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| 1 | Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors显示文摘Co-delivery of anti-cancer drugs is promising to improve the efficacy of cancer treatment.This study was aiming to investigate the potential of concurrent delivery of resveratrol(RES)and docetaxel(DTX)via polymeric nanocarriers to treat breast cancer.To this end,methoxyl poly(ethylene glycol)-poly(D,L-lactide)copolymer(mPEG-PDLA)was prepared and characterized using FTIR and 1H NMR,and their molecular weights were determined by GPC.Isobologram analysis and combination index calculation were performed to find the optimal ratio between RES and DTX to against human breast adenocarcinoma cell line(MCF-7 cells).Subsequently,RES and DTX were loaded in the mPEG-PDLA micelles simultaneously,and the morphology,particle size distribution,in vitro release,pharmacokinetic profiles,as well as cytotoxicity to the MCF-7 cells were characterized.IC50 of RES and DTX in MCF-7 cells were determined to be 23.0μg/ml and 10.4μg/ml,respectively,while a lower IC50 of 4.8μg/ml of the combination of RES and DTX was obtained.The combination of RES and DTX at a ratio of 1:1(w/w)generated stronger synergistic effect than other ratios in the MCF-7 cells.RES and DTX loaded mPEG-PDLA micelles exhibited prolonged release profiles,and enhanced cytotoxicity in vitro against MCF-7 cells.The AUC(0→t)of DTX and RES in mPEG-PDLA micelles after i.v.administration to rats were 3.0-fold and 1.6-fold higher than that of i.v.injections of the individual drugs.These findings indicated that the co-delivery of RES and DTX using mPEG-PDLA micelles could have better treatment of tumors. | Xiong Guo Zhiyue Zhao Dawei Chen Mingxi Qiao Feng Wan Dongmei Cun Yi Sun Mingshi Yang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，1： | 4 |
| 2 | Ultrasound contrast agent harmonic imaging method based on frequency-modulated signal excitation显示文摘使解调的一种非线性的成像技术超声对比代理人(UCA ) 的反应的第二个泛音部件被建议。UCA 灌注成像方法分别地从三个方面,数学原则,模拟和超声实验被调查了。调制频率(FM ) 信号刺激被介绍了第一在医药超声成像增加 Signal-to-Noise 比率(SNR ) 。如果,理论模拟和一个超声实验被执行调查 cosineenveloped 调制频率的信号刺激能在 UCA 成像被使用增加 SNR 和 Contrast-to-Tissue 比率(CTR ) 。为了获得好成像,合适的参数和权利,播送信号上的信封被需要,并且差距也在播送信号带宽和译码的匹配过滤器带宽之间被需要。一幅泛音图象与编码刺激和译码的过滤器使用被获得。结果建议用这个泛音成像方法,图象能与好 SNR 和 CTR 被得到。同时,听觉的结果被适合于理论结果很好。 | GU Jinhong WAN Mingxi WANG Supin ZONG Yujin CHEN Ping | 2006 | Chinese Journal of Acoustics2006，25，4： | 3 |
| 3 | Ultrasonic characterization of ultra-thin elastic layer using retrieve function显示文摘Using frequency domain retrieve function, a method is presented for characterizing ultra-thin plate by low frequency ultrasound. 'Ultra-thin' means that the thickness of specimen is much less than the wavlength. The throughtransmission retrieve function is examined in detail. In conjunction with the method of least squares, the amplitude spectrum, phase spectrum and complex spectrum are all used to determine the best estimation. An analysis of some typical sources of the estimate deviation is presented. The sensitivities of the retrieve function to acoustical parameters and its significance in the propagation of errors have been derived and well discussed.In experimental study the technique is employed to characterize the brass sheets ranging from 25.4μm to 152.4 pm with a broadba-nd 2 MHz transducer. It is observed that the agreement between the nominal value and the estimation is excellent. | QIAN Ming WAN Mingxi(Biomedical Engineering Dept., Xi’an Jiaotong University Xi’an 710049)CAO Wenwu(Intercollege Materials Researeh Lab., Pennsylvania State University PA 16802 U.S.A) | 1998 | Chinese Journal of Acoustics1998，17，4： | 2 |
