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| 1 | Advances and Trends on Tube Bending Forming Technologies显示文摘作为有庞大的数量和差异的一个种关键部件,弄弯的试管部分从材料和结构方面为无足轻重的人和高张力产品满足增加的需要。弄弯的试管广泛地在象航空,太空,造船,汽车,精力和护理那样的许多高端工业被使用了。弯曲的试管成为了为小产品形成生产技术的钥匙之一。经由把特征和多重缺点弄弯的分析,在试管弯曲探索普通问题上的进展在穹隆之内面关于起皱的不稳定性被总结,墙变瘦(裂开) 在拱背, springback 现象,剖面图变丑,形成的限制和过程 / 工具设计 / 优化。一些当前发达的弯曲技术以他们的优点和限制被考察。最后,鉴于高效的建筑群的迫切要求,在航空与 difficult-to-deform 和小材料把试管部件弄弯,太空域,发展趋势和相应挑战为认识到把变丑弄弯的精确、高效率的试管被介绍。 | YANG He LI Heng ZHANG Zhiyong ZHAN Mei LIU Jing LI Guanjun | 2012 | Chinese Journal of Aeronautics2012，25，1： | 86 |
| 2 | PREVALENCE AND RISK FACTORS OF PERIPHERAL ARTERIAL DISEASE IN DIABETIC PATIENTS OVER 50 YEARS OLD IN CHINA显示文摘Objective To investigate the prevalence of peripheral arterial disease (PAD) in China type 2 diabetic patients and to demonstrate the relationships between putative risk factors and PAD. Methods In total 1 397 type 2 diabetic patients aged 50 years and older were enrolled and determined ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) in 15 Class III Grade A hospitals in 7 major cities of China. Results Mean patient age was 63.7±8.2 years and mean duration of diabetes mellitus was 9.39±7.4 years. Two hundreds and seventy-two (19.47%) patients were diagnosed as PAD by ABI <0.9, 122 (18.37%) in male and 150 (20.46%) in female. PAD patients had a significantly longer duration of diabetes mellitus, higher hemoglobin Alc, and a significantly lower mean body mass index than non-PAD ones. Aging, smoking, and systolic blood pressure were found to be positively related with the prevalence of PAD. In terms of lipid profiles, no variable was found to relate with PAD. Notably, baPWV showed as the same significant guiding index for PAD, almost matched with ABI. Conclusions PAD is a common complication in China type 2 diabetic patients. Therefore, PAD screening and treatment should be emphasized for diabetic patients with high risk factors. | Heng Guan Yong-jun Li Zhang-rong XU Guang-wei Li Xiao-hui Guo Zhi-min Liu Da-jin Zou Hui-li Xing Wei Liu Zheng-yan Sheng Hao-ming Tian Da-long Zhu De-min YU Wei-te Zhuang Lu-lu Chen Jian-ping Weng | 2007 | Chinese Medical Sciences Journal2007，22，2： | 41 |
| 3 | Regulation of microglial activation in stroke显示文摘当 ischemic 击发生时,氧和精力弄空触发事件的串联,包括导致深刻大脑损害的煽动性的回答, glutamate excitotoxicity,氧化压力,和 apoptosis。煽动性的反应贡献第二等的 neuronal 损坏,它在两尖锐 ischemic 损害和大脑功能的长期的恢复上施加实质的影响。Microglia 是在常常,在正常下面的监视器大脑微型环境调节的大脑的居民免疫者房间。一旦局部缺血发生, microglia 被激活生产有害并且二个抵抗调停人的 neuroprotective 调停人,和平衡决定受伤神经原的命运。microglia 的激活被定义为经典著作(M1 ) 或选择(M2 ) :M1 microglia 分泌支持 inflammatory cytokines (TNF, IL-23, IL-1, IL-12,等等) 并且加重 neuronal 损害,而 M2 显型支持反煽动性的回答,那是修理的。它有重要翻译价值调整 M1/M2 microglial 激活最小化有害效果或最大化保护的角色。这里,我们在 ischemic 击的上下文讨论在 microglia 和神经原之间的 microglia/macrophage 激活和相互作用的各种各样的管理者。 | Shou-cai ZHAO Ling-song MA Zhao-hu CHU Heng XU Wen-qian WU Fudong LIU | 2017 | Acta Pharmacologica Sinica2017，38，4： | 38 |
| 4 | Detection of RASSF1A promoter hypermethylation in serum from gastric and colorectal adenocarcinoma patients显示文摘AIM:To evaluate the diagnostic role of serum RASSF1A promoter hypermethylation in gastric and colorectal ad- enocarcinoma. METHODS:Methylation-specific polymerase chain reac- tion (MSPCR) was used to examine the promoter meth- ylation status of the serum RASSF1A gene in 47 gastric adenocarcinoma patients, 45 colorectal adenocarcinoma patients, 60 patients with benign gastrointestinal dis- ease (30 with benign gastric disease and 30 with benign colorectal disease), and 30 healthy donor controls. Apaired study