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| 1 | XA23 Is an Executor R Protein and Confers Broad-Spectrum Disease Resistance in Rice显示文摘 | Chunlian Wang Xiaoping Zhang Yinglun Fan Ying Gao Qinlong Zhu Chongke Zheng Tengfei Qin Yanqiang Li Jinying Che Mingwei Zhang Bing Yang Yaoguang Liu Kaijun Zhao | 2015 | Molecular Plant2015，8，2： | 55 |
| 2 | Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway显示文摘Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it.Studies of sinomenine,an alkaloid from the Chinese medicinal plant,Sinomenium acutum,showed that it had inhibitory effects on several kinds of cancer.Here,we synthesized a sinomenine derivative,sino-wcj-33(SW33),tested it for antitumor activity on GBM and explored the underlying mechanism.SW33 significantly inhibited proliferation and colony formation of GBM and reduced migration and invasion of U87 and U251 cells.It also arrested the cell cycle at G2/M phase and induced mitochondria-dependent apoptosis.Differential gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3 K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the body.SW33 also induced autophagy through the PI3 K/AKT/mTOR and AMPK/mTOR pathways.Thus,SW33 appears to be a promising drug for treating GBM effectively and safely. | Xiangjin Zheng Wan Li Huanli Xu Jinyi Liu Liwen Ren Yihui Yang Sha Li Jinhua Wang Tengfei Ji Guanhua Du | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 3 | Ultrafast and broadband photodetectors based on a perovskite/organic bulk heterojunction for large-dynamic-range imaging显示文摘Organic-inorganic hybrid perovskite(OIHP)photodetectors that simultaneously achieve an ultrafast response and high sensitivity in the near-infrared(NIR)region are prerequisites for expanding current monitoring,imaging,and optical communication capbilities.Herein,we demonstrate photodetectors constructed by OIHP and an organic bulk heterojunction(BHJ)consisting of a low-bandgap nonfullerene and polymer,which achieve broadband response spectra up to 1μm with a highest external quantum efficiency of approximately 54%at 850 nm,an ultrafast response speed of 5.6 ns and a linear dynamic range(LDR)of 191 dB.High sensitivity,ultrafast speed and a large LDR are preeminent prerequisites for the practical application of photodetectors.Encouragingly,due to the high-dynamicrange imaging capacity,high-quality visible-NIR actual imaging is achieved by employing the OIHP photodetectors.We believe that state-of-the-art OIHP photodetectors can accelerate the translation of solution-processed photodetector applications from the laboratory to the imaging market. | Chenglong Li Hailu Wang Fang Wang Tengfei Li Mengjian Xu Hao Wang Zhen Wang Xiaowei Zhan Weida Hu Liang Shen | 2020 | Light(Science & Applications)2020，9，1： | 13 |
| 4 | Short-Impending Earthquake Anomaly Index Extraction of GNSS Continuous Observation Data in Yunnan,Southwestern China显示文摘This paper presents a comprehensive area expansion prediction index method to apply GNSS for short-impending prediction of earthquakes. Based on continuous GNSS observation data from Yunnan Province, a displacement field was detected after data cycle-slip repair using precision data processing software and geophysical field effect model correction. The Yunnan area was divided into 56 grid cells for displacement field interpolation to obtain a more uniform displacement field and a strain field variation time series. The pre-earthquake response of each grid-cell expansion time series was evaluated and synthesized to extract a short-impending earthquake anomaly identification index. The results show that this index indicated occurrence times and hypocenter for earthquakes of magnitude M≥5. Fourteen earthquakes were predicted accurately, and there were five false reports. This index can therefore be used for the short-impending prediction of earthquakes. | Min Hong Desheng Shao Tengfei Wu Shuangxi Zhang Yong Zhang Lingli Wang Xiaodong Qian | 2018 | Journal of Earth Science2018，29，1： | 13 |
