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| 1 | Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy显示文摘Tumor models were simulated in purebred Beagles at the T9-10 levels of the spinal cord and treated with spinal image-guided radiation therapy or conventional radiation therapy with 50 or 70 Gy total radiation. Three months after radiation, neuronal injury at the T9-10 levels was observed, including reversible injury induced by spinal image-guided radiation therapy and apoptosis induced by conventional radiation therapy. The number of apoptotic cells and expression of the proapoptotic protein Fas were significantly reduced, but expression of the anti-apoptotic protein heat shock protein 70 was significantly increased after image-guided radiation therapy compared with the conventional method of the same radiation dose. Moreover, the spinal cord cell apoptotic index positively correlated with the ratio of Fas/heat shock protein 70. These findings indicate that 3 months of radiation therapy can induce a late response in the spinal cord to radiation therapy; image-guided radiation therapy is safer and results in less neuronal injury compared with conventional radiation therapy. | Wanlong Xu Xilinbaoleri Hao Liu Ruozheng Wang Jingping Bai | 2012 | Neural Regeneration Research2012，7，35： | 23 |
| 2 | Nitrogen Biological Cycle Characteristics of Seepweed(Suaeda salsa) Wetland in Intertidal Zone of Huanghe(Yellow) River Estuary显示文摘From April 2008 to November 2009,the nitrogen(N) cycle of plantsoil system in seepweed(Suaeda salsa) wetland in the intertidal zone of the Huanghe(Yellow) River estuary was studied.Results showed that soil N had sig-nificant seasonal fluctuations and vertical distribution,and the net N mineralization rates in topsoil were significantly different in growing season(p < 0.01).The N/P ratio(9.87 ± 1.23) of S.salsa was less than 14,indicating that plant growth was limited by N.The N accumulated in S.salsa litter at all times during decomposition,which was ascribed to the N immobilization by microbes from the environment.Soil organic N was the main N stock of plant-soil system,accounting for 97.35% of the total N stock.The N absorption and utilization coefficients of S.salsa were very low(0.0145 and 0.3844,respectively),while the N cycle coefficient was high(0.7108).The results of the N turnovers among compartments of S.salsa wetland showed that the N uptake amount of aboveground part and root were 7.764 g/m2and 4.332 g/m2,respectively.The N translocation amounts from aboveground part to root and from root to soil were 3.881 g/m2 and 0.626 g/m2,respectively.The N translocation amount from aboveground living body to litter was 3.883 g/m2,the annual N return amount from litter to soil was more than 0.125(-) g/m2(minus represented immobilization),and the net N mineralization amount in topsoil(0-15 cm) in growing season was 1.190 g/m2.The assessment of N biological cycle status of S.salsa wetland indicated that N was a very important limiting factor and the ecosystem was situated in unstable and vulnerable status.The S.salsa was seemingly well adapted to the low-nutrient status and vulnerable habitat,and the N quantitative relationships determined in the compartment model might provide scientific base for us to reveal the special adaptive strategy of S.salsa to the vulnerable habitat in the following studies. | SUN Zhigao MOU Xiaojie SUN Jingkuan SONG Hongli YU Xiang WANG Lingling JIANG Huanhuan SUN Wanlong SUN Wenguang | 2012 | Chinese Geographical Science2012，22，1： | 9 |
| 3 | CAD Model-Based Intelligent Inspection Planning for Coordinate Measuring Machines显示文摘As the market competition among enterprises grows intensively and the demand for high quality products increases rapidly, product quality inspection and control has become one of the most important issues of manufacturing, and improving the efficiency and accuracy of inspection is also one of problems which enterprises must solve. It is particularly important to establish rational inspection planning for parts before inspecting product quality correctly. The traditional inspection methods have been difficult to satisfy the requirements on the speed and accuracy of modern manufacturing, so CAD-based computer-aided inspection planning (CAIP) system