|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 3 | Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentre randomised trial显示文摘 | Wendy Atkin Edward Dadswell Kate Wooldrage Ines Kralj-Hans Christian von Wagner Rob Edwards Guiqing Yao Clive Kay David Burling Omar Faiz Julian Teare Richard J Lilford Dion Morton Jane Wardle Steve Halligan | 2013 | The Lancet2013，，： | 3 |
| 4 | Computed tomographic colonography versus barium enema for diagnosis of colorectal cancer or large polyps in symptomatic patients (SIGGAR): a multicentre randomised trial显示文摘 | Steve Halligan Kate Wooldrage Edward Dadswell Ines Kralj-Hans Christian von Wagner Rob Edwards Guiqing Yao Clive Kay David Burling Omar Faiz Julian Teare Richard J Lilford Dion Morton Jane Wardle Wendy Atkin | 2013 | The Lancet2013，，： | 2 |
| 5 | Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders显示文摘 | E Joanna Baxter Linda M Scott Peter J Campbell Clare East Nasios Fourouclas Soheila Swanton George S Vassiliou Anthony J Bench Elaine M Boyd Natasha Curtin Mike A Scott Wendy N Erber Anthony R Green | 2005 | The Lancet . 2005 (9464)2005，，： | 2 |
| 6 | Detection of cesarean scars by transvaginal ultrasound显示文摘 | Vanessa Armstrong Wendy F Hansen Bradley J Van Voorhis Craig H Syrop | 2002 | Obstetrics & Gynecology2002，，1： | 2 |
| 7 | Low virological response and high relapse rates in hepatitis C genotype 1 patients with advanced fibrosis despite adequate therapeutic dosing显示文摘 | Wendy S.C. Cheng Stuart K. Roberts Geoffrey McCaughan William Sievert Martin Weltman Darrell Crawford William Rawlinson Philippa S. Marks James Thommes Bishoy Rizkalla Motoko Yoshihara Gregory J Dore | 2010 | Journal of Hepatology2010，，4： | 2 |
| 8 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 9 | Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion显示文摘 | Philip N Newsome Ingolfur Johannessen Shelagh Boyle Evangelos Dalakas Karen A Mcaulay Kay Samuel Frances Rae Lesley Forrester Marc L Turner Peter C Hayes David J Harrison Wendy A Bickmore John N Plevris | 2003 | Gastroenterology2003，，7： | 2 |
| 10 | Managemnent strategy impacts on ammonia volatilization from swine manure 显示文摘 | Daine M P Wendy J P Jeffery C L | 2005 | J Environ Qual2005，34，： | 1 |
| 11 | Alpha-tocopherol supplementation in healthy individuals reduces low - density lipoprotein oxidation but not atherosclerosis显示文摘 | Howard N Wendy J Peter R | | 0，，： | 1 |
| 12 | Crystallization in polymorphic systems:the solution-mediated transformation ofβtoαglycine显示文摘 | Ferrari E S Davey R J Wendy I | 2003 | Cryst Growth Des2003，3，1： | 1 |
| 13 | Expression patterns of imm ediate early transcription factors in human non-small cell lung caner显示文摘 | Michael F Press | 1995 | Onc1995，11，7： | 1 |
| 14 | Coping in middle childhood: Relations to competence, Type A behavior, monitoring, bluntingand locus of control显示文摘 | Liewer L Wendy J | 1991 | Developmental Psychology1991，27，4： | 1 |
| 15 | Apolipoprotein A-I, cyclodextrins and liposomes as potential drugs for the reversal of atherosclerosis显示文摘 | Wendy J | 2000 | J Pharm Pharmacol2000，52，7： | 1 |
| 16 | Hormone therapy and the progression of coronary-artery atherosclerosis in postmenopausal women 显示文摘 | Howard N Hodis Wendy J | 2003 | N Engl J Med2003，349，： | 1 |
| 17 | Short-term human prostate primary xenografts:an in vivo model of human prostate cancer vasculature and angiogenesis显示文摘 | Danny R Gray I Wendy J | 2004 | Cancer Res2004，64，3： | 1 |
| 18 | The carboxyl-terminal region of staphylococcal enterotoxin type A is required for a fully active molecule 显示文摘 | WENDY O H MARY T T MARSHA J B | 1991 | Infection and Immunity1991，59，6： | 1 |
| 19 | The utility of es-trogen receptor and progesterone receptor immunohisto-chemistry in the distinction of metastatic breast carcino-ma from other tumors in the liver 显示文摘 | Nash J W Morrison C Wendy L | 2003 | Arch Pathol Lab2003，127，12： | 1 |
| 20 | Work and Family Research in IO/OB: Content Analysis and Review of the Literature (1980- 2002)显示文摘 | Lillian T E Wendy J C Lockwood A Bordeaux C Brinley A | 2005 | Journal of Vocational Behavior2005，6，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员