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| 1 | Development, chromosome location and genetic mapping of EST-SSR markers in wheat显示文摘A number of 151695 wheat expression sequence tags (ESTs) that originated from GenBank/dbEST from July 14, 2003 to August 24, 2004 were used to search for simple sequence repeats (SSRs) with motif 2―5 bp, and 2038 simple sequence repeats (EST-SSRs), which accounted for 1.34% of EST database, were identified. Based on these SSR sequences, 249 EST-SSR primer pairs and 166 amplified clear bands in various wheat cultivars were designed. These EST-SSR markers can be used as new molecular markers in wheat and related species. Using Chinese Spring nulli-tetrasomic lines, 93 EST-SSR primer pairs and 193 EST-SSR loci were located on 19 wheat chromosomes except for 4A and 4B. Forty-three loci were mapped on 11 chromosomes of the genetic frame- work map previously constructed using recombinant inbred lines. | CHEN Haimei LI Linzhi WEI Xianyun LI Sishen LEI Tiandong HU Haizhou WANG Honggang ZHANG Xiansheng | 2005 | Chinese Science Bulletin2005，50，20： | 48 |
| 2 | Original position statistic distribution analysis study of low alloy steel continuous casting billet显示文摘The homogeneity of low alloy steels continuous casting billet obtained under different technological conditions has been investigated by original position statistic distribution analysis technique. On the basis of systematic analysis of ten thousands primary optical signals at the corresponding original positions, the quantitative statistic distribution information of each element was obtained. The biggest degrees of segregation of low alloy steel continuous casting billet were calculated accurately according to the quantitative distribution maps of the contents. It was suggested that the weight ratio in a certain content range was used to judge the homogeneity of the materials, and the two models —— the total weight ratio of contents (the degree of statistic homogeneity, H) within the permissive content range (C0±R) and the median value confidence extension ratio (the degree of statistic segregation, S) at 95% of confidence limit of weight ratio —— were put forward. The two models reflect the composition and state distribution regularity of the metal materials in a large region. The difference between the sample with high columnar crystal and the sample with high equiaxed crystal has been studied by using the two models. | WANG Haizhou ZHAO Pei CHEN Jiwen LI Meiling YANG Zhijun WU Chao | 2005 | Science China(Technological Sciences)2005，48，1： | 13 |
| 3 | Typical Geochemical Elements in Loess Deposit in the Northeastern Tibetan Plateau and Its Paleoclimatic Implication显示文摘Widespread and thick loess deposit in the northeastern Tibetan Plateau records paleoclimatic changes over the Quaternary period. In this study, we investigate a loess section located in a high terrace of the Huangshui River in the Xining Basin, and collect samples at 20-cm intervals by digging a well of 16-m depth (including paleosol S1 and S0 and several loess interlayers over the last glacial-interglacial cycle and the Holocene). Concentration of some active elements (Sr and Ca) and inert elements (Rb, Zr, Ti) in these loess samples are measured. The results show that ratios of those elements (oxide), such as Rb/Sr, Ti/Sr, and Zr/CaO ratios, would indicate sensitively paleoclimatic changes, especially the history of precipitation over the last glacial-interglacial and the Holocene. Moreover, the curves of Rb/Sr, Ti/Sr, and Zr/CaO ratios had almost the same variable trends from the bottom to the top and also closely correlated with values of magnetic susceptibility and the global marine δ18O record. But compared with the curves of magnetic susceptibility, the changes of ratios of these elements (oxide) are clearer and easy to understand. Therefore, the ratios of these typical chemical elements in the loess deposit may be used as an excellent index to investigate the history of paleoclimate, particularly precipitation changes in the northeastern Tibetan Plateau. | TAN Hongbing MA Haizhou ZHANG Xiying LU Huayu WANG Jianguo | 2006 | Acta Geologica Sinica(English Edition)2006，80，1： | 10 |