with the coordinate measuring machines (CMM) came into being. In this paper, an algorithm for adaptive sampling and collision-free inspection path generation is proposed, aiming at the CAD model-based inspection planning for coordinate measuring machines (CMM). Firstly, using the method of step adaptive subdivision and iteration , the sampling points for the specified number with even distribution will be generated automatically. Then, it generates the initial path by planning the inspection sequence of measurement points according to the values of each point's weight sum of parameters, and detects collision by constructing section lines between the probe swept-volume surfaces and the part surfaces, with axis-aligned bounding box (AABB) filtering to improve the detection efficiency. For collided path segments, it implements collision avoidance firstly aiming at the possible outer-circle features, and then at other collisions, for which the obstacle-avoiding movements are planned with the heuristic rules, and combined with a designed expanded AABB to set the obstacle-avoiding points. The computer experimental results show that the presented algorithm can plan sampling points' locations with strong adaptability for different complexity of general surfaces, and generate efficient optimum path in a short time and avoid collision effectively. | DONG Yude LIU Daxin ZHAO Han WANG Wanlong WU Juan | 2011 | Chinese Journal of Mechanical Engineering2011，24，4： | 8 |
| 4 | Three-dimensional conformal intensity-modulated radiation therapy of left femur foci does not damage the sciatic nerve显示文摘During radiotherapy to kill femoral hydatid tapeworms,the sciatic nerve surrounding the focus can be easily damaged by the treatment.Thus,it is very important to evaluate the effects of radiotherapy on the surrounding nervous tissue.In the present study,we used three-dimensional,conformal,intensity-modulated radiation therapy to treat bilateral femoral hydatid disease in Meriones meridiani.The focus of the hydatid disease on the left femur was subjected to radiotherapy(40 Gy) for 14 days,and the right femur received sham irradiation.Hematoxylin-eosin staining,electron microscopy,and terminal deoxynucleotidyl transferase-d UTP nick end labeling assays on the left femurs showed that the left sciatic nerve cell structure was normal,with no obvious apoptosis after radiation.Trypan blue staining demonstrated that the overall protoscolex structure in bone parasitized with Echinococcus granulosus disappeared in the left femur of the animals after treatment.The mortality of the protoscolex was higher in the left side than in the right side.The succinate dehydrogenase activity in the protoscolex in bone parasitized with Echinococcus granulosus was lower in the left femur than in the right femur.These results suggest that three-dimensional conformal intensity-modulated radiation therapy achieves good therapeutic effects on the secondary bone in hydatid disease in Meriones meridiani without damaging the morphology or function of the sciatic nerve. | Wanlong Xu Xibin Zhao Qing Wang Jungang Sun Jiangbo Xu Wenzheng Zhou Hao Wang Shigui Yan Hong Yuan | 2014 | Neural Regeneration Research2014，9，20： | 6 |
| 5 | Hybrid Dirac semimetal-based photodetector with efficient low-energy photon harvesting显示文摘Despite the considerable effort,fast and highly sensitive photodetection is not widely available at the low-photon-energy range(~meV)of the electromagnetic spectrum,owing to the challenging light funneling into small active areas with efficient conversion into an electrical signal.Here,we provide an alternative strategy by efficiently integrating and manipulating at the nanoscale the optoelectronic properties of topological Dirac semimetal PtSe_(2)and its van der Waals heterostructures.Explicitly,we realize strong plasmonic antenna coupling to semimetal states near the skin-depth regime(λ/10^(4)),featuring colossal photoresponse by in-plane symmetry breaking.The observed spontaneous and polarization-sensitive photocurrent are correlated to strong coupling with the nonequilibrium states in PtSe_(2)Dirac semimetal,yielding efficient light absorption in the photon range below 1.24 meV with responsivity exceeding∼0.2 A/W and noise-equivalent power(NEP)less than~38 pW/Hz^(0.5),as well as superb ambient stability.Present results pave the way to efficient engineering of a topological semimetal for high-speed and low-energy photon harvesting in areas such as biomedical imaging,remote sensing or security applications. | Lin Wang Li Han Wanlong Guo Libo Zhang Chenyu Yao Zhiqingzi Chen Yulu Chen Cheng Guo Kaixuan Zhang Chia-Nung Kuo Chin Shan Lue Antonio Politano Huaizhong Xing Mengjie Jiang Xianbin Yu Xiaoshuang Chen Wei Lu | 2022 | Light(Science & Applications)2022，11，3： | 2 |