of RASSF1A promoter methylation status in primary tumor, adjacent normal tissue, and postopera- tive serum were conducted in 25 gastric and colorectal adenocarcinoma patients who later were underwent sur- gical therapy. RESULTS:The frequencies of detection of serum RASSF1A promoter hypermethylation in gastric (34.0%) and colorectal (28.9%) adenocarcinoma patients were significantly higher than those in patients with benign gastric (3.3%) or colorectal (6.7%) disease or in healthy donors (0%) (P < 0.01). The methylation status of RASSF1A promoter in serum samples was consistent with that in paired primary tumors, and the MSPCR results for RASSF1A promoter methylation status in paired preoperative samples were consistent with those in postoperative serum samples. The serum RASSF1A promoter hypermethylation did not correlate with patient sex, age, tumor differentiation grade, surgical therapy, or serum carcinoembryonic antigen level. Although the serum RASSF1A promoter hypermethylation frequency tended to be higher in patients with distant metastases, there was no correlation between methylation status and metastasis. CONCLUSION:Aberrant CpG island methylation within the promoter region of RASSF1A is a promising biomark- er for gastric and colorectal cancer. | Yu-Cai Wang Zheng-HongYu Chang Liu Li-Zhi Xu Wen Yu Jia Lu Ren-Min Zhu Guo-Li Li Xin-Yi Xia Xiao-Wei Wei Hong-Zan Ji Heng Lu Yong Gao Wei-Min Gao Long-Bang Chen | 2008 | World Journal of Gastroenterology2008，14，19： | 26 |
| 5 | The antitumor effect of tanshinone IIA on antiproliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line显示文摘The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were investigated.The exploration of the interaction between tanshinone IIA and its target proteins provides a feasible platform for studying the anticancer mechanism of active components of herbs.The CCK-8 assay was used to evaluate the proliferative activity of A549 cells treated with tanshinone IIA(2.5 80 μmol/L) for 24,48 and 72 h,respectively.Flow cytometry was used for the detection of cell apoptosis and cell cycle perturbation.VEGF and VEGFR2 expression were studied by Western blotting.The binding mode of tanshinone IIA within thecrystal structure of the VEGFR2 protein was evaluated with molecular docking analysis by use of the CDOCKER algorithm in Discovery Studio 2.1.The CCK-8 results showed that tanshinone IIA can significantly inhibit A549 cell proliferation in a dose-and time-dependent manner.Flow cytometry results showed that the apoptosis rate of tested group was higher than the vehicle control,and tanshinone IIAtreated cells accumulated at the S phase,which was higher than the vehicle control.Furthermore,the expression of VEGF and VEGFR2 was decreased in Western blot.Finally,molecular docking analysis revealed that tanshinone IIA could be stably docked into the kinase domain of VEGFR2 protein with its unique modes to form H-bonds with Cys917 and π–π stacking interactions with Val848.In conclusion,tanshinone IIA may suppress A549 proliferation,induce apoptosis and cell cycle arrest at the S phase.This drug may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. | Jun Xie Jiahui Liu Heng Liu Shihui Liang Meigui Lin Yueyu Gu Taoli Liu Dongmei Wang Hui Gee Sui-lin Mo | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 26 |
| 6 | A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value显示文摘 | Changsong Zou Aojun Chen Lihong Xiao Heike M Muller Peter Ache Georg Haberer Meiling Zhang Wei Jia Ping Deng Ru Huang Daniel Lang Feng Li Dongliang Zhan Xiangyun Wu Hui Zhang Jennifer Bohm Renyi Liu Sergey Shabala Rainer Hedrich Jian-Kang Zhu Heng Zhang | 2017 | Cell Research2017，27，11： | 22 |
