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1Insoluble β-glucan from the cell wall of Candida albicans induces immune responses of human THP-1 monocytes through Dectin-1显示文摘背景 -glucan 是 Candida albicans 的主要结构部件(C。albicans ) 房间墙。Dectin-1 能作为主要 C 类型 lectin 模式识别受体(PRR ) 认出真菌的 -glucan 并且导致有免疫力的回答,这被表明了。在这研究,我们寻求了澄清是否从 C 的房间墙的不可溶解的 -glucan。albicans (CalG ) 能在人的 THP-1 单核白血球(一根人的尖锐 monocytic 白血病房间线) 导致有免疫力的回答并且在 vitro 与 CalG 被质问决定内在的 mechanisms.Methods 人 THP-1 单核白血球。Dectin-1,像使用费的受体(TLR2 ) , proinflammatory cytokine (TNF-) 和 chemokine (IL-8 ) 的 mRNA 表示是由即时反向的抄写聚合酶链反应(RT-PCR ) 的 assayed。TNF-8 和 IL-8 的分泌物被连接酶的 immunosorbent 试金(ELISA ) 测量。H2O2 版本被 microplate 决定荧光灯试金。西方的弄污被用来分析 THP-1 单核白血球的 IkB- phosphorylation 和 degradation.Results 暴露到导致的 CalG TNF-8.CalG 和 IL-8.CalG 的增加的基因表示和分泌物以一种时间依赖者方式导致了 H2O2 版本。有 zymolyase 的 CalG hydrolyzed 没能导致基因表示和 TNF- , IL-8 和 H2O2 版本的分泌物。CalG 起来调整 Dectin-1 的 mRNA,而 TLR2 的 mRNA 水平没被改变。与 CalG 质问的 THP-1 单核白血球以一种时间依赖者方式导致了 NF-KB 的激活。 Dectin-1 禁止者 laminarin 在 THP-1 单核白血球堵住了TNF-和 H2O2 的 导致CalG 的生产,但是没有如此的效果与抵销抗体和 .Conclusion CalG 可以玩的 LPS 禁止者(多粘菌素 B )的 anti-TLR2 在预告的处理被观察在在通过 Dectin-1 的人的 THP-1 房间的有免疫力的回答的激活的一个角色,不, TLR2.This 工作被资助从中国(号码 30671893 )的国家自然 ScienceFoundation 支持。LI Min LIU Ze-hu CHEN Qing ZHOU Wu-qing YU Mei-wen Lü Gui-xia LU Xue-lian SHEN Yong-nian LIU Wei-da WU Shao-xi 2009Chinese Medical Journal2009,,5:13
2Fungal diversity notes 367-490:taxonomic and phylogenetic contributions to fungal taxa显示文摘This is a continuity of a series of taxonomic papers where materials are examined,described and novel combinations are proposed where necessary to improve our traditional species concepts and provide updates on their classification.In addition to extensive morphological descriptions and appropriate asexual and sexual connections,DNA sequence data are also analysed from concatenated datasets(rDNA,TEF-a,RBP2 and b-Tubulin)to infer phylogenetic relationships and substantiate systematic position of taxa within appropriate ranks.Wherever new species or combinations are being proposed,we apply an integrative approach(morphological and molecular data as well as ecological features wherever applicable).Notes on 125 fungal taxa are compiled in this paper,including eight new genera,101 new species,two new combinations,one neotype,four reference specimens,new host or distribution records for eight species and one alternative morphs.The new genera introduced in this paper are Alloarthopyrenia,Arundellina,Camarosporioides,Neomassaria,Neomassarina,Neotruncatella,Paracapsulospora and Pseudophaeosphaeria.The new species are Alfaria spartii,Alloarthopyrenia italica,Anthostomella ravenna,An.thailandica,Arthrinium paraphaeospermum,Arundellina typhae,Aspergillus koreanus,Asterina cynometrae,Bertiella ellipsoidea,Blastophorum aquaticum,Cainia globosa,Camarosporioides phragmitis,Ceramothyrium menglunense,Chaetosphaeronema achilleae,Chlamydotubeufia helicospora,Ciliochorella phanericola,Clavulinopsis aurantiaca,Colletotrichum insertae,Comoclathris italica,Coronophora myricoides,Cortinarius fulvescentoideus,Co.nymphatus,Co.pseudobulliardioides,Co.tenuifulvescens,Cunninghamella gigacellularis,Cyathus pyristriatus,Cytospora cotini,Dematiopleospora alliariae,De.cirsii,Diaporthe aseana,Di.garethjonesii,Distoseptispora multiseptata,Dis.tectonae,Dis.tectonigena,Dothiora buxi,Emericellopsis persica,Gloniopsis calami,Helicoma guttulatum,Helvella floriforma,H.oblongispora,Hermatomyces subiculosa,Juncaceicola italica,Lactarius dirkii,Lentithecium