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| 1 | Antiviral activity of quercetin-3-β-O-D-glucoside against Zika virus infection显示文摘Dear Editor,The 2015–2016 outbreak of Zika virus(ZIKV)fever,first reported in Brazil during early 2015(Zanluca et al.,2015),has infected millions of people and is a global public health concern.ZIKV infections are associated with fetal microcephaly,as well as neurological | gary wong shihua he vinayakumar siragam yuhai bi majambu mbikay michel chretien xiangguo qiu | 2017 | Virologica Sinica2017，32，6： | 5 |
| 2 | Bacterial acetohydroxyacid synthase and its inhibitors-A sum- mary of their structure, biological activity and current status显示文摘 | VINAYAKUMAR G MOON-YOUNG Y | 2012 | FEBS Journal2012，279，6： | 1 |
| 3 | Animal models for filovirus infections显示文摘The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates(NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research. | Vinayakumar Siragam Gary Wong Xiang-Guo Qiu | 2018 | Zoological Research2018，39，1： | 1 |
| 4 | Prognostic significance of coronary sinus filling time in patients with angina and normal coronaries at one year follow up显示文摘 | P. Kadermuneer G.V. Vinod V. Haridasan G. Rajesh C.G. Sajeev Cicy Bastion D. Vinayakumar Dolly Mathew Biju George M.N. Krishnan | 2015 | Indian Heart Journal2015，，： | 1 |
| 5 | Mathematical Model Validation of Search Protocols in MP2P Networks显示文摘Broadcasting is a basic technique in Mobile ad-hoc network(MANET),and it refers to sending a packet from one node to every other node within the transmission range.Flooding is a type of broadcast where the received packet is retransmitted once by every node.The naive flooding technique,floods the network with query messages,while the random walk technique operates by contacting the subsets of every node’s neighbors at each step,thereby restricting the search space.One of the key challenges in an ad-hoc network is the resource or content discovery problem which is about locating the queried resource.Many earlier works have mainly focused on the simulation-based analysis of flooding,and its variants under a wired network.Although,there have been some empirical studies in peer-to-peer(P2P)networks,the analytical results are still lacking,especially in the context of P2P systems running over MANET.In this paper,we describe how P2P resource discovery protocols perform badly over MANETs.To address the limitations,we propose a new protocol named ABRW(Address Broadcast Random Walk),which is a lightweight search approach,designed considering the underlay topology aimed to better suit the unstructured architecture.We provide the mathematical model,measuring the performance of our proposed search scheme with different widely popular benchmarked search techniques.Further,we also derive three relevant search performance metrics,i.e.,mean no.of steps needed to find a resource,the probability of finding a resource,and the mean no.of message overhead.We validated the analytical expressions through simulations.The simulation results closely matched with our analyticalmodel,justifying our findings.Our proposed search algorithm under such highly dynamic self-evolving networks performed better,as it reduced the search latency,decreased the overall message overhead,and still equally had a good success rate. | Ajay Arunachalam Vinayakumar Ravi Moez Krichen Roobaea Alroobaea Saeed Rubaiee | 2021 | Computers, Materials & Continua2021，，8： | 1 |
| 6 | Secure and resilient improved image steganography using hybrid fuzzy neural network with fuzzy logic显示文摘The exponential growth in communication networks,data technology,advanced libraries,and mainly World Wide Web services has played a pivotal role in facilitating the retrieval of various types of information as needed.However,this progress has also led to security concerns related to the transmission of confidential data.Nevertheless,safeguarding these data during communication through insecure channels is crucial for obvious reasons.The emergence of steganography offers a robust approach to concealing confidential information,such as images,audio tracks,text files,and video files,in suitable media carriers.A novel technique is envisioned based on back-propagation learning.According to the proposed method,a hybrid fuzzy neural network(HFNN)is applied to the output obtained from the least significant bit substitution of secret data using pixel value dif-ferences and exploiting the modification direction.Through simulation and test results,it has been observed that the proposed methodology achieves secure steganography and superior visual quality.During the experiments,we observed that for the secret image of the cameraman,the PSNR&MSE values of the proposed technique are 61.963895 and 0.041361,respectively. | Sachin Dhawan Hemanta Kumar Bhuyan Subhendu Kumar Pani Vinayakumar Ravi Rashmi Gupta Arun Rana Alanoud Al Mazroa | 2024 | Journal of Safety Science and Resilience2024，5，1： | 0 |