| 7 | Effects of four regulating-intestine prescriptions on pathology and ultrastructure of colon tissue in rats with ulcerative colitis显示文摘AIM: To observe different histomorphologic changes of ulcerative colitis (UC) rats that were treated with four regulating-intestine prescriptions (FRIP), to investigate the curative effects of FRIP and to analyze their treatment mechanism.METHODS: The UC rat model was made by the method of 2,4-dinitro chloro benzene (DNCB) immunity and acetic acid local enema. Ninety-eight SD rats were randomly divided into seven groups, namely, the normal control group, model group, salicylazosulfapyridine (SASP) group,Wumeiwan (WMW) group, Baitouwengtang (BTWT) group,Senglingbaishusan (SLBSS) group, and Tongxieyaofang (TXYF) group. Each group had 14 rats (with equal ratio of male and female). The six animal model groups of UC-SASP, TXYF, WMW, BTWT, SLBSS, TXYF-were treated by distilled water except the normal control group. Changes of the rat's general conditions after treatment were respectively observed, the colon tissue damage scores were given out, the pathology of colonic mucosa and changes of ultrastructure were analyzed.RESULTS: Different pathological changes on histology were shown after treatment by FRIP. The colon tissue damage score in model group was higher than that of FRIP groups and SASP group (q = 4.59, 4.77, P<0.05 or q = 5.48,6.25, 5.97, P<0.01). The scores of WMW group, BTWT group and SLBSS group were lower than that of SASP (q = 4.13, P<0.05 or q = 5.31, 5.12, P<0.01). There was no remarkable difference between the damage score of TXYF group and SASP group (q = 3.75, P>0.05). In addition, some apoptosis cells were found in the pathologic control group.CONCLUSION: The model made with DNCB and acetic acid was successful, and FRIP had better curative effect and WMW was the best curative effect, BTW, SLBSS and TXYF were similar to SASP, and we discovered that apoptosis was possibly related to UC. | Heng Fan Ming-Yi Qiu Jia-Jun Mei Guan-Xin Shen Song-Lin Liu Rui Chen | 2005 | World Journal of Gastroenterology2005，11，31： | 19 |
| 8 | High porosity and low thermal conductivity high entropy(Zr0.2Hf0.2Ti0.2Nb0.2Ta0.2C显示文摘Porous ultra-high temperature ceramics(UHTCs)are promising for ultrahigh-temperature thermal insulation applications.However,the main limitations for their applications are the high thermal conductivity and densification of porous structure at high temperatures.In order to overcome these obstacles,herein,porous high entropy(Zr(0.2)Hf(0.2)Ti(0.2)Nb(0.2)Ta(0.2))C was prepared by a simple method combing in-situ reaction and partial sintering.Porous high entropy(Zr(0.2)Hf(0.2)Ti(0.2)Nb(0.2)Ta(0.2))C possesses homogeneous microstructure with grain size in the range of 100–500 nm and pore size in the range of 0.2–1μm,which exhibits high porosity of 80.99%,high compressive strength of 3.45 MPa,low room temperature thermal conductivity of 0.39 W·m^-1K^-1,low thermal diffusivity of 0.74 mm^2·s^-1and good high temperature stability.The combination of these properties renders porous high entropy(Zr(0.2)Hf(0.2)Ti(0.2)Nb(0.2)Ta(0.2))Cpromising as light-weight ultrahigh temperature thermal insulation materials. | Heng Chen Huimin Xiang Fu-Zhi Dai Jiachen Liu Yiming Lei Jie Zhang Yanchun Zhou | 2019 | Journal of Materials Science & Technology2019，35，8： | 16 |