| 5 | Raindrop Size Distribution Parameters Retrieved from Guangzhou S-band Polarimetric Radar Observations显示文摘According to the statistical shape–slope(μ–Λ) relationship observed for the first time by several 2 D-Video-Distrometers(2 DVD) in southern China, a constrained gamma(C-G) model was proposed for the retrieval of rain drop size distributions(DSDs) from Guangzhou S-band polarimetric radar observations. Two typical precipitation processes were selected to verify the accuracy of the retrieval scheme. The μ–Λ relationship: Λ = 0.0241μ2 + 0.867μ + 2.453 was obtained based on the 2 DVD observation results from at Huizhou Longmen station, which is a very representative location in the area. Relying on the Guangzhou polarimetric radar measurements of radar reflectivity(ZHH) and differential reflectivity(ZDR), the gamma(Γ) size distribution parameters(N0, μ, and Λ) can be retrieved by the C-G model retrieval scheme. The results show that the Guangzhou polarimetric radar retrievals of DSDs were close to the2 DVD observations at Guangzhou Maofengshan station. The rain rate, mass mean diameter, and normalized intercept parameter of radar retrievals were in good agreement with the 2 DVD observations, and the relative errors were less than 10%. The overall accuracy of the retrieval scheme was high. The retrieval scheme has established the relationship between the polarimetric radar measurements and gamma size distribution parameters. It will be helpful to in-depth research and application of the dual-polarization radar data in microphysical precipitation processes analysis,as well as convection-resolved numerical model data assimilation and prediction effect evaluation. | Xiantong LIU Qilin WAN Hong WANG Hui XIAO Yu ZHANG Tengfei ZHENG Lu FENG | 2018 | Journal of Meteorological Research2018，32，4： | 11 |
| 6 | Novel Water-Based Drilling and Completion Fluid Technology to Improve Wellbore Quality During Drilling and Protect Unconventional Reservoirs显示文摘The efficient exploration and development of unconventional oil and gas are critical for increasing the self-sufficiency of oil and gas supplies in China.However,such operations continue to face serious problems(e.g.,borehole collapse,loss,and high friction),and associated formation damage can severely impact well completion rates,increase costs,and reduce efficiencies.Water-based drilling fluids possess certain advantages over oil-based drilling fluids(OBDFs)and may offer lasting solutions to resolve the aforementioned issues.However,a significant breakthrough with this material has not yet been made,and major technical problems continue to hinder the economic and large-scale development of unconventional oil and gas.Here,the international frontier external method,which only improves drilling fluid inhibition and lubricity,is expanded into an internal-external technique that improves the overall wellbore quality during drilling.Bionic technologies are introduced into the chemical material synthesis process to imitate the activity of life.A novel drilling and completion fluid technique was developed to improve wellbore quality during drilling and safeguard formation integrity.Macroscopic and microscopic analyses indicated that in terms of wellbore stability,lubricity,and formation protection,this approach could outperform methods that use typical OBDFs.The proposed method also achieves a classification upgrade from environmentally protective drilling fluid to an ecologically friendly drilling fluid.The developed technology was verified in more than 1000 unconventional oil and gas wells in China,and the results indicate significant alleviation of the formation damage attributed to borehole collapse,loss,and high friction.It has been recognized as an effective core technology for exploiting unconventional oil and gas resources.This study introduces a novel research direction for formation protection technology and demonstrates that observations and learning from the natural world can provide an inexhaustible source of ideas and inspire the creation of original materials,technologies,and theories for petroleum engineering. | Guancheng Jiang Jinsheng Sun Yinbo He Kaixiao Cui Tengfei Dong Lili Yang Xukun Yang Xingxing Wang | 2022 | Engineering2022，，11： | 11 |