unicellulare,Le.voraginesporum,Leptosphaeria cirsii,Leptosphaeria irregularis,Leptospora galii,Le.thailandica,Lindgomyces pseudomadisonensis,Lophiotrema bambusae,Lo.fallopiae,Meliola citri-maximae,Minimelanolocus submersus,Montagnula cirsii,Mortierella fluviae,Muriphaeosphaeria ambrosiae,Neodidymelliopsis ranunculi,Neomassaria fabacearum,Neomassarina thailandica,Neomicrosphaeropsis cytisi,Neo.cytisinus,Neo.minima,Neopestalotiopsis cocoe¨s,Neopestalotiopsis musae,Neoroussoella lenispora,Neotorula submersa,Neotruncatella endophytica,Nodulosphaeria italica,Occultibambusa aquatica,Oc.chiangraiensis,Ophiocordyceps hemisphaerica,Op.lacrimoidis,Paracapsulospora metroxyli,Pestalotiopsis sequoiae,Peziza fruticosa,Pleurotrema thailandica,Poaceicola arundinis,Polyporus mangshanensis,Pseudocoleophoma typhicola,Pseudodictyosporium thailandica,Pseudophaeosphaeria rubi,Purpureocillium sodanum,Ramariopsis atlantica,Rhodocybe griseoaurantia,Rh.indica,Rh.luteobrunnea,Russula indoalba,Ru.pseudoamoenicolor,Sporidesmium aquaticivaginatum,Sp.olivaceoconidium,Sp.pyriformatum,Stagonospora forlicesenensis,Stagonosporopsis centaureae,Terriera thailandica,Tremateia arundicola,Tr.guiyangensis,Trichomerium bambusae,Tubeufia hyalospora,Tu.roseohelicospora and Wojnowicia italica.New combinations are given for Hermatomyces mirum and Pallidocercospora thailandica.A neotype is proposed for Cortinarius fulvescens.Reference specimens are given for Aquaphila albicans,Leptospora rubella,Platychora ulmi and Meliola pseudosasae,while new host or distribution records are provided for Diaporthe eres,Di.siamensis,Di.foeniculina,Dothiorella iranica,Do.sarmentorum,Do.vidmadera,Helvella tinta and Vaginatispora fuckelii,with full taxonomic details.An asexual state is also reported for the first time in Neoacanthostigma septoconstrictum.This paper contributes to a more comprehensive update and improved identification of many ascomycetes and basiodiomycetes.Kevin D.Hyde Sinang Hongsanan Rajesh Jeewon D.Jayarama Bhat Eric H.C.McKenzie E.B.Gareth Jones Rungtiwa Phookamsak Hiran A.Ariyawansa Saranyaphat Boonmee Qi Zhao Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Supharat Banmai Putarak Chomnunti Bao-Kai Cui Dinushani A.Daranagama Kanad Das Monika C.Dayarathne Nimali Ide Silva Asha J.Dissanayake Mingkwan Doilom Anusha H.Ekanayaka Tatiana Baptista Gibertoni Aristóteles Góes-Neto Shi-Ke Huang Subashini C.Jayasiri Ruvishika S.Jayawardena Sirinapa Konta Hyang Burm Lee Wen-Jing Li Chuan-Gen Lin Jian-Kui Liu Yong-Zhong Lu Zong-Long Luo Ishara S.Manawasinghe Patinjareveettil Manimohan Ausana Mapook Tuula Niskanen Chada Norphanphoun Moslem Papizadeh Rekhani H.Perera Chayanard Phukhamsakda Christian Richter AndréL.C.Mde A.Santiago E.Ricardo Drechsler-Santos Indunil C.Senanayake Kazuaki Tanaka T.M.D.S.Tennakoon Kasun M.Thambugala Qing Tian Saowaluck Tibpromma Benjarong Thongbai Alfredo Vizzini Dhanushka N.Wanasinghe Nalin N.Wijayawardene Hai-Xia Wu Jing Yang Xiang-Yu Zeng Huang Zhang Jin-Feng Zhang Timur S.Bulgakov Erio Camporesi Ali H.Bahkali Mohammad A.Amoozegar Lidia Silva Araujo-Neta Joseph F.Ammirati Abhishek Baghela R.P.Bhatt Dimitar Bojantchev Bart Buyck Gladstone Alves da Silva Catarina Letícia Ferreira de Lima Rafael JoséVilela de Oliveira Carlos Alberto Fragoso de Souza Yu-Cheng Dai Bálint Dima Tham Thi Duong Enrico Ercole Fernando Mafalda-Freire Aniket Ghosh Akira Hashimoto Sutakorn Kamolhan Ji-Chuan Kang Samantha C.Karunarathna Paul M.Kirk Ilkka Kytovuori Angela Lantieri Kare Liimatainen Zuo-Yi Liu Xing-Zhong Liu Robert Lücking Gianfranco Medardi Peter E.Mortimer Thi Thuong Thuong Nguyen Itthayakorn Promputtha K.N.Anil Raj Mateus A.Reck Saisamorn Lumyong Seyed Abolhassan Shahzadeh-Fazeli Marc Stadler Mohammad Reza Soudi Hong-Yan Su Takumasa Takahashi Narumon Tangthirasunun Priyanka Uniyal Yong Wang Ting-Chi Wen Jian-Chu Xu Zhong-Kai Zhang Yong-Chang Zhao Jun-Liang Zhou Lin Zhu 2016Fungal Diversity2016,,5:2
