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| 1 | Experimental study on flow characteristics of tetrahydrofuran hydrate slurry in pipelines显示文摘Tetrahydrofuran(THF) was selected as the substitute to study the flow behaviors and the mechanism of the hydrates blockage in pipelines.The slurrylike hydrates and slushlike hydrates are observed with the formation of hydrates in pipeline.There is a critical hydrate volume concentration of 50.6% for THF slurries and pipeline will be free of hydrate blockage while the hydrate volume concentration is lower than the critical volume concentration;otherwise,pipeline will be easy to be blocked.Fully turbulent flow occurs and friction factors tend to be constant when the velocity reaches 1.5 m/s.And then,constant values of friction factors that depend on the volume concentrations in the slurry were regressed to estimate the pressure drops of THF hydrate slurry at large mean velocity.Finally,a safe region,defined according to the critical hydrate volume concentration,was proposed for THF hydrate slurry,which may provide some insight for further studying the natural gas hydrate slurries and judge whether the pipeline can be run safely or not. | Wuchang Wang Shuanshi Fan Deqing Liang Yuxing Li | 2010 | Journal of Natural Gas Chemistry2010，19，3： | 26 |
| 2 | Confirmation of pelitic granulite in the Altai orogen and its geological significance显示文摘The existence of pelitic granulite in the Altai orogen was confirmed for the first time by detailed petrographic research and P-T pseudosection modeling. The pelitic granulite has the assemblage of garnet + cordierite + K-feldspar + biotite + sillimanite + plagioclase + quartz with some samples containing the paragenesis of cordierite + spinel. Peak conditions of the pelitic granulite determined from the P-T pseudosection involved P = 0.5―0.6 GPa, T = 780―800℃, belonging to medium-to low-pressure type. SHRIMP U-Pb dating of zircon presented a metamorphic age of 292.8 ± 2.3 Ma. The discovery of pelitic granulite reflects an extensional environment with high heat flow in the southern margin of the Altai orogen during the Early Permian, which provides an important petrological constraint on the evolution of the Altai orogen. | WANG Wei WEI ChunJing WANG Tao LOU YuXing CHU Hang | 2009 | Chinese Science Bulletin2009，54，14： | 11 |
| 3 | A model for estimating flow assurance of hydrate slurry in pipelines显示文摘The problem of hydrate blockage of pipelines in offshore production is becoming ever-increasing severe because oil fields in ever-increasing unusual environments have been brought in production.HCFC-141b and THF were selected as the substitutes to study the flow assurance of the hydrates in pipelines.There are critical hydrate volume concentrations for these two slurries.Hydrate slurries behave like Bingham fluids and have high agglomerating tendency when the hydrate volume concentrations are larger than the critical ones.Based on rheological behaviors of these two hydrates,a non-dimensional parameter is proposed through studying the driving forces of agglomeration among hydrate particles,which shows the agglomerating probability of hydrate particles in pipeline and can be used to judge the safety of the pipeline.Moreover,a safe model to judge the safely flow hydrate slurries was presented and verified with the experimental data,which demonstrates that the model is effective to judge whether the pipeline can be run safely or not. | Wuchang Wang Shuanshi Fan Deqing Liang Yuxing Li | 2010 | Journal of Natural Gas Chemistry2010，19，4： | 10 |
| 4 | A stretchable,asymmetric,coaxial fiber-shaped supercapacitor for wearable electronics显示文摘Nano Research volume 13,pages1686–1692(2020)Cite this article 210 Accesses 1 Citations Metrics details Abstract Fiber-shaped supercapacitors(FSCs),owing to their high-power density and feasibility to be integrated into woven clothes,have drawn tremendous attentions as a key device for flexible energy storage.However,how to store more energy while withstanding various types of mechanical deformation is still a challenge for FSCs.Here,based on a magnetron sputtering method,different pseudocapacitive materials are conformally coated on self-supported carbon nanotube aligned films.This fabrication approach enables a stretchable,asymmetric,coaxial