| 7 | Geologic investigation and mapping of the Sinus Iridum quadrangle from Clementine, SELENE, and Chang’e-1 data显示文摘The objectives of lunar satellite remote sensing are to study lunar surface characteristics, inner structure, and its evolution history. The contents of TiO 2 and FeO are assessed from Clementine UV/VIS data for Sinus Iridum. The geologic stratigraphic units and crates are interpreted visually based on SELENE Terrain Camera (TC) images and the spatial resolution of which is up to 10 m. And the geologic ages of different stratigraphic units are calculated by the crater size-frequency distributions measurements. The gravity anomaly is generated from SELENE gravity model (SGM90d) to show its difference from Mare Imbrium. Furthermore, the thickness of lunar regolith is also derived from microwave radiometer data of Chang’e-1 satellite. Integrating these results, it shows that the Sinus Iridum is different from the Mare Imbrium in inner structure and surface sedimentation. And its history of subsidence, deposition, volcanism, and impact is described. It makes sense to the future soft-landing and sampling at potential Sinus Iridum by remote sensing geologic analysis. | CHEN ShengBo , MENG ZhiGuo, CUI TengFei, LIAN Yi, WANG JingRan & ZHANG XuQing College of Geoexploration Science and Technology, Jilin University, Changchun 130026, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，12： | 10 |
| 8 | Influence of Nitrogen Flow Ratio on the Microstructure, Composition, and Mechanical Properties of DC Magnetron Sputtered Zr-B-O-N Films显示文摘Nanocrystalline ZrB 2 film and nanocomposite Zr-B-O-N films were prepared by non-reactive as well as reactive magnetron sputtering techniques, respectively. By means of X-ray diffraction analysis, electron probe microanalysis, X-ray photoelectron spectroscopy, and scanning electron microscopy, the influence of nitrogen flow ratio on the film microstructure and characteristics were investigated systematically, including the deposition rate, chemical compositions, phase constituents, grain size, chemical bonding, as well as cross-sectional morphologies. Meanwhile, the hardness and adhesion of above films were also evaluated by micro-indentation method and a scratch tester. With increasing the nitrogen flow ratio, the deposition rate of above films decreased approximately linearly, whereas the contents of N and O in the films increased gradually and tended to saturation. Moreover, the film microstructure was also altered gradually from a fine columnar microstructure to a featureless glass-structure. As the nitrogen flow ratio was 11.7%, the Zr-B-O-N film possessed an typical nanocomposite structure and presented good mechanical properties. During the process of reactive sputtering of metal borides, the introduction of nitrogen can show a pronounced suppression of columnar grain growth and strong nanocomposite structure forming ability. | Tie-Gang Wang Yanmei Liu Tengfei Zhang Doo-In Kim KwanKHo Kim | 2012 | Journal of Materials Science & Technology2012，28，11： | 10 |
| 9 | Parameter sensitivity and inversion analysis of a concrete faced rock-fill dam based on HS-BPNN algorithm显示文摘Considering the complex nonlinear relationship between the material parameters of a concrete faced rock-fill dam(CFRD) and its displacements, the harmony search(HS) algorithm is used to optimize the back propagation neural network(BPNN), and the HS-BPNN algorithm is formed and applied for the inversion analysis of the parameters of rock-fill materials. The sensitivity of the parameters in the Duncan and Chang's E-B model is analyzed using the orthogonal test design. The case study shows that the parameters φ0, K, Rf, and Kb are sensitive to the deformation of the rock-fill dam and the inversion analysis for these parameters is performed by the HS-BPNN algorithm. Compared with the traditional BPNN, the HS-BPNN algorithm exhibits the advantages of high convergence precision, fast convergence rate, and strong stability. | SUN PengMing BAO TengFei GU ChongShi JIANG Ming WANG Tian SHI ZhongWen | 2016 | Science China(Technological Sciences)2016，59，9： | 9 |
