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| 1 | Pancreatic stents for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis should be inserted up to the pancreatic body or tail显示文摘AIM To investigate the location to which a pancreatic stent should be inserted to prevent post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP).METHODS Over a ten-year period at our hospital, 296 patients underwent their first ERCP procedure and had a pancreatic stent inserted; this study included 147 patients who had ERCP performed primarily for biliary investigation and had a pancreatic stent inserted to prevent PEP. We dividedthese patients into two groups: 131 patients with a stent inserted into the pancreatic head(head group) and 16 patients with a stent inserted up to the pancreatic body or tail(body/tail group). Patient characteristics and ERCP factors were compared between the groups.RESULTS Pancreatic amylase isoenzyme(p-AMY) levels in the head group were significantly higher than those in the body/tail group [138.5(7.0-2086) vs 78.5(5.0-1266.5), P = 0.03] [median(range)]. No cases of PEP were detected in the body/tail group [head group, 12(9.2%)]. Of the risk factors for post-ERCP hyperamylasemia(≥ p-AMY median, 131 IU/L), procedure time ≥ 60 min [odds ratio(OR) 2.65, 95%CI: 1.17-6.02, P = 0.02) and stent insertion into the pancreatic head(OR 3.80, 95%CI: 1.12-12.9, P = 0.03) were identified as independent risk factors by multivariate analysis.CONCLUSION Stent insertion up to the pancreatic body or tail reduces the risk of post-ERCP hyperamylasemia and may reduce the risk of PEP. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Takuto Hikichi Hiromasa Ohira | 2018 | World Journal of Gastroenterology2018，24，22： | 13 |
| 2 | Efficacy of endoscopic ultrasonography-guided fine needle aspiration for pancreatic neuroendocrine tumor grading显示文摘AIM: To evaluate the efficacy of endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA) for grading pancreatic neuroendocrine tumors(PNETs).METHODS: A total of 22 patients were diagnosed with PNET by EUS-FNA between October 2001 and December 2013 at Fukushima Medical University Hospital.Among these cases,we targeted 10 PNET patients who were evaluated according to the World Health Organization(WHO) 2010 classification.Surgery was performed in eight patients,and chemotherapy was performed in two patients due to multiple liver metastases.Specimens obtained by EUS-FNA were first stained with hematoxylin and eosin and then stained with chromogranin,synaptophysin,CD56,and Ki-67.The specimens were graded by the Ki-67 index according to the WHO 2010 classification.Specimens obtained by surgery were graded by the Ki-67 indexand mitotic count(WHO 2010 classification).For the eight specimens obtained by EUS-FNA,the Ki-67 index results were compared with those obtained by surgery.In the two cases treated with chemotherapy,the effects and prognoses were evaluated.RESULTS: The sampling rate for histological diagnosis by EUS-FNA was 100%.No adverse effects were observed.The concordance rate between specimens obtained by EUS-FNA and surgery was 87.5%(7/8).Fo r t h e t w o c a s e s t re a t e d w i t h c h e m o t h e ra p y,case 1 received somatostatin analog therapy and transcatheter arterial infusion(TAI) targeting multiple liver metastases.Subsequent treatment consisted of everolimus.During chemotherapy,the primary tumor remained unconfirmed,although the multiple liver metastases diminished dramatically.Case 2 was classified as neuroendocrine carcinoma(NEC) according to the Ki-67 index of a specimen obtained by EUS-FNA; therefore,cisplatin and irinotecan therapy was started.However,severe adverse effects,including renal failure and diarrhea,were observed,and the therapy regimen was changed to cisplatin and etoposide.TAI targeting multiple liver metastases was performed.Although the liver metastases diminished,the primary tumor remained unconfirmed.These chemotherapy regimens had immediate effects for both unresectable neuroendocrine tumor(NET) and NEC cases.These two subjects are still alive.CONCLUSION: EUS-FNA was effective for PNET diagnosis and Ki-67 index grading for WHO 2010 classification,enabling informed decisions on unresectable PNET treatment by identifying NET or NEC. | Mitsuru Sugimoto Tadayuki Takagi Takuto Hikichi Rei Suzuki Ko Watanabe Jun Nakamura Hitomi Kikuchi Naoki Konno Yuichi Waragai Hiroyuki Asama Mika Takasumi Hiroshi Watanabe Katsutoshi Obara Hiromasa Ohira | 2015 | World Journal of Gastroenterology2015，21，26： | 6 |
