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| 1 | Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1显示文摘Brassinosteroids (BR ) 是在植物生长和开发有关键角色的必要类固醇荷尔蒙。BR 被房间表面察觉像受体的 kinase brassinosteroid 感觉迟钝 1 (BRI1 ) 。当 BR 不在时, BRI1 的 cytosolic kinase 领域(KD ) 被它的汽车禁止的 carboxyl 终点,以及由与禁止者蛋白质交往禁止, BRI1 kinase 禁止者 1 (BKI1 ) 。对 BRI1 的细胞外的域有约束力的 BR 怎么导致 BKI1 的 KD 和分离的激活进 cytosol,仍然保持不清楚。这里,我们报导在有交往的肽的建筑群的 BRI1 KD 的水晶结构源于 BKI1。我们也提供生物化学的证据那联系 BRI1 的 kinase (BAK1 ) 1 在开始 BR 发信号起一个必要作用。BRI1 和 BAK1 ectodomains 的类固醇依赖者 heterodimerization 为与 BKI1 和 transphosphorylation 竞争在正确取向带他们的细胞质的 KD。 | Jie Wang Jianjun Jiang Jue Wang Lei Chen Shi-Long Fan Jia-Wei Wu Xuelu Wang Zhi-Xin Wang | 2014 | Cell Research2014，24，11： | 12 |
| 2 | The Intrinsically Disordered Protein BKI1 Is Essential for Inhibiting BRI1 Signaling in Plants显示文摘Dear Editor, Brassinosteroids (BRs) are a class of essential polyhydroxylated steroid hormones regulating plant growth and development,and their responses to environmental cues (Clouse,2011;Yang et al.,2011).BRs are perceived at the plasma membrane by a receptor complex,which consists of two leucine-rich receptor-like kinases (LRR-RLKs),BRASSINOSTEROID INSENSITIVE 1 (BRI1) and BRI1-ASSOCIATED RECEPTOR KINASE 1 (BAK1).When activated by BRs,the receptor complex initiates a cascade of multiple kinases and phosphatases,ultimately leading to the dephosphorylation and activation of a family of closely related transcription factors,including BRI1-EMS SUPPRESSOR1 (BES1) and BRASSINAZOLE-RESISTANT1 (BZR1),to regulate the expression of thousands of target genes (Guo et al.,2013). | Jianjun Jiang Tao Wang Zhihua Wu Jie Wang Chi Zhang Haijiao Wang Zhi-Xin Wang Xuelu Wang | 2015 | Molecular Plant2015，8，11： | 7 |
| 3 | Effects of capture and captivity on plasma corticosterone and metabolite levels in breeding Eurasian Tree Sparrows显示文摘Background: Bringing free-living animals into captivity subjects them to the stress of both capture and captivity, leading to the alteration of normal physiological processes and behaviors through activation of the hypothalamic– pituitary–adrenal axis. In free-living birds, although elevated plasma corticosterone (CORT) is an important adaptation regulating physiological and behavioral responses during the process of capture and captivity stress, little information is currently available on the effects of such stress on plasma metabolite levels. Methods: We examined the effects of immediate capture and 24-h captivity on body mass, body condition, plasma CORT, and metabolite levels including glucose (Glu), triglyceride (TG), total cholesterol (TC), uric acid (UA), in breeding Eurasian Tree Sparrows (Passer montanus). Results: CORT and Glu levels were increased significantly by the stress of capture, whereas TC and UA levels decreased. Body mass, body condition declined notably after 24 h in captivity, but CORT, Glu, and UA levels increased. Furthermore, male sparrows had lower TG levels after both capture and captivity than those of females. The relationships between plasma CORT and metabolite levels varied between sexes. Conclusions: Our results revealed that the metabolic status of Eurasian Tree Sparrows could be dramatically altered by capture and captivity. Monitoring the dynamic effects of both capture and captivity on plasma CORT, metabolite levels in a free-living bird contributes to a better understanding of the stress-induced pathways involved in sexdependent energy mobilization. | Mo Li Weiwei Zhu Yang Wang Yanfeng Sun Juyong Li Xuelu Liu Yuefeng Wu Xuebin Gao Dongming Li | 2019 | Avian Research2019，10，2： | 5 |
| 4 | BKI1 Regulates Plant Architecture through Coordinated Inhibition of the Brassinosteroid and ERECTA Signaling Pathways in Arabidopsis显示文摘几百次充满白氨酸的重复像受体的 kinases (LRR-RLKs ) 玩在大量植物的不可缺少的角色发展、生理的过程。在基础、不活跃的地位控制 LRR-RLKs 的机制必要却很少学习。BKI1 是唯一的在 Arabidopsis 报导了受体 kinases 的禁止者,它否定地在 brassinosteroid 小径调整 BRI1。在这研究,我们发现 BKI1 能也与另一重要 LRR-RLK 交往, ERECTA (嗯) 。Phenotypic 分析显示出那 BKI1,包括花梗取向并且嗯一起调整植物建筑学,它是最新报导的显型在调停 BR 并且嗯调停发展进程。基因表示分析表明 BKI1 调整嗯应答的基因的一个子集。Kinase 试金证明 BKI1 禁止嗯 kinase 活动。另外, BKI1 抑制在上的版本嗯发信号主要依靠 BRI1 激活。我们的数据提供重要卓见进 RLK 的规定和激活并且建议 BKI1 作为 BRI1 的普通 suppressor 工作并且嗯发信号的小径。 | Dongxu Wang Cangjing Yang Haijiao Wang Zhihua Wu Jianjun Jiang Jingjing Liu Zhuona He Fang Chang Hong Ma Xuelu Wang | 2017 | Molecular Plant2017，10，2： | 5 |
