|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | L_(1/2) regularization显示文摘In this paper we propose an L1 /2 regularizer which has a nonconvex penalty.The L 1/2 regularizer is shown to have many promising properties such as unbiasedness, sparsity and oracle properties.A reweighed iterative algorithm is proposed so that the solution of the L 1/2 regularizer can be solved through transforming it into the solution of a series of L 1 regularizers.The solution of the L 1/2 regularizer is more sparse than that of the L 1 regularizer, while solving the L 1/2 regularizer is much simpler than solving the L 0 regularizer.The experiments show that the L 1/2 regularizer is very useful and efficient, and can be taken as a representative of the Lp(0 < p < 1) regularizer. | XU ZongBen ZHANG Hai WANG Yao CHANG XiangYu LIANG Yong | 2010 | Science China(Information Sciences)2010，53，6： | 32 |
| 3 | Therapeutic potential of siRNA-mediated combined knockdown of the lAP genes (Livin, XIAP, and Survivin) on human bladder cancer T24 cells显示文摘Livin, apoptosis (XIAP ) 的 X 连接禁止者,和 Survivin 几乎是 apoptosis 的三个著名禁止者在癌症房间只过去表示并且为癌症治疗被认为有势力目标。在现在的学习,我们发现 Livin, XIAP,和 Survivin 同时在膀胱癌症房间被表示。我们推测了那 Livin, XIAP,和 Survivin 可能在房间生长和 apoptosis 上有 synergistic 效果。我们的结果证实了联合那所有这三基因击倒能 synergistically 禁止增长和高级膀胱癌症 T24 房间的转变能力并且把房间 apoptotic 敏感提升到化疗。而且,联合了 Livin, XIAP,和 Survivin 罐头击倒显著地增加许多活跃 caspase-3,活跃 caspase-7,活跃 caspase-9,和 cytosolic Smac。我们的调查结果暗示 Livin, XIAP,和 Survivin 的那联合 silencing 可以是一个有势力为膀胱癌症的多指向的基因治疗。 | Deyong Yang Xishuang Song Jianing Zhang Lin Ye Shujing Wang Xiangyu Che Jianbo Wang Zhiwei Zhang Lina Wang Wei Shi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 29 |
| 4 | The outlook of blockchain technology for construction engineering management显示文摘Current construction engineering management suffers numerous challenges in terms of the trust,information sharing, and process automation. Blockchain which is a decentralised transaction and data management technology, has attracted increasing interests from both academic and industrial aspects since 2008. However,most of the existing research and practices are focused on the blockchain itself(i.e. technical challenges and limitations) or its applications in the finance service sector(i.e.Bitcoin). This paper aims to investigate the potential of applying blockchain technology in the construction sector.Three types of blockchain-enabled applications are proposed to improve the current processes of contract management, supply chain management, and equipment leasing, respectively. Challenges of blockchain implementation are also discussed in this paper. | Jun WANG Peng WU Xiangyu WANG Wenchi SHOU | 2017 | Frontiers of Engineering Management2017，4，1： | 20 |
| 5 | Poxue Huayu and Tianjing Busui Decoction for cerebral hemorrhage Upregulation of neurotrophic factor expression显示文摘This study established a rat model of cerebral hemorrhage by injecting autologous anticoagulated blood.Rat models were intragastrically administered 5,10,20 g/kg Poxue Huayu and Tianjing Busui Decoction,supplemented with Hirudo,raw rhubarb,raw Pollen Typhae,gadfly,Fructrs Trichosanthis,Radix Notoginseng,Rhizoma Acori Talarinowii,and glue of tortoise plastron,once a day,for 14 consecutive days.Results demonstrated that brain water content significantly reduced in rats with cerebral hemorrhage,and intracerebral hematoma volume markedly reduced after treatment.Immunohistochemical staining revealed that brain-derived neurotrophic factor,tyrosine kinase B and vascular endothelial growth factor expression noticeably increased around the surrounding hematoma.Reverse transcription-PCR revealed that brain-derived neurotrophic factor and tyrosine kinase B mRNA expression significantly increased around the surrounding hematoma.Neurologic impairment obviously reduced.These results indicated that Poxue Huayu and Tianjing Busui Decoction exert therapeutic effects on cerebral hemorrhage by upregulating the expression of brain-derived neurotrophic factor. | Jixiang Ren Xiangyu Zhou Jian Wang Jianjun Zhao Pengguo Zhang | 2013 | Neural Regeneration Research2013，8，22： | 19 |
