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| 1 | Design and development of an oral remdesivir derivative W116 against SARS-CoV-2显示文摘Dear Editor,Since the declaration of COVID-19 as a global pandemic on March 11,2020,this pandemic has been circulating for 17 months throughout the world,leading to more than 200 million infections and nearly 4.4 million deaths as of August 15,2021.The pathogen of COVID-19 is a novel coronavirus named SARS-CoV-2,which shares-79%genome sequence identity with SARS-CoV.1 At the early stage of the COVID-19 outbreak,5ARS-CoV-2 caused great panic in the hardest-hit areas due to its high transmissibility and pathogenicity.To fight the COVID-19 crisis,drug repurposing was immediately pursued in order to find potential therapeutics. | Yuanchao Xie Wanchao Yin Yumin Zhang Weijuan Shang Zhen Wang Xiaodong Luan Guanghui Tian Haji A.Aisa Yechun Xu Gengfu Xiao Jia Li Hualiang Jiang Shuyang Zhanq Leike Zhang H.Eric Xu Jingshan Shen | 2021 | Cell Research2021，31，11： | 12 |
| 2 | Pingchuan formula(平喘方) improves allergic asthma in mice through inhibiting nuclear factor-kappa B/mitogen-activated protein kinase signaling pathway显示文摘OBJECTIVE:To examine the role and decipher the mechanism of Pingchuan formula(平喘方,PCF)in treating allergic asthma.METHODS:The mice were treated with saline,dexamethasone(DXM)and PCF for 1 week after the asthma model was established and their respiratory function including respiratory resistance(RI),pulmonary dynamic compliance(Cdyn)and maximum voluntary ventilation(MVV)were measured.In addition,cellular changes in bronchoalveolar lavage fluid(BALF)and pathological changes in lung biopsy as well as the expression level ofα-smooth muscle actin(α-SMA),transforming growth factor-beta1(TGF-β1)in BALF and interleukin-5(IL-5),interleukin-13(IL-13),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),nuclear factor-kappa B-p65(NF-κBp65),inhibitor-αof nuclear transcription factorκB(IκBα),p38 mitogen-activated protein kinase(p38 MAPK),c-jun n-terminal kinase(JNK)and its phosphorylated proteins in lung tissue were also examined and compared among different groups.RESULTS:Our data suggested that the respiratory functions were significantly improved and the pathological changes ameliorated in the DXM group and the PCF group compared to the model group.Both DXM and PCF effectively decreased the number of eosinophils,lymphocytes,and neutrophils in BAL as well as the secretion ofα-SMA and TGF-β1,IL-5,IL-13,while increased the expression of TNF-αand IFN-γ.Furthermore,our study indicated that the NF-κBp65,IκBα,p38 MAPK and JNK pathways were inhibited under the treatment of PCF.CONCLUSION:Our data indicated that PCF can attenuate the inflammatory response in asthma through inhibiting the NF-κB/MAPK signaling pathway.This study not only supported the use of PCF in allergic asthma in clinic but also shed light upon afurther understanding of the disease pathogenesis. | WU Mingyun YU Jianer BAI Li XUE Zheng JIANG Shenhua LI Liqing PIAO Xiang XU Wanchao WANG Jiani SHEN Qian | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 4 |
| 3 | A complex structure of arrestin-2 bound to a G protein-coupled receptor显示文摘Arrestins comprise a family of signal regulators of G-protein-coupled receptors(GPCRs),which include arrestins 1 to 4.While arrestins 1 and 4 are visual arrestins dedicated to rhodopsin,arrestins 2 and 3(Arr2 and Arr3)areβ-arrestins known to regulate many nonvisual GPCRs.The dynamic and promiscuous coupling of Arr2 to nonvisual GPCRs has posed technical challenges to tackle the basis of arrestin binding to GPCRs.Here we report the structure of Arr2 in complex with neurotensin receptor 1(NTSR1),which reveals an overall assembly that is strikingly different from the visual arrestin–rhodopsin complex