| 9 | Advanced glycation end products promote human aortic smooth muscle cell calcification in vitro via activating NF-KB and down-regulating IGFIR expression显示文摘 | Yi WANG Zhen-yu ZHANG Xiao-qing CHEN Xiang WANG Heng CAO Shao-wen LIU | 2013 | Acta Pharmacologica Sinica2013，34，4： | 16 |
| 10 | A Novel Chloroplast-Localized Pentatricopeptide Repeat Protein Involved in Splicing Affects Chloroplast Development and Abiotic Stress Response in Rice显示文摘Pentatricopeptide 重复(PPR ) 蛋白质在更高的植物包括一个大家庭并且在 organellar RNA 新陈代谢的各种各样的方面调制 organellar 基因表示 byparticipating。在米饭,家庭包含他们的功能仍然是的 477 个成员,和 majorityof 不清楚。在这研究,我们孤立并且描绘米饭变异的、白条纹叶(wsl ) ,它在开发早的显示萎黄病有条纹或刻痕之状态。基于地图的克隆表明 WSL 编码指向叶绿体的最新识别的米饭 PPR 蛋白质。在 wsl 异种,锐气依赖者质体基因表示是显著地下面调整的,并且质体 rRNAs 和翻译 productsaccumulate 到很底层。一致地与观察, wsl 在叶绿体抄本 rpl2 拼接显示出一个强壮的缺点,在异种导致异常抄本累积和它的产品减小。wsl 显示出提高的敏感到骆驼毛的织物,咸度,和糖,并且它积累更多的 H 2 O 2 比野类型。这些结果建议减少的翻译效率可以影响异种的反应到 abioticstress.Key 词: | Junjie Tan Zhenhua Tan Fuqing Wu Peike Sheng Yueqin Heng Xinhua Wang Yulong Ren Jiulin Wang Xiuping Guo Xin Zhang Zhijun Cheng Ling Jiang Xuanming Liu Haiyang Wang Jianmin Wan | 2014 | Molecular Plant2014，7，8： | 15 |
| 11 | Overview on Submodule Topologies,Modeling,Modulation,Control Schemes,Fault Diagnosis,and Tolerant Control Strategies of Modular Multilevel Converters显示文摘In the present scenario,modular multilevel converters(MMCs)are considered to be one of the most promising and effective topologies in the family of high-power converters because of their modular design and good scalability;MMCs are extensively used in high-voltage and high-power applications.Based on their unique advantages,MMCs have attracted increasing attention from academic circles over the past years.Several studies have focused on different aspects of MMCs,including submodule topologies,modeling schemes,modulation strategies,control schemes for voltage balancing and circulating currents,fault diagnoses,and fault-tolerant control strategies.To summarize the current research status of MMCs,all the aforementioned research issues with representative research approaches,results and characteristics are systematically overviewed.In the final section,the current research status of MMCs and their future trends are emphasized. | Fujin Deng Yongqing Lu Chengkai Liu Qian Heng Qiang Yu Jifeng Zhao | 2020 | Chinese Journal of Electrical Engineering2020，6，1： | 15 |
| 12 | Porous high entropy(Zr0.2Hf0.2Ti0.2Nb0.2Ta0.2)B2: A novel strategy towards making ultrahigh temperature ceramics thermal insulating显示文摘Transition metal diborides based ultrahigh temperature ceramics(UHTCs) are characterized by high melting point, high strength and hardness, and high electrical and thermal conductivity. The high thermal conductivity arises from both electronic and phonon contributions. Thus electronic and phonon contributions must be controlled simultaneously in reducing the thermal conductivity of transition metal diborides. In high entropy(HE) materials, both electrons and phonons are scattered such that the thermal conductivity can significantly be reduced, which opens a new window to design novel insulating materials. Inspired by the high entropy effect, porous HE(Zr0.2Hf0.2Ti0.2Nb0.2Ta0.2)B2 is designed in this work as a new thermal insulting ultrahigh temperature material and is synthesized by an in-situ thermal borocarbon reduction/partial sintering process. The porous HE(Zr0.2Hf0.2Ti0.2Nb0.2Ta0.2)B2 possesses high porosity of 75.67%, pore size of 0.3–1.2 μm, homogeneous microstructure with small grain size of 400–800 nm, which results in low room temperature thermal diffusivity and thermal conductivity of 0.74 mm2 s^-1 and 0.51 W m^-1K^-1, respectively. In addition, it exhibits high compressive strength of3.93 MPa. The combination of these properties indicates that exploring porous high entropy ceramics such as porous HE(Zr0.2Hf0.2Ti0.2Nb0.2Ta0.2)B2 is a novel strategy in making UHTCs thermal insulating. | Heng Chen Huimin Xiang Fu-Zhi Dai Jiachen Liu Yanchun Zhou | 2019 | Journal of Materials Science & Technology2019，35，10： | 15 |
