘 | VICTOR V JESISS C SEBASTI)~ O | | International Journal of Greenhouse Gas Control0，，： | 1 |
| 5 | Environmental beliefs and water conservation: An empirical study显示文摘 | Victor C V Robert B B Blanca F S | 2003 | Journal of Environmental Psychology2003，23，： | 1 |
| 6 | The avian coronavirus Infectious bronchitis virus undergoes direct low-pH-dependent fusion activation during entry into host cells显示文摘 | Victor C Lisa J Chu M V | 2006 | Journal of Virology2006，80，： | 1 |
| 7 | Analytieal Modeling of Aquifer Pollution Caused by Solid Waste Depositories显示文摘 | Dmitry V Rudakov Victor C Rudakov | 1998 | Ground Water1998，5，3： | 1 |
| 8 | Preparation and characterization of N-enriched, size-defined heparan sulfate precursor oligosaccharides显示文摘 | Sigulinsky C Babu P Victor X V | 2010 | Carbohydr Res2010，345，2： | 1 |
| 9 | Quantitative analysis of p185 in breast cancer and it association with other progrnostic factor显示文摘 | Pliav FV Ricardo C Victor V | 1997 | Int J Cancer1997，74，3： | 1 |
| 10 | Gold nanopartieles supported on nanoparticulate ceria as a powerful agent against intracelhilar oxidative stress 显示文摘 | Mench6n C Martin R Apostolova N Victor V M lvaro M Herance J R Garcia H | 2012 | Small2012，8，： | 1 |
| 11 | Induction of micronuclei and binuclei in blood, gill and liver cells of fishes subchronically exposed to cadmium chloride and copper sulphate显示文摘 | TOLGA C NATASHA N G VICTOR V A | 2005 | Food and Chemical Toxicology2005，43，4： | 1 |
| 12 | The avian coronavirus Infectious bronchitis virus undergoes direct Low-pH-dependent fusion activation during entry into host cells显示文摘 | Victor C C McElroy L J Chu V | 2006 | General virol2006，，5： | 1 |
| 13 | Anxiety as a factor influencing physiological effects of acupuncture 显示文摘 | Victor V Carole R Ashley C | 2009 | Complement Ther Clin Pract2009，15，： | 1 |
| 14 | CA 19-9in pan-creatic cancer:retrospective evaluation of patients withsuspicion of pancreatic cancer显示文摘 | Victor M Laura V Carles C | 2012 | Tumor Biol2012，33，： | 1 |
| 15 | Effect of thermal pretreatment on equilibrium moisture content of lignocellulosic biomass显示文摘 | Tapas C A Cjarles J C Victor R V | 2011 | Bioresource Technology2011，102，7： | 1 |
| 16 | Dysfunctional voiding in women显示文摘 | Kevin V C Sergey R Victor W N | 2001 | J Urol2001，165，： | 1 |
| 17 | Evolving Concepts of Apoptosis in Idiopathic Puhnonary Fibrosis显示文摘 | Victor J Thannickal V Jeffrey C | 2006 | Proc Am Thorac Soc2006，3，4： | 1 |
| 18 | Experimental investigation of water impact on axisymmetric bodies 显示文摘 | BACKER G D VANTORRE M BEELS C PRE J D VICTOR S ROUCK J D BLOMMAERT C PAEPEGEM W V | 2009 | Applied Ocean Research2009，31，3： | 1 |
| 19 | Analytical Modelingof Aquifer Pollution Caused by Solid Waste Depositories显示文摘 | Dmitry V Rudakov Victor C Rudakov | 1998 | Ground Water1998，5，3： | 1 |
| 20 | Diffusion coeffi- cients in aqueous solutions of potassium chloride at high and low concentrations 显示文摘 | Victor M M L Ana C F R Luis M P V | 1998 | Journal of Molecular Liquids1998，78，： | 1 |
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