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| 1 | Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases显示文摘AIM: To evaluate and compare the expression profiles of CXCL12 (SDF-1), CCL19 (MIP-3β), CCL20 (MIP-3α) and CCL21 (6Ckine, Exodus2) and their receptors on RNA and protein levels in hepatocellular carcinoma (HCC) versus colorectal liver metastases (CRLM) and to elucidate their impact on the carcinogenesis and progression of malignant liver diseases. METHODS: Chemokine expression was analyzed by RT-PCR and ELISA in 11 cases of HCC specimens and in 23 cases of CRLM and corresponding adjacent non- tumorous liver tissues, respectively. Expressions of their receptors CXCR4, CCR6 and CCR7 were analyzed by RT- PCR and Western blot analysis in the same cases of HCC and CRLM. RESULTS: Significant up-regulation for CCL20/CCR6 was detected in both cancer types. Moreover, CCL20 demonstrated significant overexpression in CRLM in relation to the HCC tissues. Being significantly up- regulated only in CRLM, CXCR4 displayed an aberrant expression pattern with respect to the HCC tissues. CONCLUSION: Correlation of CXCR4 expression with CRLM suggests CXCR4 as a potential predictive factor for CRLM. High level expression of CCL20 and its receptor CCR6 in HCC and CRLM with marked up- regulation of CCL20 in CRLM in relation to HCC tissues indicates involvement of the CCL20/CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies. | Claudia Rubie Vilma Oliveira Frick Mathias Wagner Christina Weber Bianca Kruse Katja Kempf Jochen Knig Bettina Rau Martin Schilling | 2006 | World Journal of Gastroenterology2006，12，41： | 24 |
| 2 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 3 | Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases显示文摘AIM:To evaluate the influence of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in liver metastases of stage Ⅳ colorectal cancer(CRC) patients.METHODS:Using Real Time-PCR,enzyme-linked immunosorbent assay,Western Blots and immunohistochemistry,we have analyzed the expression of CCL20,CCR6 and proliferation marker Ki-67 in colorectal liver metastasis(CRLM) specimens from stage Ⅳ CRC patients who received preoperative FOLFOX chemotherapy(n = 53) and in patients who did not receive FOLFOX chemotherapy prior to liver surgery(n = 29).RESULTS:Of the 53 patients who received FOLFOX,time to liver surgery was ≤ 1 mo in 14 patients,≤ 1 year in 22 patients and > 1 year in 17 patients,respectively.In addition,we investigated the proliferation rate of CRC cells in liver metastases in the different patient groups.Both CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy ≤ 12 mo before liver surgery(P < 0.001) in comparison to patients who did not undergo FOLFOX treatment.Further,proliferation of CRLM cells as measured by Ki-67 was increased in patients who underwent FOLFOX treatment.CCL20 and CCR6 expression levels were significantly increased in CRLM patients who had undergone preoperative FOLFOX chemotherapy.CONCLUSION:This chemokine/receptor up-regulation could lead to increased proliferation/migration through an autocrine mechanism which might be used by surviving metastatic cells to escape cell death caused by FOLFOX. | Claudia Rubie Vilma Oliveira Frick Pirus Ghadjar Mathias Wagner Christoph Justinger Stefan Graeber Jens Sperling Otto Kollmar Martin K Schilling | 2011 | World Journal of Gastroenterology2011，17，26： | 5 |
| 4 | Engineering Improved Photosynthesis in the Era of Synthetic Biology显示文摘Much attention has been given to the enhancement of photosynthesis as a strategy for the optimization of crop productivity.As traditional plant breeding is most likely reaching a plateau,there is a timely need to accelerate improvements in photosynthetic efficiency by means of novel tools and biotechnological solutions.The emerging field of synthetic biology offers the potential for building completely novel pathways in predictable directions and,thus,addresses the global requirements for higher yields expected to occur in the 21st century.Here,we discuss recent advances and current challenges of engineering improved photosynthesis in the era of synthetic biology toward optimized utilization of solar energy and carbon sources to optimize the production of food,fiber,and fuel. | Willian Batista-Silva Paula da Fonseca-Pereira Auxiliadora Oliveira Martins Agustin Zsogon Adriano Nunes-Nesi Wagner L.Araujo | 2020 | Plant Communications2020，1，2： | 2 |
| 5 | Inflammation and Carotid Artery—Risk for Atherosclerosis Study (ICARAS)显示文摘 | Martin Schillinger Markus Exner Wolfgang Mlekusch Schila Sabeti Jasmin Amighi Robert Nikowitsch Ewald Timmel Bernhard Kickinger Christoph Minar Matthias Pones Wolfgang Lalouschek Helmut Rumpold Gerald Maurer Oswald Wagner Erich Minar | 2005 | Circulation2005，，17： | 2 |
| 6 | Hepatoid adenocarcinoma of the transverse colon显示文摘 | Jan Slotta Bernd Jüngling Yoo Kim Mathias Wagner Dorian Igna Martin Schilling | 2012 | International Journal of Colorectal Disease2012，，7： | 2 |
| 7 | Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 ( Abcb4 ) knockout mice显示文摘 | Peter Fickert Andrea Fuchsbichler Martin Wagner Gernot Zollner Arthur Kaser Herbert Tilg Robert Krause Frank Lammert Cord Langner Kurt Zatloukal Hanns-Ulrich Marschall Helmut Denk Michael Trauner | 2004 | Gastroenterology2004，，1： | 1 |