| 10 | An overview of 10-year observation of the South China Sea branch of the Pacific to Indian Ocean throughflow at the Karimata Strait显示文摘Besides the Indonesian throughflow(ITF), the South China Sea throughflow(SCSTF) also contributes to the water transport from the Pacific to the Indian Ocean. However, this South China Sea(SCS) branch at the Karimata Strait is poorly observed until 2007, even though its importance has been suggested by numerical studies for decades. In this paper, we review the nearly 10-year field measurement in the Karimata Strait by the execution of the projects of 'SCS-Indonesian Seas Transport/Exchange(SITE) and Impacts on Seasonal Fish Migration' and 'The Transport, Internal Waves and Mixing in the Indonesian Throughflow regions(TIMIT) and Impacts on Marine Ecosystem', which extend the observations from the western Indonesian seas to the east to include the main channels of the ITF, is introduced. Some major achievements from these projects are summarized. | Zexun Wei Shujiang Li R.Dwi Susanto Yonggang Wang Bin Fan Tengfei Xu Budi Sulistiyo T.Rameyo Adi Agus Setiawan A.Kuswardani Guohong Fang | 2019 | Acta Oceanologica Sinica2019，38，4： | 9 |
| 11 | Generation of ready to use (RTU) products over China based on Landsat series data显示文摘Earth observation community has entered into the era of big data.Family of Landsat sensors have collected massive medium resolution satellite images,which are valuable for long-term land surface monitoring.In order to significantly reduce the magnitude of data processing for remote sensing data users,Landsat-based Ready to Use(RTU)products have been produced.Main RTU products,including orthorectified products,land surface reflectance,land surface temperature,large-area mosaic image,and standard image map products,are described.The resulting Landsat RTU products are hosted on the RSGS earth observation data sharing web site for free download(http://gffzz959b1a8e74bf485dh5b9f6k9nv56x6u96.ffgz.tsg.suse.edu.cn/rtu/).These new products will provide consistent,standardized,multi-decadal image data for robust land cover change detection and monitoring across the Earth sciences.In the coming years,CASEarth DataBank system will be constructed,which is an intelligent data service platform for providing not only the RTU products from multi-source satellite data,but also big earth data analysis methods. | Guojin He Zhaoming Zhang Weili Jiao Tengfei Long Yan Peng Guizhou Wang Ranyu Yin Wei Wang Xiaomei Zhang Huichan Liu Bo Cheng Bo Xiang | 2018 | Big Earth Data2018，2，1： | 8 |
| 12 | One-Step, Solvothermal Synthesis of Graphene-CdS and Graphene-ZnS Quantum Dot Nanocomposites and Their Interesting Photovoltaic Properties显示文摘The synthesis of graphene-semiconductor nanocomposites has attracted increasing attention due to their interesting optoelectronic properties.However the synthesis of such nanocomposites,with decorated particles well dispersed on graphene,is still a great challenge.This work reports a facile,one-step,solvothermal method for the synthesis of graphene-CdS and graphene-ZnS quantum dot nanocomposites directly from graphene oxide,with CdS and ZnS very well dispersed on the graphene nanosheets.Photoluminescence measurements showed that the integration of CdS and ZnS with graphene significantly decreases their photoluminescence.Transient photovoltage studies revealed that the graphene-CdS nanocomposite exhibits a very unexpected strong positive photovoltaic response,while separate samples of graphene and CdS quantum dots(QDs)of a similar size do not show any photovoltaic response. | Ping Wang Tengfei Jiang Chengzhou Zhu Yueming Zhai Dejun Wang Shaojun Dong | 2010 | Nano Research2010，3，11： | 8 |
