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| 1 | 胸腔镜肺叶切除术显示文摘背景与目的:尽管14年前我们就已报道在胸腔镜下可完成解剖意义上彻底的肺叶切除和淋巴结清扫,但关于这一术式的争论以及胸外科医师们提出的如何完成这种手术的疑问,使这种术式的被接受程度受到了限制。随着对这一术式持支持态度的人不断增多,这一术式的开展也越来越广泛。本文将讨论该术式的手术技术,临床疗效,以及关于这种术式的各种争论。方法:1992—2005年间我们共进行胸腔镜肺叶切除术1315例,其中女性700例(53.2%),男性615例(46.8%),患者平均年龄71.2岁。患者术后病理诊断:良性病变53例,肺部转移性肿瘤28例,淋巴瘤5例,肺癌1015例。腺癌在原发性肺癌中占63.1%。解剖意义上彻底的肺门切除和淋巴结活检或清扫均通过观察监视器屏幕完成,切口长约5cm,不需撑开肋骨。结果:9例(0.8%)死亡(无术中死亡及出血死亡患者)。932例(84.7%)术后没有出现并发症。1100例患者中有45例(4.1%)需输血。中位住院时间3d,平均住院时间4.78d。180例(20%)患者于术后第1天或第2天出院。28例(2.5%)患者术中转为开胸手术。5例(0.57%)患者术后切口出现复发。其中2003年内,在224例肺叶切除中89%通过胸腔镜完成。结论:在胸腔镜下可完成解剖意义上彻底的肺叶切除,且并发症率和死亡率较低。术中出血及切口复发的风险很小。 | Robert J McKenna Ward Houck 罗晓阳 | 2006 | 中国癌症杂志2006，16，8： | 20 |
| 2 | Mechanisms underlying the impaired contractility of diabetic cardiomyopathy显示文摘Cardiac dysfunction is a well-known consequence of diabetes,with sustained hyperglycaemia leading to the development of a cardiomyopathy that is independent of cardiovascular disease or hypertension.Animal models of diabetes are commonly used to study the pathophysiology of diabetic cardiomyopathy,with the hope that increased knowledge will lead ultimately to better therapeutic strategies being developed.At physiological temperature,left ventricular trabeculae isolated from the streptozotocin rat model of type 1 diabetes showed decreased stress and prolonged relaxation,but with no evidence that decreased contractility was a result of altered myocardial Ca2+handling.Although sarcoplasmic reticulum(SR)Ca2+reuptake appeared slower in diabetic trabeculae,it was offset by an increase in actionpotential duration,thereby maintaining SR Ca2+content and favouring increased contraction force.Frequency analysis of t-tubule distribution by confocal imaging of ventricular tissue labeled with wheat germ agglutinin or ryanodine receptor antibodies showed a reduced T-power for diabetic tissue,but the differences were minor in comparison to other models of heart failure.The contractile dysfunction appeared to be the result of disrupted F-actin in conjunction with the increased typeⅠcollagen,with decreased myofilament Ca2+sensitivity contributing to the slowed relaxation. | Marie-Louise Ward David J Crossman | 2014 | World Journal of Cardiology2014，6，7： | 13 |
| 3 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 4 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 5 | 植物凝集素串联法富集纯化血清多个亚糖蛋白质组显示文摘蛋白质糖基化修饰是哺乳动物中最为常见的一种翻译后修饰,蛋白质的寡糖侧链具有重要的生物学意义,如蛋白质分子间及细胞间相互作用、识别、肿瘤侵袭与转移等.本实验应用寡甘露糖型亲合层析柱、唾液酸型层析柱和O-连接糖蛋白亲合层析柱从血清中序列性提取寡甘露糖型、唾液酸型的N-连接糖蛋白及O-连接的糖蛋白,一维和二维电泳图谱显示血清各亚糖蛋白组图谱差异,并对富集的唾液酸型糖蛋白质组的二维电泳图谱中12个显著的差异蛋白质点进行质谱检测,鉴定出的14个蛋白均为N-连接糖蛋白.植物凝集素序列性提取血清各亚糖蛋白质组,显著减小了血清蛋白质组的复杂性和血清蛋白浓度波动范围,提高了质谱鉴定血清中对疾病诊断和疗效监测具有重要意义的生物标志物的灵敏性. | 齐义军 王攀 牛保华 侯艳芳 晁玮霞 WARD Douglas JOHSON Philip J 马远方 | 2011 | 中国科学:生命科学2011，41，5： | 3 |
| 6 | 免疫组化标记结果显示纤维板层肝癌具有肝细胞和胆管细胞分化特征显示文摘 | Ward S C Huang J Tickoo S K 樊祥山(摘译) | 2010 | 临床与实验病理学杂志2010，26，5： | 3 |
| 7 | 加钼或未加钼的低铜日粮对牛的铜状态、生产性能和胴体品质的长期影响显示文摘用42头7月龄安格斯公牛进行试验,测定加钼或未加钼的低铜饲粮对牛的生产性能、胴体品质和铜状态的长期影响。断奶前28d给22头犊牛注射90mg铜,断奶后,饲粮中添加铜7.5mg/kg干物质,对照组不添加铜。在获得铜后第40d末,铜的添加量降低到5mg/kg干物质,施铜期后,每组1/2牛的日粮中添加钼5mg/kg干物质。生长期持续196d随后为49d的肥育期,饲喂高浓度饲粮。试验结果表明:注射铜提高了断奶时牛的血浆铜浓度(P<0.01)。从生长期开始补加铜的牛具有较高的血浆铜含量、血浆铜蓝蛋白活性、过氧化物歧化酶(SOD)活性和肝脏铜浓度(P<0.01)。补加钼降低了未添加铜组牛生长期和肥育期血浆铜含量、血浆铜蓝蛋白和过氧化物岐化酶活性,但对加铜组的牛无影响。添加铜提高了施铜期(P<0.05)和生长期(P<0.08)牛的干物质采食量(DMI)及肥育期牛的日增重量(ADG)和饲料转化效率(G/F)。补加铜的牛的背膘厚度较薄(P<0.06),肋部眼肌面积较大(P<0.09)。研究结果证明,饲粮铜浓度可能改变牛的生产性能和胴体品质。 | Ward J D Spears J W 郭艳丽 | 1999 | 国外畜牧学(草原与牧草)1999，0，3： | 3 |
