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| 1 | Geochemical evidence for submarine hydrothermal origin of the Middle-Upper Permian chert in Laibin of Guangxi, China显示文摘Lithologically, two kinds of chert can be recognized in the Middle-Upper Permian from the Tieqiao section in Laibin area, Guangxi, i.e., calcic chert occurring mainly in the Maokou Formation and pure chert mainly in the Wujiaping Formation. Geo- chemical data show that both kinds of chert contain very low Al2O3 (0-0.23%) and TiO2 (0.001%-0.024%) and low ΣREE (0.55-19.94 ppm, averaging 9.97 ppm), as well as high ratio of Fe2O3/TiO2 (17-443, averaging 111) and low ratio of Al2O3/(Al2O3+Fe2O3) (0-0.26, averaging 0.09). Given that the average value Ce anomalies in chert deposited in the ridge-proximal environment is about 0.29, and that in the pelagic environment is about 0.60, the low Ce anomalies in the Tieqiao chert (0.24-0.46, averaging 0.35) imply that they were deposited in an ocean basin with influence of submarine hydrothermal fluid and no input of terrigenous materials. The vertical variation of the silica abundance in strata (SAIS) in the Middle-Upper Permian strata, together with the Eu anomalies and the ratios of ΣREE/Fe, indicates a relationship between the hydrothermal activity and the Emeishan basalt eruption, and that submarine hydrothermal activity was stronger in the Upper Permian (the Wujiapingian Stage) than in the Middle Permian (the Maokou Stage). | QIU Zhen WANG QingChen | 2011 | Science China Earth Sciences2011，54，7： | 25 |
| 2 | Late Mesozoic extensional tectonics of the Liaodong Peninsula massif:Response of crust to continental lithosphere destruction of the North China Craton显示文摘Unlike most Precambrian cratons that have thick sub-continental lithospheric roots,the Archean lithosphere beneath the North China Craton is thin (reduced from 200 km to about 80 km),and has been replaced by a geochemically juvenile lithospheric mantle.This is a unique regional geological event,which has attracted worldwide attention.In the North China Block,Late Mesozoic extensional tectonics is evident by low-angle detachment faults,syntectonic plutons bounded by ductile faults,metamorphic core complexes (MCC) and widespread Jurassic to Cretaceous half-grabens filled by continental terrigenous deposits and volcanic rocks.At a regional scale,these structures share the same NW-SE extensional direction,while maintaining their own individual kinematics.In other words,the MCC feature a top-to-the-NW sense of shear,and syntectonic plutons are typified by a top-to-the-SE shearing deformations.Geochronological results indicate that the extensional structures were formed between 130-120 Ma.These extensional events lead to magmatic rock emplacement,distributed at the footwall of the detachment faults.Two different exhumation stages can be identified based on regional structural and magmatic interpretation:a Jurassic slow or negligible exhumation and a Cretaceous fast one assisted by normal faulting.These two cooling stages correspond to distinct geodynamic processes that occurred during the Jurassic and Cretaceous.Extensional tectonics appear to have been insignificant before the Early Cretaceous,and the process may be demonstrated by partial melting of the crust.The second stage,dominated by an extensional regime,developed after ca 120 Ma,and is tentatively correlated with crustal extension caused by lithospheric removal of the North China Craton. | LIN Wei WANG QingChen WANG Jun WANG Fei CHU Yang CHEN Ke | 2011 | Science China Earth Sciences2011，54，6： | 24 |