3An efficient probabilistic design approach for tunnel face stability by inverse reliability analysis显示文摘In order to maintain the safety of underground constructions that significantly involve geo-material uncertainties,this paper delivers a new computation framework for conducting reliability-based design(RBD)of shallow tunnel face stability,utilizing a simplified inverse first-order reliability method(FORM).The limit state functions defining tunnel face stability are established for both collapse and blow-out modes of the tunnel face failure,respectively,and the deterministic results of the tunnel face support pressure are obtained through three-dimensional finite element limit analysis(FELA).Because the inverse reliability method can directly capture the design support pressure according to prescribed target reliability index,the computational cost for probabilistic design of tunnel face stability is greatly reduced.By comparison with Monte Carlo simulation results,the accuracy and feasibility of the proposed method are verified.Further,this study presents a series of reliability-based design charts for vividly understanding the limit support pressure on tunnel face in both cohesionless(sandy)soil and cohesive soil stratums,and their optimal support pressure ranges are highlighted.The results show that in the case of sandy soil stratum,the blowout failure of tunnel face is extremely unlikely,whereas the collapse is the only possible failure mode.The parametric study of various geotechnical uncertainties also reveals that ignoring the potential correlation between soil shear strength parameters will lead to over-designed support pressure,and the coefficient of variation of internal friction angle has a greater influence on the tunnel face failure probability than that of the cohesion.Jian Ji Zheming Zhang Zhijun Wu Jiacheng Xia Yongxin Wu Qing Lüc 2021Geoscience Frontiers2021,12,5:2
4Kuguacins F-S,cucurbitane triterpenoids from Momordica charantia显示文摘JIAN CHAO C WU QING L LU L 2009Phytochemistry2009,70,1:1
5Talanta显示文摘Wang J Y Wu H L Chen Y Zhai M Qing X D Yu R Q 2013116:3472013,116,:1
6Chemometrics and Intelligent Laboratory Systems显示文摘Li Y Wu H L Qing X D Zuo Q Chen Y Yu R Q 2013127:1772013,127,:1
7Design, Synthesis and Biological Evaluation of Non-azole Inhibitors of Lanosterol 14α-Demethylase of Fungi显示文摘Novel tetralin compounds were designed and synthesized on the three-dimensional model of lanosterol 14α-demethylase of Candida albicans. All of the lead compounds exhibited potent antifungal activities, especially compounds 16, 20. The mode of the action of the lead compounds was different from that of azoles. The present study affords the possibility to develop novel antifungal agents that specifically interact with the amino acid residues in the active site and avoid the serious toxicity arising from coordination binding with the heme of mammalian P450s.Bin YAO You Jun ZHOU Jü ZHU Jia Guo Lü Yao Wu LI Jun CHENG Qing Feng JIANG Can Hui ZHENG 2006Chinese Chemical Letters2006,17,9:1