| 6 | Study on Flow Characteristics of a Turbulent Boundary Layer and Vortex Structure of High Pressure Guide Vanes in SCO_2 Turbines显示文摘In order to further understand the aerothermodynamic performance and flow loss mechanism of SCO_2 turbines, RANS equations and an SST Turbulence Model were chosen for a numerical study on the secondary flow and vortex structure of cascades using the commercial software CFX. The dimensionless vorticity analysis method was used to study the flow characteristics of the logarithmic layer and viscous sublayer in high pressure guide vane cascades. The new vortex structure and formation mechanism of the vortices were given and analyzed. Simulation results indicated that during the motion of the boundary layer in the cascades, the logarithmic layer and viscous sublayer obtain the different rotational direction vorticity, respectively. The endwall logarithmic layer and pressure side leg of the horseshoe votex gradually develop into the passage vortex, with the endwall viscous sublayer gradually developing into the corner viscous sublayer vortex II and the endwall viscous sublayer vortex I. The endwall viscous sublayer that rolled by the passage vortex is encountered with the upstream-side and radial boundary layer of the vane at the suction separation line, forming the suction separation line vortex beside the passage vortex. A pair of radial transition vortices are formed between the wake and the main stream. | HAN Wanlong WANG Yueming FENG Zhenping LI Hongzhi YAO Mingyu ZHANG Yifan | 2019 | Journal of Thermal Science2019，28，3： | 1 |
| 7 | Rapid Tooling for sand Casting Using Laminated Object Manufacturing Process 显示文摘 | Wanlong Wang James G Conley Henry W Stoll | 1999 | Rapid Prototyping Journal1999，，5： | 1 |
| 8 | Microstructure and Ultrastructure Changes of Panax ginseng Root Tip that Infected by Cylindrocarpon destructans at Early Stage显示文摘[Objectives] To study the microstructure and ultrastructure changes of P. ginseng root tip infected by C. destructans. [Methods]The paraffin section and superfine slice were used to observe the microstructure and ultrastructure of root tip of P. ginseng,respectively.[Results] Microstructure and ultrastructure observation indicated that,the morphology and structure of epidermal cells of P. ginseng were regular,cells had abundant contents,and organelles were easy to observe in control. However,after infected by C. destructans,the cell walls were thicken seven days post inoculation,particles were deposited in epidemic cells and pith,cell walls were broken,and cells began to disintegrate. Furthermore,morphology of cells was abnormal and contents in cells were decreased when infected by C. destructans. The organelles were break up,and difficult to be distinguished. [Conclusions] Through the results we deduced that,the hypha of C. destructans should firstly invade the epidermal cells of P. ginseng,and then enter into the xylem of P. ginseng root through the intercellular space,which obstructed the transport of water and inorganic salt,and finally led to death of ginseng seedlings. | Yuan GAO Wanlong DING Rong WANG Yong LI | 2018 | Medicinal Plant2018，9，1： | 0 |