| 3 | Predictive factors for the failure of endoscopic stent-instent self-expandable metallic stent placement to treat malignant hilar biliary obstruction显示文摘AIM To investigate the factors predictive of failure when placing a second biliary self-expandable metallic stents(SEMSs). METHODS This study evaluated 65 patients with an unresectable malignant hilar biliary obstruction who were examined in our hospital. Sixty-two of these patients were recruited to the study and divided into two groups: the success group, which consisted of patients in whom a stent-in-stent SEMS had been placed successfully, and the failure group, which consisted of patients in whom the stent-in-stent SEMS had not been placed successfully. We compared the characteristics of the patients, the stricture state of their biliary ducts, and the implemented endoscopic retrograde cholangiopancreatography(ERCP) procedures between the two groups.RESULTS The angle between the target biliary duct stricture and the first implanted SEMS was significantly larger in the failure group than in the success group. There were significantly fewer wire or dilation devices(ERCP catheter, dilator, or balloon catheter) passing the first SEMS cell in the failure group than in the success group. The cut-off value of the angle predicting stent-in-stent SEMS placement failure was 49.7 degrees according to the ROC curve(sensitivity 91.7%, specificity 61.2%). Furthermore, the angle was significantly smaller in patients with wire or dilation devices passing the first SEMS cell than in patients without wire or dilation devices passing the first SEMS cell. CONCLUSION A large angle was identified as a predictive factor for failure of stent-in-stent SEMS placement. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Yuki Sato Takuto Hikichi Hiromasa Ohira | 2017 | World Journal of Gastroenterology2017，23，34： | 3 |
| 4 | Endoscopic therapy for esophageal hematoma with blue rubber bleb nevus syndrome显示文摘A 57-year-old woman previously diagnosed with blue rubber bleb nevus syndrome(BRBNS) reported hematemesis. BRBNS is a rare vascular anomaly syndrome consisting of multifocal hemangiomas of the skin and gastrointestinal(GI) tract but her GI tract had never been examined. An upper gastrointestinal endoscopy revealed a large bleeding esophageal hematoma positioned between the thoracic esophagus and the gastric cardia. An endoscopic injection of polidocanol was used to stop the hematoma from bleeding. The hematoma was incised using the injectionneedle to reduce the pressure within it. Finally, argon plasma coagulation(APC) was applied to the edge of the incision. The esophageal hematoma disappeared seven days later. Two months after the endoscopic the rapy, the eso phage alulcerhealed and the hemangioma did not relapse. This rare case of a large esophageal hematoma originating from a hemangioma with BRBNS was treated using a combination of endoscopic therapy with polidocanol injection, incision, and APC. | Mika Takasumi Takuto Hikichi Tadayuki Takagi Masaki Sato Rei Suzuki Ko Watanabe Jun Nakamura Mitsuru Sugimoto Yuichi Waragai Hitomi Kikuchi Naoki Konno Hiroshi Watanabe Katsutoshi Obara Hiromasa Ohira | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 2 |
| 5 | Serial MRI of extrapontine myelinolysis of the basal ganglia:a case report显示文摘 | Waragai M Satoh T | 1998 | J Neurol Sci1998，161，2： | 1 |
| 6 | Simple mathematical model for the electrical conductivity of highly porous ceramics 显示文摘 | Mizusaki J Waragai K Tsuehiya S | 1996 | Journal of the American Ceramic Society1996，79，1： | 1 |
