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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Hyperspectral versus multispectral data for estimating leaf area index in four different biomes显示文摘 | Kyu-Sung Lee Warren B Cohen Robert E Kennedy Thomas K Maiersperger Stith T Gower | 2004 | Remote Sensing of Environment2004，，3： | 2 |
| 3 | Integrated testing of the NOXSO process: Simultaneous removed of SO2 and NOx from flue gas 显示文摘 | Yeh James T Ma Warren T Pennline Henry W | 1992 | Chem Eng Comm1992，14，： | 2 |
| 4 | Aggressive surgery for metastatic liver neuroendocrine tumors显示文摘 | Jeffrey A Norton Robert S Warren Mary G Kelly Marlene B Zuraek Robert T Jensen | 2003 | Surgery2003，，： | 2 |
| 5 | Current technique oftabularized incised plate hypospadias repair显示文摘 | Warren T Snodgrass Michael T | 2002 | Urology2002，60，1： | 1 |
| 6 | A histological evaluation of peritoneal injury and repair: implications for adhesion formation 显示文摘 | Elkins T E Stovall T G Warren J | 1987 | Obstet Gynecol1987，70，2： | 1 |
| 7 | Surface disturbance of cryptobiotic soil crusts: Nitrogenase activity,chlorophyll content,and chlorophyll degradation显示文摘 | Belnap J Harper K T Warren S D | 1994 | Arid Soil Research and Rehabilitation1994，8，： | 1 |
| 8 | Multiresolution Analysis for Surfaces of Arbitrary Topological Type显示文摘 | deRose T Lounsbery M Warren J | 1997 | ACM Transactions on Graphics1997，16，1： | 1 |
| 9 | An ontology-based approach to en- hance querying capabilities of general practice medicine for bet- termanagement of hypertension显示文摘 | Mabotuwana T Warren J | 2009 | Artif Intell Med2009，47，2： | 1 |
| 10 | Four floats measures for critical path scheduling 显示文摘 | Warren T | 1969 | Journal of Industrial Engineering1969，10，： | 1 |
| 11 | The Expanding world of trinucleotide repeats显示文摘 | Tephen T | 1996 | Science1996，271，： | 1 |
| 12 | The effects of loading and unloading treadmill walking on balance,gait,fall risk and daily function in Parkinsonism显示文摘 | Toole T Maitland CG Warren E | 2005 | Neurorehabilitation2005，20，： | 1 |
| 13 | Effect of strain hardening and strain-rate sensitivity on the penetration of aluminum targets with spherical-nosed rods显示文摘 | Warren T L Forrestal M J | 1998 | International Journal of Solids and Structures1998，35，： | 1 |
| 14 | Mean value coordinates for closed triangular meshes 显示文摘 | Ju T Schaefer S Warren J | 2005 | ACM Transactions on Graphics2005，24，3： | 1 |
| 15 | Highly Efficient Re- programming to Pluripotency and Directed Differentiati Human Cells with Synthetic Modified mRNA显示文摘 | Warren L Manos PD Ahfeldt T | 2010 | Cell on of Stem Cell2010，7，5： | 1 |
| 16 | Surface disturbance of cryptobiotic soil crusts: nitrogenase activity, chlorophyll content and chlorophyll degradation 显示文摘 | Belnap J Harper K T Warren S D | 1994 | Arid Soil Research and Rehabilitation1994，8，： | 1 |
| 17 | Triplet repeat expansion mutations:the example of fragile X syndrome显示文摘 | Warren S T Ashley C T Jr | 1995 | Annu Rev Neurosci1995，18，： | 1 |
| 18 | Growth and form of spherulites 显示文摘 | Granasy L P T Tegze G Warren J A | 2005 | Physical Review E2005，72，1： | 1 |
| 19 | Intravascular adenoviral agents in cancer patients: lessons from clinical trials 显示文摘 | Reid T Warren R Kirn D | 2002 | Cancer Gene Ther2002，9，： | 1 |
| 20 | Perforation equations for conical and ogival nose rigid projectiles into aluminum target plates 显示文摘 | Forrestal M J Warren T L | 2009 | International Journal of Impact Engineering2009，36，： | 1 |
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