| 13 | Ages, Trace Elements and Hf-Isotopic Compositions of Zircons from Claystones around the Permian-Triassic Boundary in the Zunyi Section, South China: Implications for Nature and Tectonic Setting of the Volcanism显示文摘证据的成长身体证明二叠三叠纪的边界(PTB ) 附近的那个火山作用可能在触发 PermianTriassic (PTr ) 是关键的集体扑灭。因此,在华南的 PTB 附近的灰床可以在这个事件上带信息。三暴烈的灰层,改变了到泥土,在在 Zunyi 节的 PTB 床上的 outcropped,贵州省,西南中国。从这三张灰床的锆石谷物的 U-Pb 年龄,踪迹元素,和 Hf 同位素作文用 LA-ICPMS 和 LA-MC-ICPMS 被分析。锆石主要除了二 inherited/xenocrystic 锆石(939 和 2 325 妈) 是在起源(241-279 妈) 的 magmatic。这些 magmatic 锆石的年龄显示发生在中间附近的 magmatism 的三个事件 -- 晚二叠的边界(~ 261.5 妈, MLPB ) , Wuchiapingian-Changhsingian 边界(~ 254.5 妈, WCB ) ,并且 PTB (~ 250.5 妈) 分别地。MLPB 和 WCB 附近的 magmatism 的开始的二个事件可以被归因于 magmatic 继承或重新免职。所有 magmatic 锆石分享类似的踪迹元素和 Hf 同位素作文。他们有 Y, Hf, Th 和 U 内容和 Nb/Ta 比率典型地代表从硅的计算碱的岩浆的锆石。这些锆石也与 -11.4 的 Hf (t) 价值展出充实的 Hf 同位素作文到 +0.2,它建议三个 magmatic 事件涉及大陆人外壳融化。更多的充实的 Hf 同位素作文(床 ZY13 的 Hf (t)=-11.4--4.8)(~ 250.5 妈) 在岩浆暗示古老的外壳的材料的更多的输入。magmatic 锆石的 Hf 同位素和踪迹元素作文的集成建议 magmatism 的这三个事件可以由于 Palaeo-Tethys 海洋的闭合沿着会聚的大陆边缘发生在或在西南的华南附近。 | Qiuling Gao Zhong-Qiang Chen Ning Zhang William L.Griffin Wenchen Xia Guoqing Wang Tengfei Jiang Xuefei Xia Suzanne Y.O'Reilly | 2015 | Journal of Earth Science2015，26，6： | 8 |
| 14 | The fate of fertilizer N applied to cotton in relation to irrigation methods and N dosage in arid area显示文摘Quantitative information on the fate and efficiency of nitrogen (N) fertilizer applied to coarse textured calcareous soils in arid farming systems is scarce but, as systems intensify, is essential to support sustainable agronomic management decisions. A mesh house study was undertaken to trace the fate of N fertilizer applied to cotton (Gossypium hirsutum L. cv., Huiyuan701) growing on a reconstructed profile (0-100 cm) of a calcareous (>15% CaCO 3 ) sandy loam soil. Two irrigation methods (drip irrigation, DI; and furrow irrigation, FI) and four N application rates (0, 240, 360 and 480 kg/hm 2 , abbreviated as N 0 , N 240 , N 360 , and N 480 , respectively) were applied. 15 N-labelled urea fertilizer was applied in a split application. DI enhanced the biomass of whole plant and all parts of the plant, except for root; more fertilizer N was taken up and mostly stored in vegetative parts; N utilization efficiency (NUE) was significantly greater than in FI. N utilization efficiency (NUE) decreased from 52.59% in N 240 to 36.44% in N 480 . N residue in soil and plant N uptake increased with increased N dosage, but recovery rate decreased consistently both in DI and FI. Plant N uptake and soil N residue were greater in DI than in FI. N residue mainly stayed within 0-40 cm depth in DI but within 40-80 cm depth in FI. FI showed 17.89% of N leached out, but no N leaching occurred in DI. N recovery rate in the soil-plant system was 75.82% in DI, which was markedly greater than the 55.97% in FI. DI exhibited greater NUE, greater residual N in the soil profile and therefore greater N recovery rate than in FI; also, N distribution in soil profile shallowed in DI, resulting in a reduced risk of N leaching compared to FI; and enhanced shoot growth and reduced root growth in DI is beneficial for more economic yield formation. Compared to furrow irrigation, drip irrigation is an irrigation method where N movement favors the prevention of N from being lost in the plant-soil system and benefits a more efficient use of N. | ChangZhou WEI TengFei MA XiaoJuan WANG Juan WANG | 2012 | Journal of Arid Land2012，4，3： | 7 |