| 3 | The Dabie-Sulu UHP rocks belt:review and prospect显示文摘The new results in the studies of the Dabie-Sulu UHP rocks belt during the past 5 years were summarized and discussed. The discussion included the following key points: ( i ) UHP eclogite has two kinds of country rocks, with one being UHP eclogite facies rocks and the other non-UHP granitic gneiss. ( ii ) The FeTiO3 in olivine indicated exsolution at depth of 300-400 km. However, the key point is to prove the peridotite in which the FeTiO3 in olivine was found once had been subducted down that depth. (iii ) UHP hydrous phase evidenced that fluids had taken part in the UHP metamorphism, while the meter-scale inhomogeneous distribution of O-, C-isotope indicated no fluid activity in the deep subduction environment. (iv ) No agreement has been arrived on many problems related to the tectonic background of the UHP rocks, such as 'whether or not ophiolitic rocks there exist now?', 'when did UHP metamorphism proceed?', 'what is the subdution polarity?', etc. ( V ) How did the UHP rocks exhume from mantle | Bolin Cong Qingchen Wang | 1999 | Chinese Science Bulletin1999，44，12： | 21 |
| 4 | Geochemical changes across the Ordovician-Silurian transition on the Yangtze Platform,South China显示文摘The trace element and rare earth element(REE) variations across the Ordovician-Silurian succession are presented from two outcrop sections on the Yangtze Platform:the Nanbazi section,Guizhou Province,deposited in a shallow platform interior setting,and the Wangjiawan section,Hubei Province,deposited in a deeper basinal environment.Geochemical analysis of closely spaced samples through three intervals,the Wufeng,Guanyinqiao and Longmaxi,revealed vast palaeoceanographic changes.Some geochemical proxies,including Th/U,Ni/Co,V/Cr,and V/(V+Ni) ratios,together with sedimentary facies and biotic data,indicate that an anoxic condition on the most of the Yangtze Platform during the Wufeng and Longmaxi intervals,but an oxic condition during the Guanyinqiao time.The shift of the anoxic to the oxic environment during the Guanyinqiao time coincided with a global sea-level lowstand,in parallel with the global glaciation.The Longmaxian anoxic environment was a result of a global sea-level rise,which may be synchronized with a mainly catastrophic event in the latest Ordovician.Although the two sections generally show similar variation patterns of trace and REE concentrations and some element ratios,a minor difference occurs between the Wangjiawan and Nanbazi sections,likely reflecting a difference in depositional setting during the accumulation.Such an oceanic oxygen-level variation may add a useful constraint to the current arguments on the cause and consequence of the latest Ordovician mass extinction. | YAN DeTian CHEN DaiZhao WANG QingChen WANG JianGuo | 2009 | Science China Earth Sciences2009，52，1： | 17 |
| 5 | Tectonic Framework and Deep Structure of South China and Their Constraint to Oil-Gas Field Distribution显示文摘华南能在包围区域被划分成一稳定的 craton , Yangtze Craton ( YzC ),和几条 orogenic 带,那在北方是三叠纪的 Qinling-Dabie Orogenic 带( QDOB ),在西北的 Songpan-Garz ê Orogenic 带( SGOB ),在西方,在西南的 Youjiang Orogenic 带(出生年),在东南的中间的古生代的 Huanan Orogenic 带(壁炉内部的一锅架),和沿着海岸的中生代新生代海上的 Orogenic 带(乌合之众)的中生代新生代三河的 Orogenic 带( TOB )。地震 tomographic 图象表明莫霍深度比 40 km 深,岩石圈是在 YzC 下面厚的大约 210 km。SGOB 被厚外壳(>40 km ) 和薄岩石圈(<150 km ) 描绘。壁炉内部的一锅架,出生年和乌合之众有一个薄外壳(<40 km ) 和薄岩石圈(<150 km ) 。陆上的热流动调查分别地在 TOB 和乌合之众在东方 YzC 和西方的壁炉内部的一锅架和二个高热流动区域与一个低热流动区域揭示了一个分发模式。如此的“ high-low-high ”热流动分发模式能在 welling 上面源于新生代岩流圈。所有油气体地在 YzC 的中央部分被集中。残余油水池沿着 YzC 和它的邻近的 orogenic 带的南部的边缘被发现了。从地质、地球物理的结构,在有厚岩石圈和低热流动价值的华南的区域,以及弱变丑的一个观点,可能是为进一步的石油探索的理想的区域。 | WANG Qingchen LIU Jinsong DU Zhili CAI Liguo | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 16 |
