|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease显示文摘Mitochondrial dysfunction is known to be a contributing factor to a number of diseases including chronic alcohol induced liver injury. While there is a detailed understanding of the metabolic pathways and proteins of the liver mitochondrion, little is known regarding how changes in the mitochondrial proteome may contribute to the development of hepatic pathologies. Emerging evidence indicates that reactive oxygen and nitrogen species disrupt mitochondrial function through post-translational modifications to the mitochondrial proteome. Indeed, various new affinity labeling reagents are available to test the hypothesis that post-translational modification of proteins by reactive species contributes to mitochondrial dysfunction and alcoholic fatty liver disease. Specialized proteomic techniques are also now available, which allow for identification of defects in the assembly of multi-protein complexes in mitochondria and the resolution of the highly hydrophobic proteins of the inner membrane. In this review knowledge gained from the study of changes to the mitochondrial proteome in alcoholic hepatotoxicity will be described and placed into a mechanistic framework to increase understanding of the role of mitochondrial dysfunction in liver disease. | Sudheer K Mantena Adrienne L King Kelly K Andringa Aimee Landar Victor Darley-Usmar Shannon M Bailey | 2007 | World Journal of Gastroenterology2007，13，37： | 7 |
| 2 | Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study显示文摘AIM: To determine the presence of Helicobacter species DNA in the liver of chronic hepatitis C (CHC) patients with and without cirrhosis as compared to controls, and to identify the bacterial species involved. METHODS: Seventy-nine consecutive patients (HBV and HIV negative) with a liver sample obtained after liver biopsy or hepatic resection were studied: 41 with CHC without cirrhosis, 12 with CHC and cirrhosis, and 26 controls (HCV negative). Polymerase chain reactions (PCRs) targeting Helicobacter 16S rDNA and species- specific were performed on DNA extracted from the liver. A gastric infection with H pylori was determined by serology and confirmed by 13C-urea breath test. RESULTS: Overall, Helicobacter 16S rDNA was found in 16 patients (20.2%). Although positive cases tended to be higher in CHC patients with cirrhosis (41.6%) than in those without cirrhosis (17.0%) or in controls (15.4%), the difference was not statistically significant (P =0.08). H pylori-like DNA was identified in 12 cases and H. pullorum DNA in 2, while 2 cases remained unidenti- fied. Gastric infection with H pylori was found in only 2 of these patients. CONCLUSION: Our results do not confirm the associ- ation of Helicobacter species DNA in the liver of CHC patients with advanced liver disease. The lack of correlation between positive H pylori serology and the presence of H pylori-like DNA in the liver may indicate the presence of a variant of this species. | Laurent Castéra Anne Pedeboscq Marcia Rocha Brigitte Le Bail Corinne Asencio Victor de Lédinghen Pierre-Henri Bernard Christophe Laurent Marie-Edith Lafon Maylis Capdepont Patrice Couzigou Paulette Bioulac-Sage Charles Balabaud FrancisMégraud Armelle Ménard | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 3 | Diminished insulin receptors on erythrocyte ghosts in nonobese patients with essential hypertension independent of hyperinsulinemia显示文摘 | MIGUEL V JOSE A L | 1994 | J Cardiovasc Pharmacol1994，24，： | 1 |
| 4 | Flexible energy storage devices based on nanocomposite paper显示文摘 | Victor L Pushparaj Manikoth M Shaijumon Ashavani Kumar | 2007 | PNAS2007，104，13： | 1 |
| 5 | Central pontinemyelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients 显示文摘 | Adams R D Victor M Mancall E L | 1959 | AMA Arch Neurol Psychiatry1959，81，4： | 1 |
| 6 | Inhibition of Desuvovibrio gigas hydrogenase with copper salts and other metalions显示文摘 | VICTOR M F MARIA L R PRESENTACION R | 1989 | European Journal of Biochemistry1989，185，2： | 1 |
| 7 | Mathematical modelling of three-demensional electrochemical forming of complicated surfaces 显示文摘 | Victor V L | 2001 | Journal of Materials Processing Technology2001，109，： | 1 |
| 8 | Use of molecular markers to differentiate between commercial strains of the button mushroom A-garicus bisporus显示文摘 | Ramirez L Victor M Mikel A | 2001 | FEMS Microbiology Letters2001，198，1： | 1 |
| 9 | Angiogenic nature of the'intravascular blonchioloalveolar tumor' of the lung:an electron microscopic study显示文摘 | Weldon-Linne C M Victor T A Christ M L | 1981 | Arch Pathol Lab Med1981，105，4： | 1 |
| 10 | Directional geographical routing for real-time video communications in wireless sensor networks显示文摘 | MIN C VICTOR C M L MAO S W | | 0，，17： | 1 |
| 11 | Expression patterns of slit and robo family members during vertebrate limb development显示文摘 | Neil V Victor L Izabell M | 2001 | Mechanisms of Development2001，106，： | 1 |
| 12 | Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation显示文摘 | TIE L VICTOR E BUCKWOLD M | 1999 | J Virol1999，73，2： | 1 |
| 13 | Optical performance as a function dynamic mechanical loading 显示文摘 | VICTOR L G KEITH B D GREGORY J M | 2008 | SPIE2008，5178，4： | 1 |
| 14 | “Radicle” biochemistry:the biology of root-specific metabolism显示文摘 | Hector E F Jorge M V Victor M L V | 1999 | Trends in Plant Science1999，4，6： | 1 |
| 15 | Pacemaker lead extraction with the laser sheath: results of the pacing lead extraction with the excimer sheath (PLEXES) trial 1 1 No financial support was received for performing the procedures or collecting the data, or for data analysis.显示文摘 | Bruce L Wilkoff Charles L Byrd Charles J Love David L Hayes T.Duncan Sellers Raymond Schaerf Victor Parsonnet Laurence M Epstein Robert A Sorrentino Christopher Reiser | 1999 | Journal of the American College of Cardiology1999，，6： | 1 |
| 16 | Comparison between magnetic resonance cholangiopancreatography and ERCP for evaluation of the pancreatic duct显示文摘 | Mari M Calvo Luis Bujanda Angel Calderón I?aki Heras José L Cabriada Antonio Bernal Victor Orive Elena Astigarraga | 2002 | The American Journal of Gastroenterology2002，，2： | 1 |
| 17 | Kinetics of the acid decomposition of sodium thiosulfate in dilute solutions显示文摘 | Dinegar R H Semellie R H Victor K L M 1991 | 1991 | J Am Chem Soc1991，73，： | 1 |
| 18 | Directionally Solidified Eutectic Ceramic Oxides显示文摘 | Javier L L Victor M O | 2006 | Progress in Materials Scicnce2006，51，6： | 1 |
| 19 | Effectof Technology Absorptive Capacity and Technology Proactivity on Or-ganizational Learning Innovation and Performance: An Empirical Ex-amination 显示文摘 | VICTOR J G - M ANTONIA R - M FRANCISCO J L - M | 2007 | Technology Analysis & Strategic Management2007，19，4： | 1 |
| 20 | Deformation and structural stability of layered plate microstructures subjectedto thermal loading显示文摘 | DUNN MARTIN L ZHANG Y H BRIGHT VICTOR M | 2002 | J MEMS2002，11，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员