| 6 | Stability control of surrounding rocks for a coal roadway in a deep tectonic region显示文摘In order to effectively control the deformation and failure of surrounding rocks in a coal roadway in a deep tectonic region, the deformation and failure mechanism and stability control mechanism were studied. With such methods as numerical simulation and field testing, the distribution law of the displacement, stress and plastic zone in the surrounding rocks was analyzed. The deformation and failure mechanisms of coal roadways in deep tectonic areas were revealed: under high tectonic stress, two sides will slide along the roof or floor; while the plastic zone of the two sides will extend along the roof or floor,leading to more serious deformation and failure in the corner of two sides and the bolt supporting the corners is readily cut off by the shear force or tension force. Aimed at controlling the large slippage deformation of the two sides, serious deformation and failure in the corners of the two sides and massive bolt breakage, a ‘‘controlling and yielding coupling support'' control technology is proposed. Firstly, bolts which do not pass through the bedding plane should be used in the corners of the roadway, allowing the two sides to have some degree of sliding to achieve the purpose of ‘‘yielding'' support, and which avoid breakage of the bolts in the corner. After yielding support, bolts in the corner of the roadway and which pass through the bedding plane should be used to control the deformation and failure of the coal in the corner. ‘‘Controlling and yielding coupling support'' technology has been successfully applied in engineering practice, and the stability of deep coal roadway has been greatly improved. | Xiao Tongqiang Wang Xiangyu Zhang Zhigao | 2014 | International Journal of Mining Science and Technology2014，24，2： | 16 |
| 7 | Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia显示文摘The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia(PE),in which an imbalance between the inflammation-limiting regulatory T cells(Tregs)and the inflammationmediating Th17 cells plays an essential role.Previously,we reported that the abnormal upregulation of tetraspannin CD81 in trophoblast cells(fetal component)participated in the pathogenesis of PE.However,as one of the potential immune regulatory molecules,whether CD81 induces PE by interfering with the balance of the maternal immune system has not yet been clarified.Thus,we investigated the relationship between the upregulation of CD81 in trophoblast cells and the imbalance of Treg and Th17 cells in mothers.Here,we demonstrated that upregulation of CD81 in trophoblast cells was accompanied by a decrease in Treg cells and an increase in Th17 cells in both the basal plate(placental maternal side)and peripheral blood of patients with PE.In vitro culture of naïve T cells with medium from the CD81-overexpressing trophoblast cell line HTR-8 resulted in enhanced differentiation of T cells into Th17 cells and decreased the formation of Tregs,which was dependent on the paracrine signaling of IL-6 in trophocytes,induced by CD81.In a CD81-induced PE rat model,we found a significant shift of T cell differentiation towards Th17 cells,and administration of IL-6 antibody mitigated the PE phenotype and the imbalance of the Treg/Th17 cells.These results define a vital regulatory cascade involving trophocyte-derived CD81,IL-6,and maternal Treg/Th17 cells in the pathogenesis of PE and suggests new therapeutic approaches based on CD81 and IL-6 downregulation to prevent human PE. | Hailin Ding Yimin Dai Yi Lei Zhiyin Wang Dan Liu Ruotian Li Li Shen Ning Gu Mingming Zheng Xiangyu Zhu Guangfeng Zhao Yali Hu | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 8 | Catalytic fast pyrolysis of Kraft lignin with HZSM-5 zeolite for producing aromatic hydrocarbons显示文摘 | Xiangyu LI Lu SU Yujue WANG Yanqing YU Chengwen WANG Xiaoliang LI Zhihua WANG | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 14 |
