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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Role of the endothelium in inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBD) are a complex group of diseases involving alterations in mucosal immunity and gastrointestinal physiology during both initiation and progressive phases of the disease.At the core of these alterations are endothelial cells,whose continual adjustments in structure and function coordinate vascular supply,immune cell emigration,and regulation of the tissue environment.Expansion of the endothelium in IBD(angiogenesis),mediated by inflammatory growth factors,cytokines and chemokines,is a hallmark of active gut disease and is closely related to disease severity.The endothelium in newly formed or inflamed vessels differs from that in normal vessels in the production of and response to inflammatory cytokines,growth factors,and adhesion molecules,altering coagulant capacity,barrier function and blood cell recruitment in injury.This review examines the roles of the endothelium in the initiation and propagation of IBD pathology and distinctive features of the intestinal endothelium contributing to these conditions. | Walter E Cromer J Michael Mathis Daniel N Granger Ganta V Chaitanya J Steven Alexander | 2011 | World Journal of Gastroenterology2011，17，5： | 10 |
| 3 | The Treatment-Naive Microbiome in New-Onset Crohn’s Disease显示文摘 | Dirk Gevers Subra Kugathasan Lee A. Denson Yoshiki Vázquez-Baeza Will Van Treuren Boyu Ren Emma Schwager Dan Knights Se Jin Song Moran Yassour Xochitl C. Morgan Aleksandar D. Kostic Chengwei Luo Antonio González Daniel McDonald Yael Haberman Thomas Walter | 2014 | Cell Host & Microbe2014，，： | 3 |
| 4 | Liver myofibroblasts activate protein C and respond to activated protein C显示文摘AIM:To study the protein C activation system in human liver myofibroblasts,and the effects of activated protein C(APC)on these cells.METHODS:Human liver myofibroblasts were obtained by outgrowth.Expression of protease activated receptor 1(PAR-1),endothelial protein C receptor(EPCR) and thrombomodulin(TM)was analyzed by flow cytometry.Extracellular signal-regulated kinase(ERK)1/2 activation was assessed by Western blotting using anti-phospho-ERK antibodies.Collagen synthesis was studied with real-time reverse transcription-polymerase chain reaction(RT-PCR).Activation of protein C was studied by incubating liver myofibroblasts with zymogen protein C in the presence of thrombin and detecting the generation of APC with a colorimetric assay using a peptide substrate. RESULTS:Primary cultures of human liver myofibroblasts expressed EPCR on their surface,together with PAR-1 and TM.This receptor system was functional since exposure of myofibroblasts to APC inducedERK1/2 phosphorylation in a dose-and time-dependent manner.Furthermore,APC significantly upregulated the expression of collagen mRNA,as shown by real-time RT-PCR.Collagen upregulation was controlled through the ERK pathway as it was inhibited when using the mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor PD98059.Finally,using a cell-based colorimetric assay,we showed that intact myofibroblasts converted protein C into APC in the presence of thrombin.CONCLUSION:These data suggest that APC is a new modulator of liver myofibroblast activity and contributes to the pathophysiology of chronic liver diseases. | Jennifer Gillibert-Duplantier Anne Rullier Véronique Neaud Walter Kisiel Jean Rosenbaum | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 5 | Matching Spatial Data Sets: a Statistical Approach显示文摘 | Walter V | 1999 | International Journal for Geographical Information Science1999，13，5： | 1 |
| 6 | Ecopath with Ecosim:Methods,capabilities and limitations显示文摘 | Christensen V Walters C J | 2004 | Ecological Modelling2004，172，： | 1 |
| 7 | Regulation of the promoters and transcripts of rpoH,the Escherichia coli heat shock regulatory gene显示文摘 | Erickson JW Vaughn V Walter WA | 1987 | Genes Sc Development1987，1，5： | 1 |
| 8 | Relationship between instrumental and sensory parameters of cooked sweet potato texture显示文摘 | TRUONG V D WALTER W M HAMANN D D | | 0，，02： | 1 |
| 9 | A siliconbased electrical source of surface plasmon polaritons显示文摘 | Walters RJ van Loon R V A Brunets I | 2009 | Nature Materials2009，，： | 1 |
| 10 | Soil carbon storage prediction in temperate hydromorphic soils by using morphologic index and digital elevation model显示文摘 | Chaplot V Bemoux M Walter C | 2001 | Soil Sci2001，102，： | 1 |
| 11 | Object - based classification of remote sensing data for change detection 显示文摘 | Walter V | 2004 | ISPRS - Journal of Photogrammetry and Re- mote Sensing2004，58，3： | 1 |
| 12 | Synovial tissue of the hip at power Doppler US:correlation between vascularity and power Doppler US signal显示文摘 | Walter M Harms H Krenn V | 2002 | Radiology2002，225，1： | 1 |
| 13 | Effect of Trannsmitter Turn-off Time on Transient Soundings显示文摘 | Fitterman D Walter V Anderson L | 1987 | Geosounding1987，24，： | 1 |
| 14 | Effect of stain therapy on restenosis after coronary stent implantation 显示文摘 | Walter DH Schachinger V Elsner M | 2000 | Am J Cardiol2000，85，： | 1 |
| 15 | Conservation of methylation reprogramming in mammalian development:aberrant reprogramming in cloned embryos显示文摘 | Dean W Santos F Stojkovic M Zakhartchenko V Walter J Wolf E Reik W | 2001 | Proceedings of the National Academy of Sciences2001，98，13： | 1 |
| 16 | Platelet glycoprotein Ⅲa polymorphisms and risk of coronary stent thrombosis显示文摘 | Schachinger V Elsner M | 1997 | Lancet1997，350，： | 1 |
| 17 | Segregation and linkage of several genes in cucumber显示文摘 | Walters S A Shetty N V Wehner T C | 2001 | Journal of the American Society for Horticultural Science2001，126，4： | 1 |
| 18 | Climatic adapta- tions in arctic and tropical poikilotherms 显示文摘 | Scholander P F Flagg W Walter V | 1953 | Physiological Zoolo Aw1953，26，： | 1 |
| 19 | Fe^ 2+ induces a transient Ca^2+ release from rat liver mitoehondria显示文摘 | Gogvadze V Walter PB Ames BN | 2002 | Arch Biochem Biophys2002，398，2： | 1 |
| 20 | Predictors of pneumonia in acute stroke patients admitted to a neurological inten- sive care unit显示文摘 | Walter U Knoblich R Steinhagen V | 2007 | J Neurol2007，254，10： | 1 |
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