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| 1 | Unsteady flow structures in the tip region for a centrifugal compressor impeller before rotating stall显示文摘To get an insight into the occurrence and the mechanism of flow unsteadiness in the tip region of centrifugal compressor impellers, the flow in Krain’s impeller is investigated by using both steady and unsteady RANS solver techniques. It is found that the flow unsteadiness on the pressure side is much stronger than that on the suction side. The periodical frequency of the unsteady flow is around half of the blade passing frequency. The originating mechanism of the flow unsteadiness is illustrated with the time-dependent tip leakage flow and blade loading at the tip region. Due to the blockage caused by the joint effects of broken-downed tip leakage vortex, separated fluids and tip leakage flow at downstream, a low pressure region is formed on the pressure side, consequently the blade loadings is altered. In turn, the changed blade loadings will alter the intensity of tip leakage flow. Such alternative behavior finally results in the periodic process. By comparing the calculated flow field in the cases of single-passage and four-passage models, it is confirmed that the investigated flow unsteadiness is confined in each single passage, as no phase differences are found in the model of four passages. This is different from the situation in axial compressor when the rotating instability is encountered. The flow unsteadiness only occurs at the working conditions with small mass flow rates, and the oscillation intensity will be enhanced with the decrease of mass flow rate. When the mass flow rate is too small, the flow unsteadiness in a single passage may trigger rotating stall, as the disturbance propagates in the circumferential direction. | ZHAO HuiJing WANG ZhiHeng XI Guang | 2017 | Science China(Technological Sciences)2017，60，6： | 9 |
| 2 | Component characteristics of organic matter in hydrothermal barnacle shells from Southwest Indian Ridge显示文摘In 2008–2009,hydrothermal barnacle and sediment samples were collected from the Southwest Indian Ridge during a survey of the China Ocean Mineral Resources R&D Association(COMRA).Samples were analyzed by gas chromatography-mass spectrometer(GC-MS),revealing the main organic constituents of hydrothermal barnacle and sediment to be fatty acids and alkylbenzenes.N-alkanes which possessed obvious even carbon advantage were also detected in hydrothermal sediment.The high concentrations of aromatic compounds might be the result of macromolecular thermal alteration.Microorganism in the submarine hydrothermal ecosystem,especially those related to sulfur metabolism,might be the source of the high concentrations of fatty acids detected in these samples.In high temperature and high pressure hydrothermal environments,n-alkanes which possessed obvious even carbon advantage might originate from thermal alteration of carboxylic acids and other lipid compounds. | HUANG Xin ZENG Zhigang CHEN Shuai YIN Xuebo WANG Xiaoyuan ZHAO Huijing YANG Baoju RONG Kunbo MA Yao | 2013 | Acta Oceanologica Sinica2013，32，12： | 6 |
| 3 | The existence theorem of absolute equilibrium about games on connected graph with state payoff vector显示文摘By introducing state payoff vector to every state node on the connected graph in this paper,dynamic game is researched on finite graphs.The concept of simple strategy about games on graph defined by Berge is introduced to prove the existence theorem of absolute equilibrium about games on the connected graph with state payoff vector.The complete algorithm and an example in the three-dimensional connected mesh-like graph are given in this paper. | GAO HongWei,YANG HuiJing,WANG GuiXi & YU Kun College of Mathematics,Qingdao University,Qingdao 266071,China | 2010 | Science China Mathematics2010，53，6： | 5 |
| 4 | DC-CIK联合化疗治疗非小细胞肺癌的临床疗效评价(英文)显示文摘Objective: The aim of the study was to evaluate the safety and therapeutic effects of autologous dendritic cells co-cultured with cytokine-induced killer cells (DC-CIK) combined with chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Methods: Fifty patients with advanced NSCLC (stages III to IV), who had received therapies in our Center (Department of Biotherapy, Affiliated to Cancer Hospital of Shanxi Medical University, Taiyuan, China) from August 2008 to January 2010, were treated by DC-CIK + chemotherapy as the combined treatment group; fifty advanced NSCLC patients treated with chemotherapy at the same time served as controls. The immunologic function, short-term therapeutic effects, the 1-year survival