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| 1 | Role of bile acids in the regulation of the metabolic pathways显示文摘Recent studies have revealed that bile acids(BAs)are not only facilitators of dietary lipid absorption but also important signaling molecules exerting multiple physiological functions.Some major signaling pathways involving the nuclear BAs receptor farnesoid X receptor and the G protein-coupled BAs receptor TGR5/M-BAR have been identified to be the targets of BAs.BAs regulate their own homeostasis via signaling pathways.BAs also affect diverse metabolic pathways including glucose metabolism,lipid metabolism and energy expenditure.This paper suggests the mechanism of controlling metabolism via BA signaling and demonstrates that BA signaling is an attractive therapeutic target of the metabolic syndrome. | Hiroki Taoka Yoko Yokoyama Kohkichi Morimoto Naho Kitamura Tatsuya Tanigaki Yoko Takashina Kazuo Tsubota Mitsuhiro Watanabe | 2016 | World Journal of Diabetes2016，7，13： | 11 |
| 2 | Short-type single balloon enteroscope for endoscopic retrograde cholangiopancreatography with altered gastrointestinal anatomy显示文摘AIM:To evaluate the effectiveness of a short-type single-balloon-enteroscope(SBE) for endoscopic retrograde cholangiopancreatography(ERCP) in patients with a reconstructed intestine.METHODS:Short-type SBE was developed to perform ERCP in postoperative patients with a reconstructed intestine.Short-type SBE is a direct-viewing endoscope with the following specifications:working length,1520 mm;total length,1840 mm;channel diameter,3.2 mm.In addition,short-type SBE has a water-jet channel.The study group comprised 22 patients who underwent 31 sessions of short-type SBE-assisted ERCP from June 2011 through May 2012.Reconstruction was performed by Billroth-Ⅱ(B-Ⅱ) gastrectomy in 6 patients(8 sessions),Roux-en-Y(R-Y) gastrectomy in 14 patients(21 sessions),and R-Y hepaticojejunostomy in 2 patients(2 sessions).We retrospectively studied the rate of reaching the blind end(papilla of Vater or choledochojejunal anastomosis),mean time required to reach the blind end,diagnostic success rate(defined as the rate of successfully imaging the bile and pancreatic ducts),therapeutic success rate(defined as the rate of successfully completing endoscopic treatment),mean procedure time,and complications.RESULTS:Among the 31 sessions of ERCP,the rate of reaching the blind end was 88% in B-Ⅱ gastrectomy,91% in R-Y gastrectomy,and 100% in R-Y hepaticojejunostomy.The mean time required to reach the papilla was 18.3 min in B-Ⅱ gastrectomy,21.1 min in R-Y gastrectomy,and 32.5 min in R-Y hepaticojejunostomy.The diagnostic success rates in all patients and those with an intact papilla were respectively 86% and 86% in B-Ⅱ gastrectomy,90% and 87% in R-Y gastrectomy,and 100% in R-Y hepaticojejunostomy.The therapeutic success rates in all patients and those with an intact papilla were respectively 100% and 100% in B-Ⅱ gastrectomy,94% and 92% in R-Y gastrectomy,and 100% in R-Y hepaticojejunostomy.Because the channel diameter was 3.2 mm,stone extraction could be performed with a wire-guided basket in 12 sessions,and wireguided intraductal ultrasonography could be performed in 8 sessions.As for complications,hyperamylasemia(defined as a rise in serum amylase levels to more than 3 times the upper limit of normal) occurred in 1 patient(7 sessions) with a B-Ⅱ gastrectomy and 4 patients(19 sessions) with an R-Y gastrectomy.After ERCP in patients with an R-Y gastrectomy,2 patients(19 sessions) had pancreatitis,1 patient(21 sessions) had gastrointestinal perforation,and 1 patient(19 sessions) had papillary bleeding.Pancreatitis and bleeding were both mild.Gastrointestinal perforation improved after conservative treatment.CONCLUSION:Short-type SBE is effective for ERCP in patients with a reconstructed intestine and allows most conventional ERCP devices to be used. | Hiroshi Yamauchi Mitsuhiro Kida Kosuke Okuwaki Shiro Miyazawa Tomohisa Iwai Miyoko Takezawa Hidehiko Kikuchi Maya Watanabe Hiroshi Imaizumi Wasaburo Koizumi | 2013 | World Journal of Gastroenterology2013，19，11： | 10 |