fiber-shaped supercapacitors with high performance.The asymmetric electrode configuration that consists of CNT@NiO@MnOx cathode and CNT@Fe2O3 anode successfully extends the FSC’s electrochemical window to 1.8 V in an aqueous electrolyte.As a result,a high specific capacitance of 10.4 F·cm^−3 is achieved at a current density of 30 mA·cm^−3 corresponding to a high energy density of 4.7 mWh·cm^−3.The mechanical stability of the stretchable FSC is demonstrated with a sustainable performance under strains up to 75%and a capacitance retention of 95%after 2,000 cycles under 75%strain. | Hua Yuan Guang Wang Yuxing Zhao Yang Liu Yang Wu Yuegang Zhang | 2020 | Nano Research2020，13，6： | 7 |
| 5 | Advanced smart biomaterials and constructs for hard tissue engineering and regeneration显示文摘Hard tissue repair and regeneration cost hundreds of billions of dollars annually worldwide, and the need has substantially increased as the population has aged. Hard tissues include bone and tooth structures that contain calcium phosphate minerals.Smart biomaterial-based tissue engineering and regenerative medicine methods have the exciting potential to meet this urgent need. Smart biomaterials and constructs refer to biomaterials and constructs that possess instructive/inductive or triggering/stimulating effects on cells and tissues by engineering the material's responsiveness to internal or external stimuli or have intelligently tailored properties and functions that can promote tissue repair and regeneration. The smart material-based approaches include smart scaffolds and stem cell constructs for bone tissue engineering; smart drug delivery systems to enhance bone regeneration; smart dental resins that respond to pH to protect tooth structures; smart pH-sensitive dental materials to selectively inhibit acid-producing bacteria; smart polymers to modulate biofilm species away from a pathogenic composition and shift towards a healthy composition; and smart materials to suppress biofilms and avoid drug resistance. These smart biomaterials can not only deliver and guide stem cells to improve tissue regeneration and deliver drugs and bioactive agents with spatially and temporarily controlled releases but can also modulate/suppress biofilms and combat infections in wound sites. The new generation of smart biomaterials provides exciting potential and is a promising opportunity to substantially enhance hard tissue engineering and regenerative medicine efficacy. | Ke Zhang Suping Wang Chenchen Zhou Lei Cheng Xianling Gao Xianju Xie Jirun Sun Haohao Wang Michael D.Weir Mark A.Reynolds Ning Zhang Yuxing Bai Hockin H.K.Xu | 2018 | Bone Research2018，6，4： | 6 |
| 6 | Hydrate agglomeration modeling and pipeline hydrate slurry flow behavior simulation显示文摘Dynamic modeling and numerical simulation of hydrate slurry flow behavior are of great importance to offshore hydrate management.For this purpose, a dynamic model of hydrate agglomeration was proposed in this paper.Based on population balance equation, the frame of the dynamic model was established first, which took both hydrate agglomeration and hydrate breakage into consideration.Then, the calculating methods of four key parameters involved in the dynamic model were given according to hydrate agglomeration dynamics.The four key parameters are collision frequency, agglomeration efficiency, breakage frequency and the size distribution of sub particles resulting from particle breakage.After the whole dynamic model was built, it was combined with several traditional solid–liquid flow models and then together solved by the CFD software FLUENT 14.5.Finally, using this method, the influences of flow rate and hydrate volume fraction on hydrate particle size distribution, hydrate volume concentration distribution and pipeline pressure drop were simulated and analyzed. | Guangchun Song Yuxing Li Wuchang Wang Kai Jiang Zhengzhuo Shi Shupeng Yao | 2019 | Chinese Journal of Chemical Engineering2019，27，1： | 6 |
