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| 1 | Oxylipin Pathway in Rice and Arabidopsis显示文摘植物发展了复杂发信号的小径协调回答到发展、环境的信息。oxylipin 小径是一个枢轴的 lipid-basedsignaling 网络,几竞争分支小径镇静,那决定植物“适应各种各样的刺激的 sability。oxylipin 小径的激活导致称为“ oxylipins ”的生物学上活跃的代谢物的 de novosynthesis。这些代谢物的相对层次是每植物硬币沙的不同指示物决定植物的能力适应不同刺激。oxylipin 小径, allene 氧化物 syn-thase (AOS ) 和水疗院过氧化物 lyase (HPL ) 的二个主要分支分别地为发信号的混合物, jasmonates 和醛的生产负责。这里,我们作为单子叶植物的模型和双子叶的系统在米饭和 Arabidopsis 比较并且形成对照 AOS 和 HPLbranch 小径的规定。Theseanalyses 提供新卓见进在单音的简易窄床和 dicots 表明小径,和为压力改编负责的过程的复杂网络的 JA 和醛的进化。 | E. Wassim Chehab John V. Perea Banu Gopalan Steve Theg Katayoon Dehesh | 2007 | Journal of Integrative Plant Biology2007，49，1： | 12 |
| 2 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 3 | 妊娠期间糖尿病管理显示文摘美国妊娠期间的糖尿病患病率一直在增加,多数是妊娠期糖尿病(GDM),其余主要是1型糖尿病和2型糖尿病合并妊娠。妊娠期间糖尿病血糖控制不佳导致流产、死胎等各种风险增加。妊娠期间的糖尿病管理包括糖尿病及糖尿病前期患者应进行孕前咨询、孕前化验和就诊、血糖监测,知晓妊娠期间的血糖和HbA_1c控制目标,GDM的管理包括筛查和诊断、生活方式管理如医学营养疗法和药物治疗等。此外,还包括1型糖尿病和2型糖尿病合并妊娠的管理,应用阿司匹林对先兆子痫的影响,妊娠期高血压监测及用药注意,还有产后护理、哺乳期以及避孕等多方面内容。 | Wassim El-Harake 谈力欣 王晓昆 许樟荣 | 2019 | 临床荟萃2019，34，2： | 8 |
| 4 | 1612例正畸患者上颌锥形侧切牙患病率调查显示文摘目的调查正畸患者上颌恒侧切牙发生锥形牙的患病状况。方法对1612例在正畸科就诊患者的病历资料进行上颌侧切牙形态研究,对不同性别和不同错(牙合)类型的患病率进行卡方检验。结果上颌锥形侧切牙的总体患病率为7.6%,男性患病率(8.3%)与女性患病率(7.1%)之间差异无统计学意义(P>0.05)。安氏Ⅱ类错(牙合)畸形中锥形牙的患病率(10.1%)显著高于Ⅰ类(6.1%)和Ⅲ类(6.0%)(P<0.05)。锥形侧切牙双侧发生者占40.2%,单侧发生者占59.8%,其中右侧(35.2%)多于左侧(24.6%)。结论上颌锥形侧切牙在正畸人群中的发病率高于普通人群,其在安氏Ⅱ类错(牙合)畸形患者中的患病率显著高于Ⅰ类和Ⅲ类错(牙合)畸形患者。 | Wassim Bouzid 花放 熊晖 热孜万.克衣木 贺红 | 2012 | 中华临床医师杂志(电子版)2012，6，15： | 6 |
| 5 | Extracellular matrix components in peripheral nerve repair:how to affect neural cellular response and nerve regeneration?显示文摘Peripheral nerve injury is a serious problem affecting significantly patients' life.Autografts are the 'gold standard' used to repair the injury gap,however,only 50% of patients fully recover from the trauma.Artificial conduits are a valid alternative to repairing peripheral nerve.They aim at confining the nerve environment throughout the regeneration process,and providing guidance to axon outgrowth.Biocompatible materials have been carefully designed to reduce inflammation and scar tissue formation,but modifications of the inner lumen are still required in order to optimise the scaffolds.Biomicking the native neural tissue with extracellular matrix fillers or coatings showed great promises in repairing longer gaps and extending cell survival.In addition,extracellular matrix molecules provide a platform to further bind growth factors that can be released in the system over time.Alternatively,conduit fillers can be used for cell transplantation at the injury site,reducing the lag time required for endogenous Schwann cells to proliferate and take part in the regeneration process.This review provides an overview on the importance of extracellular matrix molecules in peripheral nerve repair. | Alba C.de Luca Stephanie P.Lacour Wassim Raffoul Pietro G.di Summa | 2014 | Neural Regeneration Research2014，9，22： | 5 |
