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| 1 | Comparison of simple discectomy and instrumented posterior lumbar interbody fusion for treatment of lumbar disc herniation combined with Modic endplate changes显示文摘 | Cao Peng Chen Zhe Zheng Yuehuan Wang Yuren Jiang Leisheng Yang Yaoqi Zhuang Chengyu Liang Yu Zheng Tao Gong Yaocheng Zhang Xingkai Wu Wenjian Qiu Shijing | 2014 | Chinese Medical Journal2014，，15： | 15 |
| 2 | Intracellular and Extracellular Phosphatidylinositol 3-Phosphate Produced by Phytophthora Species Is Important for Infection显示文摘Phytophthora 病原体生产的 RxLR 受动器被建议了把 3 磷酸盐(PtdIns (3 ) P ) 绑在 phosphatidylinositol 调停他们的 translocation 进主人房间或到增加他们在 planta 的稳定性。因为在植物的 PtdIns (3 ) P 的层次是低的,我们检验了 Phytophthora 种类是否可以生产 PtdIns (3 ) 支持感染的 P。我们观察了 P 特定的 GFP 生物传感器能绑在 P 的那 PtdIns (3 ) 。parasitica 和 P。sojae hyphae 短暂地在 Nicotiana benthamiana 的感染期间离开 secreting 生物传感器,建议 hyphae 暴露了 PtdIns (3 ) 他们的血浆膜上的 P 或分泌 PtdIns (3 ) P。phosphatidylinositol 3-kinases (PI3K ) 的 Silencing 基因,有 LY294002 的处理,或 PtdIns (3 ) 的表示由 P 的 P 有约束力的蛋白质。sojae 在大豆上减少了病原体的毒力,显示综合病原体的 PtdIns (3 ) P 为完整的毒力被要求。PtdIns (3 ) 的分泌物 P 有约束力的蛋白质或由 N 的 PI3P-5-kinase。benthamiana 叶子显著地由 P 增加了抵抗的水平到感染。parasitica 和 P。capsici。一起,我们的结果支持假设那 Phytophthora 种生产外部 PtdIns (3 ) 帮助感染的 P,例如支持 RxLR 受动器的入口进宿主细胞。我们的结果源于 P。sojae RxLR 受动器 Avr1b 证实 N 终点和这个受动器的 C 终点能绑 PtdIns (3 ) P。 | Shan Lu | 2013 | Molecular Plant2013，6，5： | 7 |
| 3 | Breast cancer stem-like cells can promote metastasis by activating platelets and down-regulating antitumor activity of natural killer cells显示文摘OBJECTIVE:To investigate whether cancer stem cells(CSCs) more efficiently activating platelets and evading immune surveillance than non-CSCs thus promoting metastasis.METHODS:We enriched and identified sphereforming cells(SFCs) and coincubated washed platelets with several platelet activators including collagen,4T1 and SFCs.Platelet-coating tumor cells,platelet activation and TGF-β1 release were analyzed.Then natural kell cells(NK) were incubated with supernatants of different activated platelet samples what we called sample release(SR).The degranulation assay and NKG2 D expression on NK cells were conducted by flow cytometry.Finally tissue factor(TF) expression of SFCs or 4T1 were evaluated by western blot.RESULTS:Breast cancer cell line 4T1 could form spheres in serum-free medium at low adherence.Sphere-forming cells expressed high levels of the CD24-/lowCD44 + stem cell phenotype.Both sphere-forming cells or 4T1 were coated with abundant platelets while sphere-forming cells induced significantly higher expression of platelet activating receptor CD62 p than 4T1 did(P < 0.01).And sphere-forming cells induced platelets to produce more TGF-β1 than 4T1 did(P < 0.01).Furthermore,sample releases induced by sphere-forming cells caused more vigorous inhibition of NK cells antitumor reactivity(P < 0.05) and reduced NKG2 D expression(P < 0.01).The final results showed that sphere-forming cells expressed higher levels of TF than 4T1(P < 0.05).CONCLUSION:Our findings indicate that CSCs could efficiently activate platelets,induce platelets to secrete more TGF-β1,decrease NKG2 D expression and inhibit antitumor activity of NK cell,compared with 4T1.And higher levels of TF expression of CSCs may account for this correlation of CSCs and platelets. | Wang Shuo Zhang Ying Cong Weihong Liu Jie Zhang Yuren Fan Huiting XuYonggang Lin Hongsheng | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 5 |
