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| 1 | 低剂量利福昔明可预防肝硬化失代偿期患者的并发症并提高生存率显示文摘利福昔明已被推荐作为肝性脑病(HE)和自发性细菌性腹膜炎(SBP)的预防药物。该研究旨在探讨低剂量利福昔明是否能预防肝硬化患者的整体并发症和延长生存期。在这项多中心随机开放标签的前瞻性研究中,200例失代偿期肝硬化患者按1∶1的比例随机分配。利福昔明组患者给予利福昔明400 mg,每日2次,疗程6个月,其余治疗策略在两组患者中尽量保持不变。主要疗效终点是总并发症发生率和无肝移植生存率。次要终点是各种主要肝硬化相关并发症的发生率,以及Child-Pugh评分和分级。 | ZENG X SHENG X WANG PQ 朱玉凡 牛俊奇 | 2021 | 临床肝胆病杂志2021，37，3： | 15 |
| 2 | Necessity and indications of invasive treatment for Budd-Chiari syndrome显示文摘BACKGROUND:The development of collaterals in Budd-Chiari syndrome has been described and these collaterals play an important role in the presentation of this disease.These collaterals are diagnostic and their use in management strategy has never been evaluated.This study aimed to investigate the indications,feasibility and necessity of invasive treatment for patients with Budd-Chiari syndrome and to determine whether such a strategy is necessary for optimal management.METHODS:Twenty-nine patients who had been treated at our unit were enrolled in this study.Based on physical and biochemical examination,and hemodynamic compensation by collaterals,18 patients underwent radiological intervention (group A),while the other 11 had no invasive treatment (group B).The related hemodynamic parameters were acquired when percutaneous angiography was performed.RESULTS:In group A,all patients underwent successfully inferior vena cava (IVC) balloon angioplasty with or without stenting.Four patients also underwent hepatic vein angioplasty.In these patients,the mean IVC pressure before and after treatment was statistically different (29.3±9.2 vs 15.1±4.6 mmHg,P<0.01).The mean IVC pressure was much lower in group B than in group A (12.9±2.4 vs 29.3±9.2 mmHg,P<0.01),but there was no difference from that of the patients after radiological treatment (12.9±2.4 vs 15.1±4.6 mmHg,P>0.05).Median follow-up was 32.3 months (mean 21.3 months;range 3-61 months).In the course of follow-up,the patients in group A survived with good systemic status except for re-stenosis in one patient who underwent re-canalization of the IVC.In group B,10 patients had good systemic status except one patient who had a meso-caval shunt because of deterioration.CONCLUSIONS:The rationale of 'early diagnosis and early treatment' is not suitable for all patients with Budd-Chiari syndrome.Satisfactory survival can be achieved in some patients without invasive treatment,who are completely compensated by rich collaterals.Nonetheless,a positive treatment procedure should be performed if the patient's situation worsens in the course of regular follow-up. | Department of General Surgery (Fu Y,Sun YL,Ma XX,Xu PQ,Feng LS,Tang Z and Luo CH),Institute of Hepatic Vascular Disease (Sun YL),Department of Radiological Intervention (Guan S and Wang ZW),First Affiliated Hospital,Zhengzhou University School of Medicine,Zhengzhou 450052,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 10 |
| 3 | MicroRNA: A matter of life or death显示文摘Progressive cell loss due to apoptosis is a pathological hallmark implicated in a wide spectrum of degenerative diseases such as heart disease, atherosclerotic arteries and hypertensive vessels, Alzheimer's disease and other neurodegenerative disorders. Tremendous efforts have been made to improve our understanding of the molecular mechanisms and signaling pathways involved in apoptosistic cell death. Once ignored completely or overlooked as cellular detritus, microRNAs (miRNAs) that were discovered only a decade ago, have recently taken many by surprise. The importance of miRNAs has steadily gained appreciation and miRNA biology has exploded into a massive swell of interest with enormous range and potential in almost every biological discipline because of their widespread expression and diverse functions in both animals and humans. It has been established that miRNAs are critical regulators of apoptosis of various cell types. These small molecules act by repressing the expression of either the proapoptotic or antiapoptotic