| 6 | Relationship between VEGFA polymorphisms and serum VEGF protein levels and recurrent spontaneous miscarriage显示文摘 | Wassim Y. Almawi Fabiola Lisa Saldanha Naeema A. Mahmood Intissar Al-Zaman Mai S. Sater Fekria E. Mustafa | 2013 | Human Reproduction2013，，： | 2 |
| 7 | 面向边缘智能的两阶段对抗知识迁移方法显示文摘对抗样本的出现,对深度学习的鲁棒性提出了挑战.随着边缘智能的兴起,如何在计算资源有限的边缘设备上部署鲁棒的精简深度学习模型,是一个有待解决的问题.由于精简模型无法通过常规的对抗训练获得良好的鲁棒性,提出两阶段对抗知识迁移的方法,先将对抗知识从数据向模型迁移,然后将复杂模型获得的对抗知识向精简模型迁移.对抗知识以对抗样本的数据形式蕴含,或以模型决策边界的形式蕴含.具体而言,利用云平台上的GPU集群对复杂模型进行对抗训练,实现对抗知识从数据向模型迁移;利用改进的蒸馏技术将对抗知识进一步从复杂模型向精简模型的迁移,最后提升边缘设备上精简模型的鲁棒性.在MNIST,CIFAR-10和CIFAR-100这3个数据集上进行验证,实验结果表明:提出的这种两阶段对抗知识迁移方法可以有效地提升精简模型的性能和鲁棒性,同时加快训练过程的收敛性. | 钱亚冠 马骏 何念念 王滨 顾钊铨 凌祥 Wassim Swaileh | 2022 | 软件学报2022，33，12： | 2 |
| 8 | An Invariance Principle for Nonlinear Hybrid and Impulsive Dynamical Sys terns 显示文摘 | VIJAY S C SANJAY P B WASSIM M H | 2003 | Nonlinear Analysis2003，53，： | 1 |
| 9 | Diagnosis and treatment of midline prostatic cysts显示文摘 | Hicham A. Moukaddam Maurice C. Haddad Khaled El-Sayyed Wassim Wazzan | 2002 | Clinical Imaging2002，，1： | 1 |
| 10 | Protein Z Variants Associated With Protein Z Plasma Levels and With Risk of Idiopathic Recurrent Miscarriage显示文摘 | Fatima S. Al-Shaikh Mai S. Sater Ramzi R. Finan Eddie Racoubian Tala M. Abu-Hijleh Fekria E. Mustafa Wassim Y. Almawi | 2013 | Reproductive Sciences2013，，9： | 1 |
| 11 | Controller Design with Regional Pole Constraints显示文摘 | Wassim M Haddad Dennis S Bernstein | 1992 | 37 (1) :54 -691992，37，1： | 1 |
| 12 | Large beam-column tests on concrete-filled composite 显示文摘 | Amir Mirmiran Mohsen Shahawy Charle El Khoury Wassim Naguib | 2000 | ACI Structure Journal2000，97，2： | 1 |
| 13 | Middleware for wireless sensor networks:Approaches,challenges,and proiects显示文摘 | Wassim M Zoubir M | 2006 | IEEE Computer Society2006，7，3： | 1 |
| 14 | Creep Modeling for Concrete-filled Steel Tubes显示文摘 | Wassim Naguib Amir Mirmiran | 2003 | Journal of Constructional Steel Reasearch2003，59，13： | 1 |
| 15 | Differential contribution of MTHFR C 677 T variant to the risk of diabetic nephropathy in Lebanese and Bahraini Arabs显示文摘 | Rita Nemr Rabha A. Salman Lamees H. Jawad Eman A. Juma Sose H. Keleshian Wassim Y. Almawi | 2010 | Clinical Chemistry and Laboratory Medicine2010，，8： | 1 |
| 16 | Mixture - of - Experts framework for adaptive kalman filtering显示文摘 | WASSIM S CHEAR ROBERT H Bishop JOYDEEPoydeep Ghosh | 1997 | IEEE Transactions on Systems Man and Cybernetics Part B : Cybernetics1997，27，3： | 1 |
| 17 | The inkjet printing process for Lyocell and cotton fibres, part 1 : the significance of pre- treatment chemicals and their relationship with colour strength, absorbed dye fixation and ink penetration显示文摘 | KAIMOUZ Wassim Ahmad WARDMAN Roger H CHRISTIE Robert M | 2010 | Dyes and Pigments2010，4，： | 1 |