| 4 | PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway显示文摘The activity of proteinase is reported to correlate with the development and progression of nonalcoholic fatty liver disease(NAFLD).Puromycin-sensitive aminopeptidase(PSA/NPEPPS)is an integral nontransmembrane enzyme that functions to catalyze the cleavage of amino acids near the N-terminus of polypeptides.A previous study suggested that this enzyme acts as a regulator of neuropeptide activity;however,the metabolic function of this enzyme in the liver has not been explored.Here,we identified the novel role of PSA in hepatic lipid metabolism.Specifically,PSA expression was lower in fatty livers from NAFLD patients and mice(HFD,ob/ob,and db/db).PSA knockdown in cultured hepatocytes exacerbated diet-induced triglyceride accumulation through enhanced lipogenesis and attenuated fatty acid β-oxidation.Moreover,PSA mediated activation of the master regulator of antioxidant response,nuclear factor erythroid 2-related factor 2(NRF2),by stabilizing NRF2 protein expression,which further induced downstream antioxidant enzymes to protect the liver from oxidative stress and lipid overload.Accordingly,liver-specific PSA overexpression attenuated hepatic lipid accumulation and steatosis in ob/ob mice.Furthermore,in human liver tissue samples,decreased PSA expression correlated with the progression of NAFLD.Overall,our findings suggest that PSA is a pivotal regulator of hepatic lipid metabolism and its antioxidant function occurs by suppressing NRF2 ubiquitination.Moreover,PSA may be a potential biomarker and therapeutic target for treating NAFLD. | Bangliang Huang Xin Xiong Linlin Zhang Xiufei Liu Yuren Wang Xiaoli Gong Qian Sang Yongling Lu Hua Qu Hongting Zheng Yi Zheng | 2021 | Journal of Molecular Cell Biology2021，13，7： | 4 |
| 5 | Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells显示文摘 | Yuren Wei Dong Wang Christopher L. Gentile Michael J. Pagliassotti | 2009 | Molecular and Cellular Biochemistry (-)2009，，1： | 2 |
| 6 | Crack and size-dependence of shear modulus in a drying particulate film显示文摘We utilized controlled vertical drying deposition (CVDD) method,which can fabricate a uniform face-center-cubic (FCC) structure film,to investigate the crack formation and the size dependence of shear modulus in a drying particulate film.We found that both crack spacing and shear modulus depend on colloidal particle size.They drop with increase of particle radius (R) in a single range.Furthermore,compared with the shear modulus variation of a dry particulate film,it was found that both solid part and liquid part in a drying particulate film play equivalent roles in the film mechanical behavior. | CAO He LAN Ding WANG YuRen | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，6： | 1 |
| 7 | An adaptive tradeoff model for constrained evolutionaryoptimization显示文摘 | Wang Yong Cai Zixing Zhou Yuren et ai | 2008 | IEEE Trans on Evolutionary Computation2008，12，1： | 1 |
| 8 | Comparison of Sodium Hyaluronate of Different Molecular Weight Treated Knee Osteoarthritis显示文摘 | ZHOU QING WANG YUREN ZHOU ZIDE | 2000 | Acta universitatis medicinalis secondae shanghai2000，20，4： | 1 |
| 9 | Wide-band un- derwater acoustic absorption based on locally resonant unit and interpenetrating network structure 显示文摘 | Jiang Hcng Wang Yuren Zhang Milan | 2010 | Ghinese Physics B2010，19，26： | 1 |
| 10 | Molecular Mechanisms of Traditional Chinese Medicine Resculpture Effect on the Process of Tumor Immunoedit ing显示文摘 | Li Jie Lin Hongsheng Wang Xiaotong Zhang Yuren | 2014 | World Science and Technology2014，9，20： | 1 |
| 11 | Microrheological Insights into the Dynamics of Amyloplasts in Root Gravity-Sensing Cells显示文摘在察觉到严肃的房间的 Amyloplast 沉积的 Biomechanical 分析。 | Zhongyu Zheng Junjie Zou Hanhai Li Shan Xue Yuren Wang Jie Le | 2015 | Molecular Plant2015，8，4： | 1 |