| 5 | Petrogenesis of Early Carboniferous Ultramafic-Mafic Volcanic Rocks in the Southern Changning-Menglian Belt,Southeastern Tibetan Plateau:Implications for the Evolution of the Paleo-Tethyan Ocean显示文摘The Changning-Menglian Belt represents the main Paleo-Tethyan Suture in the southeastern Tibetan Plateau,which divides Gondwana-and Eurasia-derived continental fragments from each other.The belt contains ultramafic-mafic volcanic rocks that provide evidence of the tectonic processes which operated during the evolution of the Paleo-Tethyan Ocean.New geochemical data for Early Carboniferous volcanics in the southern Changning-Menglian Belt show that wehrlites have cumulate and poikilitic textures,and contain low-Fo(84.2-87.2)olivine,clinopyroxene with low Mg#values(79.4-85.6),and spinel with high Cr#values(67.8-72.4).Estimated equilibrium temperatures obtained using olivine-spinel Fe-Mg exchange geothermometry range from 978℃ to 1373℃(mean=1205℃;n=3).These observations combined with a lack of reaction or melt impregnation textures indicate that these units represent magmatic cumulates rather than having formed as a result of mantle-melt reactions.Both wehrlites and basalts in the belt have subparallel rare earth element(REE)-and primitive-mantle-normalized multi-element patterns with slightly positive Nb-Ta anomalies,but negligible Eu and Zr-Hf anomalies.The volcanics have similar Sr-Nd-Pb isotopic compositions withεNd(t)values of 4.2-4.5(mean=4.3;n=3)and 4.0-4.4(mean 4.2;n=4),respectively,and also have similar immobile element ratios,such as Nb/La,Nb/U,Th/La,Zr/Nb,Th/Ta,La/Yb,Nb/Th,Nb/Y,and Zr/Y.These characteristics indicate both units have ocean island basalt(OIB)-like geochemical affinities,consistent with the fact that the clinopyroxene in the wehrlites is compositionally similar to OIB-related cumulus clinopyroxene.This suggests that both the wehrlites and basalts were derived from similar parental magmas that underwent generally closed-system magmatic differentiation dominated by fractionation of the olivine and clinopyroxene.This parental magma was likely generated in an oceanic seamount setting from an OIB-type mantle source(i.e.,asthenospheric mantle)containing garnet-spinel lherzolite material.Combing this new data with that from oceanic seamount volcano-sedimentary suites derived from previous research enables the identification of a mature late Paleozoic ocean basin between the passive northeastern Gondwanan margin and the northward-migrating microcontinent of Lanping-Simao. | XIE Zhipeng WU Xuelu WANG Tengfei XUE Chuandong YANG Tiannan WANG Wei SUI Binxi XIN Di | 2022 | Acta Geologica Sinica(English Edition)2022，96，3： | 2 |
| 6 | Beamforming and fronthaul compression design for intelligent reflecting surface aided cloud radio access networks显示文摘Owing to the inherent central information processing and resource management ability,the cloud radio access network(C-RAN)is a promising network structure for an intelligent and simplified sixth-generation(6G)wireless network.Nevertheless,to further enhance the capacity and coverage,more radio remote heads(RRHs)as well as high-fidelity and low-latency fronthaul links are required,which may lead to high implementation cost.To address this issue,we propose to exploit the intelligent reflecting surface(IRS)as an alternative way to enhance the C-RAN,which is a low-cost and energy-efficient option.Specifically,we consider the uplink transmission where multi-antenna users communicate with the baseband unit(BBU)pool through multi-antenna RRHs and multiple IRSs are deployed between the users and RRHs.RRHs can conduct either point-to-point(P2P)compression or Wyner-Ziv coding to compress the received signals,which are then forwarded to the BBU pool through fronthaul links.We investigate the joint design and optimization of user transmit beamformers,IRS passive beamformers,and fronthaul compression noise covariance matrices to maximize the uplink sum rate subject to fronthaul capacity constraints under P2P compression and Wyner-Ziv coding.By exploiting the Arimoto-Blahut algorithm and semi-definite relaxation(SDR),we propose a successive convex approximation approach to solve non-convex problems,and two iterative algorithms corresponding to P2P compression and Wyner-Ziv coding are provided.Numerical results verify the performance gain brought about by deploying IRS in C-RAN and the superiority of the proposed joint design. | Yu ZHANG Xuelu WU Hong PENG Caijun ZHONG Xiaoming CHEN | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，1： | 0 |