| 9 | Numerical simulation of low pressure die-casting aluminum wheel显示文摘The FDM numerical simulation software,ViewCast system,was employed to simulate the low pressure die casting(LPDC)of an aluminum wheel.By analyzing the mold-filling and solidification stage of the LPDC process,the distribution of liquid fraction,temperature field and solidification pattern of castings were studied.The potential shrinkage defects were predicted to be formed at the rim/spoke junctions,which is in consistence with the X-ray detection result.The distribution pattern of the defects has also been studied.A solution towards reducing such defects has been presented.The cooling capacity of the mold was improved by installing water pipes both in the side mold and the top mold.Analysis on the shrinkage defects under forced cooling mode proved that adding the cooling system in the mold is an effective method for reduction of shrinkage defects. | Mi Guofa Liu Xiangyu Wang Kuangfei Fu Hengzhi | 2009 | China Foundry2009，6，1： | 11 |
| 10 | Transcriptional Regulation of miR528 by OsSPL9 Orchestrates Antiviral Response in Rice显示文摘Many microRNAs (miRNAs) are critical regulators of plant antiviral defense.However,little is known about how these miRNAs respond to virus invasion at the transcriptional level.We previously show that defense against Rice stripe virus (RSV) invasion entailed a reduction of miR528 accumulation in rice,alleviating miR528-mediated degradation of L-Ascorbate Oxidase (AO) mRNA and bolstering the antiviral activity of AO.Here we show that the miR528-A0 defense module is regulated by the transcription factor SPL9.SPL9 displayed high-affinity binding to specific motifs within the promoter region of miR528 and activated the expression of miR528 gene in vivo.Loss-of-function mutations in SPL9 caused a significant reduction in miR528 accumulation but a substantial increase of AO mRNA,resulting in enhanced plant resistance to RSV.Conversely,transgenic overexpression of SPL9 stimulated the expression of miR528 gene,hence lowering the level of AO mRNA and compromising rice defense against RSV.Importantly,gain in RSV susceptibility did not occur when SPL9 was overexpressed in mir528 loss-of-function mutants,or in transgenic rice expressing a miR528-resistant AO.Taken together,the finding of SPL9-mediated transcriptional activation of miR528 expression adds a new regulatory layer to the miR528-A0 antiviral defense pathway. | Shengze Yao Zhirui Yang Rongxin Yang Yu Huang Ge Guo Xiangyue Kong Ying Lan Tong Zhou He Wang Wenming Wang Xiaofeng Cao Jianguo Wu Yi Li | 2019 | Molecular Plant2019，12，8： | 10 |
| 11 | Progress of regional oceanography study associated with western boundary current in the South China Sea显示文摘Recent progress of physical oceanography in the South China Sea (SCS) associated with the western boundary current (WBC) and eddies is reviewed in this paper. It includes Argo observations of the WBC, eddy detection in the WBC based on satellite images, cross-continental shelf exchange in the WBC, eddy-current interaction, interannual variability of the WBC, air-sea interaction, the SCS throughflow (SCSTF), among others. The WBC in the SCS is strong, and its structure, variability and dynamic processes on seasonal and interannual time scales are yet to be fully understood. In this paper, we summarize progresses on the variability of the WBC, eddy-current interaction, air-sea interaction, and the SCSTF achieved in the past few years. Firstly, using the drifting buoy observations, we point out that the WBC becomes stronger and narrower after it reaches the central Vietnam coast. The possible mechanisms influencing the ocean circulation in the northern SCS are discussed, and the dynamic mechanisms that induce the countercurrent in the region of northern branch of WBC in winter are also studied quantitatively using momentum balance. The geostropic component of the WBC was diagnosed using the ship observation along 18°N, and we found that the WBC changed significantly on interannual time scale. Secondly, using the ship observations, two anti-cyclonic eddies in the winter of 2003/2004 in the northern SCS, and three anti-cyclonic eddies in the summer of 2007 along 18°N were studied. The results show that the two anti-cyclonic eddies can propagate southwestward along the continental shelf at the speed of first Rossby wave (~0.1 ms-1 ) in winter, and the interaction between the three anti-cyclonic eddies in summer and the WBC in the SCS is preliminarily revealed. Eddies on the continental shelf of northern SCS propagated