| 12 | Microstructure and mechanical properties of a novel Zr-based bulk metallic glass composite显示文摘Zr48.5Cu46.5Al5 bulk metallic glass (BMG) com- posites with diameters of 3 and 4 mm were prepared through suction casting in an arc melting furnace by modulating the alloy composition around the monothetic BMG composition of the high glass forming ability. Microstructural charac- terization reveals that the composites contain micron-sized CuZr phase with martensite structure, as well as nano-sized Zr2Cu crystalline particles and Cu10Zr7 plate-like phase em- bedded in an amorphous matrix. Room temperature com- pression tests showed that the composites exhibited signifi- cant strain hardening and obvious plastic strain of 7.7% for 3 mm and 6.4% for 4 mm diameter samples, respectively. | SUN Yufeng WANG Yuren GUO Jian WEI Bingchen LI Weihuo | 2005 | Chinese Science Bulletin2005，50，24： | 1 |
| 13 | An adaptive trade-off model for constrained evolutionary optimization显示文摘 | Wang Yong Cai Zixing Zhou Yuren | 2008 | IEEE Transactions on Evolutionary Computation2008，12，1： | 1 |
| 14 | A CLASS OF HAMILTONIAN AND EDGE SYMMETRIC CAYLEY GRAPHS ON SYMMETRIC GROUPS显示文摘Let S\-n be the symmetric group, g\++\-i=(123i),g\+-\-i=(1i32) and M\++\-n={g\++\-i∶4≤i≤n}, then M\++\-n is a minimal generating set of S\-n ,where n ≥5.It is proved that Cayley graph Cay( S\-n,M\++\-n∪M\+-\-n) is Hamiltonian and edge symmetric. | Wang Shiying\ Zhang Yuren\ Liu Yan | 1999 | Applied Mathematics(A Journal of Chinese Universities)1999，14，4： | 1 |
| 15 | Preparation of Cu-based Bulk Metallic Glass Matrix Composites显示文摘在 situ 包含的金属性的玻璃(BMG ) 矩阵 composites 形成了的 Cu_(47 )Ti_(34 )Zr_(11 ) Ni_8 体积 TiC 粒子和 delta-TiCu 树突阶段被铜开发模子演员组。composites 的热稳定性和微观结构被调查。房间温度耐压试验表明合成样品展出更高的破裂力量和 0.2 percent-0.5 百分比的不同塑料紧张,把 Ti_(34 ) 与 correspondingCu_(47 ) 的作比较 Zr_(11 ) Ni_8 整体的 BMG。 | Yufeng SUN Yuren WANG Bingchen WEI Weihuo LI | 2006 | Journal of Materials Science & Technology2006，22，1： | 1 |
| 16 | An adaptive trade-off model for constrained evolutionary optimization 显示文摘 | WANG YONG CAI ZIXING ZHOU YUREN | 2008 | IEEE Transactions on Evolutionary Computation2008，12，1： | 1 |
| 17 | Microgravity Material Research in China:2012–2014显示文摘During 2012–2014, the main research activities from microgravity material research were focused on, which include study of microgravity effects on collagen fibrillogenesis and HAP crystallization, microgravity experiments using drop tube, and research of thermoelectric materials for space.This paper summarizes all these activities. | WANG Yuren DAI Guoliang WANG Jing FENG Shaobo LUO Xinghong ZHOU Yanfei CHEN Lidong YU Yude | 2014 | 空间科学学报2014，34，5： | 0 |
| 18 | Enhanced crystallization resistance and thermal stability via suppressing the metastable superlattice phase in Ni-(Pd)-P metallic glasses显示文摘Virtually,glass formation is to avoid crystallization during solidification,i.e.,a consequence of the competition between the undercooled liquid and primary crystalline phases.It is found that the crystallization resistance of the binary Ni-P system was drastically enhanced with alloying of Pd and correspondingly,the critical size for glass formation increased significantly from the micrometer to millimeter scale.Thermodynamically,the introduction of Pd could effectively increase the atomic size mismatch and heat of mixing,which are beneficial to stabilize the supercooled liquid.Kinetically,the introduction of Pd not only successfully suppresses the formation of metastable superlattice phase,which is prone to nucleation and growth in the supercooled liquid state,but also changes the crystallization mechanism from the primary to eutectic mode.The current finding sheds light on understanding glass formation of the most studied Pd-Ni-P system and the glass-forming ability in general. | Qing Du Xiongjun Liu Yihuan Cao Yuren Wen Dongdong Xiao Yuan Wu Hui Wang Zhaoping Lu | 2020 | Journal of Materials Science & Technology2020，42，7： | 0 |