| 7 | E-voting system using cloud-based hybrid blockchain technology显示文摘With the invention of Internet-enabled devices,cloud and blockchain-based technologies,an online voting system can smoothly carry out election processes.During pandemic situations,citizens tend to develop panic about mass gatherings,which may influence the decrease in the number of votes.This urges a reliable,flexible,transparent,secure,and cost-effective voting system.The proposed online voting system using cloud-based hybrid blockchain technology eradicates the flaws that persist in the existing voting system,and it is carried out in three phases:the registration phase,vote casting phase and vote counting phase.A timestamp-based authentication protocol with digital signature validates voters and candidates during the registration and vote casting phases.Using smart contracts,third-party interventions are eliminated,and the transactions are secured in the blockchain network.Finally,to provide accurate voting results,the practical Byzantine fault tolerance(PBFT)consensus mechanism is adopted to ensure that the vote has not been modified or corrupted.Hence,the overall performance of the proposed system is significantly better than that of the existing system.Further performance was analyzed based on authentication delay,vote alteration,response time,and latency. | Beulah Jayakumari S Lilly Sheeba Maya Eapen Jani Anbarasi Vinayakumar Ravi A.Suganya Malathy Jawahar | 2024 | Journal of Safety Science and Resilience2024，5，1： | 0 |
| 8 | Non-typhoidal salmonella:an unusual cause of spontaneous bacterial peritonitis in decompensated cirrhosis显示文摘Salmonella typhimurium, a non-typhoidal salmonella, is an unusual cause of spontaneous bacterial peritonitis (SBP). It isusually reported in asymptomatic patients with normal or high ascitic fluid protein levels with underlying immunosuppression,as high opsonic activity in the ascitic fluid of these patients protects them from the usual organisms causingspontaneous bacterial peritonitis, unless they are exposed to a particularly virulent organism like salmonella. We report acase of culture-proven non-typhoidal salmonella in a patient with decompensated cirrhosis, with low protein and withoutany underlying immunosuppression, and no other source to explain its origin. | Tony Joseph Prasanth Sobhan Suthanu Bahuleyan Anil John Shanid Abdul Sathar Srijaya Sreesh Kattoor Ramakrishnan Vinayakumar | 2014 | Gastroenterology Report2014，2，3： | 0 |
| 9 | Multi-Criteria Fuzzy-Based Decision Making Algorithm to Optimize the VHO Performance in Hetnets显示文摘Despite the seemingly exponential growth of mobile and wireless communication,this same technology aims to offer uninterrupted access to different wireless systems like Radio Communication,Bluetooth,and Wi-Fi to achieve better network connection which in turn gives the best quality of service(QoS).Many analysts have established many handover decision systems(HDS)to enable assured continuous mobility between various radio access technologies.Unbrokenmobility is one of themost significant problems considered in wireless communication networks.Each application needs a distinct QoS,so the network choice may shift appropriately.To achieve this objective and to choose the finest networks,it is important to select a best decision making algorithm that chooses the most effective network for every application that the user requires,dependent on QoS measures.Therefore,the main goal of the proposed system is to provide an enhanced vertical handover(VHO)decision making programby using aMulti-CriteriaFuzzy-Based algorithm to choose the best network.Enhanced Multi-Criteria algorithms and a Fuzzy-Based algorithm is implemented successfully for optimal network selection and also to minimize the probability of false handover.Furthermore,a double packet buffer is utilized to decrease the packet loss by 1.5%and to reduce the number of handovers up to 50%compared to the existing systems.In addition,the network setup has an optimized mobilitymanagement system to supervise the movement of the mobile nodes. | A.Prithiviraj A.Maheswari D.Balamurugan Vinayakumar Ravi Moez Krichen Roobaea Alroobaea Saeed Rubaiee Sankar Sennan | 2022 | Computers, Materials & Continua2022，，1： | 0 |