| 13 | End-stage liver disease score and future liver remnant volume predict post-hepatectomy liver failure in hepatocellular carcinoma显示文摘BACKGROUND Hepatocellular carcinoma(HCC)is the world’s sixth most common malignant tumor and the third cause of cancer death.Although great progress has been made in hepatectomy,it is still associated with a certain degree of risk of posthepatectomy liver failure(PHLF),which extends the length of hospital stay and remains the leading cause of postoperative death.Studies have shown that assessment of hepatic functional reserve before hepatectomy is beneficial for reducing the incidence of PHLF.AIM To assess the value of model for end-stage liver disease(MELD)score combined with standardized future liver remnant(sFLR)volume in predicting PHLF in patients undergoing hepatectomy for HCC.METHODS This study was attended by 238 patients with HCC who underwent hepatectomy between January 2015 and January 2018.Discrimination of sFLR volume,MELD score,and sFLR/MELD ratio to predict PHLF was evaluated according to the area under the receiver operating characteristic curve.RESULTS The patients were divided into two groups according to whether PHLF occurred after hepatectomy.The incidence of PHLF was 8.4%in our research.The incidence of PHLF increased with the decrease in sFLR volume and the increase in MELD score.Both sFLR volume and MELD score were considered independent predictive factors for PHLF.Moreover,the cut-off value of the sFLR/MELD score to predict PHLF was 0.078(P<0.001).This suggests that an sFLR/MELD≥0.078 indicates a higher incidence of PHLF than an sFLR/MELD<0.078.CONCLUSION MELD combined with sFLR is a reliable and effective PHLF predictor,which is superior to MELD score or sFLR volume alone. | Fan-Hua Kong Xiong-Ying Miao Heng Zou Li Xiong Yu Wen Bo Chen Xi Liu Jiang-Jiao Zhou | 2019 | World Journal of Clinical Cases2019，7，22： | 14 |
| 14 | High entropy(Yb0.25Y0.25Lu0.25Er0.25)2SiO5 with strong anisotropy in thermal expansion显示文摘A novel high entropy(HE) rare earth monosilicate(Yb0.25Y0.25Lu0.25Er0.252 SiO5 was synthesized by solid-state reaction method.X-ray diffraction and scanning electron microscopy analysis indicate that a single solid solution is formed with homogeneous distribution of rare-earth elements.HE(Yb0.25Y0.25Lu0.255 Er0.252 SiO5 exhibits excellent phase stability and anisotropy in thermal expansion.The coefficients of thermal expansion(CTEs) in three crystallographic directions are:αa=(2.57±0.07)×10^-6 K^-1,αb=(8.07±0.13)×10^-6 K^-1,αc=(9.98±0.10)×10^-6 K^-1.The strong anisotropy in thermal expansion is favorable in minimizing the coating/substrate mismatch if preferred orientation of HE(Yb0.25Y0.25Lu0.25Er0.252 SiO5 is controlled on either metal or ceramic substrate. | Heng Chen Huimin Xiang Fu-Zhi Dai Jiachen Liu Yanchun Zhou | 2020 | Journal of Materials Science & Technology2020，36，1： | 14 |