| 7 | Intergrowth texture in Au-Ag-Te minerals from Sandaowanzi gold deposit,Heilongjiang Province:Implications for ore-forming environment显示文摘Sandaowanzi gold deposit,Heilongjiang Province,is the only single telluride type gold deposit so far documented in the world,in which 90% of gold is hosted in gold-silver telluride minerals.Optical microscope observation,scanning electron microscope,electron probe and X-ray diffraction analysis identified abundant intergrowth textures in the Au-Ag-Te minerals,typified by sylvanite-hosting hessite crystals and hessite-hosting petzite crystals.The intergrown minerals and their chemistry are consistent,and the hosted minerals are mostly worm-like or as oriented stripes,evenly distributed in the hosting minerals,with clear and smooth interfaces.These suggest an exsolution origin for the intergrowth texture.With reference to the phase-transformation temperature derived from synthesis experiments of tellurides,the exsolution texture of Au-Ag-Te minerals implies that the veined tellurides formed at 150-220℃.The early stage disseminated tellurides formed at log f(Te 2) from 13.6 to 7.8,log f(S 2) from 11.7 to 7.6,whereas the late stage veined tellurides formed at log f(Te 2) ranging from 11.2 to 9.7 and log f(S 2) from 16.8 to 12.2. | XU Hong YU YuXing WU XiangKe YANG LiJun TIAN Zhu GAO Shen WANG QiuShu | 2012 | Chinese Science Bulletin2012，57，21： | 6 |
| 8 | Quantitative reconstruction of the paleosalinity in the Daihai Lake,Inner Mongolia,China显示文摘Ostracods are small bivalved aquatic crustaceans. They secrete shells of low-Mg calcite that are often preserved in lake sediments. Recent work has shown that the uptake of trace elements (especially Mg and Sr) into the shell may be a function of the salinity and temperature of the host water. We measured Sr/Ca ratios in living ostracod valves from the species of genus Limnocythere cf. inopinata and Sr2+/Ca2+ ratios of the host water to calculate distribution coefficient of genus Limnocythere cf. inopinata in the Daihai Lake. A function for Sr2+/Ca2+ ratio and salinity was established by measuring a series of Sr2+/Ca2+ ratios and salinities of the lake water in different places of the Daihai Lake. Finally paleosalinities of the lake water were quantitatively reconstructed by the Sr/Ca ratios of ostracod shells of the same species in sediment core of the Daihai Lake. | SHEN Ji Ryo Matsumoto WANG Sumin ZHU Yuxing | 2001 | Chinese Science Bulletin2001，46，1： | 5 |
| 9 | Extensive Inter-plant Protein Transfer between Cuscuta Parasites and Their Host Plants显示文摘Cuscuta species(dodders)are holoparasites that totally rely on host plants to survive.Although various mobile proteins have been identified to travel within a plant,whether and to what extent protein transfer between Cuscuta and host plants remain unclear.We found that hundreds to more than 1500 proteins were transferred between Cuscuta and the host plants Arabidopsis and soybean,and hundreds of interplant mobile proteins were even detected in the seeds of Cuscuta and the host soybean.Different hosts bridge-connected by dodder were also found to exchange hundreds of proteins.Quantitatively,the mobile proteins represent a few to more than 10%of the proteomes of foreign plants.Using Arabidopsis plants expressing different reporter proteins,we further showed that these reporter proteins could travel between plants and,importantly,retained their activity in the foreign plants.Comparative analysis between the interplant mobile proteins and mRNAs indicated that the majority of mobile proteins were not de novo synthesized from the translocated mRNAs,but bona fide mobile proteins.We propose that large-scale inter-plant protein translocation may play an important role in the interactions between host plants and dodder and even among the dodder bridge-connected hosts. | Nian Liu Guojing Shen Yuxing Xu Hui Liu Jingxiong Zhang Shalan Li Jing Li Cuiping Zhang Jinfeng Qi Lei Wang Jianqiang Wu | 2020 | Molecular Plant2020，13，4： | 3 |
| 10 | An elastic electrode model for wave propagation analysis in piezoelectric layered structures of film bulk acoustic resonators显示文摘Wave propagation in a piezoelectric layered structure of a film bulk acoustic resonator(FBAR) is studied. The accurate results of dispersion relation are calculated using the proposed elastic electrode model for both electroded and unelectroded layered plates. The differences of calculated cut-off frequencies between the current elastic electrode model and the simplified inertial electrode model(often used in the quartz resonator analysis) are illustrated in detail, which shows that an elastic electrode model is indeed needed for the accurate analysis of FBAR. These results can be used as an accurate criterion to calibrate the 2-D theoretical model for a real finite-size structure of FBAR. | Feng Zhu Yuxing Zhang Bin Wang Zhenghua Qian | 2017 | Acta Mechanica Solida Sinica2017，30，3： | 3 |