| 6 | Seismic tomography showing subduction and slab breakoff of the Yangtze block beneath the Dabie-Sulu orogenic belt显示文摘Seismic tomography reveals that a subducted ancient block has been preserved beneath the Moho of the Dabie-Sulu orogenic belt. Taking into account of geological and geochronological data, we inferred from the tomographic images that the Yangtze block was subducted northward beneath the Sino-Korean block and broken off at the depth <200 km during 200-190 Ma. The slab breakoff of the Yangtze block is the most important dynamic mechanism to control the exhumation of UHP rocks. | Peifen Xu Ruomei Sun Futian Liu Qingchen Wang Bolin Cong | 2000 | Chinese Science Bulletin2000，45，1： | 7 |
| 7 | Development of joints and shear fractures in the Kuqa depression and its implication to regional stress field switching显示文摘The superimposed basin must have undergone the changes of regional stress field. Study on the nature and switch of regional stress field of superimposed basin is very useful to understanding its stress state and tectonic events during its formation and evolution. As sensitive markers of small stress changes, joint and shear fracture, characterized by consistency of ori-entation over wide area, can be used to reconstruct paleostress state and its evolution. Detailed observations and analysis on the orientations, geometrical patterns, sequences of joints and shear fractures and their chronological relation to faults and folds show that, the NEE-SWW systematic joints and NNW-SSE systematic joints developed in the Mesozoic and Cenozoic strata are much more prominent than NW-SE systematic joints and shear fractures with different orientations. And the NWW-SEE and NW-SE systematic joints formed later than NEE-SWW systematic joints but earlier than shear fractures with different orientations. According to the rela-tionships between joint and shear fractures and stress, the NEE-SWW systematic joints are in-ferred to result from lateral weak extension caused by the late Cretaceous regional uplift, while the NNW-SSE and NW-SE systematic joints are interpreted as syn-tectonic deformation relating to strong N-S compression in the Neogene. But some conjugate shear fractures occur probably due to sinistral strike-slip faulting in the Kuqa depression. At the beginning of the Neogene, the stress field changed and the maximal principal stress s1 switched from vertical to horizontal. | ZHANG Zhongpei WANG Qingchen | 2004 | Science China Earth Sciences2004，47，z2： | 7 |
| 8 | Rutile U-Pb age for the ultra-high pressure eclogite from the Dabie Mountains, central China: Evidence for rapid cooling显示文摘The U-Pb isotope compositions of rutile, om-phacite and garnet in the eclogite from the Jinheqiao area in the Southern Dabie ultrahigh-pressure metamorphic zonewere analyzed. The consistent high precision U-Pb age (218± 1.2) Ma of rutile in eclogite from the Dabie Mountains was obtained by two ways of isochron and common Pb correction based on the composition of omphacite. This proves that the omphacite in eclogite has a U/Pb ratio (μ = 2.8) low enough to be used for common Pb correction in the analyses of rutile. Under the rapid cooling condition (40℃/Ma) the closure temperature for U-Pb diffusion in rutile is about 470℃. Thus, this U-Pb age of rutile proves that 218 Ma should be the cooling age of eclogite at 470℃ instead of the peak meta-morphic age. | LI Qiuli LI Shuguang ZHOU Hongying LI Huimin HONG Ji’an WANG Qingchen H.J.Massonne | 2002 | Chinese Science Bulletin2002，47，1： | 5 |