| 4 | A fast tissue stiffness-dependent elastography for HIFU-induced lesions inspection显示文摘 | Dachun Zhang Siyuan Zhang Mingxi Wan | | 0，，08： | 1 |
| 5 | Design and experiment of 256-element ultrasound phased array for noninvasive focused ultrasound surgery显示文摘 | Lu Mingzhu Wan Mingxi Xu Feng | 2006 | Ultrasonics2006，44，1： | 1 |
| 6 | Focused Beam Control for Ultrasound Surgery with Spherical-Section Phased Array: Sound Field Calculation and Genetic Optimization Algorithm显示文摘 | Lu Mingzhu Wan Mingxi Xu Feng | 2005 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2005，52，8： | 1 |
| 7 | Enhancing the Antitumor Effects of Adriamycin Nanoparticles by Pretreating Liver Cancer with Diethyldithiocarbamate 显示文摘 | Wan Mingxi Mo Jian | 2002 | J Chin Pharm Sci2002，11，3： | 1 |
| 8 | Ultrasound imaging and evaluation of lesion induced by High Intensity Focused Ultrasound显示文摘现在的学习是为检测 HIFU 调查微分成像方法(高紧张集中了超声) 导致的损害和为有木头的损害评估的变细的变化的评价光谱差别算法。在 vitro 的牛的肌肉和肝的实验结果被获得。为损害察觉的几个算法 - 绝对差别(广告) ,加绝对差别(悲伤) 并且加摆平的差别(SSD )- 与几种窗户尺寸和阀值价值被分析。当时,三个变细参数与相比评估织物的度损坏。它被发现吝啬的变细的那个变化() 是一个有效参数评估损害。 | ZHONG Hui WAN Mingxi JIANG Yifeng WANG Supin | 2006 | Chinese Journal of Acoustics2006，25，2： | 1 |
| 9 | Aerodynamic characteristics of laryngectomees breathing quietly and speaking with the electrolarynx 显示文摘 | Hanjun Liu Mingxi Wan Supin Wang | 2004 | Journal of Voice2004，18，4： | 1 |
| 10 | Low frequency ultrasonic multi-mode Lamb wave method for characterizing the ultra-thin transversely isotropic laminate composite: Theory and experiment显示文摘A low-frequency multi-mode ultrasonic Lamb wave method suitable for character- izing the thickness, the density and the elastic constants of the ultra-thin transversely isotropic laminate composite is presented. The 'ultra-thin' here means that the thickness of the plate is much less than the wavelength of the ultrasonic wave so that the echoes from the front and back faces of the plate can’t be separated in the time domain. The dispersion equations for the low frequency ultrasonic Lamb waves with the propagation directions parallel and vertical to the fiber direction are derived. In conjunction with the least square algorithm method, the secant algorithm is used to estimate the parameters of the ultra-thin fiber-reinforced composite layer. The evaluation errors and the sensitivity of the method to different paramters of the thin composite are analyzed. The technique has been used to characterize the ultra-thin grass fiber reinforced PES composite with thickness down to ten percents of the ultrasonic wavelength. It is observed that the agreement between the nominal and the estimation values is reasonably good. | ZHANG Rui, WAN Mingxi, CHEN Xiao, (Department of Biomedical Engineering Xi’an Jiaotong University Xi’an 710049) CAO Wenwu is with the Intercollege Materials Research Laboratory The Pennsylvania State University University Park, PA, 16802, USA | 2001 | Chinese Journal of Acoustics2001，20，4： | 1 |