| 7 | Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit显示文摘 | Waragai M Nagamitsu S Xu W | 2006 | J Neurosci Res2006，83，7： | 1 |
| 8 | Alpha-synuclein and DJ-l as potential biological fluid biomarkers for Parkinson's disease显示文摘 | Waragai M Sekiyama K Sekigawa A | | 0，，11： | 1 |
| 9 | MRI and clinical features in amyotrophic lateral sclerosis显示文摘 | | 1997 | Neuroradiology1997，39，12： | 1 |
| 10 | High-frequency oscillation (HFO) prevents activation of NF-kappaB found with conventional mechanical ventilation (CMV) in surfactant-depleted rabbit lung显示文摘 | Waragai A Yamashita H Hosoi K | 2007 | Pediatr Pulmonol2007，42，5： | 1 |
| 11 | P2X7 Receptor Signaling Pathway as a Therapeutic Target for Neurodegenerative Diseases显示文摘 | Takato Takenouchi Kazunari Sekiyama Akio Sekigawa Masayo Fujita Masaaki Waragai Shuei Sugama Yoshifumi Iwamaru Hiroshi Kitani Makoto Hashimoto | 2010 | Archivum Immunologiae et Therapiae Experimentalis2010，，2： | 1 |
| 12 | Plasma levels of DJ-1 as a possible marker for marker for progression of sporadic Parkinson's disease显示文摘 | Waragai M Nakai M Wei J | | 0，，01： | 1 |
| 13 | The somatotopic localisation of the descending cortical tract in the cerebral peduncle: a study using MRI of changes following Wallerian degeneration in the cerebral peduncle after a supratentorial vascular lesion显示文摘 | Waragai M Watanabe H Iwabuchi S | 1994 | Neuroradiology1994，36，5： | 1 |
| 14 | Pancreatic neuroendocrine tumor Grade 1 patients followed up without surgery:Case series显示文摘Among the three grades of neuroendocrine tumors(NETs),the prognosis for Grade 1(G1) with surgery is very good.Therefore,we evaluated the prognoses of pancreatic NET(PNET) G1 patients without surgery.A total of 8 patients who were diagnosed with NET G1,with an observation period of more than 6 mo until surgery or without surgery,were recruited.The patients who underwent surgery were ultimately diagnosed using specimens obtained during the surgery,whereas the patients who did not undergo surgery were diagnosed using specimens obtained by endoscopic ultrasonography-guided fine needle aspiration.Overall,we mainly evaluated the observation period and tumor growth.The observation period for the five cases with surgery ranged from 6-80 mo,and tumor growth was observed in one case.In contrast,the observation period for the three cases without surgery ranged from 17-54 mo,and tumor growth was not observed.Therefore,although the first-choice treatment for NETs is surgery,our experience includes certain NET G1 patients who were followed up without surgery. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Satoshi Kawana Yuko Hashimoto Takuto Hikichi Hiromasa Ohira | 2017 | World Journal of Clinical Oncology2017，8，3： | 1 |
| 15 | Increased level of DJ-1in the cerebrospinal fluids of sporadicParkinson’s disease显示文摘 | Waragai M Wei J Fujita M Nakai M Ho G J Masliah E | 2006 | Biochem Biophys Res Commun2006，345，： | 1 |
| 16 | Wallerian degeneration of the cortico-descending tract in the cerebral peduncle following a supratentorial cerebrovascular lesion detected by MRI- the relationship between Wallerian degeneration at the center of the cerebral peduncle and functional recovery of paresis显示文摘 | Waragai M Iwbuchi S | 1993 | Rinsho Shinkeigaku1993，33，11： | 1 |
| 17 | Role of genomics in translational research for Parkinson' s disease 显示文摘 | Sekiyama K Takamatsu Y Waragai M | 2014 | BioehemBiophys Res Commun2014，452，2： | 1 |
| 18 | JNK activation is associated with intracellular beta-amyloid accumulation 显示文摘 | Shoji M Iwakami N Takeuchi S Waragai M Suzuki M Kanazawa I | 2000 | Brain Res Mol Brain Res2000，85，12： | 1 |
| 19 | Alpha-synuclein and DJ-1 as potential biological fluid biomarkers for Parkinson's disease显示文摘 | Waragai M Sekiyama K Sekigawa A | 2010 | Inter- national Journal of Molecular Sciences2010，11，11： | 1 |
| 20 | MRI and SPECT studies of dural arteriovenous fistulas presenting as pure progressive dementia with leukoencephalopathy:a cause of treatable dementia显示文摘 | Waragai M Takeuchi H Fukushima T | 2006 | Eur J Neurol2006，13，： | 1 |
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