8Nanostructured ternary composites of graphene/Fe20/polyaniline for high-performance su- percapacitors 显示文摘XI F X QING L H WU L 2012J Mater Chem2012,,16:1
9Timing, duration, and transitions of the last interglacial Asian monsoon 显示文摘Yuan Daoxian Cheng Hai Edwards R L Dykoski C A Kelly M J Zhang Meiliang Qing Jiaming Lin Yushi Wang Yongjin Wu Jiangyin Dorale J A An Zhisheng Cai Yanjun 2004Science2004,304,5670:1
10Refined families of Dothideomycetes:orders and families incertae sedis in Dothideomycetes显示文摘Numerous new taxa and classifications of Dothideomycetes have been published following the last monograph of families of Dothideomycetes in 2013.A recent publication by Honsanan et al.in 2020 expanded information of families in Dothideo-mycetidae and Pleosporomycetidae with modern classifications.In this paper,we provide a refined updated document on orders and families incertae sedis of Dothideomycetes.Each family is provided with an updated description,notes,including figures to represent the morphology,a list of accepted genera,and economic and ecological significances.We also provide phylogenetic trees for each order.In this study,31 orders which consist 50 families are assigned as orders incertae sedis in Dothideomycetes,and 41 families are treated as families incertae sedis due to lack of molecular or morphological evidence.The new order,Catinellales,and four new families,Catinellaceae,Morenoinaceae Neobuelliellaceae and Thyrinulaceae are introduced.Seven genera(Neobuelliella,Pseudomicrothyrium,Flagellostrigula,Swinscowia,Macroconstrictolumina,Pseudobogoriella,and Schummia)are introduced.Seven new species(Acrospermum urticae,Bogoriella complexoluminata,Dothiorella ostryae,Dyfrolomyces distoseptatus,Macroconstrictolumina megalateralis,Patellaria microspora,and Pseu-domicrothyrium thailandicum)are introduced base on morphology and phylogeny,together with two new records/reports and five new collections from different families.Ninety new combinations are also provided in this paper.Sinang Hongsanan Kevin D.Hyde Rungtiwa Phookamsak Dhanushka N.Wanasinghe Eric H.C.McKenzie V.Venkateswara Sarma Robert Lücking Saranyaphat Boonmee Jayarama D.Bhat Ning-Guo Liu Danushka S.Tennakoon Dhandevi Pem Anuruddha Karunarathna Shu-Hua Jiang Gareth E.B.Jones Alan J.L.Phillips Ishara S.Manawasinghe Saowaluck Tibpromma Subashini C.Jayasiri Diana Sandamali Ruvishika S.Jayawardena Nalin N.Wijayawardene Anusha H.Ekanayaka Rajesh Jeewon Yong-Zhong Lu Chayanard Phukhamsakda Asha J.Dissanayake Xiang-Yu Zeng Zong-Long Luo Qing Tian Kasun M.Thambugala Dongqin Dai Milan C.Samarakoon K.W.Thilini Chethana Damien Ertz Mingkwan Doilom Jian-Kui(Jack)Liu Sergio Pérez-Ortega Ave Suija Chanokned Senwanna Subodini N.Wijesinghe Mekala Niranjan Sheng-Nan Zhang Hiran A.Ariyawansa Hong-Bo Jiang Jin-Feng Zhang Chada Norphanphoun Nimali Ide Silva Vinodhini Thiyagaraja Huang Zhang Jadson D.P.Bezerra Ricardo Miranda-González AndréAptroot Hiroyuki Kashiwadani Dulanjalee Harishchandra Emmanuël Sérusiaux Pranami DAbeywickrama Dan-Feng Bao Bandarupalli Devadatha Hai-Xia Wu Kwang Hee Moon Cecile Gueidan Felix Schumm Digvijayini Bundhun Ausana Mapook Jutamart Monkai Chitrabhanu S.Bhunjun Putarak Chomnunti Satinee Suetrong Napalai Chaiwan Monika C.Dayarathne Jing Yang Achala R.Rathnayaka Jian-Chu Xu Jiesheng Zheng Gang Liu Yao Feng Ning Xie 2020Fungal Diversity2020,,6:1
11Preparation, characterization of MCM-56 and catalytic activity in one-step synthesis of MIBK from acetone显示文摘Piao Ping Yang Jian Feng Yu Zhen Wang Mei Ping Xu Qing Sheng Liu Xu Wei Yang Tong Hao Wu 2004Catalysis Communications2004,,2:1