southeastward with a maximum speed of 0.09 ms-1 , and those to the east of Vietnam coast had the largest kinetic energy, both of which imply strong interaction between eddy activity and WBC in the SCS. Thirdly, strong intraseasonal variability (ISV) of sea surface temperature (SST) near the WBC regions was found, and the ISV signal of SST in winter weakens the ISV signal of latent heat flux by 20%. Fourthly, the long-term change of SCSTF volume transport and its connection with the ocean circulation in the Pacific were discussed. | WANG DongXiao LIU QinYan XIE Qiang HE ZhiGang ZHUANG Wei SHU YeQiang XIAO XianJun HONG Bo WU XiangYu SUI DanDan | 2013 | Chinese Science Bulletin2013，58，11： | 10 |
| 12 | Protective effects of Jiayan Kangtai granules on autoimmune thyroiditis in a rat model by modulating Th17/Treg cell balance显示文摘OBJECTIVE: To investigate the protective effects of Jiayan Kangtai(JYKT) granules, consisting of 9 Chinese herbs, in a rat model of autoimmune thyroiditis(AIT), and the possible underlying mechanism.METHODS: Female Lewis rats(6-8 weeks) were randomly apportioned to 5 groups of 10, including a normal control. AIT was induced in the untreated AIT-model group, and rats treated subsequently with daily low, medium, or high dose JYKT granules. After 12 weeks, plasma levels of thyroid autoantibodies and morphological changes in the thyroid were detected by enzyme-linked immunosorbent assay and histological examination, respectively. The presence of interleukin(IL)-6,IL23 p19, and IL-2 in thyroid tissue was assessed by immunohistochemical staining. The percentages of T helper(Th)17 cells and regulatory T cells(Tregs) in the peripheral blood were analyzed by flow cytometry. Relevant levels of cytokines and proteins were examined via bead-based multiplex flow cytometry and ELISA, respectively. Expressions of genes and proteins regulated by Th17 cells and Tregs were shown by real-time PCR and Western blot.RESULTS: Compared to the control, AIT-model rats had higher plasma concentrations of thyroid autoantibodies. The high-dose JYKT rats showed significantly lower levels of thyroid autoantibodies compared with the AIT model group. Rats in the AIT-JYKT groups also had fewer thyroid lesions and less lymphocytic infiltration, a lower percentage of Th17 cells, and a higher percentage of Tregs, compared with the AIT-model. Rats given high-dose JYKT had a significantly lower Th17/Treg ratio compared with the AIT model. Differences in plasma cytokine concentrations and relevant gene and protein expressions in the spleens of JYKT-treated rats and the AIT group suggested an association between JYKT treatment and lower Th17 cell percentage and higher Treg activity.CONCLUSION: JYKT treatment appeared to be protective against AIT in rats, possibly via the regulation of the Th17 cell/Treg imbalance in AIT. | Hou Yi Wang Tieshan Guo Xiangyu Sun Wen Guo Xuan Wu Lili Qin Lingling Zhang Chengfei Liu Tonghua | 2018 | Journal of Traditional Chinese Medicine2018，38，3： | 9 |
| 13 | Recanalisation therapy in patients with acute ischaemic stroke caused by large artery occlusion:choice of therapeutic strategy according to underlying aetiological mechanism?显示文摘Various mechanisms underlie causative large artery occlusion(LAO)in patients with acute ischaemic stroke.Cardioembolic and atherosclerotic occlusions are the two most common types.The pathophysiological changes and responses to mechanical thrombectomy(MT)and antithrombotic treatments including thrombolysis,antiplatelet and anticoagulation therapy may vary among patients with different aetiological mechanisms of occlusion.Atherosclerotic occlusion is inclined to have relatively abundant collaterals and larger area of penumbra,hence a relatively wider time window for reperfusion therapy,while poor response to medical thrombolysis and MT.Severe residual stenosis and reocclusion occurred frequently after MT in atherosclerotic LAO.Angioplasty and stenting as rescue or the first-line therapy and more intensified antiplatelet therapy beyond related recommendations in the current guidelines are sometimes used in managing acute causative LAO because of poor recanalisation after recommended standard thrombolysis or MT therapy,which are usually based on individual experience.Standard protocol to establish emergent aetiological diagnosis of causative LAO and individualised aetiology-specific treatment strategy is needed. | Chenglin Tian Xiangyu Cao Jun Wang | 2017 | Stroke & Vascular Neurology2017，2，4： | 9 |
