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| 1 | Correlations Between Single Nucleotide Polymorphisms,Cognitive Dysfunction,and Postmortem Brain Pathology in Alzheimer's Disease Among Han Chinese显示文摘In this study, the distribution of five Alzheimer's disease(AD)-related single nucleotide polymorphisms(SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain pathological analysis. The associations among SNPs,clinical daily cognitive states, and postmortem neuropathological changes were analyzed in 110 human brains from the Chinese Academy of Medical Sciences/Peking Union Medical College(CAMS/PUMC) Human Brain Bank.APOE ?4(OR = 4.482, P = 0.004), the RS2305421 GG genotype(adjusted OR = 4.397, P = 0.015), and the RS10498633 GT genotype(adjusted OR = 2.375,P = 0.028) were associated with a higher score on the ABC(Ab plaque score, Braak NFT stage, and CERAD neuritic plaque score) dementia scale. These results advance our understanding of the pathogenesis of AD,the relationship between pathological diagnosis and clinical diagnosis, and the SNPs in the Han population for future research. | Qian Yang Kang Chen Hanlin Zhang Wanying Zhang Changlin Gong Qing Zhang Pan Liu Tianyi Sun Yuanyuan Xu Xiaojing Qian Wenying Qiu Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 5 |
| 2 | Optimization of Rooting Medium for Tissue Culture Seedlings of Dendrobium officinale by Response Surface Methodology显示文摘[Objectives] To increase the survival rate of tissue culture seedlings of Dendrobium officinale,and optimize the conditions of rooting medium by the response surface methodology( RSM). [Methods]The effects of 6-BA concentration,NAA concentration,potato amount and the amount of mashed banana on the growth of seedlings were determined by single factor experiment and were analyzed by Box-Behnken design and response surface methodology. [Results]The optimal culture conditions: rooting medium 1/2 MS + 6-BA 0. 24 mg/L + mashed banana 87. 63 g/L + potato 89. 30 g/L + NAA 0. 52 mg/L + sucrose 20. 0 g/L + activated carbon 4. 0 g/L + agar 7. 0 g/L,p H 5. 8,and light intensity 2 000 Lx. [Conclusions]The model established by response surface methodology has a good predictability and could be used to optimize the conditions of tissue culture and rooting medium of D. officinale. | Wenshu PENG Aibing JI Wanying GONG Cong LIU Ying ZENG Qiaomei WANG Liang YAN | 2018 | Medicinal Plant2018，9，5： | 2 |
| 3 | Breeding of Leptin Receptor Gene Knockout Mice and Genotype Identification of the Offspring显示文摘The leptin( LP) receptor gene heterozygous mice were mated in four ways. Genomic DNA was extracted from offspring tails and analyzed by PCR. The result showed that the ratios of the offspring genotypes fit the Mendel's laws. The male and female LP^(-/-)mice( DB / DB mice) were infertile. LP^(-/-)mice could be effectively bred by mating of male and female LP^(+/-)mice. PCR methods could identify LP^(-/-)mice precisely. | Ji Aibing Yan Liang Peng Wenshu Liu Cong Gong Wanying Wang Qiaomei | 2016 | Animal Husbandry and Feed Science2016，8，4： | 0 |
| 4 | Revealing the role of mo doping in promoting oxygen reduction reaction performance of Pt_(3)Co nanowires显示文摘Highly active and durable electrocatalysts towards oxygen reduction reaction(ORR)are imperative for the commercialization application of proton exchange membrane fuel cells.By manipulating ligand effect,structural control,and strain effect,we report here the precise preparation of Mo-doped Pt_(3)Co alloy nanowires(Pt_(3)Co-Mo NWs)as the efficient catalyst towards ORR with high specific activity(0.596 mA cm^(−2))and mass activity(MA,0.84 A mg^(−1)_(Pt)),much higher than those of undoped counterparts.Besides activity,Pt_(3)Co-Mo NWs also demonstrate excellent structural stability and cyclic durability even after 50,000 cycles,again surpassing control samples without Mo dopants.According to the strain maps and DFT calculations,Mo dopants could modify the electronic structure of both Pt and Co to achieve not only optimized oxygen-intermediate binding energy on the interface but also increased the vacancy formation energy of Co,together leading to enhanced activity and durability.This work provides not only a facile methodology but also an in-depth investigation of the relationship between structure and properties to provide general guidance for future design and optimization. | Zhiping Deng Wanying Pang Mingxing Gong Zhehui Jin Xiaolei Wang | 2022 | Journal of Energy Chemistry2022，31，3： | 0 |
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