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| 1 | 中国糖尿病:流行病学、基因易感性和个性化治疗的临床应用显示文摘近些年来,中国2型糖尿病患病率出现快速增长,这使得2型糖尿病已经成为了一个重要的公共卫生问题。和欧洲人相比,相中国2型糖尿病诊断患者年龄较小、且体重指数较低。为了今后预防和干预项目的实施,有必要对此现象进行深入研究。除环境因素外,基因对于2型糖尿病的发生和发展起到至关重要的作用。迄今为止已经被识别的2型糖尿病的易感基因位点达百余个。就个体而言,大多数2型糖尿病的基因变异效应量较小(每个危险等位基因增加10%~20%的2型糖尿病风险)。可以利用多个等位基因来计算遗传风险得分,进而预测2型糖尿病和识别高危人群。此外,预防2型糖尿病的并发症和死亡时应优先考虑个性化的药物治疗。本研究回顾了2型糖尿病基因病因学近期的流行病学研究趋势和进展情况,并对2型糖尿病个性化治疗进行了深入探讨。 | Hu C Jia W 姜莹莹(编译) | 2019 | 中华预防医学杂志2019，53，2： | 18 |
| 2 | Sol-gel derived HA/TiO_2 double coatings on Ti scaffolds for orthopaedic applications显示文摘Hydroxyapatite/titania (HA/TiO2) double layers were coated onto Ti scaffolds throughout for orthopaedic applications by sol-gel method. Differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and X-ray diffractometry (XRD) were used for the characterisation of the phase transformations of the dried gels and coated surface structures. Scanning electron microscope (SEM) equipped with energy dispersive spectrometry (EDS) was used for the observation and evaluation of the morphology and phases of the surface layers and for the assessment of the in vitro tests. The in vitro assessments were performed by soaking the HA/TiO2 double coated samples into the simulated body fluid (SBF) for various periods. The TiO2 dipping-coating method at a speed of 12 cm/min, followed by a heat treatment at 600 ℃ for 20 min. The HA la lyaeyre wr wasa ssu cbosaetqeude bnytl ya dipping-coated on the outer surface at the same speed and then heat-treated at difference temperatures. The results indicat that the HA phase begins to crystallize after a heat treatment at 560 ℃. The crystallinity increases obviously at 760 ℃. SEM observations find no delamination or crack at the interfaces of HA/TiO2 and TiO2/Ti. The HA/TiO2 coated Ti scaffolds displays excellent bone-like apatite forming ability when it is soaked into SBF. Ti scaffolds after HA/TiO2 double coatings can be anticipated as promising implant materials for orthopaedic | XU W HU W Y LI M H MA Q Q P. D. HODGSON WEN C E | 2006 | 中国有色金属学会会刊:英文版2006，16，B01： | 5 |
| 3 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 4 | Analytical study on possible self-excited oscillation in S-shaped regions of pump-turbines显示文摘 | Zhou J X Karney B W Hu M Xu J C | 2011 | Proceedings of the Institution of Mechanical Engineers2011，，8： | 2 |
| 5 | Natural Convective Boiling in Vertical Rectangular Narrow Channels 显示文摘 | Xia C Hu W Guo Z Y | 1996 | Experimental Thermal and Fluid Science1996，12，： | 2 |
| 6 | Does dying at home influence the good death of terminal cancer patients? 显示文摘 | Yao C A Hu W Y Lai Y F | 2007 | J Pain Symptom Manage2007，34，5： | 1 |
| 7 | Capacitive and textural characteristics of hydrous manganese oxide prepared by anodic deposition显示文摘 | HU C C TSOU T W | 2002 | Electrochem Acta2002，47，： | 1 |
| 8 | Inhibition of retroviral pathogenesis by RNA interference显示文摘 | Hu W Y Myers C P Kilzer J M | 2002 | Curr Biol2002，12，： | 1 |
| 9 | A novel and low-temperation hydrothermal synthesis of SnO2 nanorod显示文摘 | Guo C X Cao M H Hu C W | 2004 | Inorganic Chemistry Communication2004，7，： | 1 |
| 10 | Chemistry and physics in one dimension:synthesis and properties of nanowires and nanotubes显示文摘 | HU J ODOM T W LIEBER C M | 1999 | Acc Chem Res1999，32，： | 1 |
| 11 | Effects of Sericite Modified by Macromolecular Dispersant on the Thermal, Mechanical and Electrical Properties of the NR/SBR Composites显示文摘 | HU W Z RU X ZHANG Y C | 2011 | Journal of Macromolecular Science Part A-Pure and Applied Chemistry2011，48，11： | 1 |
| 12 | Hydroxyapatite/ti- tania sol-gel coatings on titanium-zirconium alloy for bi- omedical applications 显示文摘 | Wen C E Xu W Hu W Y | 2007 | Acta Biomaterialia2007，3，3： | 1 |
| 13 | Optimal diets for prevention of coro- nary heart disease 显示文摘 | HU F B WILLETT W C | 2002 | JAMA2002，288，20： | 1 |
| 14 | A homochiral porous metal-organic framework for highly enantioselective heterogeneous asymmetric catalysis显示文摘 | Wu C D Hu A Zhang L Lin W | | 0，，： | 1 |
| 15 | Conferring polytetrafluoroethylene micropowders with hydrophilicity using dopamine chemistry and the application as water-based lubricant additive显示文摘 | Zhang H Hu H Y Ye W C | 2011 | Journal of Applied Polymer Science2011，122，5： | 1 |
| 16 | Erectile function restoration after repair of resected cavernous nerves by adipose - derived stem cells combined with autologous vein graft in rats 显示文摘 | Ying C Hu W Cheng B | 2014 | Cell Mel Neurebio12014，34，3： | 1 |
| 17 | Embrittlement of T-200 Maraging Steel in a Hydrogen Sulfide Solution显示文摘 | TSAY L W HU Y F CHEN C | 2005 | Corro- sion Science2005，47，4： | 1 |
| 18 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 19 | A rotationally invariant two- phasescheme for corner detection 显示文摘 | Hsin-teng Hu W C | 1996 | Pattern Recognition1996，28，5： | 1 |
| 20 | Ideal capacitive behavior of hydrous manganese oxide prepared by anodie deposition显示文摘 | HU C C TSOU T W | 2002 | Electrochem Commun2002，4，： | 1 |
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