| 18 | Application-layerEnd-to-end Security for Mcommerce显示文摘 | Wassim I Kayssi A | 2004 | Journal of Network and ComputerApplications2004，27，1： | 1 |
| 19 | Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and threedimensional in vitro models显示文摘BACKGROUND Colorectal cancer(CRC) is the second leading cause of cancer-related mortality.Cancer stem cells(CSCs) in CRC, which are spared by many chemotherapeutics,have tumorigenic capacity and are believed to be the reason behind cancer relapse. So far, there have been no effective drugs to target colon CSCs. Diiminoquinone(DIQ) has shown promising effects on targeting colon cancer.However, there is limited research on the effects of DIQ on eradicating CSCs in CRC.AIM To investigate the anticancer potential of DIQ on colon CSCs in two-dimensional(2D) and three-dimensional(3D) models using colonospheres and patient-derived organoids.METHODS Various 2D methods have been used to assess the effect and the mechanism of DIQ on HCT116and HT29 cell lines including cell proliferation and viability assays, migration and invasion assays,immunofluorescence staining, and flow cytometry. The potency of DIQ was also assessed in 3D culture using the sphere formation assay and colon cancer patient-derived organoid model.RESULTS Our results showed that DIQ significantly inhibited cell proliferation, migration, and invasion in HCT116 and HT29 cell lines. DIQ treatment induced apoptosis along with an accumulation of HCT116 and HT29 cancer cells in the sub-G1 region and an increase in reactive oxygen species in both CRC cell lines. DIQ reduced sphere-forming and self-renewal ability of colon cancer HCT116and HT29 stem/progenitor cells at sub-toxic doses of 1 μmol/L. Mechanistically, DIQ targets CSCs by downregulating the main components of stem cell-related-catenin, AKT, and ERK oncogenic signaling pathways. Potently, DIQ displayed a highly significant decrease in both the count and the size of the organoids derived from colon cancer patients as compared to control and 5-fluorouracil conditions.CONCLUSION This study is the first documentation of the molecular mechanism of the novel anticancer therapeutic DIQ via targeting CSC, a promising compound that needs further investigation. | Alissar Monzer Kevork Wakimian Farah Ballout Samar Al Bitar Amani Yehya Mariam Kanso Nour Saheb Ayman Tawil Samer Doughan Maher Hussein Deborah Mukherji Walid Faraj Hala Gali-Muhtasib Wassim Abou-Kheir | 2022 | World Journal of Gastroenterology2022，28，33： | 1 |
| 20 | Robust stabilization for systems with parametric uncertainty and time delay 显示文摘 | Vikram K Wassim M H | 1999 | J of the Franklin Institute1999，336，： | 1 |
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