| 4 | Liuwei Dihuang pill suppresses metastasis by regulating the wnt pathway and disrupting β-catenin/T cell factor interactions in a murine model of triple-negative breast cancer显示文摘OBJECTIVE:To investigate if the Liuwei Dihuang pill(LWDHP)can inhibit metastasis to the liver and lungs in mice bearing triple-negative breast cancer(TNBC),and the molecular mechanism underpinning this action.METHODS:Ninety-nine TNBC bearing-mice were distributed randomly to five groups:control(Con),paclitaxel(PTX),low-dose LWDHP(LLP,2.3 g·kg^-1·d^-1),middle-dose LWDHP(MLP,4.6 g·kg^-1·d^-1)and high-dose LWDHP(HLP,9.2 g·kg^-1·d^-1).The LWDHP were administered(p.o.)to the agonal stage.The morphology of BC cells was observed by hematoxylin&eosin staining.Expression of axin-2,β-catenin,T cell factor(TCF),cyclin-D1 and vascular endothelial growth factor(VEGF)was detected by western blotting or immunofluorescence.β-catenin/TCF-1 interaction was measured using a co-immunoprecipitation assay.RESULTS:After LWDHP treatment,metastasis of BC cells to the lungs and liver was inhibited,expression of axin-2 was increased,expression of TCF-1,β-catenin,cyclin-D1 and VEGF was decreased,andβ-catenin/TCF-1 interaction was disrupted.CONCLUSION:The LWDHP could inhibit metastasis of BC cells to the liver and lungs.The molecular mechanism underlying this action may be regulation of protein expression andβ-catenin/TCF-1 interactions in the Wnt pathway. | Zheng Lixiang Zheng Qing Yu Zhipeng Wang Jian Ren Xiaoying Gong Yan Yang Xue Hunag Ping Weng Meizhi Liu Hongning Liu Haizhou | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 9 |
| 5 | State-of-the-Art Review of High-Throughput Statistical Spatial-Mapping Characterization Technology and Its Applications显示文摘Macroscopic materials are heterogeneous,multi-elementary,and complex.No material is homogeneous or isotropic at a certain small scale.Parts of the material that differ from one another can be termed'natural chips.'At different spots on the material,the composition,structure,and properties vary slightly,and the combination of these slight differences establishes the overall material performance.This article presents a state-of-the-art review of research and applications of high-throughput statistical spatialmapping characterization technology based on the intrinsic heterogeneity within materials.Highthroughput statistical spatial-mapping uses a series of rapid characterization techniques for analysis from the macroscopic to the microscopic scale.Datasets of composition,structure,and properties at each location are obtained rapidly for practical sample sizes.Accurate positional coordinate information and references to a point-to-point correspondence are used to set up a database that contains spatialmapping lattices.Based on material research and development design requirements,dataset spatialmapping within required target intervals is selected from the database.Statistical analysis can be used to select a suitable design that better meets the targeted requirements.After repeated verification,genetic units that reflect the material properties are determined.By optimizing process parameters,the assembly of these genetic unit(s)is verified at the mesoscale,and quantitative correlations are established between the microscale,mesoscale,macroscale,practical sample,across-the-scale span composition,structure,and properties.The high-throughput statistical spatial-mapping characterization technology has been applied to numerous material systems,such as steels,superalloys,galvanization,and ferrosilicon alloys.This approach has guided the composition and the process optimization of various materials. | Haizhou Wang Lei Zhao Yunhai Jia Dongling Li Lixi Yang Yuhua Lu Guang Feng Weihao Wan | 2020 | Engineering2020，6，6： | 7 |
| 6 | Editorial for Special Issue on Materials Genome Engineering显示文摘With the rapid advancement of computing and information technology at the turn of the 21st century,the power of data collection and processing has multiplied tremendously.Based on this a game-changing advancement,science is at the advent of the “fourth paradigm”of massive data plus artificial intelligence,in which the efficiency of scientific research is continuously improved,research time is shortened,and research cost is reduced[1]. | Haizhou Wang Jianxin Xie | 2020 | Engineering2020，6，6： | 6 |