by a 90°rotation of Arr2 relative to the receptor.In this new configuration,intracellular loop 3(ICL3)and transmembrane helix 6(TM6)of the receptor are oriented toward the N-terminal domain of the arrestin,making it possible for GPCRs that lack the C-terminal tail to couple Arr2 through their ICL3.Molecular dynamics simulation and crosslinking data further support the assembly of the Arr2‒NTSR1 complex.Sequence analysis and homology modeling suggest that the Arr2‒NTSR1 complex structure may provide an alternative template for modeling arrestin–GPCR interactions. | Wanchao Yin Zhihai Li Mingliang Jin Yu-Ling Yin Parker Wde Waal Kuntal Pal Yanting Yin Xiang Gao Yuanzheng He Jing Gao Xiaoxi Wang Yan Zhang Hu Zhou Karsten Melcher Yi Jiang Yao Cong X.Edward Zhou Xuekui Yu H.Eric Xu | 2019 | Cell Research2019，29，12： | 4 |
| 4 | Durability of nano ZnO antibacterial cotton fabric to sweat 显示文摘 | Li Qun Chen Shuilin Jiang Wanchao | 2007 | Journal of Applied Polymer Science2007，103，1： | 1 |
| 5 | Synthesis of am- phiphilic polystyrene-b-poly(acrylic acid) diblock copolymers by iodide-mediated radical polymerization 显示文摘 | Li Bingyi Shi Yan Zhu Wanchao | 2006 | Polym J2006，38，4： | 1 |
| 6 | Geometrical structures, and electronic and transport properties of a novel two-dimensional β-GaS transparent conductor显示文摘二维(2D ) 材料为灵活电子学是高度有希望的,并且 graphene 是唯一的学习得好的透明售票员。此处,密度功能的理论被用来在一张 2D 气体表上经由 H 的吸附探索新透明进行材料。这吸附在 H 附近导致本地结构的几何变化。计算电子结构与 0.67 eV 的重要 Burstein 苔藓移动在 H 吸附和 2.72 eV 的大光乐队差距之上揭示 2D 气体材料的金属性的特征。模仿的电的抵抗力象 10 4 O 一样低 ? ???? ?? 眠瑩 ? 敲灳 ' ?潴爠 ' 虙賾[楢楬祴愠摮挠湯楴畮畯 ? | Zhangxian Chen Liang Huang Yongjie Xi Ran Li Wanchao Li Guoqin Xu Hansong Cheng | 2015 | Nano Research2015，8，10： | 1 |
| 7 | Bio degradation of cyfluthrin by fungi 显示文摘 | WANCHAO CHEN WEN LI YAN YANG | 2015 | Journal ofAgricultural and Food Chemistry2015，63，3： | 1 |
| 8 | Dynamic patterns of the translatome in a hybrid triplet show translational fractionation of the maize subgenomes显示文摘Heterosis,the phenomenon in which hybrids outperform their parents,has been utilized in maize(Zea mays L.)for over 100 years.To provide a more complete understanding of heterosis,we collected a comprehensive transcriptome and translatome dataset on seedling leaves for B73,Mo17,and their F1 hybrid,which provided a dynamic landscape of transcriptomic and translatomic variation in maize.Although additivity accounted for a large proportion of variation at two omics-levels,an elevated nonadditive effect was observed in the translatome,especially in the translated subgenome maize1 genes,and the genes that switched from additivity in the transcriptome to nonadditivity in the translatome were significantly enriched in the subgenome maize1.Many genes with allele-specific expression and translation show dramatic regulatory switches between the transcriptome and translatome,and partial genes with allele-specific translation underlying regulatory mechanism also exhibited subgenome bias.Interestingly,we found the translated isoforms show different expression patterns compared with transcriptome and more genes changed their dominant isoforms during the genetic flow from parents to the hybrid at the translatome level.The translated genes with switched dominant isoforms significantly biased to the subgenome maize2 while genes with conserved dominant isoforms significantly enriched in subgenome maize1.Together,the dynamic changed patterns in translatome across hybrid and parental lines show translational fractionation of the maize subgenomes,which may be associated with heterosis in maize and provides a potential theoretical basis for breeding. | Wanchao Zhu Sijia Chen Tifu Zhang Jia Qian Zi Luo Han Zhao Yirong Zhang Lin Li | 2022 | The Crop Journal2022，10，1： | 1 |