| 14 | Bioinspired Self-Healing Organic Materials: Chemical Mechanisms and Fabrications显示文摘 | Xiangyu Yin Zhilu Liu Daoai Wang Xiaowei Pei Bo Yu Feng Zhou | 2015 | Journal of Bionic Engineering2015，12，1： | 8 |
| 15 | Failure mechanism and stability control technology of rock surrounding a roadway in complex stress conditions显示文摘To solve the problem of supporting three downhill coal structures in the Yongan Coal Mine of Shanxi Jincheng, we studied the regular development of stress and plastic zones and characteristics of deformation of rock surrounding roadway groups after a period of roadway driving, mining one side as well as mining both sides, we used FLAC 3D for our numerical and theoretical analyses. Field test were carried out, where we revealed the deformation mechanism of roadways and its coal pillars in complex stress conditions. We proposed a roadway stability control technology using backwall grouting with high-water rapid hardening material and combined support with bolt and cable anchoring after mining both sides. Our field practices showed that deformation of rock surrounding roadways can be controlled with this technology. | Yu Yang Bai Jianbiao Chen Ke Wang Xiangyu Xiao Tongqiang Chen Yong | 2011 | Mining Science and Technology2011，21，3： | 8 |
| 16 | Floor heave characteristics and control technology of the roadway driven in deep inclined-strata显示文摘Based on in-mine instrumentation and theoretical analysis of the unsymmetrical large-deformation that occurred in the roadway after excavation,Differential Floor Heave(DFH)was found to be the main reason for roadway failure.It needs to be pointed out that the specific roadway was driven in inclined rock strata.In addition,the factors that contribute to the occurrence of DFH are discussed in detail.It is believed that DFH is triggered by the unsymmetrical stress distribution in the floor and the different rock types encountered near the two floor corners.Hence,DFH control should be focused on the left floor corner where shearing failure occurs initially and the left floor surface where tensile failure is more severe.The proposed DFH control strategies include unsymmetrical grouting for the whole roadway,re-design of the roof and ribs support,reinforcement of the weak zones,and release of the concentrated stress in the earlier stage.Meanwhile,it is recommended that in the later stage,both bolts and cable bolts with higher strength and the backfilling technique using the coal measure rocks and concrete should be employed in the reversed-arch floor.The field instrumentation results,after using the proposed control strategies,indicate that large deformation in a DFH roadway has been successfully controlled. | Wang Meng Guo Guanlong Wang Xiangyu Guo Yu Dao Vietdoan | 2015 | International Journal of Mining Science and Technology2015，25，2： | 7 |
| 17 | Dechlorination of disinfection by-product monochloroacetic acid in drinking water by nanoscale palladized iron bimetallic particle显示文摘Nanoscale palladized iron(Pd/Fe)bimetallic particles were prepared by reductive deposition method.The particles were characterized by X-ray diffraction(XRD),X-ray fluorescence(XRF),scanning electron microscope(SEM),transmission electron microscope(TEM),and Brunauer-Emmett-Teller-nitrogen(BET-N_2)method.Data obtained from those methods indicated that nanoscale Pd/Fe bimetallic particles containedα-Fe^0.Detected Pd to Fe ratio by weight(Pd/Fe ratio)was close to theoretical value. Spherical granules with di... | CHEN, Chao WANG, Xiangyu CHANG, Ying LIU, Huiling | 2008 | Journal of Environmental Sciences2008，20，8： | 7 |