genes to produce antiapoptotic or proapoptotic effects. Appealing evidence has been accumulating for the involvement of miRNAs in human diseases associated with apoptotic cell death and the potential of miRNAs as novel therapeutic targets for the treatment of the diseases. This editorial aims to convey this message and to boost up the research interest by providing a timely, comprehensive overview on regulation of apoptosis bymiRNAs and a synopsis on the pathophysiologic implications of this novel regulatory network based on the currently available data in the literature. It begins with a brief introduction to apoptosis and miRNAs, followed by the description of the fundamental aspects of miRNA biogenesis and action, and the role of miRNAs in regulating apoptosis of cancer cells and cardiovascular cells. Speculations on the development of miRNAs as potential therapeutic targets are also presented. Remarks are also provided to point out the unanswered questions and to outline the new directions for the future research of the field. | Zhiguo Wang, Research Center, Montreal Heart Institute and Department of Medicine, University of Montreal, Montreal, PQ H1T 1C8, Canada | 2010 | World Journal of Biological Chemistry2010，1，4： | 6 |
| 4 | Instrumented posterior lumbar interbody fusion in adult spondylolisthesis显示文摘 | Yu CH Wang CT Chen PQ | | 0，，12： | 1 |
| 5 | The postural stability control and gait pattern of idiopathic scoliosis adolescents显示文摘 | Chen PQ Wang JL Tsuang YH | 1998 | Clin Biomech(Bristol Avon)1998，13，： | 1 |
| 6 | Instrumented posterior lumbar interbody fusion in adult spondylolisthesis 显示文摘 | Yu CH Wang CT Chen PQ | 2008 | Clin Orthop Relat Res2008，466，12： | 1 |
| 7 | Dynamic CT evaluation of tumor vascularity in renal cell carcinoma显示文摘 | Wang JH Min PQ Wang PJ | 2006 | MR2006，186，： | 1 |
| 8 | Dynamic CT evaluation of tumor vascularity in renal cell carcinoma显示文摘 | Wang JH Min PQ Wang PJ | 2006 | AJR2006，186，5： | 1 |
| 9 | Current situation and re- understanding of syndrome and formula syndrome in Chinese medicine 显示文摘 | Wang J Wang PQ Xiong XJ | 2012 | Intern Med2012，，： | 1 |
| 10 | Shear-induced changes in endothelin-1 secretion of microvascular endothelial cells显示文摘 | Wang GX Cai SX Wang PQ | 2002 | Microvasc Res2002，63，2： | 1 |
| 11 | Instrumented posterior lumbar interbody fusion in adult spondylolisthesis显示文摘 | Yu CH Wang CT Chen PQ | | 0，，12： | 1 |
| 12 | Pharmacokinetics of matrine in rats显示文摘 | Wang PQ Chert SX Zhou X | 1996 | J Shanghai Second Med Univ1996，16，4： | 1 |
| 13 | Instrumented posterior lumbar interbody fusion in aduh spondylolisthesis 显示文摘 | Yu CH Wang CT Chen PQ | 2008 | Clin Orthop Relat Res2008，466，12： | 1 |
| 14 | Displaying of themeridian courses over human body surface with the thermal imaging system显示文摘 | Hu XL Wang PQ Wu BH | 1996 | Rev Pau Acup1996，2，1： | 1 |
| 15 | Mice overexpressing wild- type human alpha-synuclein display alterations in colonic myenteric ganglia and defecation 显示文摘 | Wang L Magen I Yuan PQ | 2012 | Neurogastroenterol Motil2012，24，9： | 1 |
| 16 | Distribution of the antisepticresistance genes qacEDettal in 331 clinical isolates of Pseudomonas aeruginosa in China显示文摘 | Wang CX Cai PQ Guo Y etal | 2007 | J Hosp Infect2007，66，1： | 1 |
| 17 | Simultaneous determination of oxiracetam and its degraded substance in rat plasma by HPLC-MS /MS and its application to pharmacokinetic study after a single high-dose intravenous administration 显示文摘 | Wan XH Wang H Ma PQ | 2014 | J Chromatogr B Analyt Technol Biomed Life Sci2014，969，： | 1 |
| 18 | Dynamic CT evaluation of tumor vascularity in renal cell carcinoma显示文摘 | Wang JH Min PQ Wang PJ | 2006 | AJR2006，186，5： | 1 |
| 19 | Instrumented posterior lumbar interbody fusion in adult spondylolisthesis 显示文摘 | Yu CH Wang CT Chen PQ | 2008 | Clin Orthop2008，466，： | 1 |
| 20 | PLGA/polymeric lipo- some for targeted drug and gene co-delivery显示文摘 | Wang H J Zhao PQ Su WY | 2010 | Biomateri- als2010，31，33： | 1 |
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