| 9 | Magnetostratigraphic study of Cretaceous depositional succession in the northern Kuqa Depression,Northwest China显示文摘There are some quite different disputes about chronostratigraphic division of the Cretaceous in the Kuqa Depression, northern margin of the Tarim Basin. We then carried on a magnetostratigraphic study on Cretaceous succession in the Kuqa River and Kezilenuer Channel profiles. Detailed paleomag- netic analyses on 446 specimens from 265 sites permit a construction of a preliminary magnetic polar- ity sequence for the Cretaceous strata. Together with paleobiologic constraints from calcareous nannofos- sils, magnetostratigraphic results show that the Bash- enjiqike Formation was probably deposited during the late Campanian to Maastrichtian stages of the Late Cretaceous, ranging from about 79.1 to 65.6 Ma. On the other hand, magnetozones identified from the Yageliemu, Shushanhe, and Baxigai formations may principally correlate with chrons M18r to M3 of the Geomagnetic Polarity Time Scale (GPTS). This cor- relation suggests that these three formations were very likely to be formed during the early-middle stage of the Early Cretaceous between the Berriasian to the early Berremian stages (141.9―124.1Ma). Therefore it is possible that the Bashenjiqike Formation con- tacts the underlying strata with an unconformity and there is a giant sedimentary hiatus during the period of the late Barremian to early Maastrichtian stages in the Kuqa Depression. | PENG Shoutao LI Zhong HUANG Baochun LIU Tao WANG Qingchen | 2006 | Chinese Science Bulletin2006，51，1： | 5 |
| 10 | A Versatile Crosslinking Strategy on Facile Fabrication of Fluorescent Hydrogels via o-Phthalaldehyde Ternary Condensation显示文摘It is of great sighificance to develop rapid crosslinking strategies to enrich the functions of hydrogels and simplify the preparation process of hydrogels.Herein,we applied the ternary condensation reaction of o-phthalaldehyde(OPA)with thiol and amino moieties to con struct hydrogel n etworks with fast gelati on rate,excellent mecha nical stre ngth,and favorable stability. | Qingchen Cao Hufei Wang Xing Wang Decheng Wu | 2021 | Chinese Journal of Chemistry2021，39，8： | 4 |
| 11 | Environmental Redox Changes of the Ancient Sea in the Yangtze Area during the Ordo-Silurian Transition显示文摘摘要:广泛有机物(OM ) 富有的外形(黑页岩) 在 Yangtze 区域发生在 Ordo 志留纪边界继任,华南。为了在 Ordo 志留纪期间调查 Yangtze 海的氧化还原作用变化,转移,二 OM 节(在在 Zhangjiajie 的 Yichang,湖北省,和 Sanjiaguan 的 Wangjiawan,湖南省) 跨骑 Ordo 志留纪边界被学习。在这研究完成的大小包括总数的内容 Fe 的器官的碳( TOC ),黄铁矿硫,和不同种类,包括dithionite可引出的 Fe (喂),黄铁矿 Fe ( FeP ),HCI可引出的 Fe ( FeH ),和全部的 Fe ( FeT )在黑页岩,象另外的氧化还原作用代理一样,例如 S/C 比率,在高度反应的 Fe 之间的比率( FeHR =喂了+ FeP )并且 FeT ,和Fep/(FeP + FeH )比率,作为 pyritization ( DOP )的度知道。在 Wangjiawan 节,中间的 Ashgill 沉积有高 FeHR/FeT 比率(0.20-0.77;avg。0.45 ) ,高 DOP 价值(0.21-0.72;avg。0.54 ) ,并且器官的碳内容的一个相对经常的硫内容独立人士。由对比,中间早, Hirnantian 存款通常有低 FeHR/FeT 比率(0.10-0.35;avg。0.21 ) ,低 DOP 价值(0.11-0.40;avg。0.28 ) ,并且 S/C 价值在正常海洋的价值上正在聚类(S/C = 0.36 ) 。迟了的 Hirnantian 和早 Rhuddanian 存款,类似于那些中间的 Ashgill 存款,被高 FeHR/FeT 比率描绘(0.32-0.49;avg。0.41 ) ,高 DOP 价值(0.46-0.68;avg。0.53 ) 并且相当经常的硫内容。