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| 1 | Epstein-Barr virus infection and persistence in nasopharyngeal epithelial cells显示文摘Epstein-Barr virus(EBV) infection is closely associated with undifferentiated nasopharyngeal carcinoma(NPC), strongly implicating a role for EBV in NPC pathogenesis; conversely, EBV infection is rarely detected in normal nasopharyngeal epithelial tissues. In general, EBV does not show a strong tropism for infecting human epithelial cells, and EBV infection in oropharyngeal epithelial cells is believed to be lytic in nature. To establish life-long infection in humans, EBV has evolved efficient strategies to infect B cells and hijack their cellular machinery for latent infection. Lytic EBV infection in oropharyngeal epithelial cells, though an infrequent event, is believed to be a major source of infectious EBV particles for salivary transmission. The biological events associated with nasopharyngeal epithelial cells are only beginning to be understood with the advancement of EBV infection methods and the availability of nasopharyngeal epithelial cell models for EBV infection studies. EBV infection in human epithelial cells is a highly inefficient process compared to that in B cells, which express the complement receptor type 2(CR2) to mediate EBV infection. Although receptor(s) on the epithelial cell surface for EBV infection remain(s) to be identified, EBV infection in epithelial cells could be achieved via the interaction of glycoproteins on the viral envelope with surface integrins on epithelial cells, which might trigger membrane fusion to internalize EBV in cells. Normal nasopharyngeal epithelial cells are not permissive for latent EBV infection, and EBV infection in normal nasopharyngeal epithelial cells usually results in growth arrest. However, genetic alterations in premalignant nasopharyngeal epithelial cells, including p16 deletion and cyclin D1 overexpression, could override the growth inhibitory effect of EBV infection to support stable and latent EBV infection in nasopharyngeal epithelial cells. The EBV episome in NPC is clonal in nature, suggesting that NPC develops from a single EBV-infected nasopharyngeal epithelial cell, and the establishment of persistent and latent EBV infection in premalignant nasopharyngeal epithelium may represent an early and critical event for NPC development. | Chi Man Tsang Wen Deng Yim Ling Yip Mu-Sheng Zeng Kwok Wai Lo Sai Wah Tsao | 2014 | Chinese Journal of Cancer2014，33，11： | 8 |
| 2 | MULTIPHOTON MICROSCOPY:A NEW APPROACH IN PHYSIOLOGICAL STUDIES AND PATHOLOGICAL DIAGNOSIS FOR OPHTHALMOLOGY显示文摘Multiphoton microscopy(MPM),with the advantages of improved penetration depth,decreased photo-damage,and optical sectioning capability,has become an indispensable tool for biomedical imaging.The combination of multiphoton fluorescence(MF)and second-harmonic generation(SHG)microscopy is particularly effective in imaging tissue structures of the ocular surface.This work is intended to be a review of advances that MPM has made in ophthalmic imaging.The MPM not only can be used for the label-free imaging of ocular structures,it can also be applied for investigating the morphological alterations in corneal pathologies,such as keratoconus,infected keratitis,and corneal scar.Furthermore,the corneal wound healing process after refractive surgical procedures such as conductive keratoplasty(CK)can also be studied with MPM.Finally,qualitative and quantitative SHG microscopy is effective for characterizing corneal thermal denaturation.With additional development,multiphoton imaging has the potential to be developed into an effective imaging technique for in vivo studies and clinical diagnosis in ophthalmology. | CHIU-MEI HSUEH WEN LO SUNG-JAN LIN TSUNG-JEN WANG FUNG-RUNG HU HSIN-YUAN TAN CHEN-YUAN DONG | 2009 | Journal of Innovative Optical Health Sciences2009，2，1： | 2 |