| 9 | Synthesis of am- phiphilic polystyrene-b-poly( acrylic acid) diblock copolymers by iodide-mediated radical polymerization 显示文摘 | Li Bingyi Shi Yan Zhu Wanchao | 2006 | Polym J2006，38，4： | 1 |
| 10 | Investigation on peritectic solidification in Sn-Ni peritectic alloys through in-situ observation显示文摘The solidification of Sn-Ni peritectic alloys in which both the primary Ni_(3)Sn_(2)and peritectic Ni_(3)Sn_(4)phases were intermetallic compound phases(IMCs)with narrow solubility ranges was investigated through confocal laser scanning microscope.Analysis on the interface migration at different cooling rates shows that the rate of peritectic reaction is much smaller than previous reports,and the growth of peritectic phase is mainly attributed to direct precipitation from the melt in Sn-Ni alloy after peritectic reaction.In addition,different from other peritectic alloys where the solidified phases are solid solution phases,the'step'growth of both Ni_(3)Sn_(2)and Ni_(3)Sn_(4)phases was observed.The dependences of the step thickness on both the cooling rate and solidification time were measured,which shows that the step thicknesses of both phases gradually decrease as solidification proceeds.This was confirmed to be attributed to the difference between the actual and equilibrium melt concentrations during solidification.In addition,the increase of the normal growth velocity of Ni_(3)Sn_(4)phase with increasing cooling rate was also proved through both the experimental observation and quantitative prediction. | Peng Peng Anqiao Zhang Jinmian Yue Shengyuan Li Wanchao Zheng Li Lu | 2021 | Journal of Materials Science & Technology2021，，31： | 0 |
| 11 | Molecular recognition of itch-associated neuropeptides by bombesin receptors显示文摘Dear Editor,Itch,especially persistent itch(or chronic pruritus)in patients with allergic skin diseases and/or neuropathic problems,significantly affects sleep,mood and individual health.Extensive efforts have been made to develop novel therapeutic strategies to fight itch.Unfortunately,there is no FDA-approved treatment for chronic pruritus despite great efforts in antipruritic research in the past few decades. | Changyao Li Youwei Xu Heng Liu Hongmin Cai Yi Jiang H.Eric Xu Wanchao Yin | 2023 | Cell Research2023，33，2： | 0 |
| 12 | Large-scale translatome profiling annotates the functional genome and reveals the key role of genic 30 untranslated regions in translatomic variation in plants显示文摘The translatome,a profile of the translational status of genetic information within cells,provides a new perspective on gene expression.Although many plant genomes have been sequenced,comprehensive translatomic annotations are not available for plants due to a lack of efficient translatome profiling techniques.Here,we developed a new technique termed 30 ribosome-profiling sequencing(30Ribo-seq)for reliable,robust translatomic profiling.30Ribo-seq combines polysome profiling and 30 selection with a barcoding and pooling strategy.Systematic translatome profiling of different tissues of Arabidopsis,rice,and maize using conventional ribosome profiling(Ribo-seq)and 30Ribo-seq revealed many novel translational genomic loci,thereby complementing functional genome annotation in plants.Using the low-cost,efficient 30Ribo-seq technique and genome-wide association mapping of translatome expression(eGWAS),we performed a population-level dissection of the translatomes of 159 diverse maize inbred lines and identified 1,777 translational expression quantitative trait loci(eQTLs).Notably,local eQTLs are significantly enriched in the 30 untranslated regions of genes.Detailed eQTL analysis suggested that sequence variation around the polyadenylation(polyA)signal motif plays a key role in translatomic variation.Our study provides a comprehensive translatome annotation of plant functional genomes and introduces 30Ribo-seq,which paves the way for deep translatomic analysis at the population level. | Wanchao Zhu Jing Xu Sijia Chen Jian Chen Yan Liang Cuijie Zhang Qing Li Jinsheng Lai Lin Li | 2021 | Plant Communications2021，2，4： | 0 |
