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| 1 | Discovery of a pterodactylid pterosaur from the Yixian Formation of western Liaoning,China显示文摘A well-preserved pterosaur with nearly complete skull is described from the Lower Cretaceous Yixian Formation at Sihetun in western Liaoning. It is characterized by a low and long crestless skull, slender and pointed teeth, long metacarpal, nearly equal length of metatarsals I -III and short pedal digit V. It is referred to a new genus and species of the family Pterodactylidae: Haopterus gracilis gen. et sp. nov. This is the first pterosaur with a nearly complete skull from the Jehol Biota; it also represents the first non-controversial fossil record of Pterodactylidae in Asia. Haopterus is more derived than Pterodactylus from the Late Jurassic Solnhofen in Germany. This discovery extends the distribution of the family Pterodactylidae from Europe and Africa to Asia and its latest occurrence from the Late Jurassic to the Early Cretaceous. The discovery of Haopterus gracilis provides further evidence for the study of the originand radiation of the Jehol Biota; it also sheds new light on the evolution and | WANG Xiaolin & LU Junchang1. Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China 2. College of Earth Sciences and Resources, China University of Geo-sciences, Beijing 100083, China 3. Department of Geological Sciences, Southern Methodist University, Dallas, TX 75275, USA | 2001 | Chinese Science Bulletin2001，46，13： | 17 |
| 2 | Immunization with chlamydial plasmid protein pORF5 DNA vaccine induces protective immunity against genital chlamydial infection in mice显示文摘To validate the immune protective efficacy of pORF5 DNA vaccine and to analyze potential mechanisms related to this protection. In this study, pORF5 DNA vaccine was constructed and evaluated for its protective immunity in a mouse model of genital chlamydial infection. Groups of BALB/c mice were immunized intranasally with pORF5 DNA vaccine. Humoral and cell mediated immune responses were evaluated. The clearance ability of chlamydial challenge from the genital tract and the chlamy- dia-induced upper genital tract gross pathology and histopathological characterization were also de- tected. The results showed that the total and the IgG2a anti-pORF5 antibody levels in serum were sig- nificantly elevated after pcDNA3.1-pORF5 vaccination, as were the total antibody and IgA levels in vaginal fluids. pcDNA3.1-pORF5 induced a significantly high level of Th1 response as measured by robust gamma interferon (IFN-γ). Minimal IL-4 was produced by immune T cells in response to the re-stimulation with pORF5 protein or the inactive elementary body in vitro. pcDNA3.1-pORF5-vacci- nated mice displayed significantly reduced bacterial shedding upon a chlamydial challenge and an accelerated resolution of infection. 100% of pcDNA3.1-pORF5 vaccinated mice successfully resolved the infection by day 24. pcDNA3.1-pORF5-immunized mice also exhibited protection against patho- logical consequences of chlamydial infection. The stimulated index was significantly higher than that of mice immunized with pcDNA3.1 and PBS (P<0.05). Together, these results demonstrated that immu- nization with pORF5 DNA vaccine is a promising approach for eliciting a protective immunity against a genital chlamydial challenge. | LI ZhongYu1,2, WANG ShiPing1, Wu YiMou2, ZHONG GuangMing3 & CHEN Ding3 1 Xiangya School of Medicine, Central South University, Changsha 410078, China 2 Department of Microbiology and Immunology, University of South China, Hengyang 421001, China 3 University of Texas Health Science Center at San Antonio, TX 78229, USA | 2008 | Science China(Life Sciences)2008，51，11： | 16 |