| 11 | Cryo-EM structure of human bile salts exporter ABCB11显示文摘Dear Editor,Bile is a complex aqueous secretion produced by the liver that facilitates the digestion of lipids in the small intestine.A group of ATP binding cassette(ABC)transporters localizing at the apical canalicular domain of hepatocytes are responsible for the secretion of the bile organic solutes to the bile canaliculi,1 including organic anions,cholesterol,bile salts,glutathione,organic cations and phospholipid(Fig.1a).To date,the 3-D structures of ABCG2,ABCG5/G8,ABCB1,ABCB4 have been reported,2'3 leaving the structures of ABCB11 and ABCC2 unknown,despite we can get some information from the homologous structures of ABCC1,4 ABCB1 and ABCB4. | Liang Wang Wen-Tao Hou Li Chen Yong-Liang Jiang Da Xu Linfeng Sun Cong-Zhao Zhou&Yuxing Chen | 2020 | Cell Research2020，30，7： | 2 |
| 12 | Achieving high throughput and TCP Reno fairness in delay-based TCP over large networks显示文摘运输控制协议(TCP ) 广泛地在象 FTP,电子邮件和 http 那样的相连、无线的因特网应用程序被使用了。众多的拥挤回避算法被建议了在各种各样的情形改进 TCP 的表演,特别为高速度和无线网络。尽管不同算法可以在不同网络条件下面完成不同性能改进,设计能越过大量网络条件表现很好的一个拥挤算法仍然是大挑战。基于延期的 TCP 有一个潜力在挑战上面克服。然而,有 TCP Reno 的基于延期的 TCP 的不公平问题广泛地在宽区域网络上堵住基于延期的 TCP 的推广。在这份报纸,我们建议了一个新奇基于延期的拥挤控制算法,命名快适合,它能在两个极端高速度网络优雅地表现,以及与广泛地部署的 TCP Reno 使公平体面和宽区域网络招待。快适合作为主要输入使用排队延期控制 TCP 拥挤窗户。包损失被用作一个第二等的信号适应地调整主要控制过程的参数。理论分析和试验性的结果证明算法的表演显著地作为与另外的最先进的算法相比被改进,当维持好公平时。 | Jingyuan WANG Jiangtao WEN Yuxing HAN Jun ZHANG Chao LI Zhang XIONG | 2014 | Frontiers of Computer Science2014，8，3： | 2 |
| 13 | Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection显示文摘Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury(SCI).Antioxidant therapies that reduce the reactive oxygen and nitrogen species(RONS)overgeneration and inflammation are proved promising for improving the outcomes.However,efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging.Here,a single-atom cobalt nanozyme(Co-SAzyme)with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI.Among SAzymes featuring different single metal-N sites(e.g.,Mn,Fe,Co,Ni,and Cu),this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide(H_(2)O_(2)),superoxide anion(O_(2)·^(-)),hydroxyl radical(·OH),nitric oxide(·NO),and peroxynitrite(ONOO^(-))that overexpressed in the early stage of SCI.The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy.In vitro results showed that the Co-SAzyme reduced the apoptosis and pro-inflammatory cytokine levels of microglial cells under oxidative stress.In addition,the Co-SAzyme combined with minocycline achieved remarkable improved functional recovery and neural repairs in the SCI-rat model. | Yuxing Jiang Hongtao Rong Yifan Wang Shange Liu Peng Xu Zhen Luo Lamei Guo Tao Zhu(✉) Hongpan Rong Dingsheng Wang Jiatao Zhang Yu Yi Hao Wang | 2023 | Nano Research2023，16，7： | 2 |
| 14 | A non-nucleophilic gel polymer magnesium electrolyte compatible with sulfur cathode显示文摘Magnesium/sulfur battery(Mg/S)has recently received wide attention due to its high theoretical energy density(3,260 Wh/L)and low cost.To further improve its safety and flexibility,developing a polymer electrolyte that can be compatible with both electrophilic S and Mg is critical.Here,we report a magnesium chloride-(fluorinated tetraethylene glycolic)borate(MgCl-FTGB)based non-nucleophilic,gel-type polymer electrolyte for Mg/S battery via a facile synthetic method through commercially available reagents.This electrolyte coupled with glass fiber allows reversible Mg deposition/dissolution(100%coulombic efficiency)with low polarization(500μA/cm^2,300/300 mV),and shows a wide electrochemical window of 4.8 V(vs.Mg/Mg^2+).Mg/S battery assembled with this electrolyte can cycle over 50 times with a high specific discharge capacity retention of over 1,100 mAh/g. | Haiyan Fan Yuxing Zhao Jianhua Xiao Jifang Zhang Min Wang Yuegang Zhang | 2020 | Nano Research2020，13，10： | 2 |
