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| 1 | Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium显示文摘Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey's fibers of the periodontal ligament (PDL). However, little is known about the regulatory morphogens that control differentiation and function of these progenitor cells, as well as the progenitor cells involved in crown and root formation. We investigated the role of bone morphogenetic protein-2 (Bmp2) in these processes by the conditional removal of the Bmp2 gene using the Sp7-Cre-EGFP mouse model. Sp7-Cre-EGFP first becomes active at E18 in the first molar, with robust Cre activity at postnatal day 0 (P0), followed by Cre activity in the second molar, which occurs after P0. There is robust Cre activity in the periodontium and third molars by 2 weeks of age. When the Bmp2 gene is removed from Sp7+ (Osterix+) cells, major defects are noted in root, cellular cementum and periodontium formation. First, there are major cell autonomous defects in root-odontoblast terminal differentiation. Second, there are major alterations in formation of the PDLs and cellular cementum, correlated with decreased nuclear factor IC (Nfic), periostin and α-SMA+ cells. Third, there is a failure to produce vascular endothelial growth factor A (VEGF-A) in the periodontium and the pulp leading to decreased formation of the microvascular and associated candidate stem cells in the Bmp2-cKOSp7-Cre-EGFP . Fourth, ameloblast function and enamel formation are indirectly altered in the Bmp2-cKOSp7-Cre-EGFP . These data demonstrate that the Bmp2 gene has complex roles in postnatal tooth development and periodontium formation. | Audrey Rakian Wu-Chen Yang Jelica Gluhak-Heinrich Yong Cui Marie A Harris Demitri Villarreal Jerry Q Feng Mary MacDougall Stephen E Harris | 2013 | International Journal of Oral Science2013，5，2： | 14 |
| 2 | Response of a sedum green-roof to individual rain events 显示文摘 | Villarreal E L Bengtsson L | 2005 | Ecological En- gineering2005，25，1： | 1 |
| 3 | Hypocalci- uria during pregnancy as a risk factor of preeclampsia显示文摘 | SEGOVIA B L VEGA I T VILLARREAL E C | 2004 | Ginecol Obstet Mex2004，72，： | 1 |
| 4 | NMDA receptor antagonists sustain LTP and spatial memory: active processes mediate LTP decay显示文摘 | Villarreal DM Do V Haddad E | 2002 | Nat Neurosci2002，5，1： | 1 |
| 5 | Iron and vitamin A micronutrient status, risk factors for their deficiencies and anthropometric assessment in preschool child from Funza municipality, Colombia显示文摘 | proveda E Cuartas A Villarreal E | 2007 | Biomédiea2007，27，1： | 1 |
| 6 | The increase in antioxidant capacity after wounding depends on the type of fruit or vegetable tissue显示文摘 | REYES L F VILLARREAL J E CISNEROS-ZEVALLOS L | 2007 | Food Chem2007，101，： | 1 |
| 7 | Response of a Sedum green-roof to individual rain events显示文摘 | VILLARREAL E L BENGTSSON L | 2005 | Ecological Engineering2005，28，1： | 1 |
| 8 | Innovation, organisation and governance in Spanish universities 显示文摘 | Villarreal E | 2001 | Tertiary Education and Management2001，，2： | 1 |
| 9 | Analysis of a rainwater collection system for domestic water supply in Ringdansen,Norrkoping,Sweden显示文摘 | VILLARREAL E L DIXON A | 2005 | Building and Environment2005，40，： | 1 |
| 10 | Comparison of extraction methods for the isolation of volatile compounds from distilled alcoholic beverages显示文摘 | Jorge A Pino A Villarreal E Roncal | 1994 | Nahrung1994，38，3： | 1 |
| 11 | Response of a sedum green-roof to individual rain events 显示文摘 | Villarreal E L Bengtsson L | 2005 | Ecological Engineering2005，25，1： | 1 |
| 12 | Molecular characterization of infectious bronchitis virus strains isolated from the enteric contents of brazilian laying hens and broilers显示文摘 | Villarreal L Y Brandao B Chaeon P E | 2007 | Avian Dis2007，51，4： | 1 |
| 13 | Inner city stormwater con- trol using a combination of best management practices 显示文摘 | Villarreal E L Davies A S Bengtsson L | 2004 | Ecologi- cal Engineering2004，22，： | 1 |
| 14 | Serum free proline and hydroxyproline in patients with chronic liver disease显示文摘 | Mata J M Kershenobich D Villarreal E | 1975 | Gastroenterology1975，68，51： | 1 |
| 15 | Identification of turkey astrovirus and turkey coronavirus in an outbreak of poult enteritis and mortality syndrome显示文摘 | M S Assayag Brandao P E | 2006 | Revista Brasileira de Ciencia Avicola2006，8，： | 1 |
| 16 | Usefulness of procalcitoninfor diagnosing infection in critically ill patients with liver cirrhosis显示文摘 | Villarreal E Vacacela K Gordonet M | 2016 | Med Intensiva2016，40，2： | 1 |
| 17 | Coexistence of enzootic nasal adenocarcinoma and Jaagsiekte retrovirus infection in sheep显示文摘 | Ortin A Perez De Villarreal M Minguijon E | 2004 | J Comp Pathol2004，131，4： | 1 |
| 18 | ERK phosphorylation is required for retention of trace fearmemory显示文摘 | Villarreal J S Barea-Rodriguez E J | 2006 | Neurobiol Learn Mem2006，85，1： | 1 |
| 19 | Coexistence of enzootie nasal adenocarcinoma and jaagsiekte retrovirus in- fection in sheep显示文摘 | Ortin A Perez de Villarreal M Minguilon E | 2004 | J Comp Pathol2004，131，： | 1 |
| 20 | Theincrease in antioxidant capacity after wounding depends on the typeof fruit or vegetable tissue显示文摘 | REYES L F VILLARREAL J E CISNEROS-ZEVALLOS L | 2007 | Food Chemistry2007，101，： | 1 |
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