| 3 | Collagen crosslinking of porcine sclera using genipin显示文摘 | Liu TX Wang Z | 2013 | Acta Ophthalmol2013，91，4： | 1 |
| 4 | Mechanisms of inactivation of Hepatitis A Virus by chlorine 显示文摘 | Li JW Zhong TX Wang XW | 2002 | Applied and Environmental Microbiology2002，68，10： | 1 |
| 5 | Self-assembly of gold nanoparticles to carbon nanotubes using a thiol-terminated pyrene as interlin- ker显示文摘 | Liu L Wang TX Li JX | 2003 | Chemical Physics Letters2003，367，56： | 1 |
| 6 | Myelin activates FAK/Akt/NF-kappa B pathways and provokes CR3-dependent inflammatory response in murine system显示文摘 | Sun X Wang X Chen TX | 2010 | Plos One2010，5，2： | 1 |
| 7 | Symptomatic intracranial vertebral ar- tery atherosclerotic stenosis ( ≥70% ) with concurrent contralateral ver- tebral atherosclerotic diseases in 88 patients treated with the intracranial stenting 显示文摘 | Wang ZL Gao BL Li TX | 2015 | Eur J Radio12015，84，9： | 1 |
| 8 | Myelin activates FAK/Akt/NF-kB pathways and provokes CR3-dependent inflammatory response in murine system显示文摘 | Sun X Wang X Chen TX | 2010 | PLoS ONE2010，5，2： | 1 |
| 9 | Effects of ginkgonealie acid on the growth, acidogenicity, adherence, and biofilm of Streptococcus mu- tans in vitro显示文摘 | He JZ Wang SD Wu TX | 2013 | Folia Microbiol2013，58，2： | 1 |
| 10 | Mir-144 selectively regulates embryonic alpha-hemoglobin synthesis during primitive erythropoiesis 显示文摘 | Fu YF Du TF Dong M Zhu KY Jing CB Zhang Y Wang L Fan HB Chert Y Jin Y Yue GP Chen S J Chen Z Huang QH Jing Q Deng M Liu TX | 2009 | Blood 20092009，134，： | 1 |
| 11 | In vitro and in vivo studies on gelatiu-siloxane nanoparticles conjugated with SynB peptide to increase drug delivery to the brain显示文摘 | Tian XH Wei F Wang TX | 2012 | Int J Nanomedicine2012，7，： | 1 |
| 12 | Accurate identification of closely related Dendrobium species with multiple species-specific gDNA probes 显示文摘 | Li TX Wang JK Lu ZH 2005 | 2005 | Journal of Biochemical and Biophysical Methods2005，62，2： | 1 |
| 13 | Synergistic effects of cell- penetrating peptide Tat and fusogenic peptide HA2-enhaneed cel- lular internalization and gene transduction of organosilica nanop- articles显示文摘 | YE SF TIAN MM WANG TX | 2012 | Nanomedieine2012，8，6： | 1 |
| 14 | Preliminary findings of recanalization and stenting for symptomatic vertebrobasilar arteryocclusion lasting more than 24 h: a retrospective analysis of 21 cases显示文摘 | He YK Wang ZL Li TX | 2013 | Eur J Radiol2013，82，： | 1 |
| 15 | Effects of oxide additives on sheet resistance of W thick film conductor显示文摘 | Liang TX Sun WZ Wang XH | 1996 | J Mater Sci1996，31，： | 1 |
| 16 | Nonisothermal melt and cold crystallization kinetics of poly(aryl ether ether ketone ketone)显示文摘 | Liu TX Mo ZS Wang SG | | 0，，03： | 1 |
| 17 | The observation of activatedplatelet in patients with coronary artery disease显示文摘 | Wu TX Zhang QL Wang W | 2003 | Practical Ger-iatrics J2003，17，： | 1 |
| 18 | Upregulation of IL-6, IL-8 and CCL2 gene expression after acute inflammation: Correlation to clinical pain显示文摘 | Wang XM Hamza M Wu TX | 2009 | Pain2009，142，3： | 1 |
| 19 | Reversal of muhidrug resistance by 5,5'-dimethoxylariciresinol-4-O-13-D-glueoside in doxorubicin-resistant human leukemia K562/DOX显示文摘 | Wang TX Shi XY Cong Y et ol | 2013 | Indian Journal of Pharmacology2013，45，6： | 1 |
| 20 | Impact of decomposing Cinnamomum septentrionale leaf litter on the growth of Eucalyptus grandis saplings 显示文摘 | Huang WW Hu TX Chen H Wang Q Hu H Tu L Jing L | 2013 | Plant Physiol Biochem2013，70，： | 1 |
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