| 15 | 中国地理人的解决研究的概述和进步显示文摘增加的中国都市化和工业化在地理,建筑学,并且城市的计划的领域里推动了更大的注意到人的解决和人陆地的关系的学习。我们使用了 bibliometric 方法和统计软件在 16 本中国地理杂志在人的解决上考察 180 篇文章。我们发现中国地理人的解决研究被下列描绘:( 1 )大多数研究在在媒介的模式放大的宏规模,城市的解决区别和理想集中于人的解决扩展,估价指示物,为城市、农村的解决的模型,理论探索和单个因素的、人的解决和复杂、地理存活率的计划惯例,解决环境的全面评估,并且计划社区单位在微规模,社区解决;关于推进人的解决的社会文化的调查和警告。(2 ) 没有进步在综合并且集成方法系统被取得了。PSR 当模特儿, DPSIR 模型被用于指向机制,当标准解决评估系统被问询表调查由物理与经济的指示物组成时。在另一方面,基于 GIS 的空间聚类是最近的年里的一个经常的焦点。在瓷器都市化和工业化的上下文以内在人的解决和理论系统上开创研究将在中国城市和区域的可持续性上提供指导。下列五个方面要求更大的注意:(1 ) 关于人的解决的自然适用性研究,和人的解决的调查要求在城市的环境,相应估价指示物,系统,和进化有关生态地合适的解决反映不同要求的范围,并且居民的影响社会经济的属性。(2 ) 空间时间的评估和可持续性在各种各样的规模在城市、农村的人的解决上研究,集中于在象在城市之间的城市簇和比较那样的各种各样的规模的进化和空间区别,在城市和社区以内。(3 ) 为人的解决进化研究的理论和技术的开发包括察觉技术和方法,数据采矿测量,并且预报并且地区性、城市的人的解决进化进程,机制和模式的模拟。(4 ) 在为有效管理和开发集中于优化,模式,和政策的人的解决的控制上研究。(5 ) 估计人的解决系统服务值并且建立合适的人的解决系统,包括社会、经济、文化、生态的服务值。 | MA Renfeng WANG Tengfei ZHANG wenzhong YU Jianhui WANG Dai CHEN Li JIANG Yanpeng FENG Gequn | 2016 | Journal of Geographical Sciences2016，26，8： | 6 |
| 16 | State of the Art and Prospects in Metal-Organic Framework-Derived Microwave Absorption Materials显示文摘Microwave has been widely used in many fields,including communication,medical treatment and military industry;however,the corresponding generated radiations have been novel hazardous sources of pollution threating human’s daily life.Therefore,designing high-performance microwave absorption materials(MAMs)has become an indispensable requirement.Recently,metal-organic frameworks(MOFs)have been considered as one of the most ideal precursor candidates of MAMs because of their tunable structure,high porosity and large specific surface area.Usually,MOF-derived MAMs exhibit excellent electrical conductivity,good magnetism and sufficient defects and interfaces,providing obvious merits in both impedance matching and microwave loss.In this review,the recent research progresses on MOF-derived MAMs were profoundly reviewed,including the categories of MOFs and MOF composites precursors,design principles,preparation methods and the relationship between mechanisms of microwave absorption and microstructures of MAMs.Finally,the current challenges and prospects for future opportunities of MOF-derived MAMs are also discussed. | Shuning Ren Haojie Yu Li Wang Zhikun Huang Tengfei Lin Yudi Huang Jian Yang Yichuan Hong Jinyi Liu | 2022 | Nano-Micro Letters2022，14，4： | 6 |
| 17 | Synthesis of Ordered Multivalent Mn-TiO2 Nanospheres with Tunable Size: A High Performance Visible-Light Photocatalyst显示文摘一个灵巧、可再现的方法在范围与可控制的尺寸为订的锐钛矿 Mn-TiO2 nanospheres 的合成被开发了由简单地改变锰(II ) 的数量的 200300 nm 增加的氯化物。样品被X光检查描绘衍射( XRD ),X光检查光电子光谱学( XPS ),扫描电子显微镜( SEM ),和传播电子显微镜( TEM )大小,并且锰在多价的形式(Mn4+/Mn3+)存在并且在锐钛矿 TiO2 格子代替一些Ti4+,这被发现。Mn 的存在显著地影响形态学和 TiO2 的高温度的稳定性,并且扩大它的轻吸收范围。表面 photovoltage 和光电流大小表明在 Mn 和 TiO2 之间的一个电子相互作用是现在, Mn 在用作一个电子领受人并且有效地在 TiO2 禁止了充电再结合;这被认为在可见光的照耀下面为在玫瑰精 B (RhB ) 的降级的材料的高度有效的 photocatalytic 活动负责(> 420 nm ) 。 | Haiyan Li Dejun Wang Haimei Fan Tengfei Jiang Xinglin Li Tengfeng Xie | 2011 | Nano Research2011，4，5： | 5 |
| 18 | Protective effect of oxysophoridine on cerebral ischemia/reperfusion injury in mice显示文摘Oxysophoridine, a new alkaloid extracted from Sophora alopecuroides L., has been shown to have a protective effect against ischemic brain damage. In this study, a focal cerebral ischemia/reperfusion injury model was established using middle cerebral artery occlusion in mice. Both 62.5, 125, and 250 mg/kg oxysophoridine, via intraperitoneal injection, and 6 mg/kg nimodipine, via intragastric administration, were administered daily for 7 days before modeling. After 24 hours of reperfusion, mice were tested for neurological deficit, cerebral infarct size was assessed and brain tissue was collected. Results showed that oxysophoridine at 125, 250 mg/kg and 6 mg/kg nimodipine could reduce neurological deficit scores, cerebral infarct size and brain water content in mice. These results provided evidence that oxysophoridine plays a protective role in cerebral ischemia/reperfusion injury. In addition, oxysophoridine at 62.5, 125, and 250 mg/kg and 6 mg/kg nimodipine increased adenosine-triphosphate content, and decreased malondialdehyde and nitric oxide content. These compounds enhanced the activities of glutathione-peroxidase, superoxide dismutase, catalase, and lactate dehydrogenase, and decreased the activity of nitric oxide synthase. Protein and mRNA expression levels of N-methyl-D-aspartate