| 13 | The CropGPT project:Call for a global,coordinated effort in precision design breeding driven by Al using biological big data显示文摘Since the beginning of humanity,people have been seeking practical solutions to meet their most basic need:food.The advent of agriculture greatly increased the food supply and led to a rapid increase in the human population.Enhanced food production via agriculture can be attributed to both improved crop management practices and crop breeding through genetics.Plant(crop)breeding has been categorized into four major stages based on the techniques employed(Wallace et al.,2018). | Wanchao Zhu Rui Han Xiaoyang Shang Tao Zhou Chengyong Liang Xiaomeng Qin Hong Chen Zaiwen Feng Hongwei Zhang Xingming Fan Weifu Li Lin Li | 2024 | Molecular Plant2024，17，2： | 0 |
| 14 | Enormous Promotion of Photocatalytic Activity through the Use of Near-Single Layer Covalent Organic Frameworks显示文摘Enhancing the charge separation efficiency is highly effective strategy in improving the photocatalytic activity of covalent organic frameworks(COFs)which have the problems of low conductivity and difficult dissociation of excitons.In this work,we report the sevenfold increase in apparent quantum efficiency resulting from the use of a near-single layer COF(SLCOF)in photocatalytic hydrogen evolution compared with bulk COF.Detected by transient absorption spectroscopy characterization,100% of photogenerated long-lived electrons in the near-SLCOF can be extracted and participate in the photocatalytic process.However,the electron extraction efficiency declined to only about 11% when the COFs were increased to eight layers,implying the difficulty of charge migration among COFs interlayers.The near-SLCOF was prepared by deposition of selfexfoliated COFs colloids on SiO_(2),driven by their strong affinity.This work not only sheds light on the significant influence of COF layer thickness on the charge separation efficiency but also provides a new route to prepare and stabilize COF layers for practical applications. | Xiaomin Ren Chunzhi Li Wanchao Kang He Li NaTa Sheng Ye Linyan Hu Xiuli Wang Can Li Qihua Yang | 2022 | CCS Chemistry2022，4，7： | 0 |
| 15 | Structural genomics of the human dopamine receptor system显示文摘The dopaminergic system,including five dopamine receptors(D1R to D5R),plays essential roles in the central nervous system(CNS);and ligands that activate dopamine receptors have been used to treat many neuropsychiatric disorders,including Parkinson’s Disease(PD)and schizophrenia.Here,we report cryo-EM structures of all five subtypes of human dopamine receptors in complex with G protein and bound to the pan-agonist,rotigotine,which is used to treat PD and restless legs syndrome.The structures reveal the basis of rotigotine recognition in different dopamine receptors.Structural analysis together with functional assays illuminate determinants of ligand polypharmacology and selectivity.The structures also uncover the mechanisms of dopamine receptor activation,unique structural features among the five receptor subtypes,and the basis of G protein coupling specificity.Our work provides a comprehensive set of structural templates for the rational design of specific ligands to treat CNS diseases targeting the dopaminergic system. | Peiyu Xu Sijie Huang Brian E.Krumm Youwen Zhuang Chunyou Mao Yumu Zhang Yue Wang Xi-Ping Huang Yong-Feng Liu Xinheng He Huadong Li Wanchao Yin Yi Jiang Yan Zhang Bryan L.Roth H.Eric Xu | 2023 | Cell Research2023，33，8： | 0 |
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