| 10 | Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala,India显示文摘AIM:To molecularly characterize hepatitis B virus(HBV)isolates from Kerala and to relate them to the clinical manifestation of infection.METHODS:Sera and clinical data were collected from91 patients diagnosed with chronic HBV infection and HBV-related hepatocellular carcinoma(HCC).HBV from44 HCC,22 cirrhotic and 25 chronic hepatitis patients were genotyped by sequencing of the complete S region or by restriction fragment length polymorphism assays.The basic core promoter/precore region was sequenced.The complete surface DNA sequences were assembled and aligned manually,and then compared with the sequences of HBV of genotypes(A-J)from GenBank.The evolutionary history was inferred using the Neighbor-Joining method and the evolutionary distances computed using the Kimura 2-parameter method.Bootstrapping was performed using 1000 replicates.The TaqMan BS-1 probe was used to quantify HBV DNA at a lower detection limit of approximately20 IU/mL.Continuous variables were compared using an independent Student’s t test.Theχ2test or Fisher’s exact test was used to compare categorical variables.The differences were considered statistically significant at P<0.05.RESULTS:Irrespective of disease status,the predominant genotype was A(72%);95%belonging to subgenotype A1,followed by genotypes D(27%)and C(1%).HCC patients infected with subgenotype A1were significantly younger than those infected with D.Mutation A1762T/G1764A was significantly associated with HCC in both genotypes A and D.Mutation G1862T was more frequent in subgenotype A1(P<0.0001),and in combination with A1762T/G1764A,it was significantly associated with HBV from HCC patients.Mutation C1766T/T1768A was significantly associated with genotype A(P=0.05)and HCC(P=0.03).The preS2start codon M1T/I mutation was unique to genotype A strains(15.6%)from all disease groups and occurred at a higher frequency in isolates from HCC patients(P=0.076).A higher frequency of preS deletion mutants(33.3%)was observed in genotype A from HCC compared with non-HCC patients,but did not reach statistical significance.The preS2:F22L mutation was found in genotypes A and D.CONCLUSION:Kerala is the first Indian state in which subgenotype A1 has been found to predominate in liver disease patients who developed HCC at a relatively young age. | Deepak Gopalakrishnan Mark Keyter Kotacherry Trivikrama Shenoy Kondarappassery Balakumaran Leena Lakshmikanthan Thayumanavan Varghese Thomas KR Vinayakumar Charles Panackel Arun T Korah Ramesh Nair Anna Kramvis | 2013 | World Journal of Gastroenterology2013，19，48： | 0 |
| 11 | Analytical Comparison of Resource Search Algorithms in Non-DHT Mobile Peer-to-Peer Networks显示文摘One of the key challenges in ad-hoc networks is the resource discovery problem.How efciently&quickly the queried resource/object can be resolved in such a highly dynamic self-evolving network is the underlying question?Broadcasting is a basic technique in the Mobile Ad-hoc Networks(MANETs),and it refers to sending a packet from one node to every other node within the transmission range.Flooding is a type of broadcast where the received packet is retransmitted once by every node.The naive ooding technique oods the network with query messages,while the random walk scheme operates by contacting subsets of each node’s neighbors at every step,thereby restricting the search space.Many earlier works have mainly focused on the simulation-based analysis of ooding technique,and its variants,in a wired network scenario.Although,there have been some empirical studies in peer-to-peer(P2P)networks,the analytical results are still lacking,especially in the context of mobile P2P networks.In this article,we mathematically model different widely used existing search techniques,and compare with the proposed improved random walk method,a simple lightweight approach suitable for the non-DHT architecture.We provide analytical expressions to measure the performance of the different ooding-based search techniques,and our proposed technique.We analytically derive 3 relevant key performance measures,i.e.,the avg.number of steps needed to nd a resource,the probability of locating a resource,and the avg.number of messages generated during the entire search process. | Ajay Arunachalam Vinayakumar Ravi Moez Krichen Roobaea Alroobaea Jehad Saad Alqurni | 2021 | Computers, Materials & Continua2021，，7： | 0 |
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