| 3 | Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonists on gastrointestinal motor activity in dogs显示文摘AIM:To study the effects of 5-hydroxytryptamine(5-HT)receptor antagonists on normal colonic motor activity in conscious dogs.METHODS:Colonic motor activity was recorded using a strain gauge force transducer in 5 dogs before and after 5-HT2B,5-HT3 and 5-HT4 receptor antagonist administration.The force transducers were implanted on the serosal surfaces of the gastric antrum,terminal ileum,ileocecal sphincter and colon.Test materials or vehicle alone was administered as an intravenous bolus injection during a quiescent period of the whole colon in the interdigestive state.The effects of these receptor antagonists on normal gastrointestinal motor activity were analyzed.RESULTS:5-HT2B,5-HT3 and 5-HT4 receptor antagonists had no contractile effect on the fasting canine terminal ileum.The 5-HT3 and 5-HT4 receptor antagonists inhibited phaseⅢof the interdigestive motor complex of the antrum and significantly inhibited colonic motor activity.In the proximal colon,the inhibitory effect was dose dependent.Dose dependency,however,was not observed in the distal colon.The 5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity.CONCLUSION:The 5-HT3 and 5-HT4 receptor antagonists inhibited normal colonic motor activity.The5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity. | Hiroki Morita Erito Mochiki Nobuyuki Takahashi Kiyoshi Kawamura Akira Watanabe Toshinaga Sutou Atsushi Ogawa Mitsuhiro Yanai Kyoichi Ogata Takaaki Fujii Tetsuro Ohno Souichi Tsutsumi Takayuki Asao Hiroyuki Kuwano | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 4 | Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis显示文摘 | Anakk Sayeepriyadarshini Watanabe Mitsuhiro Ochsner Scott A McKenna Neil J Finegold Milton J Moore David D | 2011 | Journal of Clinical Investigation2011，，1： | 2 |
| 5 | Relation Between Plasma Adiponectin, High-Sensitivity C-Reactive Protein, and Coronary Plaque Components in Patients With Acute Coronary Syndrome显示文摘 | Hiromasa Otake Junya Shite Toshiro Shinke Satoshi Watanabe Yusuke Tanino Daisuke Ogasawara Takahiro Sawada Ken-ichi Hirata Mitsuhiro Yokoyama | 2008 | The American Journal of Cardiology2008，，1： | 1 |
| 6 | Improvement of oxygen barrier of PET film with diamond-like carbon film by plasma-source ion implantation显示文摘 | Mitsuhiro Yoshid Takeshi Tanaka Satoshi Watanabe | 2003 | Surface and Coatings Technology2003，，17： | 1 |
| 7 | Feasibility of gastric endoscopic submucosal dissection in elderly patients aged≥80 years显示文摘BACKGROUND Endoscopic resection,especially endoscopic submucosal dissection(ESD),is increasingly performed in elderly patients with early gastric cancer,and lesions beyond the expanded indications are also resected endoscopically in some patients.It is essential to assess whether gastric ESD is safe and suitable for elderly patients and investigate what type of lesions carry an increased risk of ESD-related complications.AIM To assess the efficacy and feasibility of gastric ESD for elderly patients,and define high-risk lesions and prognostic indicators.METHODS Among a total of 1169 sessions of gastric ESD performed in Kanagawa Cancer Center Hospital from 2006 to 2014,179 sessions(15.3%)were performed in patients aged≥80 years,and 172 of these sessions were done in patients with a final diagnosis of gastric cancer.These patients were studied retrospectively to evaluate short-term outcomes and survival.The short-term outcomes included the rates of en bloc resection and curative resection,complications,and procedurerelated mortality.Curability was assessed according to the Japanese Gastric Cancer Treatment Guidelines 2010.Fisher’s exact test was used to statistically analyze risk factors.Clinical characteristics of each group were compared using Fisher’s exact test and Mann-Whitney U test.Survival rates at each time point were based on Kaplan-Meier estimation.Overall survival rates were compared between patients with gastric cancer in each group with use of the log-rank test.To identify prognostic factors that jointly predict the hazard of death while controlling for model overfitting,we used the least absolute shrinkage and selection operator(LASSO)Cox regression model including factors curative/noncurative,age,gender,body mass index,prognostic nutritional index,Charlson comorbidity index(CCI),Glasgow prognostic score,neutrophil-to-lymphocyte ratio,and antithrombotic agent use.We selected the LASSO Cox regression model that resulted in minimal prediction error in 10-fold cross-validation.P<0.05 was considered statistically significant.RESULTS The en bloc dissection rate was 97.1%,indicating that a high quality of treatment was achieved even in elderly patients.As for complications,the rates of bleeding,perforation and aspiration pneumonitis were 3.4%,1.1%and 0.6%,respectively.These complication rates indicated that ESD was not associated with a particularly higher risk in elderly patients than in nonelderly patients.A dissection incision>40 mm,lesions associated with depressions,and lesions with ulcers were risk factors for post-ESD bleeding,and location of the