这些数据在间隔期间在 Yangtze 海架上建议海洋的血缺氧的出现中间的 Ashgill,迟了的 Hirnantian 和早 Rhuddanian,和通气并且氧化的水兵调节在期间中间早 Hirnantian 时间。中间早, Hirnantian 通气了事件是有全球冰川的经期的伴随物,多半在架海床之上源于 glacio 海面升降的海平面的秋天和冷、稠密的氧化的水的随后的循环。因此,突然的变化从从迟了的 Hirnantian 氧化了到缺氧的海洋的水,早 Rhuddanian 从海面升降的海水平的冰期后的上升被结果。在 subemergent 高地附近从 Sanjiaguan 节与数据结合了,水列的咸度层化被很低的 S/C 比率强烈证实(0.00-0.08, avg。0.02 ) ,低 FeHR/FeT 比率(0.10-0.37, avg。0.27 ) ,低 DOP 价值(0.01-0.27, avg。0.10 ) ,并且 TOC 内容(0.72%-4.27% , avg。2.55%) 。在这种情形下面,缺氧的水列能在 halocline,脱盐的水在上面形成了下面形成了。在 Wangjiawan 节, TOC 内容通常高(0.94-9.32% , avg。4.44%) ,但是低(0.35%-2.12% , avg。1.29%) 在里面中间早,与海洋的 oxic 阶段是重合的和到 stratal 厚度的器官的内容的关系,建议有机物的累积被氧主要控制的 Hirnantian 水列铺平;在另一方面,生产率和 depositional 率可能也在器官的累积和保藏起了一个作用。 | YAN Detian CHEN Daizhao WANG Qingchen WANG Jianguo CHU Yang | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 3 |
| 12 | Ectopic expression of BdCIPK31 confers enhanced low-temperature tolerance in transgenic tobacco plants显示文摘Calcineurin 象 B 一样蛋白质(CBL ) , Ca 2+ 传感器,和它的交往的蛋白质 kinases (CIPK ) 在植物反应起必要作用强调。然而,很少研究在低温度的反应集中了于 CIPK 的功能。在现在的学习, BdCIPK31,在 Brachypodium distachyon 的寒冷应答的 CIPK,被发现参予低温度的反应。BdCIPK31 的宫外的表示在转基因的烟草授与冷忍耐。进一步的分析显示 BdCIPK31 的那个表达式在低温度的处理下面在转基因的植物改进了 ROS 解毒和 omsoprotectant 生合成,建议 BdCIPK31 在到导致寒冷的氧化、渗透的压力的植物改编断然工作。而且, BdCIPK31 能 upregulate 在寒冷下面的一些代表性的压力相关的基因的表情强调。在结论,这些调查结果建议 BdCIPK31 在植物寒冷反应断然工作。 | Qingchen Luo Qiuhui Wei Ruibin Wang Yang Zhang Fan Zhang Yuan He Guangxiao Yang Guangyuan He | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 3 |
| 13 | TGF-β1-supplemented decellularized annulus fibrosus matrix hydrogels promote annulus fibrosus repair显示文摘Annulus fibrosus(AF)repair remains a challenge because of its limited self-healing ability.Endogenous repair strategies combining scaffolds and growth factors show great promise in AF repair.Although the unique and beneficial characteristics of decellularized extracellular matrix(ECM)in tissue repair have been demonstrated,the poor mechanical property of ECM hydrogels largely hinders their applications in tissue regeneration.In the present study,we combined polyethylene glycol diacrylate(PEGDA)and decellularized annulus fibrosus matrix(DAFM)to develop an injectable,photocurable hydrogel for AF repair.We found that the addition of PEGDA markedly improved the mechanical strength of DAFM hydrogels while maintaining their porous structure.Transforming growth factor-β1(TGF-β1)was further incorporated into PEGDA/DAFM hydrogels,and it could be continuously released from the hydrogel.The in vitro experiments showed that TGF-β1 facilitated the migration of AF cells.Furthermore,PEGDA/DAFM/TGF-β1 hydrogels supported the adhesion,proliferation,and increased ECM production of AF cells.In vivo repair performance of the hydrogels was assessed using a rat AF defect model.The results showed that the implantation of PEGDA/DAFM/TGF-β1 hydrogels effectively sealed the AF defect,prevented nucleus pulposus atrophy,retained disc height,and partially restored the biomechanical properties of disc.In addition,the implanted hydrogel was infiltrated by cells resembling AF cells and well integrated with adjacent AF tissue.In summary,findings from this study indicate that TGF-β1-supplemented DAFM hydrogels hold promise for AF repair. | Qiang Wei Dachuan Liu Genglei Chu Qifan Yu Zhao Liu Jiaying Li Qingchen Meng Weishan Wang Fengxuan Han Bin Li | 2023 | Bioactive Materials2023，，1： | 3 |