| 9 | Dose escalation guided by^(18)F-FDG PET/CT for esophageal cancer显示文摘Objective:To assess the feasibility of dose escalation guided by ^(18)F-deoxyglucose positron emission tomography/computer tomography(^(18)F-FDG PET/CT)for esophageal cancer(EC).Methods and materials:Ten random patients treated with definitive chemoradiotherapy and pre-therapeutic ^(18)FFDG PET/CT were included in this study.Retrospectively,a threshold of 50%of SUVmax was used to define the high FDG uptake region of the GTV(GTVPET).Three intensity-modulated radiation therapy(IMRT)plans were generated,delivering three dose levels to three different planning target volumes(PTVs).50.4 Gy delivered to PTV50.4 was defined on computed tomography(CT)as Plan50.4,63 Gy was delivered to PTV63 was defined as GTV plus a uniform margin of 0.5 cm as Plan63,and 70 Gy delivered to PTV70 was defined as GTVPET plus a 0.5 cm margin as Plan70.A dosimetric comparison was performed based on normal tissue complication probability(NTCP)for the lung and heart.Results:Clinically acceptable dose escalation failed for 2 of 10 patients in Plan63 due to heart dose constraints.One patient failed heart dose constraint for Plan70.Two patients failed spinal cord constraint for Plan63.Three patients failed lung dose constraints for both Plan63 and Plan70,two of which were even not suitable for Plan50.4 for the same reason.NTCP modeling for lung showed increased risk for Plan63 and Plan70 compared to Plan50.4.The difference between Plan63 and Plan70 was insignificant.NTCP modeling for heart showed an increased risk from 6.38%of Plan50.4 to 8.88%of Plan70(P=0.009)or 9.79%of Plan63(P=0.007).The risk of heart mortality was significantly higher for Plan63 than Plan70(P=0.047).Conclusions:Selective boosting of sub-volumes based on ^(18)F-FDG PET/CT is feasible way with a modest increase in the risk of cardiac and lung toxicities. | Bingjie Fan Chengqiang Li Fengchun Mu Wenru Qin Linlin Wang Xindong Sun Chunni Wang Bing Zou Shijiang Wang Wanlong Li Man Hu | 2021 | Radiation Medicine and Protection2021，2，2： | 0 |
| 10 | Hyperoside promotes pollen tube growth by regulating the depolymerization effect of actin depolymerizing factor 1 on microfilaments in okra显示文摘Mature pollen germinates rapidly on the stigma,extending its pollen tube to deliver sperm cells to the ovule for fertilization.The success of this process is an important factor that limits output.The flavonoid content increased signi ficantly during pollen germination and pollen tube growth,which suggests it may play an important role in these processes.However,the speci fi c mechanism of this involvement has been little researched.Our previous research found that hyperoside can prolong the flowering period of Abelmoschus esculentus(okra),but its speci fic mechanism is still unclear.Therefore,in this study,we focused on the effect of hyperoside in regulating the actin-depolymerizing factor(ADF),which further affects the germination and growth of pollen.We found that hyperoside can prolong the effective pollination period of okra by 2-3-fold and promote the growth of pollen tubes in the style.Then,we used Nicotiana benthamiana cells as a research system and found that hyperoside accelerates the depolymerization of intercellular micro fi laments.Hyperoside can promote pollen germination and pollen tube elongation in vitro.Moreover,AeADFl was identi fied out of all AeADF genes as being highly expressed in pollen tubes in response to hyperoside.In addition,hyperoside promoted AeADF1-mediated micro filament dissipation according to micro filament severing experiments in vitro.In the pollen tube,the gene expression of AeADFl was reduced to 1/5 by oligonucleotide transfection.The decrease in the expression level of AeADFl partially reduced the promoting effect of hyperoside on pollen germination and pollen tube growth.This research provides new research directions for flavonoids in reproductive development. | Biying Dong Qing Yang Zhihua Song Lili Niu Hongyan Cao Tengyue Liu Tingting Du Wanlong Yang Meng Qi Ting Chen Mengying Wang Haojie Jin Dong Meng Yujie Fu | 2021 | Horticulture Research2021，8，1： | 0 |
| 11 | Population genomics provides insights into the evolution and adaptation of tree shrews(Tupaia belangeri)in China显示文摘Physiological adaptation of tree shrews(Tupaia belangeri)to changing environmental temperature has been re-ported in detail.However,the T.belangeri origin(mainland or island),population history,and adaptation to histor-ical climate change remain largely unknown or controversial.Here,for thefirst time,we sequenced the simplified genome of 134 T.belangeri individuals from 12 populations in China and further resequenced one individual from each population.Using population genomic approaches,wefirst observed considerable genetic variation in T.be-langeri.Moreover,T.belangeri populations formed obvious genetic structure and reflected