| 3 | Efficacy of transient elastography in screening for large esophageal varices in patients with suspicious or proven liver cirrhosis显示文摘 | Huay‐Min WANG Gin‐Ho LO Wen‐Chi CHEN Ping‐I HSU Hsien‐Chung YU Chiun‐Ku LIN Hoi‐Hung CHAN Wei‐Lun TSAI Feng‐Woei TSAY Tsan‐Ping LIU E‐Ming WANG Kwok‐Hung LAI | 2012 | Journal of Digestive Diseases2012，，8： | 2 |
| 4 | Adakites from continental collision zones: Melting of thickened lower crust beneath southern Tibet 显示文摘 | Chung S L Liu D Y Ji J Q Chu M F Lee H Y Wen D J Lo C H Lee T Y Qian Q Zhang Q | 2003 | Geology2003，31，11： | 1 |
| 5 | Serum Adipokine Levels in Renal Transplant Recipients显示文摘 | K.-H. Shu M.-J. Wu C.-H. Chen C.-H. Cheng T.-M. Yu Y.-W. Chuang S.-T. Huang S.-F. Tsai Y.-C. Lo S.-C. Weng M.-C. Wen H.-C. Ho | 2014 | Transplantation Proceedings2014，，2： | 1 |
| 6 | Image vector quantization using geometric transform and lossless index coding显示文摘 | HU Y C WEN C H LO C C et a| | 2013 | Optical Engineer- ing2013，52，3： | 1 |
| 7 | Study of the root antioxidative system of tomatoes and eggplants under waterlogged conditions显示文摘 | Lin K H R Wen C C Lo H F | | Plant Science0，167，： | 1 |
| 8 | Zircon SHRIMP U–Pb ages of the Gangdese Batholith and implications for Neotethyan subduction in southern Tibet显示文摘 | Da-Ren Wen Dunyi Liu Sun-Lin Chung Mei-Fei Chu Jianqing Ji Qi Zhang Biao Song Tung-Yi Lee Meng-Wang Yeh Ching-Hua Lo | 2008 | Chemical Geology2008，，3： | 1 |
| 9 | Adakites from continental collision zones:Melting of thickened lower crust beneath southern Tibet显示文摘 | Chung S L Liu D Y Ji J Q Chu M F Lee H Y Wen D J Lo C H Lee T Y Qian Q and Zhang Q | | 0，，11： | 1 |
| 10 | Effect of precursor concentration on the characteristics of nanoscale zero valent iron and its reactivity of nitrate显示文摘 | Ya Hsuan Liou Shang-Lien Lo Wen Hui Kuan | 2006 | Water Research2006，40，13： | 1 |
| 11 | Publicly verifiable authenticated encryption显示文摘 | WEN H A LO C M HWANG T | 2003 | Electronics Letters2003，39，19： | 1 |
| 12 | Stable gold nanoparticle conjugation to internal DNA positions:Facile generation of discrete gold nanoparticle-DNA assemblies显示文摘 | Wen Y Mclaughlin C K Lo P K | 2010 | Bioconjugate Chemistry2010，21，8： | 1 |
| 13 | 0-to a-phase transformation subsystem induced bya-A1203-seeding in boehmite- derived nano-sized alumina powders显示文摘 | Yen F S Lo H S Wen H L | 2003 | Journal of Crystal Growth2003，249，： | 1 |
| 14 | Zircon SHRIMP U-Pb ages of the Gandese Batholith and implications for Neotethyan subduction in southern Tibet 显示文摘 | Wen Da-ren Liu Dunyi Chung Sun-lin Chu Mei-fei Ji Jianqing Zhang Qi Song Biao Lee Tung-yi Yeh Meng-wang Lo Ching-hua | 2008 | Chem Geol2008，252，34： | 1 |
| 15 | The effect of high and low frequency electroacupuncture in pain after lower abdominal surgery显示文摘 | Lin JG Lo MW Wen YR | 2002 | Pain2002，99，3： | 1 |
| 16 | Publicly Verifiable Authenticated Encryption显示文摘 | Wen H A Lo C M Hwang T | 2003 | Electronic Letters2003，39，19： | 1 |
| 17 | An empirical study on the correlation between knowledge management ca- pability and competitiveness in Taiwan s industries 显示文摘 | LIU PANG - LO CHEN WEN - CHIN TSAI CHIH - HUNG | 2004 | Technova- tion2004，24，12： | 1 |
| 18 | Stabilization of copper - contaminated sludge using the microwave sintering显示文摘 | Ching - Lung Chen Shang - Lien Lo Wen - Hui Kuan Ching - Hong Hsieh | 2009 | Journal of Hazardous Materials2009，168，23： | 1 |
| 19 | Characterization of Apolipoprotein E Genetic Variations in Taiwanese: Association with Coronary Heart Disease and Plasma Lipid Levels显示文摘 | June Hsieh Wu Sing-Kai Lo Ming-Shien Wen Jau-Tsuen Kao | 2002 | Human Biology2002，，1： | 1 |
| 20 | Computer simulation of thermally sensitive telechelic star polymer显示文摘 | LO VERSO F LIKOS C N LWEN H | 2007 | J Chem Phys C2007，111，15： | 1 |
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