| 15 | High entropy(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12:A novel high temperature stable thermal barrier material显示文摘Ytterbium aluminum garnet(Yb3Al5O12)is considered as a promising thermal barrier material.However,the main limitations of Yb3Al5O12 for thermal barrier applications are relative low thermal expansion coefficient and high thermal conductivity.In order to overcome these obstacles,herein,a new high entropy(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 ceramic was designed,and then powders and bulk were prepared through solid-state reaction method and spark plasma sintering(SPS),respectively.The thermal expansion coefficient of HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 is(8.54±0.29)×10^-6 K^-1 at 673 K–1273 K,which is about 9%higher than that of Yb3Al5O12.The thermal conductivity of HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 ceramic is 3.81 W·m^-1 K^-1 at 300 K,which is about 18%lower than that of Yb3Al5O12.Moreover,there is no reaction between HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 and thermally grown(TG)Al2O3 even at 1600℃.After annealing at 1590℃for 18 h,the average grain size of HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 increases only from 1.56μm to 2.27μm.Close thermal expansion coefficient to TG Al2O3,low thermal conductivity,good phase stability,excellent chemical compatibility with TG Al2O3 and slow grain growth rate make HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 promising for thermal barrier applications. | Heng Chen Zifan Zhao Huimin Xiang Fu-Zhi Dai Wei Xu Kuang Sun Jiachen Liu Yanchun Zhou | 2020 | Journal of Materials Science & Technology2020，47，13： | 14 |
| 16 | Overexpression and Immunosuppressive Functions of Transforming Growth Factor 1,Vascular Endothelial Growth Factor and Interleukin-10 in Epithelial Ovarian Cancer显示文摘Objective: Transforming growth factor-1 (TGF-β1), vascular endothelial growth factor (VEGF), and interleukin-10 (IL-10) may be critical cytokines in the microenvironment of a tumor, playing roles in immune suppression. This study was conducted to elucidate the roles and immunosuppressive functions of these cytokines in epithelial ovarian cancer (EOC). Methods: The expression levels of TGF-β1, VEGF and IL-10 in malignant tissue were evaluated by immune-histochemistry and compared with corresponding borderline, benign, and tumor-free tissues. Moreover, relationships among the levels of these cytokines and correlations between expression and the prognosis of EOC were analyzed by Pearson rank correlations and multi-factor Logistic regression. The roles of TGF-β1, VEGF, and IL-10 in the immunosuppressive microenvironment of ovarian cancer were studied through dendritic cell (DC) maturation and CD4+CD25+FoxP3+Treg generation in vitro experiments. Results: TGF-β1, VEGF, and IL-10 were expressed in 100%, 74.69%, and 54.96% of EOC patients, respectively. TGF-β1 was an independent prognostic factor for EOC. IL-10 was significantly co-expressed with VEGF. In vitro, VEGF and TGF-β1 strongly interfered with DC maturation and consequently led to immature DCs, which secreted high levels of IL-10 that accumulated around the tumor site. TGF-β1 and IL-10 induced Treg generation without antigen presentation in DCs. Conclusions: TGF-β1, VEGF and IL-10 play important roles in EOC and can lead to frequent immune evasion events. | Chan-zhen Liu Li Zhang Xiao-hong Chang Ye-xia Cheng Hong-yan Cheng Xue Ye Tian-yun Fu Jun Chen Heng Cui | 2012 | Chinese Journal of Cancer Research2012，24，2： | 13 |