rate, the life quality, the chemotherapy side effects were compared between the two groups, the safety and therapeutic effects of DC-CIK cells therapy were observed too. Results: There was no obvious change of subsets of T cells in peripheral blood before and after therapy in DC-CIK + chemotherapy group, and IFN-γ was improved after therapy in this group (P < 0.05); in chemotherapy alone group, the ratios of CD3+CD4+, CD3+CD8+, CD3-CD56+ cells and the secretion of IL-2, TNF-α decreased significantly after therapy (P < 0.05); the ratios of CD3+CD8+, CD3+CD56+ were improved after cell culture (P < 0.05). The disease control rate (DCR) of DC-CIK + chemotherapy group was higher than that in the chemotherapy alone group (78.0% vs 56.0%, P < 0.05); the 1-year survival rates of DC-CIK + chemotherapy group and chemotherapy alone group were 50% and 44% respectively, had no significant difference. Compared with chemotherapy alone group, the occurrence of chemotherapy side effects (including bone marrow suppression, nausea and vomiting, peripheral nerve toxicity) was less in the DC-CIK + chemotherapy group (P < 0.05). The physical and appetite were better in DC-CIK + chemotherapy group after therapy. Conclusion: To compare with simple chemotherapy, DC-CIK + chemotherapy for advanced NSCLC is safe and effective, and it can improve patients' life quality and remission rate, and prolong their survival time. | Junping Zhang Guanghua Mao Yaping Han Xiaoling Yang Huijing Feng Linzi Jia Ting Zhi Yan Xiao Libin Zhang Jiangtao Wang Tianliang Shi | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，2： | 3 |
| 5 | Silica Nanoparticles-mediated Stable Genetic Transformation in Nicotiana tabacum显示文摘 | FU Yuqin LI Luhua WANG Hui JIANG Yuan LIU Huijing CUI Xiyan WANG Piwu LU Changli | 2015 | Chemical Research in Chinese Universities2015，31，6： | 3 |
| 6 | Kidney injury molecule-1 is a potential receptor for SARS-CoV-2显示文摘COVID-19 patients present high incidence of kidney abnormalities,which are associated with poor prognosis and mortality.The identification of SARS-CoV-2 in the kidney of COVID-19 patients suggests renal tropism of SARS-CoV-2.However,whether there is a specific target of SARS-CoV-2 in the kidney remains unclear.Herein,by using in silico simulation,coimmunoprecipitation,fluorescence resonance energy transfer,fluorescein isothiocyanate labeling,and rational design of antagonist peptides,we demonstrate that kidney injury molecule-1(KIM1),a molecule dramatically upregulated upon kidney injury,binds with the receptor-binding domain(RBD)of SARS-CoV-2 and facilitates its attachment to cell membrane,with the immunoglobulin variable Ig-like(Ig V)domain of KIM1 playing a key role in this recognition.The interaction between SARS-CoV-2 RBD and KIM1 is potently blockaded by a rationally designed KIM1-derived polypeptide AP2.In addition,our results also suggest interactions between KIM1 Ig V domain and the RBDs of SARS-CoV and MERS-CoV,pathogens of two severe infectious respiratory diseases.Together,these findings suggest KIM1 as a novel receptor for SARS-CoV-2 and other coronaviruses.We propose that KIM1 may thus mediate and exacerbate the renal infection of SARS-CoV-2 in a‘vicious cycle’,and KIM1 could be further explored as a therapeutic target. | Chen Yang Yu Zhang Xia Zeng Huijing Chen Dong Yang Yuchen Chen Ziwei Shen Xiaomu Wang Xinran Liu Mingrui Xiong Hong Chen Kun Huang | 2021 | Journal of Molecular Cell Biology2021，13，3： | 2 |
| 7 | Effects of psycho-scene-drama on empathic ability of patients with chronic schizophrenia显示文摘Objective:The purpose of the current study was to determine the effects of psycho-scene drama on the empathic ability of patients with chronic schizophrenia.Methods:One hundred sixteen in-patients with chronic schizophrenia were randomly di-vided into study and control groups(n=58 cases each).The original anti-psychotic drugs were not changed in either group.In the study group,the therapy was combined with psychological scene drama with a treatment course of 3 months.Before and after treatment,the interpersonal reaction index scale(Chinese version[IRI-C]),negative syndrome scale(SANS),social function assessment scale for patients with mental diseases(SSPI),Rosenberg self-esteem scale(SES),the emotional-social loneliness inventory(ESLI),and the Texas social behavior inventory(TSBI)were utilized for measurements.Results:A comparison of the IRI-C total,PT,FS,and EC factor scores before and after treatment in the study group was significantly different(P<0.01);the PD factor score before and after treatment was not statistically significant(P>0.05).A