| 7 | Characterization of two constitutive promoters RPS28 and EIF1 for studying soybean growth,development,and symbiotic nodule development显示文摘Native promoters that can drive high and stable transgene expression are important tools for modifying plant traits.Although several such promoters have been reported in soybean(Glycine max),few of them function at multiple growth and development stages and during nodule development.Here,we report that the promoters of 40S RIBOSOMAL PROTEIN SMALL SUBUNIT S28(RPS28)and EUKARYOTIC TRANSLATION INITIATION FACTOR 1(EIF1)are ideal for high expression of transgene.Through bioinformatic analysis,we determined that RPS28 and EIF1 were highly expressed during soybean growth and development,nodule development,and various biotic and abiotic stresses.Fusion of both RPS28 and EIF1 promoters,with or without their first intron,with the reporter geneβ-GLUCURONIDASE(uidA)in transgenic soybean,resulted in high GUS activity in seedlings,seeds,and nodules.Fluorimetric GUS assays showed that the RPS28 promoter and the EIF1 promoter yielded high expression,comparable to the soybean Ubiquitin(GmUbi)promoter.RPS28 and EIF1 promoters were also highly expressed in Arabidopsis thaliana and Nicotiana benthamiana.Our results indicate the potential of RPS28 and EIF1 promoters to facilitate future genetic engineering and breeding to improve the quality and yield of soybean,as well as in a wide variety of other plant species. | Shengcai Chen Yaqi Peng Qi Lv Jing Liu Zhihua Wu Haijiao Wang Xuelu Wang | 2022 | aBIOTECH2022，3，2： | 0 |
| 8 | D-type neuropeptide decorated AIEgen/RENP hybrid nanoprobes with light-driven ROS generation ability for NIR-Ⅱ fluorescence imaging-guided through-skull photodynamic therapy of gliomas显示文摘Glioma is one of the most common malignant tumors of the central nervous system,leading high mortality rates in human.Aggregation-induced emission(AIE)photosensitizers-based photodynamic therapy(PDT)has emerged as a promising therapeutic strategy for least-invasive treatment of glioma,which involves local irradiation of the tumor using an external near-infrared(NIR)laser.Unfortunately,most AIE photosensitizers suffered from poorly penetration of the visible light excitation,bad spatiotemporal resolution in deep tissues and low efficient blood-brain barrier(BBB)crossing ability,which greatly limited the clinical practice of AIE photosensitizers for especially deep-seated brain tumor treatment.In this work,we developed a multifunctional NIR-driven theranostic agent through hybrid of AIE photosensitizers TIND with rare-earth doping nanoparticles(RENPs)NaGdF4:Nd/Yb/Tm with up/down dual-mode conversion luminescence.The theranostic agent was further decorated with D-type neuropeptide DNPY for crossing BBB and targeting glioma.Under the 808-nm light irradiation,the down-conversion NIR-II luminescence could indicate the position glioma and the upconversion NIR-I luminescence could trigger the AIE photosensitizers producing reactive oxygen species to inhibit orthotopic glioma tumor growth in situ.These results demonstrate that the integration of Dtype neuropeptide,AIE photosensitizers and RENPs could be promising candidates for in vivo NIR-II fluorescence image-guided through-skull PDT treatments of brain tumors. | Xuelu He Yuan Luo Yanying Li Yuanbo Pan Ryan T.K.Kwok Lulu He Xiaolin Duan Pengfei Zhang Aiguo Wu Ben Zhong Tang Juan Li | 2024 | Aggregate2024，5，1： | 0 |
| 9 | Hydrophobic 1-octadecanethiol functionalized copper catalyst promotes robust high-current CO_(2) gas-diffusion electrolysis显示文摘The electrocatalytic reduction of CO_(2) presents a promising strategy in addressing environmental and energy crisis.Significant progress has been achieved via CO_(2) gas diffusion electrolysis,to react at high selectivity and high rate.However,the gas diffusion layer(GDL)of the gas diffusion electrode(GDE)still suffers from low tolerance and limited active sites.Here,the hydrophobic 1-octadecanethiol molecular was functionalized over the Cu catalyst layer of the GDE,which simultaneously stabilizes the GDL and exposes abundant active solid-liquid-gas three-phase interfaces.The resultant GDE exhibits multi-carbon(C_(2+))product selectivity over faradaic efficiency(FE)of 70.0%in the range of 100 to 800 mA·cm^(-2),with the peak FE^(c2+)of 85.2%at 800 mA·cm^(-2).Notably,the strengthened GDE could continuously drive high-current electrolysis for more than 100 h without flooding.This work opens a new way to improve CO_(2) gas diffusion electrolysis via surface molecular engineering. | Liangyao Xue Xuefeng Wu Yuanwei Liu Beibei Xu Xuelu Wang Sheng Dai Pengfei Liu Huagui Yang | 2022 | Nano Research2022，15，2： | 0 |
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