| 15 | Orchestrated cellular,biochemical,and biomechanical optimizations endow platelet-rich plasma-based engineered cartilage with structural and biomechanical recovery显示文摘Recently,biomaterials for cartilage regeneration has been intensively investigated.However,the development of scaffolds that capture regenerated cartilage with biomechanical and structural recovery has rarely been reported.To address this challenge,platelet-rich plasma(PRP)-based cartilage constructs with a well-orchestrated symphony of cellular,biochemical and biomechanical elements were prepared by simultaneously employing chondrogenic progenitor cells(CPCs)as a cell source,optimizing platelet concentration,and adding an enzyme-ion activator.It was shown that this triple-optimized PRP+CPC construct possessed increased biomechanical properties and suitable biochemical signals.The following in vitro study demonstrated that the triple-optimized PRP+CPC constructs generated cartilage-like tissue with higher expression levels of chondrogenic-specific markers,more deposition of cartilage-specific extracellular matrix(ECM),and greater biomechanical values than those of the other constructs.Twelve weeks after the construct was implanted in a cartilage defect in vivo,histological analysis,qPCR,and biomechanical tests collectively showed that the triple-optimized constructs yielded a more chondrocyte-like cell phenotype with a higher synthesis of Col-Ⅱand aggrecan.More importantly,the triple-optimized constructs facilitated cartilage regeneration with better biomechanical recovery than that of the other constructs.These results demonstrate the efficacy of the triple-optimization strategy and highlight the simplicity and potency of this PRP+CPC construct for cartilage regeneration. | Ketao Wang Ji Li Yuxing Wang Yaqiang Wang Yuanyuan Qin Fei Yang Mingzhu Zhang Heng Zhu Zhongli Li | 2021 | Bioactive Materials2021，6，11： | 2 |
| 16 | Small-signal modeling and parameter extraction method for a multigate GaAs pHEMT switch显示文摘This paper presents an accurate small-signal model for multi-gate GaAs pHEMTs in switching-mode.The extraction method for the proposed model is developed.A 2-gate switch structure is fabricated on a commercial 0.5μm AlGaAs/GaAs pHEMT technology to verify the proposed model.Excellent agreement has been obtained between the measured and simulated results over a wide frequency range. | Lin Luo Jun Liu Guofang Wang Yuxing Wu | 2020 | Journal of Semiconductors2020，41，3： | 2 |
| 17 | Cryo-EM structure of human lysosomal cobalamin exporter ABCD4显示文摘Dear Editor,Cobalamin,also known as vitamin B12,can only be biosynthesized by certain bacteria and archaea.As an essential nutrient for humans,it should be obtained from daily food.1 Exogenous cobalamin is taken up by the cell through an endocytosis process,then released into the lysosome as a free form,and finally pumped out to the cytosol for utilization.2 The human ATP-binding cassette(ABC)transporter ABCD4 localized on lysosomal membrane is indispensable for the efflux of cobalamin from lysosome to cytosol.3 Mutations in ABCD4 gene may result in cobalamin deficiency and inborn diseases.The patients suffer from combined symptoms:hypotonia,lethargy,poor feeding,bone marrow suppression,macrocytic anemia,and heart defects.3 However,the absence of the structure of human ABCD4 limits our understanding of the molecular mechanism of pathogenesis. | Da Xu Zhang Feng Wen-Tao Hou Yong-Liang Jiang Liang Wang Linfeng Sun Cong-Zhao Zhou Yuxing Chen | 2019 | Cell Research2019，29，12： | 2 |
| 18 | Anti-hypertensive and endothelia protective effects of Fufang Qima capsule(复方芪麻胶囊) on primary hypertension via adiponectin/adenosine monophosphate activated protein kinase pathway显示文摘OBJECTIVE:To investigate the potential mechanism of the vascular remodeling effect and provide additional information about anti-hypertension activity of Fufang Qima capsule(复方芪麻胶囊,QM).METHODS:Spontaneous hypertensive rats(SHRs)were used to study the underlying mechanism of the anti-hypertension activity of QM.In this study,SHRs were randomly divided into 5 groups:model group,Telmisartan group(7.2 mg/kg,p.o.),and three QM groups(0.9298,1.8596,and 3.7192 g/kg,p.o.).Wistar Kyoto rats(WKY)were used as normal control group.Blood pressure(BP),aorta,perivascular adipose tissue(PVAT)histology were investigated to evaluate the effect of QM.Nitric oxide(NO)and endothelial nitric oxide synthase(eNOS)phosphorylation were