| 17 | MicroRNA changes of bone marrow-derived mesenchymal stem cells differentiated into neuronal-like cells by Schwann cell-conditioned medium显示文摘Bone marrow-derived mesenchymal stem cells differentiate into neurons under the induction of Schwann cells. However, key microRNAs and related pathways for differentiation remain unclear. This study screened and identified differentially expressed microRNAs in bone marrow- derived mesenchymal stem cells induced by Schwann cell-conditioned medium, and explored targets and related pathways involved in their differentiation into neuronal-like cells. Primary bone marrow-derived mesenchymal stem cells were isolated from femoral and tibial bones, while primary Schwann cells were isolated from bilateral saphenous nerves. Bone marrow-derived mesenchymal stem cells were cultured in unconditioned (control group) and Schwann cell-conditioned medium (bone marrow-derived mesenchymal stem cell + Schwann cell group). Neuronal differentiation of bone marrow-derived mesenchymal stem cells induced by Schwann cell-conditioned medium was observed by time-lapse imaging. Upon induction, the morphology of bone marrow-derived mesencaymal stem cells changed into a neural shape with neurites. Results of quantitative reverse transcription-polymerase chain reaction revealed that nestin mRNA expression was upregulated from 1 to 3 days and downregulated from 3 to 7 days in the bone marrow-derived mesenchymal stem cell + Schwann cell group. Compared with the control group, microtubule-associated protein 2 mRNA expression gradually increased from 1 to 7 days in the bone marrow-derived mesenchymal stem cell + Schwann cell group. After 7 days of induction, microRNA analysis iden:ified 83 significantly differentially expressed microRNAs between the two groups. Gene Ontology analysis indicated enrichment of microRNA target genes for neuronal projection development, regulation of axonogenesis, and positive regulation of cell proliferation. Kyoto Encyclopedia of Genes and Genomes pathway analysis demonstrated that Hippo, Wnt, transforming growth factor-beta, and Hedgehog signaling pathv/ays were potentially associated with neural differentiation of bone marrow-derived mesenchymal stem cells. This study, which carried out successful microRNA analysis of neuronal-like cells differentiated from bone marrow-derived mesenchymal stem cells by Schwann cell induction, revealed key microRNAs and pathways involved in neural differentiation of bone marrow-derived mesenchymal stem cells. All protocols were approved by the Animal Ethics Committee of Institute of Radiation Medicine, Chinese Academy of Medical Sciences on March 12, 2017 (approval number: DWLI-20170311). | Zhi-Jian Wei Bao-You Fan Yang Liu Han Ding Hao-Shuai Tang Da-Yu Pan Jia-Xiao Shi Peng-Yuan Zheng Hong-Yu Shi Heng Wu Ang Li Shi-Qing Feng | 2019 | Neural Regeneration Research2019，14，8： | 13 |
| 18 | Achieving strong microwave absorption capability and wide absorption bandwidth through a combination of high entropy rare earth silicide carbides/rare earth oxides显示文摘Developing electromagnetic(EM) wave absorbing materials with low reflection coefficient and optimal operating frequency band is urgently needed on account of the increasingly serious EM pollution. However, the applications of common EM absorbing materials are encumbered by poor high-temperature stability, poor oxidation resistance, narrow absorption bandwidth or high density. Herein, the strong EM absorption capability and wide efficient absorption bandwidth of high entropy ceramics are reported for the first time, which are designed by a combination of the novel high entropy(HE) rare earth silicide carbides/rare earth oxides(RE3 Si2 C2/RE2 O3). Three HE powders, i.e., HERSC-1(HE(Tm0.2 