comparison of the IRI-C total score and each factor score before and after treatment in the control group was not significantly different(P>0.05).A comparison of the IRI-C total,PT,and EC factor scores between the study and control groups after treatment was significantly different(P<0.05).A comparison of the FS factor score between the study and control groups before and after treatment was significantly different(P<0.01);the PD factor score was not significantly different(P>0.05).A comparison of the SANS total,SSPI total,SES total,and ESLI total scores between the two groups after treatment was significantly different(P<0.05).Conclusion:The psycho-scene drama can improve the empathic ability of patients with chronic schizophrenia,improve the negative symptoms and social function,increase the self-esteem and self-confidence,and reduce the loneliness in social interactions. | Hongmei Tian Weifang Niu Ping Liu Na Wang Huijing Yu Zhanhong Zhao | 2014 | Family Medicine and Community Health2014，2，4： | 2 |
| 8 | Generating Giant Membrane Vesicles from Live Cells with Preserved Cellular Properties显示文摘Biomimetic giant membrane vesicles,with size and lipid compositions comparable to cells,have been recognized as an attractive experimental alternative to living systems.Due to the similarity of their membrane structure to that of body cells,cell-derived giant plasma membrane vesicles have been used as a membrane model for studying lipid/protein behavior of plasma membranes.However,further application of biomimetic giant membrane vesicles has been hampered by the side-efects of chemical vesiculants and the utilization of osmotic bufer.We herein develop a facile strategy to derive giant membrane vesicles(GMVs)from mammalian cells in biofriendly medium with high yields.Tese GMVs preserve membrane properties and adaptability for surface modifcation and encapsulation of exogenous molecules,which would facilitate their potential biological applications.Moreover,by loading GMVs with therapeutic drugs,GMVs could be employed for drug transport to tumor cells,which represents another step forward in the biomedical application of giant membrane vesicles.Tis study highlights biocompatible GMVs with biomimicking membrane surface properties and adaptability as an ideal platform for drug delivery strategies with potential clinical applications. | Qiaoling Liu Cheng Bi Jiangling Li Xuejiao Liu Ruizi Peng Cheng Jin Yang Sun Yifan Lyu Hui Liu Huijing Wang Can Luo Weihong Tan | 2019 | Research2019，，1： | 2 |
| 9 | Bifunctional copper modified graphitic carbon nitride catalysts for efficient tetracycline removal:Synergy of adsorption and photocatalytic degradation显示文摘In order to efficiently re move tetracycline in wastewater through the synergistic effect of adsorption and photocatalytic degradatio n,a series of novel composite materials(Cu doped g-C_(3)N_(4))were synthesized by two-pot hydrothermal method.It was found that the composite materials with optimized ratio(Cu/CN-1)displayed outstanding adsorption and photocatalytic performance as compared with pure g-C_(3)N_(4) photocatalyst.The removal efficiency of tetracycline(TC,50 mg/L)reached almost 99%within 30 min by Cu/CN-1 through the synergy of adsorption and photocatalysis under visible-light irradiation,which was the highest re moval efficiency ever reported.The adsorption kinetics and isotherms of TC on the Cu/CN-1 were well fitted with the pseudo-second-order kinetic model and Langmuir model,respectively.Moreover,it was confirmed that the main effective reactive groups were O_(2)^·and h^(+) in photocatalytic process.The Cu/CN-1 exhibited high stability and excellent reusability after five cycle experiments.Finally,the mechanism of synergy between Cu and g-C_(3)N_(4) was proposed:on the one hand,the decoration of Cu particles significantly increased the adsorption sites of Cu/CN-1 to tetracycline,on the other hand,the modification of Cu particles effectively inhibits charge recombination and broadens the visible light absorption range of the photocatalyst.This study provided a promising photocatalyst to be used for TC removal in the actual wastewater. | Huijing Wang Jun Zhang Pu Wang Linlin Yin Yu Tian Junjing Li | 2020 | Chinese Chemical Letters2020，31，10： | 2 |