| 7 | An Anomalous Behavior Detection Model in Cloud Computing显示文摘This paper proposes an anomalous behavior detection model based on cloud computing. Virtual Machines(VMs) are one of the key components of cloud Infrastructure as a Service(Iaa S). The security of such VMs is critical to Iaa S security. Many studies have been done on cloud computing security issues, but research into VM security issues, especially regarding VM network traffic anomalous behavior detection, remains inadequate.More and more studies show that communication among internal nodes exhibits complex patterns. Communication among VMs in cloud computing is invisible. Researchers find such issues challenging, and few solutions have been proposed—leaving cloud computing vulnerable to network attacks. This paper proposes a model that uses Software-Defined Networks(SDN) to implement traffic redirection. Our model can capture inter-VM traffic, detect known and unknown anomalous network behaviors, adopt hybrid techniques to analyze VM network behaviors, and control network systems. The experimental results indicate that the effectiveness of our approach is greater than 90%, and prove the feasibility of the model. | Xiaoming Ye Xingshu Chen Haizhou Wang Xuemei Zeng Guolin Shao Xueyuan Yin Chun Xu | 2016 | Tsinghua Science and Technology2016，21，3： | 5 |
| 8 | Advancement of maxillary anterior segment by distraction osteogenesis for severe maxillary retrusion in cleft lip and palate显示文摘 | Gao Feng Yang Minlie Zhao Zhenmin Sun Xiaomei Yin Ningbei Wang Yongqian Song Tao Li Haidong Wu Di Yin Jiapeng Cao Yimei Tong Haizhou | 2014 | Chinese Medical Journal2014，，3： | 4 |
| 9 | Catalytic methanation of syngas over Ni-based catalysts with different supports显示文摘Co-precipitation method was selected for the preparation of Ni/Al_2O_3, Ni/ZrO_2 and Ni/CeO_2 catalysts, and their performances in methanation were investigated in this study. The structure and surface properties of these catalysts were characterized by BET, XRD, H_2-TPD, TEM and H_2-TPR. The results showed that the catalytic activity at low temperature followed the order: Ni/Al_2O_3>Ni/ZrO_2>Ni/CeO_2. Ni/Al_2O_3 catalyst presented the best catalytic performance with the highest CH_4 selectivity of 94.5%. The characterization results indicated that the dispersion of the active component Ni was the main factor affecting the catalytic activity and the one with higher dispersion gave better performance. | Yincong Liu Lingjun Zhu Xiaoliu Wang Shi Yin Furong Leng Fan Zhang Haizhou Lin Shurong Wang | 2017 | Chinese Journal of Chemical Engineering2017，25，5： | 3 |
| 10 | Seasonal Interaction of River Water-Groundwater-Salt Lake Brine and Its Influence on Water-Salt Balance in the Nalenggele River Catchment in Qaidam Basin,NW China显示文摘Identifying interactions among river water,groundwater and salt lake brine is important for sustainable exploitation of brine mineral resources.In this study,we investigated the water exchange rate in dry and wet seasons,and assessed the influence of seasonal water exchange on brine concentration and crystallization process in the Nalenggele(NLGL)catchment of Qaidam Basin,China.The results show that the surface water infiltration and groundwater recharge rates in the wet season were 2.81×10^(-3)and 1.15×10^(-3)m^(3)/(s·m)in upstream,1.63×10^(-2)and 1.53×10^(-2)m^(3)/(s·m)in midstream,and 2.83×10^(-4)and 6.82×10^(-5)m^(3)/(s·m)in downstream,respectively;while their counterparts in the dry season were 9.81×10^(-4)and 5.05×10^(-4)m^(3)/(s·m)in upstream,and 8.34×10^(-3)and 7.78×10^(-3)m^(3)/(s·m)in midstream,respectively.The water exchange strongly influenced brine concentration and crystallinzation process,with brine chemistry belonging to 3K_(2)SO_(4)·Na_(2)SO_(4) and KCl types in wet and dry seasons,respectively.The strong water exchange in wet season destroyed the water-salt balance,while the low water exchange rate in dry season facilitated preparation of KCl products. | Jibin Han Jianxin Xu Lei Yi Zheng Chang Jianping Wang Haizhou Ma Baoyun Zhang Hongchen Jiang | 2022 | Journal of Earth Science2022，33，5： | 3 |