| 19 | Antimony doped CsPbI_(2)Br for high-stability all-inorganic perovskite solar cells显示文摘All-inorganic perovskites,adopting cesium(Cs+)cation to completely replace the organic component of A-sites of hybrid organic–inorganic halide perovskites,have attracted much attention owing to the excellent thermal stability.However,all-inorganic iodine-based perovskites generally exhibit poor phase stability in ambient conditions.Herein,we propose an efficient strategy to introduce antimony(Sb^(3+))into the crystalline lattices of CsPbI_(2)Br perovskite,which can effectively regulate the growth of perovskite crystals to obtain a more stable perovskite phase.Due to the much smaller ionic radius and lower electronegativity of trivalent Sb^(3+)than those of Pb^(2+),the Sb^(3+)doping can decrease surface defects and suppress charge recombination,resulting in longer carrier lifetime and negligible hysteresis.As a result,the all-inorganic perovskite solar cells(PSCs)based on 0.25%Sb^(3+)doped CsPbI_(2)Br light absorber and screen-printable nanocarbon counter electrode achieved a power conversion efficiency of 11.06%,which is 16%higher than that of the control devices without Sb^(3+)doping.Moreover,the Sb^(3+)doped all-inorganic PSCs also exhibited greatly improved endurance against heat and moisture.Due to the use of low-cost and easy-to-process nanocarbon counter electrodes,the manufacturing process of the all-inorganic PSCs is very convenient and highly repeatable,and the manufacturing cost can be greatly reduced.This work offers a promising approach to constructing high-stability all-inorganic PSCs by introducing appropriate lattice doping. | Mengfei Zhu Lina Qin Yuren Xia Junchuan Liang Yaoda Wang Daocheng Hong Yuxi Tian Zuoxiu Tie Zhong Jin | 2024 | Nano Research2024，17，3： | 0 |
| 20 | Mutations in Exons of the CYP17-Ⅱ Gene Affect Sex Steroid Concentration in Male Japanese Flounder(Paralichthys olivaceus)显示文摘As a specific gene of fish,cytochrome P450c17-Ⅱ(CYP17-Ⅱ) gene plays a key role in the growth,development and reproduction level of fish.In this study,the single-stranded conformational polymorphism(SSCP) technique was used to characterize polymorphisms within the coding region of CYP17-Ⅱ gene in a population of 75 male Japanese flounder(Paralichthys olivaceus).Three single nucleotide polymorphisms(SNPs) were identified in CYP17-Ⅱ gene of Japanese flounder.They were c.G594A(p.G188R),c.G939A and c.G1502A(p.G490D).SNP1(c.G594A),located in exon 4 of CYP17-Ⅱ gene,was significantly associated with gonadosomatic index(GSI).Individuals with genotype GG of SNP1 had significantly lower GSI(P < 0.05) than those with geno-type AA or AG.SNP2(c.G939A) located at the CpG island of CYP17-Ⅱ gene.The mutation changed the methylation of exon 6.Indi-viduals with genotype AA of SNP2 had significantly lower serum testosterone(T) level and hepatosomatic index(HSI) compared to those with genotype GG.The results suggested that SNP2 could influence the reproductive endocrine of male Japanese flounder.How-ever,the SNP3(c.G1502A) located in exon 9 did not affect the four measured reproductive traits.This study showed that CYP17-Ⅱ gene could be a potentially useful candidate gene for the research of genetic breeding and physiological aspects of Japanese flounder. | MA Ruiqin HE Feng WEN Haishen LI Jifang SHI Bao SHI Dan LIU Miao MU Weijie ZHANG Yuanqing HU Jian HAN Weiguo ZHANG Jianan WANG Qingqing YUAN Yuren LIU Qun | 2012 | Journal of Ocean University of China2012，11，1： | 0 |
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