| 14 | Single-cell atlas reveals a distinct immune profile fostered by T cell-B cell crosstalk in triple negative breast cancer显示文摘Background:Characterizing the unique immune microenvironment of each tumor is of great importance for better predicting prognosis and guiding cancer immunotherapy.However,the unique features of the immune microenvironment of triple negative breast cancer(TNBC)compared with other subtypes of breast cancer remain elusive.Therefore,we aimed to depict and compare the immune landscape among TNBC,human epidermal growth factor receptor 2-positive(HER2^(+))breast cancer,and luminal-like breast cancer.Methods:Single-cell RNA sequencing(scRNA-seq)was performed on CD45^(+)immune cells isolated from human normal breast tissues and primary breast tumors of various subtypes.By analyzing the scRNA-seq data,immune cell clusters were identified and their proportions as well as transcriptome features were compared among TNBC,human HER2^(+)breast cancer,and luminal-like breast cancer.Pseudotime and cell-cell communication analyses were also conducted to characterize the immune microenvironment.Results:ScRNA-seq data of 117,958 immune cells were obtained and 31 immune clusters were identified.A unique immunosuppressive microenvironment in TNBC was decoded as compared to that in HER2^(+)or luminal-like breast cancer,which was characterized by higher proportions of regulatory T cells(Tregs)and exhausted CD8+T cells and accompanied by more abundant plasma cells.Tregs and exhausted CD8+T cells in TNBC exhibited increased immunosuppression signature and dysfunctional scores.Pseudotime analyses showed that B cells tended to differentiate to plasma cells in TNBC.Cell-cell communication analyses indicated that these unique features are fostered by the diversified T cell-B cell crosstalk in TNBC.Based on the T cell-B cell crosstalk,a prognostic signaturewas established that could effectively predict the prognosis status for patients with TNBC.Additionally,it was found that TNBC had a higher proportion of cytotoxic natural killer(NK)cells,whereas HER2^(+)or luminal-like breast cancer lost this feature,suggesting thatHER2^(+)or luminal-like breast cancer,but not TNBC,may benefit from NK-based immunotherapy.Conclusions:This study identified a distinct immune feature fostered by T cell-B cell crosstalk in TNBC,which provides better prognostic information and effective therapeutic targets for breast cancer. | Shuning Ding Niu Qiao Qingchen Zhu Yiwei Tong Shengyue Wang Xiaosong Chen Qiang Tian Yichuan Xiao Kunwei Shen | 2023 | Cancer Communications2023，43，6： | 2 |
| 15 | Could tectonic overpressure cause ultrahigh-pressure metamorphism?显示文摘Could ultrahigh-pressure metamorphic rocks be caused, at depth of 32 km, by tectonic overpressure resulting from differential stress? The differential stress is limited by rock strength, which depends on strain rate and temperature. Therefore, tectonic overpressure could not go beyond 1 GPa, and could not cause the uitrahigh-pressure metamorphism. | Qingchen Wang Jingbo Liu Bolin Cong | 1999 | Chinese Science Bulletin1999，44，24： | 2 |
| 16 | Geochemistry of the Middle to Late Permian limestones from the marginal zone of an isolated platform(Laibin,South China)显示文摘Major,trace and rare earth elements were measured in 27 samples of the Middle to Late Permian limestones from the Tieqiao section located on the marginal zone of an isolated platform(Laibin,South China).Shale-normalized REE+Y patterns of all samples show notably negative Ce anomalies(0.21–0.66,average 0.33),slightly positive Gd anomalies(1.08–1.30,average1.20),and positive Y anomalies with superchondritic Y/Ho ratios(36–91,average 55),which