12Families of Dothideomycetes显示文摘Dothideomycetes comprise a highly diverse range of fungi characterized mainly by asci with two wall layers(bitunicate asci)and often with fissitunicate dehiscence.Many species are saprobes,with many asexual states comprising important plant pathogens.They are also endophytes,epiphytes,fungicolous,lichenized,or lichenicolous fungi.They occur in terrestrial,freshwater and marine habitats in almost every part of the world.We accept 105 families in Dothideomycetes with the new families Anteagloniaceae,Bambusicolaceae,Biatriosporaceae,Lichenoconiaceae,Muyocopronaceae,Paranectriellaceae,Roussoellaceae,Salsugineaceae,Seynesiopeltidaceae and Thyridariaceae introduced in this paper.Each family is provided with a description and notes,including asexual and asexual states,and if more than one genus is included,the type genus is also characterized.Each family is provided with at least one figure-plate,usually illustrating the type genus,a list of accepted genera,including asexual genera,and a key to these genera.A phylogenetic tree based on four gene combined analysis add support for 64 of the families and 22 orders,including the novel orders,Dyfrolomycetales,Lichenoconiales,Lichenotheliales,Monoblastiales,Natipusillales,Phaeotrichales and Strigulales.The paper is expected to provide a working document on Dothideomycetes which can be modified as new data comes to light.It is hoped that by illustrating types we provide stimulation and interest so that more work is carried out in this remarkable group of fungi.Kevin D.Hyde E.B.Gareth Jones Jian-Kui Liu Hiran Ariyawansa Eric Boehm Saranyaphat Boonmee Uwe Braun Putarak Chomnunti Pedro W.Crous Dong-Qin Dai Paul Diederich Asha Dissanayake Mingkhuan Doilom Francesco Doveri Singang Hongsanan Ruvishika Jayawardena James D.Lawrey Yan-Mei Li Yong-Xiang Liu Robert Lücking Jutamart Monkai Lucia Muggia Matthew P.Nelsen Ka-Lai Pang Rungtiwa Phookamsak Indunil C.Senanayake Carol A.Shearer Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Nalin N.Wijayawardene Saowanee Wikee Hai-Xia Wu Ying Zhang Begoña Aguirre-Hudson S.Aisyah Alias AndréAptroot Ali H.Bahkali Jose L.Bezerra D.Jayarama Bhat Erio Camporesi Ekachai Chukeatirote Cécile Gueidan David L.Hawksworth Kazuyuki Hirayama Sybren De Hoog Ji-Chuan Kang Kerry Knudsen Wen-Jing Li Xing-Hong Li Zou-Yi Liu Ausana Mapook Eric H.C.McKenzie Andrew N.Miller Peter E.Mortimer Alan J.L.Phillips Huzefa A.Raja Christian Scheuer Felix Schumm Joanne E.Taylor Qing Tian Saowaluck Tibpromma Dhanushka N.Wanasinghe Yong Wang Jian-Chu Xu Supalak Yacharoen Ji-Ye Yan Min Zhang 2013Fungal Diversity2013,,6:1
13Simultaneous determi- nation of plant growth regulators in environmental samples using chemometrics-assisted excitation-emission matrix flu- orescence: Experimental study on theprediction quality of second-order calibration method 显示文摘Qing x D Wu H L Nie C C 2013Talanta2013,103,:1
14A novel method to estimate the chemical rank of three-way data for second-order cali- bration显示文摘Li Y Wu H L Qing X D 2013Chemom InteU Lab Syst2013,127,:1
15Osteopontin expression in progressive renal injury in remnant kidney;role of angiotensin Ⅱ 显示文摘Yu Xue Qing Wu Leonard L Huang Xiao Ru 2000Kidney Int2000,58,4:1
16Timing, duration and transitions of the last interglacial Asian Monsoon显示文摘YUAN D X CHENG H EDWARDS R L DYKOSKI C A KELLY M J ZHANG M L QING J M LIN Y S WANG Y J WU J J DORALE J A AN Z S CA1 Y J 2004Science2004,304,5670:1