| 10 | Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57CDKN1C and TP53INP1 in mantle cell lymphoma显示文摘Objective: To explore the effect of dysregulation of epigenetic regulator EZH1 and EZH2 on the proliferation in MCL and the underlying mechanisms.Methods: In this study, we elucidated the role of EZH1 and EZH2 overexpression by immunohistochemistry and correlated them to clinical outcome in 41 MCL patients.Quantitative real-time PCR and Western blot were applied to confirm the level of EZH1 and EZH2 in well-characterized MCL cell lines which were compared to those of na?ve B cells.Then we manipulated the expression of EZH1 and EZH2 in MCL cells using CRISPR/Cas9 system to directly investigate their functional roles in MCL.We also evaluated the effect of two small molecule selective inhibitors, EPZ005687 and UNC1999, on MCL cell proliferation, cell cycle distribution and apoptosis in vitro.Finally, we performed RNA-sequencing(RNA-Seq) and Chromatin immunoprecipitation(ChIP) assay to further gain insight into the underlying molecular mechanisms.Results: We found that EZH2 protein is overexpressed in approximately half of this cohort of MCL cases.More importantly, the overexpression of EZH2 is associated with poor OS in the patients.Nevertheless, simple EZH2 depletion in vitro has little impact on the viability of MCL cells, predominantly because of the consequent up-regulation of EZH1.Consistently, UNC1999, a dual EZH1/2 inhibitor, unlike the EZH2 selective inhibitor EPZ005687, exerts a potent inhibitory effect on MCL cells.Furthermore, we discover CDKN1C and TP53 INP1 as the two important cell cycle regulators, the expression of which are repressed by EZH1/2 mediated epigenetic regulation and are restored by EZH1/2 dual inhibition.Conclusions: Our study suggests that EZH2 participates in the pathogenesis of MCL which may serve as a potential biomarker for prognosis prediction.The dual inhibition of EZH1/2 is a promising therapeutic strategy for MCL. | Wei Li Chengfeng Bi Yating Han Tian Tian Xianhuo Wang Huijing Bao Xiaoying Xu Xuhan Zhang Lu Liu Weiwei Zhang Hai Gao Huaqing Wang Huilai Zhang Bin Meng Xi Wang Kai Fu | 2019 | Cancer Biology & Medicine2019，16，3： | 2 |
| 11 | A Study of Configuration Evolution of an Operational IP Backbone Network显示文摘Configuration errors are proved to be the main reasons for network interruption and anomalies.Many researchers have paid their attention to configuration analysis and provisioning,but few works focus on understanding the configuration evolution.In this paper,we uncover the configuration evolution of an operational IP backbone based on the weekly reports gathered from January 2006 to January 2013.We find that rate limiting and launching routes for new customers are configured most frequently.In addition,we conduct an analysis of network failures and find that link failures are the main causes for network failures.We suggest that we should configure redundant links for the links which are easy to break down.At last,according to the analysis results,we illustrate how to provide semi-automated configuration for rate limiting and adding customers. | Fuliang Li Jiahai Yang Huijing Zhang Xingwei Wang Suogang Li Jianping Wu | 2017 | China Communications2017，14，6： | 1 |
| 12 | Retrieval of two-dimensional self-couple harmonics in non-zero mean multiplicative noise 显示文摘 | WANG Fei WANG Shuxun DOU Huijing | 2002 | Journal of Jilin University (Information Science Edition)2002，20，2： | 1 |
| 13 | The mathematical model for evaluating fatigue resistance of SG tubular fabric: relationship between textile parameters and fatigue performance 显示文摘 | Huijing Z Wang L Li Y L | 2010 | Journal of Biomaterials Applications2010，24，7： | 1 |
| 14 | The mathematical model for evaluating fatigue resistance of SG tubular fabric:relationship between textile parameters and fatigue performance显示文摘 | Zhao Huijing Wang Lu Li Yuling | 2010 | Journal of Biomaterials Applications2010，24，7： | 1 |
| 15 | n-Mn02 Nanowires as Building Blocks for the Construction of 3D Macro-Assemblies显示文摘 | Long Y HuiJ F Wang P P | 2012 | Sensors and Actuators B2012，48，： | 1 |
| 16 | EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via STAT3-mediated transcription显示文摘TSPAN family of protei ns are gen erally con sidered to assemble as multimeric complexes on the plasma membra ne.Our previous work uncovered that TSPAN8 can translocate into the nucleus as a membrane-free form,a process that requires TSPAN8 palmitoylation and association with cholesterol to promote its extraction from the plasma membrane and subsequent binding with 14-3-30 and importin-p.However,what upstream signal(S)regulate(s)the nuclear translocation of TSPAN8,the potential function of TSPAN8 in the n ucleus,and the un derlying molecular mechanisms all remai n unclear.Here,we dem on strate that,epidermal growth factor receptor(EGFR)signaling induces TSPAN8 nuclear translocation by activating the kinase AKTZ which in turn directly phosphorylates TSPAN8 at