|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Why microglia kill neurons after neural disorders? The friendly fire hypothesis显示文摘Neuroinflammation plays a fundamental role on the pathophysiology of acute and chronic neural disorders.Microglia activation is a major event following central nervous system inflammation displaying different phenotypes with beneficial and detrimental actions(a Janus face).The reason for this apparent duality is unknown.We have previously shown that following experimental middle cerebral artery occlusion in the rat brain,microglia seem to support and impair adult neurogenesis in the same ischemic striatum.Based on these results,we raised the hypothesis that in the same pathologic environment,gradients of different ligands distributed over different anatomical niches might contribute to both detrimental and beneficial microglial phenotypes.These ligands(“danger signals”)are released by dying cells and bind to microglial receptors in their membranes.Activation of different microglial receptors induces downstream biochemical pathways culminating in a spectrum of microglial phenotypes like M1 and M2 and others.In this paper,we first review the immune functions of microglia and the role of toll-like receptors on the fight against infections.We then briefly revise the dual role of microglia after neural disorders.We then propose a novel hypothesis to explain the Janus face of microglia during the pathophysiology of central nervous system diseases:the“friendly fire hypothesis”.According to this idea“danger signals”or danger associated molecular patterns released by stressed,damaged and/or dying cells during stroke,trauma and other diseases might activate microglial pattern-recognition receptors(i.e.,toll like receptors)or other unidentified receptors normally activated by pathogens.This could activate the same genetic and biochemical machinery used by microglia to fight against pathogens even in the absence of infection.According to this notion,microglia may cause bystander neuronal damage with a kind of blind“friendly fire”,fighting against a non-existing infection during non-infectious disorders,like stroke and trauma.The“friendly fire hypothesis”is a novel proposal to explain why microglia may be detrimental and beneficial after acute and chronic neural disorders and may direct future investigations for developing of neuroprotective agents. | Walace Gomes-Leal | 2019 | Neural Regeneration Research2019，14，9： | 9 |
| 2 | Microglial activation and adult neurogenesis after brain stroke显示文摘The discovery that new neurons are produced in some regions of the adult mammalian brain is a paradigm-shift in neuroscience research.These new-born cells are produced from neuroprogenitors mainly in the subventricular zone at the margin of the lateral ventricle,subgranular zone in the hippocampal dentate gyrus and in the striatum,a component of the basal ganglia,even in humans.In the human hippocampus,neuroblasts are produced even in elderlies.The regulation of adult neurogenesis is a complex phenomenon involving a multitude of molecules,neurotransmitters and soluble factors released by different sources including glial cells.Microglia,the resident macrophages of the central nervous system,are considered to play an important role on the regulation of adult neurogenesis both in physiological and pathological conditions.Following stroke and other acute neural disorders,there is an increase in the numbers of neuroblast production in the neurogenic niches.Microglial activation is believed to display both beneficial and detrimental role on adult neurogenesis after stroke,depending on the activation level and brain location.In this article,we review the scientific evidence addressing the role of microglial activation on adult neurogenesis after ischemia.A comprehensive understanding of the microglial role after stroke and other neural disorders it is an important step for development of future therapies based on manipulation of adult neurogenesis. | Ijair R.C.dos Santos Michelle Nerissa C.Dias Walace Gomes-Leal | 2021 | Neural Regeneration Research2021，16，3： | 5 |
| 3 | Neurogenesis in the hippocampus of adult humans: controversy “fixed” at last显示文摘The presence of adult neurogenesis in the mammalian brain has been a theme of intense controversy for a long time since the original report by Altman and Das (1965). The scientific community, for about 30 years, has difficulties to accept that progenitor cells give rise to new neurons in some specific regions of the mammalian adult brain, the neurogenic niches (Kuhn et al., 1996;Doetsch et al., 1997, 1999). | Silene M.A. Lima Walace Gomes-Leal | 2019 | Neural Regeneration Research2019，14，11： | 3 |
| 4 | Isolated systolic hypertension is characterized by increased aortic stiff-ness and endothelial dysfunction显示文摘 | Walace SM McEniery CM Maki-Petaja KM | 2007 | Hypertension2007，50，1： | 1 |
| 5 | Teaching psychiatric inpatients to re-enter the community:A brief method of improving the continuity of care显示文摘 | Kopelowicz A Walace CJ Zarate R | | 0，，： | 1 |
| 6 | Following the threads of an innovation : the history of standardized patients in medical education显示文摘 | P Walace | 1997 | Canadian Metallurgical Quarterly1997，13，2： | 1 |
| 7 | Inflammatory of the atherosclerotic cap and shoulder of the plaque is a common and locally observed feature in unruptured plaque of femorsl and croonary arteries显示文摘 | PasterkampG SchoneveldAH van der WalAC | 1999 | Arterioscler Thromb Vasv Biol1999，19，： | 1 |
| 8 | Recent activation of the plaque immune response in coronary lesions underlying acute coronary syndromes显示文摘 | Piek JJ de Boer OJ | 1998 | HeaTt1998，80，： | 1 |
| 9 | The relationship between oxygen uptake reserve and heart rate reserve is affected by intensity and duration during aerobic exercise at constant work rate显示文摘 | Felipe AC Adrian WM Walace D | | 0，，02： | 1 |
| 10 | Fiber-optic pH sensor based on Poly( o -methoxyaniline)显示文摘 | Maria Del Pilar Taboada Sotomayor Marco-A. De Paoli Walace Alves de Oliveira | 1997 | Analytica Chimica Acta1997，，2： | 1 |
| 11 | Visual results and complications of phacoemulsification with intraocular lens implantation performed by ophthalmology residents显示文摘 | Cruz OA Walace GW Gay CA | 1992 | Ophthalmology1992，99，3： | 1 |
| 12 | Visual results and complications of phacoemulsitleation with intraocular lens implantation performed byophthalmology residents 显示文摘 | Cruz OA Walace GW Gay CA | 1992 | Ophthamology1992，99，3： | 1 |
| 13 | Atherosclerotic plaque rupture-pathologic basis of plaque stability and instability 显示文摘 | WalAC BeckerAE | 1999 | Cardiovas Res1999，41，： | 1 |
| 14 | Isolated systolic hypertension is characterized by increased aortic stiffness and endothelial dysfunction显示文摘 | Walace SM McEniery CM Maki-Petaja EM | 2007 | Hypertension2007，50，1： | 1 |
| 15 | Effect of adding acetogenicbacteria on methane production by mixed rumen microorganism显示文摘 | LOPEZ S MCITOSH F M WALACE R J | 1989 | Anim Feed Sci Technol1989，78，： | 1 |
| 16 | Mitochondrial DNA mutation assicited with Leber,s hereditary opticneuropathy显示文摘 | SINGH G LOTT M T | 1998 | Science1998，242，： | 1 |
| 17 | The site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology显示文摘 | vander WalAC Becker AE vander Loos CM | 1994 | Circulation1994，89，： | 1 |
| 18 | 寻找完美之旅——新西兰公路骑行探索显示文摘在壮美的新西兰南岛,我们骑行探索了静谧的公路、湛蓝的湖泊、耸立的山峰,也认识了瓦纳卡(Wanaka)和皇后镇(Queenstown)那些富有趣味的人们,当然更不能忘了他们的啤酒。 | Wade Walace Leoric | 2015 | 中国自行车2015，0，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员