measured.Adiponectin(APN)secretion,as well as APN signal pathway proteins including APN,adiponectin receptors(R1 and R2)and adenosine 5’-monophosphate-activated protein kinase(AMPK)were all analyzed.RESULTS:QM significantly reduced BP and ameliorated the vascular pathological change,i.e.intima media thicken and collagen fiber hyperplasia.Meanwhile,QM increased concentration of NO and the phosphorylation of eNOS in the aorta.The anti-hypertensive and endothelia-protective effect of QM could be attributed to activating APN/AMPK pathway by up-regulating the expression of APN in PVAT and APN Receptor 2,AMPKαand phosphorylated AMPKαin the aorta.CONCLUSION:The QM alleviation effect mechanism for primary hypertension was via modulating the APN/AMPK signal pathway. | ZHAO Zhiyue SHI Zhenyu ZHANG Zhenzhen LI Yinghong ZENG Xiaohui CHEN Yuxing YAO Nan ZHOU Min SU Hui WANG Qinghai JIN LiLi | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 2 |
| 19 | Impact of Initial Storm Intensity and Size on the Simulation of Tropical Cyclone Track and Western Pacific Subtropical High Extent显示文摘Typhoon Megi, the 13 th typhoon of the 2010 typhoon season, was selected for case study by utilizing the Weather Research and Forecasting(WRF) model. Twelve sensitivity experiments with various initial tropical cyclone(TC) intensities and sizes were conducted to investigate their impacts on the simulation of typhoon track. Interaction between TC and the western Pacific subtropical high(WPSH) was also analyzed to explore the mechanism for the impact on TC track of the initial TC intensity and size. Numerical results indicate that the simulated TC size and TC track are sensitive to initial TC intensity and size. Stronger initial TC intensity and larger initial TC size often lead to larger simulated TC size and make TC turn northward earlier. Further analysis suggests that, with the increase of initial TC intensity and size, more air mass enters into the TC region, which subsequently reduces the extent of WPSH.As a result, the steering flow changes significantly and eventually causes the TC to turn northward earlier. The present study confirms that the initial TC intensity and size have certain influences on the TC track simulation, which demonstrates the importance of accurate initial condition for successful simulation of the TC intensity and TC track.Moreover, it also deepens our understanding of the interaction between TC and WPSH, provides helpful clues for the TC track change study, and discusses the future directions for improvement of TC track forecast. | Yuxing WANG Yuan SUN Qianfeng LIAO Zhong ZHONG Yijia HU Kefeng LIU | 2017 | Journal of Meteorological Research2017，31，5： | 2 |
| 20 | Auditory deprivation modifies the expression of brain-derived neurotrophic factor and tropomyosin receptor kinase B in the rat auditory cortex显示文摘The development and plasticity of central auditory system can be influenced by the change of peripheral neuronal activity. However, the molecular mechanism participating in the process remains elusive. Brain-derived neurotrophic factor(BDNF) binding with its functional receptor tropomyosin receptor kinase B(TrkB) has multiple effects on neurons. Here we used a rat model of auditory deprivation by bilateral cochlear ablation, to investigate the changes in expression of BDNF and Trk B in the auditory cortex after auditory deprivation that occurred during the critical period for the development of central auditory system. Reverse transcription-quantitative polymerase chain reaction(RTqPCR) and immunohistochemistry methods were adopted to detect the m RNA and protein expression levels of BDNF and TrkB in the auditory cortex at 2, 4, 6 and 8 weeks after surgery, respectively. The change in the expression of BDNF and TrkB mRNAs and proteins followed similar trend. In the bilateral cochlear ablation groups, the BDNF-TrkB expression level initially decreased at 2 weeks but increased at 4 weeks followed by the reduction at 6 and 8 weeks after cochlear removal, as compared to the age-matched sham control groups. In conclusion, the BDNF-TrkB signaling is involved in the plasticity of auditory cortex in an activity-dependent manner. | Yuxing Wang Ou Xu Yanxing Liu Hong Lu | 2017 | Journal of Otology2017，12，1： | 2 |
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