| 8 | Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging显示文摘 | Hannes G. Kenngott Martin Wagner Matthias Gondan Felix Nickel Marco Nolden Andreas Fetzer Jürgen Weitz Lars Fischer Stefanie Speidel Hans-Peter Meinzer Dittmar B?ckler Markus W. Büchler Beat P. Müller-Stich | 2014 | Surgical Endoscopy2014，，3： | 1 |
| 9 | Delayed postischmic hyporthemia improves long-term behavioral outcome after cerebral hypoxia-is- chemia in neonatal rats显示文摘 | Wagner BP Nedelcu J Martin E | 2002 | Pediatric Res2002，51，3： | 1 |
| 10 | Gastrectomy with isoperistaltic jejunal parallel pouch in a 15-year-old adolescent boy with gastric adenocarcinoma and autosomal recessive agammaglobulinemia显示文摘 | Jan E. Slotta Sabine Heine Anne Kauffels Thomas Krenn Frank Grünhage Mathias Wagner Norbert Graf Martin K. Schilling Jochen Schuld | 2011 | Journal of Pediatric Surgery2011，，9： | 1 |
| 11 | Maize Carbohydrate Partitioning Defective33 Encodes an MCTP Protein and Functions in Sucrose Export from Leaves显示文摘To sustain plant growth,development,and crop yield,sucrose must be transported from leaves to distant parts of the plant,such as seeds and roots.To identify genes that regulate sucrose accumulation and transport in maize(Zea mays),we isolated carbo/iydrafe part/f/ofi/ngf defecf/Ve33(cpd33),a recessive mutant that accumulated excess starch and soluble sugars in mature leaves.The cpd33 mutants also exhibited chlorosis in the leaf blades,greatly diminished plant growth,and reduced fertility.Cpd33 encodes a protein containing multiple C2 domains and transmembrane regions.Subcellular localization experiments showed the CPD33 protein localized to plasmodesmata(PD),the plasma membrane,and the endoplasmic reticulum.We also found that a loss-of-function mutant of the CPD33 homolog in Arabidopsis,QUIRKY,had a similar carbohydrate hyperaccumulation phenotype.Radioactively labeled sucrose transport assays showed that sucrose export was significantly lower in cpd33 mutant leaves relative to wild-type leaves.However,PD transport in the adaxial-abaxial direction was unaffected in cpd33 mutant leaves.Intriguingly,transmission electron microscopy revealed fewer PD at the companion cell-sieve element interface in mutant phloem tissue,providing a possible explanation for the reduced sucrose export in mutant leaves.Collectively,our results suggest that CPD33 functions to promote symplastic transport into sieve elements. | Thu M.Tran Tyler J.McCubbin Saadia Bihmidine Benjamin T.Julius R.Frank Baker Martin Schauflinger Clifford Weil Nathan Springer Paul Chomet Ruth Wagner Jeff Woessner Karen Grote Jeanette Peevers Thomas L.Slewinski David M.Braun | 2019 | Molecular Plant2019，12，9： | 1 |
| 12 | Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer via Gata6- Dependent Dedifferentiation of Acinar Cells in Mice显示文摘 | Patrick C. Hermann Patricia Sancho Marta Ca?amero Paola Martinelli Francesc Madriles Patrick Michl Thomas Gress Ricardo de Pascual Luis Gandia Carmen Guerra Mariano Barbacid Martin Wagner Catarina R. Vieira Alexandra Aicher Francisco X. Real Bruno Sainz C | 2014 | Gastroenterology2014，，： | 1 |
| 13 | Applications of geochemical, and remote sensing methods to exploration, field development, and production 显示文摘 | WAGNER MANFRED WAGNER MARTIN PISKE JOACHIM | | Surface Exploration Case0，，： | 1 |
| 14 | Lovastatin induces VSMC differentiation through inhibition of Rheb and roTOR显示文摘 | WAGNER R J MARTIN K A POWELL R J | 2010 | Am J Physiol Cell Physiol2010，299，1： | 1 |
| 15 | The Carbon Kuznets Curve: A Cloudy Picture Emitted by Bad Econometrics? 显示文摘 | Martin Wagner | 2008 | Resource and Energy Economics2008，30，3： | 1 |
| 16 | Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration显示文摘 | Andreas Geier Martin Wagner Christoph G. Dietrich Michael Trauner | 2006 | BBA - Molecular Cell Research2006，，3： | 1 |
| 17 | E-valuation of pyrimidine metabolising enzymes and in vitro uptake of 3- fluoro-3-deoxythymidine ( FLT) in pancreatic cancer cell lines显示文摘 | Seitzl Ulrike Wagner Martin Neumaierl Bernd | 2002 | Ew Nuc Med2002，29，9： | 1 |
| 18 | Antiulcerogenic activity of Alchornea castaneaefolia : Effects on somatostatin, gastrin and prostaglandin显示文摘 | Clélia Akiko Hiruma-Lima Tamara Roberta Calvo Clenilson Martins Rodrigues Fábio Donizete Pezzuto Andrade Wagner Vilegas Alba Regina Monteiro Souza Brito | 2005 | Journal of Ethnopharmacology2005，，1： | 1 |
| 19 | Enhanced ENA-78 and IL-8 Expression in Patients with Malignant Pancreatic Diseases显示文摘 | Vilma Oliveira Frick Claudia Rubie Mathias Wagner Stefan Graeber Henner Grimm Berit Kopp Bettina M. Rau Martin K. Schilling | 2008 | Pancreatology . 2008 (4-5)2008，，4： | 1 |
| 20 | Hepatic artery embolization for treatment of patients with hereditary hemorrhagic telangiectasia and symptomatic hepatic vascular malformations显示文摘 | Ajay Chavan Martin Caselitz Karl-Friedrich Gratz Joachim Lotz Timm Kirchhoff Plinio Piso Siegfried Wagner Michael Manns Michael Galanski | 2004 | European Radiology2004，，11： | 1 |
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