| 11 | A novel method for evaluating tissue inhomogeneity in elastography显示文摘基于信号为在跨修正的操作以前在 elastography 评估织物不同类的一个新奇方法被建议的分割的预压力和压缩以后的无线电频率(RF ) 回响的微分 Renyi 信息(DRI ) 的察觉。在 vitro,实验被执行支持 DRI 方法的表演。试验性的结果说明那进本地织物不同类的珍贵卓见能通过分析能提供信息在 elastography 帮助紧张评价算法的学习的回响片断的 DRI 曲线被获得。 | BAI Peirui, WAN Mingxi WAN Mingxi WANG Supin ZHANG Dachun DANG Jun | 2006 | Progress in Natural Science:Materials International2006，16，5： | 1 |
| 12 | The Analysis for the Efficiency Properties of the Fuel Cell Engine显示文摘 | Hou Yongping Zhuang Mingxi Wan Gang | 2007 | Renew Energy2007，32，7： | 1 |
| 13 | Optimal design and experimental measurement of the subharmonic characterizations of encapsulated microbubble显示文摘在超声域以内基于包含的 microbubbles 的一个理论运动方程, microbubbles 的次谐波描述被一台计算机最佳地设计并且分析帮助设计系统。microbubbles 的次谐波反应上的尺寸,壳弹性和声学的压力的效果理论上被计算为非破坏性的次谐波成像获得最佳的参数。另外,有不同的壳弹性的 microbubbles 被准备,并且他们的次谐波回答在理论计算和好次谐波改进能被与 3m 的吝啬的尺寸使用包含的 microbubbles 获得的声学的测量表演的 vitro.The 结果被测量,它与 material.It 也被显示出的壳的合适的比率从表面活化剂答案被准备最好的操作声学的压力是为非破坏性的次谐波 ima 的 200~400 | ZONG Yujin WAN Mingxi WANG Suping CHEN Hong ZHANG Guolu | 2006 | Chinese Journal of Acoustics2006，25，1： | 1 |
| 14 | Effects of ultrasound and additives on the function and structure of trypsin显示文摘 | TIAN Zhongmin WAN Mingxi WANG Supin | 2004 | Ultrasonic Sonocheraistry2004，11，6： | 1 |
| 15 | A Fast Snake Model Basedon Non-linear Diffusion for Medical Image Segmentation显示文摘 | Wei Min Zhou Yongjin Wan Mingxi | 2004 | Computerized Medical Imaging and Graphics2004，28，3： | 1 |
| 16 | Nano-coated microbubbles ultrasound contrastagentsbasedsurfactants 显示文摘 | Yongfeng Du Mingxi Wan Supin Wang | 2003 | Chemicaltechnology2003，54，6： | 1 |
| 17 | Bioeffects Of low-intensity ultrasound in vitro: Apoptosis, protein prgfile alteration, and! po- tential molecular mechanism 显示文摘 | Feng Yi Tian Zhongmin Wan Mingxi | 2010 | Journal of Ultrasound in Medi- cine2010，29，6： | 1 |
| 18 | A Transient Semi-Empirical Voltage Model of a Fuel Cell Stack显示文摘 | Yongping Hou Mingxi Zhuang Gang Wan | 2007 | International Journal of Hydrogen Energy2007，32，： | 1 |
| 19 | Elasticity imaging for regularly spaced structures utilizing WT matched filtering method显示文摘Based on wavelet transform of time-scale domain, a new strain estimation method is presented to position the regular scatterers, calculate the local scatterer spacing and its change, and estimate the internal strain distribution of tissue mimicking phantom. Simulation and experiment results for uniform and nonuniform phantoms show the internal strain of regularly spaced structures can be estimated accurately using this method and the influence of global boundary condition on the estimated strain distribution can be eliminated by reconstructing the real elasticity distribution. This approach has the potentials to become a valuable tool for the regularly spaced structures. | CUI Yaoyao, WAN Mingxi, ZHEN Bin, LI Junbo and WANG Supin(Department of Biomedical Engineering, Xi’an Jiaotong University, Xi’an 710049, China) | 2002 | Progress in Natural Science:Materials International2002，12，8： | 1 |
| 20 | 胚胎干细胞体外减数分裂获得功能配子显示文摘随着不孕不育症的全球性高发,通过体外培养的方式获得功能配子被认为是解决不孕不育症生殖细胞缺乏问题最为有效的途径,但过往的研究表明真实的再现减数分裂过程是体外获得功能配子难以逾越的障碍。 | Quan Zhou Mei Wang Yan Yuan Xuepeng Wang Rui Fu Haifeng Wan Mingming Xie Mingxi Liu Xuejiang Guo Ying Zheng Guihai Feng Qinghua Shi 赵小阳 沙家豪 周琪 | 2017 | 科学新闻2017，19，4： | 0 |
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