| 8 | 超顺磁性氧化铁(SPIO)对比剂肝脾MR成像的比较研究显示文摘目的 比较两种超顺磁性氧化铁 (superparamagneticironoxide ,SPIO)对比剂 ,Ferumoxides及SHU 5 5 5A在肝脾MR成像中的效应。材料与方法 3 6例已知为肝转移癌患者于SPIO造影前后进行T2 WI快速自旋回波成像 (T2 WITSE)及T1WI梯度回波快速去相位成像 (T1WIFLASH)。扫描仪为 1.0TMR机。 18例患者行Ferumoxides增强后 90分钟进行MR成像 ;另 18例行SHU 5 5 5A快速团注增强 ,注药后即刻、3 0秒及 480秒行T1WIFLASH成像 ,10分钟行T2 WITSE成像。测量肝脾、肝转移癌SPIO增强前后的信号强度(signalintensity ,SI) ,计算两种SPIO对比剂在肝脾、肝转移癌增强前后SI变化的百分比 (percentagesignalintensitychange ,PSIC)及病灶 肝脏对比噪声比 (lesion to livercontrast to noiseratio ,CNR)及其变化 (ΔCNR)。结果 在T2 WITSE图像上 ,两种SPIO对比剂造成的肝实质SI下降无显著性差异 (P >0 .0 5 )。Ferumoxides引起的脾信号下降显著大于SHU 5 5 5A(P <0 .0 5 )。两种SPIO对比剂均导致肝转移癌CNR显著增高。T1WIFLASH图像上 ,两种对比剂均可导致延迟像上肝脏SI的轻度下降及肝转移癌CNR下降 ,两者肝脏PSIC之间无显著性差异。T1WI上两种对比剂均可导致脾脏SI显著升高 ,两者脾脏PSIC之间无显著性差异 (P >0 .0 5 ) | 陈峰 Ward J Robinson P J | 2001 | 临床放射学杂志2001，20，3： | 3 |
| 9 | Is iron overload in alcohol-related cirrhosis mediated by hepcidin?显示文摘In this case report we describe the relationship between ferritin levels and hepcidin in a patient with alcohol-related spur cell anemia who underwent liver transplantation.We demonstrate a reciprocal relation-ship between serum or urinary hepcidin and serum ferritin,which indicates that inadequate hepcidin production by the diseased liver is associated with elevated serum ferritin.The ferritin level falls with increasing hepcidin production after transplantation.Neither inflammatory indices(IL6)nor erythropoietin appear to be related to hepcidin expression in this case.We suggest that inappropriately low hepcidin production by the cirrhotic liver may contribute substantially to elevated tissue iron stores in cirrhosis and speculate that hepcidin replacement in these patients may be of therapeutic benefi t in the future. | Tariq Iqbal Azzam Diab Douglas G Ward Matthew J Brookes Chris Tselepis Jim Murray Elwyn Elias | 2009 | World Journal of Gastroenterology2009，15，46： | 2 |
| 10 | Hepatocellular carcinoma in the cirrhotic liver: double-contrast MR imaging for diagnosis显示文摘 | Ward J Guthrie JA Scott DJ | 2000 | Radiology2000，216，1： | 2 |
| 11 | The microwave processability of semicrystalline polymers显示文摘 | M Chen J W Hellgeth E J Siochi T C Ward J E Mcgrath | 1993 | Polymer Engineering and Science1993，33，17： | 2 |
| 12 | The oxidative dehydrogenation of ethane by nitrous oxide over molybdenum oxide supported on silica gel显示文摘 | M B Ward M J Lin J H Lousford | 1977 | J Catal1977，50，： | 2 |
| 13 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 14 | The Establishment of ultraviolet spectral emission scales using synchrotron radiation显示文摘 | KEY P J WARD T H | 1978 | Metrologia1978，14，1： | 2 |
| 15 | Plants pass the salt显示文摘 | Ward J M Hirschi K D Sze H | 2003 | Trends Plant Sci2003，8，5： | 2 |
| 16 | Review multiple sequence alignment in phylogenetic analysis显示文摘 | Aloysius P Daniel J Ward W | 2000 | Molecular Phylogenetics and Evolution2000，16，3： | 1 |
| 17 | Negative regulation of macrophage activation in response to IFN-γ and lipopolysaccharide by the STK/RON receptor tyrosine kinase显示文摘 | Ward J Correll P H | 1999 | J Immunol1999，163，： | 1 |
| 18 | Optical harmonics and nonlinear phenomena显示文摘 | Ward J F | 1963 | Rev Mod Phys1963，35，： | 1 |
| 19 | Mammalian keratin gene families: organization for genes coding for the B2 high-sulphur proteins sheep wool 显示文摘 | Powell B C Sleigh M J Ward K A | 1983 | Nucleic Acids Res1983，11，： | 1 |
| 20 | Urogenital carcinogenesis in female CD 1 mice induced by in utero arsenic exposure is exacerbated by postnatal diethylstilbestrol treatment显示文摘 | Waalkes MP Liu J Ward JM | 2006 | Cancer Res2006，66，3： | 1 |
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