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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018,26,12: | 29 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018,26,3: | 6 |
| 3 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019,17,3: | 5 |
| 4 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013,23,9: | 3 |
| 5 | On the location and profile of spike-layer solutions to a singularly perturbed semilinear Dirichlet problems: Intermediate solutions 显示文摘 | Ni W M Takagi I Wei J C | 1998 | Duke Math J1998,94,3: | 2 |
| 6 | Elevation of circulating and ventricular adrenomedullin in human congestive heart failure 显示文摘 | JOUGASAKI M WEI C M Mc KINLEY L J | 1995 | Circulation1995,92,3: | 2 |
| 7 | Tooth loss and alveolar remodeling in Sinosaurus triassicus (Dinosauria: Theropoda) from the Lower Jurassic strata of the Lufeng Basin, China显示文摘Pathological or traumatic loss of teeth often results in the resorption and remodeling of the affected alveoli in mammals. However, instances of alveolar remodeling in reptiles are rare. A remodeled alveolus in the maxilla of the Chinese theropod Sinosaurus (Lower Jurassic Lower Lufeng Formation) is the first confirmed example of such dental pathology in a dinosaur. Given the known relationship between feeding behavior and tooth damage in theropods (teeth with spalled enamel, tooth crowns embedded in bone) and the absence of dentary, maxillary, and premaxillary osteomyelitis, traumatic loss of a tooth is most likely the cause of alveolar remodeling. Based on the extent of remodeling, the injury and subsequent tooth loss were non-fatal in this individual. | XING LiDa BELL Phil R ROTHSCHILD Bruce M RAN Hao ZHANG JianPing DONG ZhiMing ZHANG Wei CURRIE Philip J | 2013 | Chinese Science Bulletin2013,58,16: | 2 |
| 8 | The cellular automaton model of investment behavior in the stock market显示文摘 | Wei Y M Ying S J Fan Y | 2003 | Physica A2003,325,34: | 1 |
| 9 | Characterization of high-molecular weight glutenin subunit genes from Elytrigia elongate显示文摘 | Wang J R Yan Z H Wei Y M | 2006 | Plant Breeding2006,125,: | 1 |
| 10 | Comparison of the Population Capacity of Hematopoietic and Mesenchymal Stem Cells in Experimental Colitis Rat Model显示文摘 | Wei Y M Nie Y Q Lai J Y | 2009 | Transplantation2009,88,1: | 1 |
| 11 | Determination of glycyrrhetic acid in human plasma by HPLC-MS method and investigation of its pharmacokinetics 显示文摘 | Zhao W J Wang B J Wei C M | 2008 | J Clin Pharm Ther2008,33,: | 1 |
| 12 | Comparison of epoxy resins for applications in light - emitting diodes 显示文摘 | Huang J C Chu Y P Wei M | 2004 | Advances in polymer technology2004,23,4: | 1 |
| 13 | Active immunogene therapy of cancer with vaccine on the basis of chicken homologous matrix metalloproteinase-2显示文摘 | Su J M Wei Y Q Tian L | 2003 | Cancer Res2003,63,: | 1 |
| 14 | Soluble adhesion rnoleciles in coronary surgery and cardiopulmonary bypass with pump prime aprotinin显示文摘 | WEI M LAURIKKA J KUUKASJARVI P | 2002 | Scand Cardiovase J2002,36,6: | 1 |
| 15 | Pro-and antiinflammatory eytokine signaling:reciprocal antagonism regulates interferongamma production by human natural killer cells显示文摘 | YU J WEI M BECKNELL B | 2006 | Immunity2006,24,5: | 1 |
| 16 | Parasitism and olfactory responses of Dastarcus helophoroides ( Coleoptera: Bothrideri- dae) to different Cerambycid hosts显示文摘 | Wei J R Yang Z Q Poland T M | 2009 | BioControl2009,54,: | 1 |
| 17 | Maximum - Likelihood Classification for Digital Amplitude - Phase Modulations显示文摘 | Wei Wen Mendel J M | 2000 | IEEE Transactionson Commu- nications2000,48,2: | 1 |
| 18 | Isolation and characterization endophytic bacteria from Sedum alfredii Hance and their potential to promote phytoextraction of zinc polluted soil 显示文摘 | LONG X X CHEN X M CHEN Y G WONG J W WEI Z B WU Q T | 2010 | World Journal Microbiology Biotechnology2010,27,: | 1 |
| 19 | ATF5 increases cisplatin-induced apoptosis through up-regulation of Cyc- lin D3 transcription in HeLa cells 显示文摘 | WEI Y Y JIANG J H SUN M Y | 2006 | Biochem Biophys Res Commun2006,339,2: | 1 |
| 20 | Spectrally wide-band terahertz wave modulator Based on optically tuned graphene 显示文摘 | Weis P Garcia-Pomar J L Hoh M | 2012 | ACS Nano2012,6,10: | 1 |