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	题名	作者	年代	出处	被引量
1	Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD.	Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao	2017	Bone Research2017，5，1：	9
2	Preparation and characterization of gelatin gel with a gradient structure 显示文摘	Wang Y L Cheng G X Yao K D	2000	Polymer Int2000，49，12：	1
3	Silicon isotope fractionation in bamboo and its significance to the biogeochemical cycle of silicon显示文摘	DING T P ZHOU J X WAN D F	2008	Geochimica et Cosmochimica Acta2008，72，5：	1
4	Reformation of medical educa- tion in China显示文摘	Xu D Sun B Wan X	2010	Lancet2010，375，：	1
5	Combination of HSCCC and Sephadex LH-20 methods-An approach to isolation and purification of the main individual theaflavins from black tea 显示文摘	Yang C J Li D X Wan X C	2008	J Chromatogr B2008，861，1：	1
6	Combination of HSCCC and Sephadex LH-20 methods: An approach to isolation and purification of the main individual theaflavins from black tea 显示文摘	Yang C J Li D X Wan X C	2008	J Chromatogr B2008，861，1：	1
7	A new existence theory for positive periodic to functional differential equations 显示文摘	Wan A Jiang D Xu X	2004	Comput Math Ap- pl2004，，47：	1
8	Post growth alignment of SWNTs by an electric field显示文摘	Zhou Z P Wan D Y Dou X Y	2006	Carbon2006，44，1：	1
9	Hierarchical map building based UKF-SLAM approach for AUV 显示文摘	Shao G Wan L Shen X D	2013	Applied Me-chanics and Materials2013，437，：	1
10	Absorption Rate into a MDEA Aqueous Solution Blended with Piperazine under a High CO_2 Partial Pressure显示文摘	Zhang X Wan H L Weng W Z Yi X D		0，，1：	1
11	Study on microstructure and ther-modynamics of nacre in mussel shell 显示文摘	Ren F Z Wan X D Ma Z H	2009	Materials Chemistry andPhysics2009，114，1：	1
12	Circadian rhythms govern cardiac repolarization and arrhythmogenesis 显示文摘	Jeyaraj D Haldar S M Wan X	2012	Nature2012，483，7387：	1
13	查看详情显示文摘	Qian X F Wan Y Wen Y L Jia N Q Li H X Zhao D Y		0，，：	1
14	Constitutive equations in creepof 7B04 aluminum alloys 显示文摘	Li C Wan M Wu X D	2010	Materials Science and Engi-neering: A2010，527，1617：	1
15	Synthesis and characteriza- tion of water-soluble conducting copolymer poly (aniline- co-o-amlnobenzenesulfonlc acid) 显示文摘	Fan J H Wan M X Zhu D B	1998	Journal of Polymer Science: Part A :Polymer Chemistry1998，36，：	1
16	Study on microstructure and thermodynamics of nacre in mussel shell 显示文摘	REN F Z WAN X D MA Z H	2009	Materials Chemistry and Physics2009，114，：	1
17	Rehydration reactivity of recycled mortar from concretewaste experienced to thermal treatment显示文摘	SHUI Z H XUAN D X WAN H W	2008	Constructionand Building Materials2008，22，8：	1
18	Biological protection of hardwood logs destined for panel manufacturing using Gliocladium roseum a- gainst biodegradation显示文摘	Yang D Q Wang X M Wan H	2007	Biocontrol2007，52，：	1
19	Effect of modified ferroelectric on nonthermal plasma process for toluene decomposition显示文摘	Zhu T Wan Y D He X W	2011	Fresenins Environmental Bulletin2011，20，1：	1
20	Effects of arbuscular mycorrhizal fungi on the rooting and growth of beach plum (Prunus maritima) cuttings 显示文摘	Zai X M Qin P Wan S W Zhao F G Wang G Yan D L	2007	J Hort Sci Biotech2007，82，6：	1

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