receptor subunit NR1 were markedly inhibited in the presence of 250 mg/kg oxysophoridine and 6 mg/kg nimodipine. Our experimental findings indicated that oxysophoridine has a neuroprotective effect against cerebral ischemia/reperfusion injury in mice, and that the effect may be due to its ability to inhibit oxidative stress and expression of the N-methyl-D-aspartate receptor subunit NR1. | Hongbo Wang Yuxiang Li Ning Jiang Xiaoping Chen Yi Zhang Kuai Zhang Tengfei Wang Yinju Hao Lin Ma Chengjun Zhao Yanrong Wang Tao Sun Jianqiang Yu | 2013 | Neural Regeneration Research2013，8，15： | 5 |
| 19 | Seasonal variation of water transport through the Karimata Strait显示文摘Four trawl-resistant bottom mounts, with acoustic Doppler current profilers(ADCPs) embedded, were deployed in the Karimata Strait from November 2008 to June 2015 as part of the South China Sea-Indonesian Seas Transport/Exchange and Impact on Seasonal Fish Migration(SITE) Program, to estimate the volume and property transport between the South China Sea and Indonesian seas via the strait. The observed current data reveal that the volume transport through the Karimata Strait exhibits significant seasonal variation. The winteraveraged(from December to February) transport is –1.99 Sv(1 Sv=1×10~6 m^3/s), while in the boreal summer(from June to August), the average transport is 0.69 Sv. Moreover, the average transport from January 2009 to December2014 is –0.74 Sv(the positive/negative value indicates northward/southward transport). May and September are the transition period. In May, the currents in the Karimata Strait turn northward, consistent with the local monsoon. In September, the southeasterly trade wind is still present over the strait, driving surface water northward, whereas the bottom flow reverses direction, possibly because of the pressure gradient across the strait from north to south. | Yan Wang Tengfei Xu Shujiang Li R.Dwi Susanto Teguh Agustiadi Mukti Trenggono Wei Tan Zexun Wei | 2019 | Acta Oceanologica Sinica2019，38，4： | 5 |
| 20 | Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference显示文摘Reverse transcription-polymerase chain reaction(RT-PCR)is an essential method for specific diagnosis of SARS-CoV-2 infection.Unfortunately,false negative test results are often reported.In this study,we attempted to determine the principal causes leading to false negative results of RT-PCR detection of SARS-CoV-2 RNAs in respiratory tract specimens.Multiple sputum and throat swab specimens from 161 confirmed COVID-19 patients were tested with a commercialfluorescent RT-PCR kit targeting the ORF1 ab and N regions of SARS-CoV-2 genome.The RNA level of a cellular housekeeping gene ribonuclease P/MRP subunit p30(RPP30)in these specimens was also assessed by RT-PCR.Data for a total of 1052 samples were retrospectively re-analyzed and a strong association between positive results in SARS-CoV-2 RNA tests and high level of RPP30 RNA in respiratory tract specimens was revealed.By using the ROC-AUC analysis,we identified Ct cutoff values for RPP30 RT-PCR which predicted false negative results for SARS-CoV-2 RT-PCR with high sensitivity(95.03%–95.26%)and specificity(83.72%–98.55%)for respective combination of specimen type and ampli-fication reaction.Using these Ct cutoff values,false negative results could be reliably identified.Therefore,the presence of cellular materials,likely infected host cells,are essential for correct SARS-CoV-2 RNA detection by RT-PCR in patient specimens.RPP30 could serve as an indicator for cellular content,or a surrogate indicator for specimen quality.In addition,our results demonstrated that false negativity accounted for a vast majority of contradicting results in SARS-CoV-2 RNA test by RT-PCR. | Yafei Zhang Changtai Wang Mingfeng Han Jun Ye Yong Gao Zhongping Liu Tengfei He Tuantuan Li Mengyuan Xu Luping Zhou Guizhou Zou Mengji Lu Zhenhua Zhang | 2020 | Virologica Sinica2020，35，6： | 5 |
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