| 11 | A modified scar model with controlled tension on secondary wound healing in mice显示文摘Pathological scars might cause a distorted appearance and restricted mobility,and the study of scar pathophysiology has been hindered by the absence of a reliable model.In this study,we introduce a model with a modified device to induce controlled tension on a wound healing by secondary intention to overcome the shortcomings of the model generated by Aarabi et al.We investigated and recommend an induction of 0.1 N/mm^(2) tension on day 7 for 14 days to mimic the characteristics of human scars.A 3.5-fold increase in scar tissue and a 2-fold increase in collagen production were induced by the modified model.Histologically,the modified method increased scar thickness.However,no significant difference was found in cell density between the two groups.This modified procedure significantly increased scar tissue,which could be used for further cellular and biomolecular research.The mechanical force applied to the wound became measurable and controllable.This method is more convenient for researchers to observe in realtime and for providing timely adjustments of the tension used in this modified model. | Zi Wang Xin Huang Tao Zan Qingfeng Li Haizhou Li | 2020 | Burns & Trauma2020，8，1： | 2 |
| 12 | Validation of spectrum method for improving efficiency of continuous-wave & Q-switched Tm-doped yttrium aluminum garnet laser显示文摘Tm^(3+)-doped 2-μm lasers benefit many applications such as atmospheric sensing,medical treatment,and spectroscopy[1-3].Therefore,in the past two decades,both continuous-wave(CW)and pulse operations have | HaiZhou Huang Pan Gao HuaGang Liu Jian-Hong Huang Juan Wang KaiMing Ruan Wen Weng Hui Zheng ZiXiong Lin ShuTao Dai Jing Deng WenXiong Lin | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 2 |
| 13 | Original position statistic distribution analysis (Original Position Analysis)- new analytical method in the research and quality evaluation of materials显示文摘 | Haizhou Wang | 2002 | Science in China (series B)2002，32，6： | 1 |
| 14 | Several problems about the metallurgy analysis of 21th century显示文摘 | Haizhou Wang | 2000 | Steel and Iron2000，35，1： | 1 |
| 15 | The metallurgy material analysis toward new century显示文摘 | Haizhou Wang | 2001 | LIHUA JIANYAN (Chemistry)2001，37，1： | 1 |
| 16 | Microarray gene expression analysis of chemosensitivity for docetaxel,cisplatin and 5-fluorouracil(TPF)combined chemotherapeutic regimen in hypopharyngeal squamous cell carcinoma显示文摘Objective: To screen out a set of candidate genes which could help to determine whether patients with hypopharyngeal squamous cell carcinoma(HSCC) could benefit from docetaxel, cisplatin and 5-fluorouracil(TPF)induction chemotherapy.Methods: Gene-expression profiles in 12 TPF-sensitive patients were compared to 9 resistant controls by microarray analysis. Subsequently, expression levels of potential biomarkers in chemosensitive cell line Fa Du after TPF treatment were observed by quantitative real-time polymerase chain reaction(q RT-PCR).Results: Through microarray analysis, 1,579 differentially expressed genes were identified, of which 815 were up-regulated in TPF chemotherapy-responsive tissues whereas 764 were down-regulated. Gene ontology(GO)analysis suggested these genes participating in physiological processes including transcription and its regulation,cellular signal transduction and metabolic process. Additionally, Kyoto Encyclopedia of Genes and Genomes(KEGG) database revealed that MAPK and Jat/STAT signaling pathways occupied important roles in TPF chemotherapeutic sensitivity. Moreover, in vitro cell culture experiments revealed the expression alternations of IL-6, MAPK14, JUN, CDK5 and CAMK2 A exposed to TPF treatment by q RT-PCR, whilst providing an insight into the mechanism underlying TPF chemotherapeutic response in HSCC.Conclusions: These results provided a battery of genes related to TPF chemotherapeutic sensitivity and might act as molecular targets in HSCC treatment. Moreover, these candidate biomarkers could contribute to HSCC individualized treatment. | Meng Lian Haizhou Wang Jugao Fang Jie Zhai Ru Wang Xixi Shen Yifan Yang Zhihong Ma Honggang Liu | 2017 | Chinese Journal of Cancer Research2017，29，3： | 1 |
| 17 | Determination of trace elements in superalloy by ICP-MS显示文摘 | Hu Jingyu Wang Haizhou | 2001 | Microchimica Acta2001，137，34： | 1 |
| 18 | Determination of trace silverin supralloys and steel by ICP-MS 显示文摘 | Hu Jingyu Liu Zheng Wang Haizhou | 2002 | Anal Chim Acta2002，451，2： | 1 |
| 19 | Determination of Trace Elements in super alloy by ICP-MS显示文摘 | Hu Jingyu Wang Haizhou | 2001 | Mikrochim Acta2001，137，： | 1 |
| 20 | A measure- ment study of polluting a large-scale P2P IlaTV system 显示文摘 | Wang haizhou Chen xingshu Wang wenxian | | China Communications0，8，2： | 1 |
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