Ser129,an event essential for its binding with 14-3-30 and importin B1.In the nucleus,phosphorylated TSPAN8 interacts with STAT3 to enhance its chromatin occupancy and therefore regulates transcription of downstream cancer-promoting genes,such as MYC,BCL2,MMP9,etc.The EGFR-AKT-TSPAN8-STAT3 axis was found to be hyperactivated in multiple human cancers,and associated with aggressive phe no type and dismal prog nosis.We further developed a humanized mono clonal antibody hT8Ab4 that specifically recognizes the large extracellular loop of TSPAN8(TSPAN8-LEL),thus being able to block the extract!on of TSPAN8 from the plasma membrane and consequently its nuclear localization.Importantly,both in vitro and in vivo studies demonstrated an antitumor effect of hT8Ab4.Collectively,we discovered an unconventional function of TSPAN8 and dissected the underlying molecular mechanisms,which not only showcase a new layer of biological complexity of traditional membrane proteins,but also shed light on TSPAN8 as a novel therapeutic target for refractory cancers. | Xiaoqing Lu Liwei An Guangjian Fan Lijuan Zang Weiyi Huang Junjian Li Jun Liu Weiyu Ge Yuwei Huang Jingxuan Xu Shaoqian Du Tianhao Zhou Huijing Yin Li Yu Shi Jiao Hongxia Wang | 2022 | Cell Research2022，32，4： | 1 |
| 17 | THICKNESS-SHEAR VIBRATION OF A RECTANGULAR QUARTZ PLATE WITH PARTIAL ELECTRODES显示文摘We study free vibration of a thickness-shear mode crystal resonator of AT-cut quartz. The resonator is a rectangular plate partially and symmetrically electroded at the center with rectangular electrodes. A single-mode, three-dimensional equation governing the thickness-shear displacement is used. A Fourier series solution is obtained. Numerical results calculated from the series show that there exist trapped thickness-shear modes whose vibration is mainly under the electrodes and decays rapidly outside the electrodes. The effects of the electrode size and thickness on the trapped modes are examined. | Huijing He Jiashi Yang John A. Kosinski Ji Wang | 2013 | Acta Mechanica Solida Sinica2013，26，2： | 1 |
| 18 | In vitro fatigue properties of prototype textile components of endovascular devices显示文摘 | ZHAO Huijing WANG Lu LI Yuling | 2009 | Fibers and Polymers2009，10，1： | 1 |
| 19 | Characteristics of silicon and oxygen isotopic compositions of basalts near East Pacific Rise 13°N显示文摘In this study,13 groups of silicon and oxygen isotopes and major elements of the basalts near the East Pacific Rise 13°N are used to study the fractionation of silicon and oxygen isotopes.Among these data,δ30Si values of basalts vary from 0.4‰to 0.2‰with a mean value ofδ30Si of(0.18±0.22)‰.Theδ18O values range from 4.1‰ to 6.4‰ with a meanδ18O value of(+5.35±0.73)‰.Since theδ30Si values increase in the series of basalt-basaltic andesite-andesite,andδ18O values display a positive correlation with the SiO2content,we propose that the fractionation of silicon and oxygen isotopes is influenced by the SiO2content in igneous rocks.Compared with the igneous rocks from Manus Basin with clinopyroxene as their dominant mineral phase,MORBs in this study containing olivine and plagioclase as primary minerals have lowerδ18O andδ30Si values,indicating that the fractionation of silicon and oxygen isotopes is also affected by different Si-O bridges in silicate minerals.Furthermore,our samples from the EPR are defined as E-MORB based on K/Ti ratios.Probably,the difference inδ30Si andδ18O between our samples and a normal MORB are cause by the enriched components in E-MORBs. | WANG Xiaoyuan ZHAO Huijing ZENG Zhigang YIN Xuebo CHEN Shuai MA Yao | 2013 | Acta Oceanologica Sinica2013，32，12： | 1 |
| 20 | Adhesion hysteresis of a film-terminated fibrillar array显示文摘Motivated by the recent biomimic design of microstructured adhesive surfaces,we study adhesion between a film-terminated fibrillar array and a rigid substrate.Using a two-dimensional model and ignoring the deformation of the fibers and the backing layer,we show that the adhesion behavior is dominated by a dimensionless parameter reflecting the global flexibility of the terminal film.In particular,if the parameter is larger than 0.4,the adhesion is reversible;otherwise one or more hysteresis loops will appear after an approach-retraction cycle,leading to significant increase in the specific separation work.The result is expected to help not only optimal design of the structure,but also other applications such as micro-manipulation in micromechanical systems. | YAN ShunPing HE LingHui WANG HuiJing | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，6： | 1 |
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