different demographic histories;they generally exhibited high genetic diversity,although the isolated populations had relatively low ge-netic diversity.The results presented in this study indicate that T.b.modesta and T.b.tonquinia were separated recently and with a similar population dynamics.Second,physical barriers rather than distance were the driving factors of divergence,and environmental heterogeneity may play an important role in genetic differentiation in T.belangeri.Moreover,our analyses highlight the role of historical global climates in the T.belangeri population dynamics and indicate that the decrease of the T.belangeri population size may be due to the low temperature.Finally,we identified the olfaction-associated adaptive genes between different altitude populations and found that olfactory-related genes of high-altitude populations were selectively eliminated.Our study provides demographic history knowledge of T.belangeri;their adaption history offers new insights into their evolution and adaptation,and provides valuable baseline information for conservation measures. | Yue REN Ting JIA Hao ZHANG Wanlong ZHU Zhengkun WANG | 2023 | Integrative Zoology2023，18，1： | 0 |
| 12 | Interactive information disclosure and non-penalty regulatory review risk显示文摘Using monthly data from the Shenzhen Stock Exchange's‘Hudongyi’platform and comment letters from December 2014 to December 2018,this study investigates the influence of interactive information disclosure on non-penalty regulatory review risk.The findings reveal that the richness and activeness of interactive information disclosure are positively associated with regulatory review risk.Moreover,the non-penalty regulatory review is effective as it significantly reduces the probability of receiving a comment letter in the subsequent three periods.The timeliness of interactive information disclosure is negatively associated with regulatory review risks.Additionally,we find that newspaper media coverage partially mediates the relationship between interactive information disclosure and regulatory review risk.For companies with low levels of internal governance,in low-competitive industries,and state-owned companies,the positive relationship between the number of investor questions and regulatory review risk is strengthened.These findings enrich the literature on the determinants of regulatory review risk and the economic consequences of interactive information disclosure in emerging markets. | Meng Wang Yongjie Zhang Yizhe Dong Gaofeng Zou Wanlong Zhao | 2023 | Journal of Management Science and Engineering2023，8，1： | 0 |
| 13 | Characterization of interfaces: Lessons from the past for the future of perovskite solar cells显示文摘A photovoltaic technology historically goes through two major steps to evolve into a mature technology. The first step involves advances in materials and is usually accompanied by the rapid improvement of power conversion efficiency. The second step focuses on interfaces and is usually accompanied by significant stability improvement. As an emerging generation of photovoltaic technology, perovskite solar cells are transitioning to the second step of their development when a significant focus shifts toward interface studies and engineering. While various interface engineering strategies have been developed, interfacial characterization is crucial to show the effectiveness of interfacial modification. Here, we review the characterization techniques that have been utilized in studying interface properties in perovskite solar cells. We first summarize the main roles of interfaces in perovskite solar cells, and then we discuss some typical characterization methodologies for morphological, optical,and electrical studies of interfaces. Successful experiences and existing problems are analyzed when discussing some commonly used methods. We then analyze the challenges and provide an outlook for further development of interfacial characterizations. This review aims to evoke strengthened research devotion on novel and persuasive interfacial engineering. | Wanlong Wang Dongyang Zhang Rong Liu Deepak Thrithamarassery Gangadharan Furui Tan Makhsud I.Saidaminov | 2022 | Journal of Semiconductors2022，43，5： | 0 |
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