| 18 | Improved clinical outcomes of rhG-CSF-mobilized blood and marrow haploidentical transplantation compared to propensity score-matched rhG-CSF-primed peripheral blood stem cell haploidentical transplantation:a multicenter study显示文摘The effects of haploidentical rhG-CSF-mobilized blood and marrow transplantation(HBMT) on hematological malignances are well established. Previous prospective single-center studies have demonstrated better survival after HBMT versus haploidentical rhG-CSF-mobilized peripheral blood stem cell transplantation(HPBSCT) for acute leukemia(AL) not in remission(NR) or in more than the second complete remission(>CR2). To test the hypothesis that HBMT is still superior to HPBSCT for patients with AL, multiple myeloma(MM), or non-Hodgkin lymphoma(NHL) in CR1/CR2 and for patients with chronic myeloid leukemia in the first and second chronic phase lacking a matched donor, we designed a propensity score method-based multicenter study.Hematopoietic recovery, acute graft-versus-host disease(aGVHD), and chronic GVHD were comparable between the HBMT group(n=168) and the HPBSCT group(n=42). No significant differences were found in non-relapse mortality rate(20.17%±3.58%and 27.24%±7.16%, P=0.18) or relapse rate(19.96%±3.72% and 28.49%±8.25%, P=0.32) between the HBMT group and the HPBSCT group. HBMT recipients had better overall survival(65.0%±4.2% and 54.2%±8.3%, P=0.037) and disease-free survival(59.9%±4.6% and 44.3%±8.7%, P=0.051). Multivariate analysis showed that HPBSCT was associated with poorer DFS(HR(95%CI), 1.639(0.995–2.699), P=0.052). Our comparisons showed that HBMT was superior to HPBSCT as a post-remission treatment for patients lacking an identical donor. | Xiangyu Zhao Feng Gao Xiaohui Zhang Yu Wang Lanping Xu Kaiyan Liu Xiaosu Zhao Yingjun Chang Han Wei Huan Chen Yuhong Chen Zhengfan Jiang Xiaojun Huang | 2016 | Science China(Life Sciences)2016，59，11： | 7 |
| 19 | Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal Residual Disease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation显示文摘Leukemia relapse is still the leading cause of treatment failure after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for B cell acute lymphoblastic leukemia (B-ALL). Relapsed patients with BALL after allo-HSCT have a very short median survival. Minimal residual disease (MRD) is predictive of forthcoming hematological relapse after hematopoietic stem cell transplantation (HSCT);furthermore, eliminating MRD effectively prevents relapse. Donor lymphoblastic infusion (DLI) is the main established approach to treat B-ALL with MRD after allo-HSCT. However, about one-third of patients with MRD are non-responsive to DLI and their prognosis worsens. Although donor-derived cluster of differentiation (CD)19-directed chimeric antigen receptor-modified (CAR) T cells (CART19s) can potentially cure leukemia, the efficiency and safety of infusions with these cells have not yet been investigated in patients with MRD after HSCT. Between September 2014 and February 2018, six patients each received one or more infusions of CART19s from HSCT donors. Five (83.33%) achieved MRD-negative remission, and one case was not responsive to the administration of CAR T cells. Three of the six patients are currently alive without leukemia. No patient developed acute graft-versus-host disease (aGVHD), and no patient died of cytokine release syndrome. Donor-derived CAR T cell infusions seem to be an effective and safe intervention for patients with MRD in B-ALL after allo-HSCT and for those who were not responsive to DLI. | Yifei Cheng Yuhong Chen Chenhua Yan Yu Wang Xiangyu Zhao Yao Chen Wei Han Lanping Xu Xiaohui Zhang Kaiyan Liu Shasha Wang Lungji Chang Lei Xiao Xiaojun Huang | 2019 | Engineering2019，5，1： | 7 |
| 20 | 数字滤波初始化(DFI)在高水平分辨率模式中的应用显示文摘数字滤波初始化应用的前提假设之一是不平衡重力惯性波在频率谱上与有天气意义的波动不重叠。随着水平分辨率的不断提高,数值模式能够解析的重力波具有波长更短、频率更高的性质,模式中有天气意义的波动与高频噪声的界线更加模糊,因此,数字滤波初始化在高分辨率模式中的应用性能尚未明确。以一次深对流过程为例,在3 km水平分辨率条件下采用不同滤波参数配置进行数字滤波初始化试验,试图对高水平分辨率预报初始场中高频噪声特征、如何区分具有天气意义的高频信号和虚假噪声、数字滤波初始化在数值预报模式(WRF)高水平分辨率条件下的应用性能等一系列相关问题给出初步的认识。试验结果表明,在针对高分辨率模式进行数字滤波初始化时,原有应用于低分辨率模式的初始化配置参数已不适用,必须根据高分辨率噪声的特点重新设计相应的滤波方案。即使在'无噪声'状态下,有天气意义的信息在模式中也具有与虚假高频噪声一致的表现形式,即大的地面气压变化倾向。数字滤波初始化的确能对特定切断频率的高频振荡进行滤波,但无法区分其性质究竟是具有天气意义的高频信号,还仅仅只是虚假的高频噪声。如果要达到滤除初始场中高频噪声的理想效果、并且消除积分过程中的高频振荡,必须延长滤波时间窗,但这是以增加额外的积分时间、以及有可能损害气象上有意义的波动为代价的。滤波效果越显著,滤波结果对初始场的改变越大,这两个方面实质上是有冲突的,因此,在应用数字滤波初始化时必须在滤波效果可接受和保证预报性能两方面之间进行妥协。最后就数字滤波初始化在高分辨率有限区域数值模式中的可能应用提出了具体的建议。 | 陈敏 Huang Xiangyu Wang Wei | 2012 | 气象学报2012，70，1： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员