are consistent with those of modern shallow seawater.Their relative LREEs enrichment with higher NdSN/YbSN ratios(0.58–1.80)than those of modern shallow seawater(0.21–0.50)suggests complicated sources of REEs for all samples.Compared with geochemical features of sediments influenced by terrigenous particles and hydrothermal fluids,it is concluded that ambient shallow seawater was the primary source of REEs in these limestones.Comparing the indicators of REE+Y elements(REE,NdSN/YbSN,Ce/Ce*,Gd/Gd*,Eu/Eu*and Y/Ho)in limestones with those in bedded cherts from the Tieqiao section,we consider that limestone and bedded chert have similar sources of REE+Y elements:ambient shallow seawater with more or less hydrothermal fluids.In addition,there is a completely negative correlation between CaCO3and SiO2contents in limestones and bedded cherts.These results imply that precipitation of CaCO3was inhibited by that of SiO2which was derived mainly from hydrothermal fluid,especially in bedded cherts from the Tieqiao section. | QIU Zhen WANG QingChen YAN DeTian | 2013 | Science China Earth Sciences2013，56，10： | 2 |
| 17 | Call in question and discussion: Are there sandwiched low-grade metamorphic slabs within UHP metamorphic rocks in the Dabieshan terrane?显示文摘Some geologists reported their discovery of sandwiched low-grade metamorphic slabs within UHP metamorphic Complexes in Changpu, Yuexi County, Anhui Province. They also suggested that some coesite-bearing eclogites are igneous veins, which intruded low-grade metamorphic slabs and other related rocks. Moreover they further called in question to UHP matamorphic process and continental collision tectonism in the Dabieshan terrane. Based on our recent study so-called low-grade metamorphic slabs are strongly deformed fabric, fine-grained and tectonic recrystallized mylonites and tectonites. Their protolith rocks are garnet-bearing orthogneiss, eclogite and marble, as well as a few amounts of strongly deformed acid and basic veins. Their metamorphic, geochemical and geochronological characteristics are also identical with UHPM rocks and regional country orthogneisses. Therefore we conclude that there are not low-grade metamorphic slabs sand wiched with UHP metamorphic rocks in the Dabieshan terrane. | ZHAI Mingguo JIANG Laili WANG Qingchen CONG Bolin | 2000 | Chinese Science Bulletin2000，45，2： | 2 |
| 18 | Genetic Fingerprint Concerned with Lymphatic Metastasis of Human Lung Squamous Cancer显示文摘背景与目的筛选肺鳞癌患者淋巴转移差异表达基因群。方法原发癌组织及区域淋巴结取自10例接受完全性肺癌切除手术的肺鳞癌患者。根据组织来源将标本分为三组:不伴淋巴转移的肺鳞癌组织(TxN-,n=5)、伴有淋巴转移的肺鳞癌组织(TxN+,n=5)及相应转移淋巴结中的肺鳞癌细胞(N+,n=5)。对各组进行激光显微切割以获得纯净癌细胞,T7RNA线性扩增获取足够量的RNA,实验通道和参照通道分别标记以后与含6000个已知人类基因或表达序列标签的cDNA基因芯片杂交,扫描荧光信号以后进行数据分析。结果共有37个基因可将TxN+组与TxN-组区分开,其中在TxN+组高表达的基因有8个,主要涉及蛋白合成、信号传导、伴侣蛋白和酶等。有29个基因在TxN-组高表达,这些基因主要编码细胞周期调节子、转导子、信号传导蛋白以及细胞凋亡调节蛋白。比较N+组与TxN+组却没有发现具有显著性的差异表达基因。结论肺鳞癌的淋巴转移表型的获得可能是早期事件。这些差异基因的发现有助于阐明肺鳞癌淋巴转移的分子机制和寻找新的治疗靶点。 | Mingjian GE Mei WANG Qingchen WU Zhiming QIN Li CHEN Liangbin LI Li LI Xiaolong ZHAO | 2009 | 中国肺癌杂志2009，12，9： | 2 |
| 19 | Correction:Assessment of wind and photovoltaic power potential in China显示文摘Following publication of the original article[1],the authors reported some errors in Table 5.The correct Table 5 has been provided in this Correction.The original article[1]has been updated. | Yang Wang Qingchen Chao Lin Zhao Rui Chang | 2022 | Carbon Neutrality2022，1，1： | 2 |
| 20 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
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