Y0.2 Dy0.2 Gd0.2 Tb0.2)3 Si2 C2),HERSC-2 HE(Tm0.2 Y0.2 Dy0.2 Gd0.2 Tb0.2)3 Si2 C2/HE(Tm0.2 Y0.2 Dy0.2 Gd0.2 Tb0.2)2 O3) and HERSC-3(HE(Tm0.2 Y0.2 Dy0.2 Gd0.2 Tb0.2)3 Si2 C2/HE(Tm0.2 Y0.2 Dy0.2 Gd0.2 Tb0.2)2 O3), are synthesized. Although HERSC-1 exhibits a limited absorption effect(the minimum reflection loss(RLmin) is-11.6 d B at 3.4 mm) and a relatively narrow effective absorption bandwidth(EAB) of 1.7 GHz, the optimal absorption RLminvalue and EAB of HERSC-2 and HERSC-3 are-40.7 d B(at 2.9 mm), 3.4 GHz and-50.9 d B(at 2.0 mm), 4.5 GHz,respectively, demonstrating strong microwave absorption capability and wide absorption bandwidth.Considering the better stability, low density and strong EM absorption effect, HE ceramics are promising as a new type of EM absorbing materials. | Heng Chen Biao Zhao Zifan Zhao Huimin Xiang Fu-Zhi Dai Jiachen Liu Yanchun Zhou | 2020 | Journal of Materials Science & Technology2020，47，12： | 12 |
| 19 | Cultivated land information extraction in UAV imagery based on deep convolutional neural network and transfer learning显示文摘The development of precision agriculture demands high accuracy and efficiency of cultivated land information extraction. As a new means of monitoring the ground in recent years, unmanned aerial vehicle(UAV) low-height remote sensing technique, which is flexible, efficient with low cost and with high resolution, is widely applied to investing various resources. Based on this, a novel extraction method for cultivated land information based on Deep Convolutional Neural Network and Transfer Learning(DTCLE) was proposed. First, linear features(roads and ridges etc.) were excluded based on Deep Convolutional Neural Network(DCNN). Next, feature extraction method learned from DCNN was used to cultivated land information extraction by introducing transfer learning mechanism. Last, cultivated land information extraction results were completed by the DTCLE and e Cognition for cultivated land information extraction(ECLE). The location of the Pengzhou County and Guanghan County, Sichuan Province were selected for the experimental purpose. The experimental results showed that the overall precision for the experimental image 1, 2 and 3(of extracting cultivated land) with the DTCLE method was 91.7%, 88.1% and 88.2% respectively, and the overall precision of ECLE is 90.7%, 90.5% and 87.0%, respectively. Accuracy of DTCLE was equivalent to that of ECLE, and also outperformed ECLE in terms of integrity and continuity. | LU Heng FU Xiao LIU Chao LI Long-guo HE Yu-xin LI Nai-wen | 2017 | Journal of Mountain Science2017，14，4： | 11 |
| 20 | Three new species of imitator-group of the genus Macrophya(Hymenoptera,Tenthredinidae) from China显示文摘Three species, Macrophya circulotibialis Li, Liu & Heng, sp. nov., M. curvatitheca Li, Liu & Heng, sp. nov. and M. changbaina Li, Liu & Heng, sp. nov., of the imitator-group of the genus Macrophya Dahlbom(Hymenoptera, Tenthredinidae) from China are described as new to science. A key to all known species of the imitator-group from China is provided. The specimens examined in this study, including all holotypes and paratypes of the new species, are deposited in the Insect Collection of Central South University of Forestry and Technology, Changsha, Hunan, China, and the Department of Zoology, National Museum of Nature and Science, Amakubo, Tsukuba, Ibaraki, Japan. | Meng-Meng Liu Xue-Mei Heng Xiang-Mei Liang Yi-Hai Zhong Ze-Jian Li | 2015 | Zoological Systematics2015，40，2： | 11 |
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