17Timing,duration,and transitions of the last interglacial Asian monsoon显示文摘Yuan Daoxian Cheng Hai Edwards R L Dykoski C A Kelly M J Zhang Meiliang Qing Jiaming Lin Yushi Wang Yongjin Wu Jiangying Dorale J A An Zhisheng Cai Yanjun 0,,:1
18Adaptive regularization-based space-time super-resolution reconstruction 显示文摘SONG H QING L WU Y 2013Signal Processing: Image Communication2013,28,7:1
19The protective effects of Levilactobacillus brevis FZU0713 on lipid metabolism and intestinal microbiota in hyperlipidemic rats显示文摘Levilactobacillus brevis FZU0713, a potential probiotic previously isolated from the traditional brewing process of Hongqu rice wine, may have the beneficial effects on improving lipid metabolism. This study aimed to evaluate the in vivo protective effects and possible mechanism of L. brevis FZU0713 on the disturbance of lipid metabolism in hyperlipidemic rats fed a high-fat diet(HFD). Results showed that oral administration of L. brevis FZU0713 could significantly inhibit obesity, ameliorate the lipid metabolism disorder, including serum/liver biochemical parameters and hepatic oxidative stress in HFD-fed rats. Histopathological result also indicated that dietary intervention of L. brevis FZU0713 could reduce the accumulation of lipid droplets in liver induced by 8 weeks HFD feeding. Furthermore, L. brevis FZU0713 intervention significantly increased the fecal levels of short-chain fatty acids(SCFAs, including acetate, propionate, butyrate, isobutyrate, valerate and isovalerate)in HFD-fed rats, which may be closely related to the changes of intestinal microbial composition and metabolic function. Intestinal microbiota profiling by 16S rRNA gene sequencing revealed that L. brevis FZU0713 intervention significantly altered the relative abundance of Coprococcus, Butyricicoccus, Intestinimonas, Lachnospiraceae FCS020 group, Ruminococcaceae_NK4A214 group, Ruminococcaceae_UCG-005 and UCG-014 at genus levels. Based on Spearman's rank correlation coefficient, serum and liver lipid metabolism related biochemical parameters were positively correlated with genera Ruminococcus, Pediococcus and Lachnospiraceae, but negatively correlated with genera Pseudoflavonifractor, Butyricicoccus and Intestinimonas. Furthermore, liver metabolomics analysis demonstrated that L. brevis FZU0713 had a significant regulatory effect on the composition of liver metabolites in hyperlipidemic rats, especially the levels of some important biomarkers involved in the metabolic pathways of arachidonic acid metabolism, primary bile acid biosynthesis, amino sugar and nucleotide sugar metabolism, taurine and hypotaurine metabolism, biosynthesis of unsaturated fatty acid, fructose and mannose metabolism, tyrosine metabolism, etc. Additionally, oral administration of L. brevis FZU0713 significantly regulated the mR NA levels of liver genes(including Acat2, Acox1, Hmgcr, Cd36, Srebp-1c and Cyp7a1)involved in lipid metabolism and bile acid homeostasis. In conclusion, our findings provide the evidence that L. brevis FZU0713 has the potential to improve disturbance of lipid metabolism by regulating intestinal microflora and liver metabonomic profile. Therefore, L. brevis FZU0713 may be used as a potential probiotic strain to produce functional food to prevent hyperlipidemia.Xiaoyun Fan Qing Zhang Weiling Guo Qi Wu Jinpeng Hu Wenjian Cheng Xucong Lü Pingfan Rao Li Ni Youting Chen Lijiao Chen 2023Food Science and Human Wellness2023,12,5:0
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