lesion in the upper third of the stomach was a risk factor for perforation in elderly patients(P<0.05).Location of the lesion in the lower third of the stomach tended to be associated with a higher risk of bleeding.The overall survival(OS)did not differ significantly between curative and noncurative ESD(P=0.69).In patients without additional surgery,OS rate was significantly lower in patients with a high CCI(≥2)than in those with a low CCI(≤1)(P<0.001).CONCLUSION Gastric ESD is feasible even in patients aged≥80 years.Observation without additional surgery after noncurative ESD is reasonable,especially in elderly patients with CCI≥2. | Yasuhiro Inokuchi Ayaka Ishida Kei Hayashi Yoshihiro Kaneta Hayato Watanabe Kazuki Kano Mitsuhiro Furuta Kosuke Takahashi Hirohito Fujikawa Takanobu Yamada Kouji Yamamoto Nozomu Machida Takashi Ogata Takashi Oshima Shin Maeda | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，1： | 1 |
| 8 | Microstructureand joint strength of friction stir spot welded 6022 aluminum alloysheets and plated steel sheets 显示文摘 | Feng Keyan Watanabe Mitsuhiro Kumai Shinji | 2011 | Journal of the Japan Institute ofLight Metals2011，61，9： | 1 |
| 9 | Improvement of oxygen barrier of PET film with diamond-like carbon film by plasma-source ion implantation显示文摘 | Mitsuhiro Yoshid Takeshi Tanaka Satoshi Watanabe Masaru Shinohara Jong-Wan Lee Toshinori Takagi | 2003 | Surface and Coatings Technology2003，，17： | 1 |
| 10 | Comparison of 2D and 3D carbon/carbon composites with respect to damage and fracture resistance 显示文摘 | Mohamed S Hiroshi Hattab Shuichi Wakayamaa Mitsuhiro Watanabe Kiyoshi Miyagawa | 2003 | Carbon2003，，41： | 1 |
| 11 | Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation显示文摘 | Watanabe Mitsuhiro Houten Sander M Mataki Chikage | 2006 | Nature2006，439，7075： | 1 |
| 12 | Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis显示文摘 | Mika Watanabe Jun Kato Izumi Inoue Noriko Yoshimura Takeichi Yoshida Chizu Mukoubayashi Hisanobu Deguchi Shotaro Enomoto Kazuki Ueda Takao Maekita Mikitaka Iguchi Hideyuki Tamai Hirotoshi Utsunomiya Nobutake Yamamichi Mitsuhiro Fujishiro Masataka Iwane Ta | 2012 | Int J Cancer2012，，11： | 1 |
| 13 | Preparation of activated carbon from petroleum coke by KOH chemical activation for adsorption heat pump显示文摘 | Takayuki Kawano Mitsuhiro Kubota Maurice S. Onyango Fujio Watanabe Hitoki Matsuda | 2007 | Applied Thermal Engineering2007，，8： | 1 |
| 14 | Primary Hepatic Leiomyosarcoma in a Woman After Renal Transplantation: Report of a Case显示文摘 | Hideto Fujita Masato Kiriyama Taiichi Kawamura Toru Ii Shigeru Takegawa Shotaro Dohba Yasuhiko Kojima Mitsuhiro Yoshimura Akihiko Kobayashi Satoru Ozaki Kishichiro Watanabe | 2002 | Surgery Today2002，，5： | 1 |
| 15 | Spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein: techniques and its significance显示文摘 | Wataru Kimura Mitsuhiro Yano Shuichiro Sugawara Shinji Okazaki Tamie Sato Toshiyuki Moriya Toshihiro Watanabe Hiroto Fujimoto Koji Tezuka Akiko Takeshita Ichiro Hirai | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，6： | 1 |
| 16 | Comparison of 2D and 3D carbon/carbon composites with respect to damage and fracture resistance显示文摘 | Mohamed S Aly-Hassan Hiroshi Hatta Shuichi Wakayama Mitsuhiro Watanabe Kiyoshi Miyagawa | 2002 | Carbon2002，，5： | 1 |
| 17 | Pore structure and water adsorptivity of petroleum coke-derived activated carbon for adsorption heat pump–Influence of hydrogen content of coke显示文摘 | Mitsuhiro Kubota Tatsuya Ito Fujio Watanabe Hitoki Matsuda | 2011 | Applied Thermal Engineering2011，，8： | 1 |
| 18 | Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer显示文摘 | Takeichi Yoshida Jun Kato Izumi Inoue Noriko Yoshimura Hisanobu Deguchi Chizu Mukoubayashi Masashi Oka Mika Watanabe Shotaro Enomoto Toru Niwa Takao Maekita Mikitaka Iguchi Hideyuki Tamai Hirotoshi Utsunomiya Nobutake Yamamichi Mitsuhiro Fujishiro Masatak | | Int J Cancer0，，6： | 1 |
| 19 | Relation Between Plasma Adiponectin, High-Sensitivity C-Reactive Protein, and Coronary Plaque Components in Patients With Acute Coronary Syndrome显示文摘 | Hiromasa Otake Junya Shite Toshiro Shinke Satoshi Watanabe Yusuke Tanino Daisuke Ogasawara Takahiro Sawada Ken-ichi Hirata Mitsuhiro Yokoyama | 2008 | The American Journal of Cardiology2008，，1： | 1 |
| 20 | Brown slits for colorectal adenoma crypts on conventional magnifying endoscopy with narrow band imaging using the X1 system显示文摘BACKGROUND Accurate diagnosis of colorectal premalignant polyps,including adenomas,is vital in clinical practice.AIM To investigate the diagnostic yields of novel findings of brown slits for adenomas.METHODS Patients who underwent colonoscopy at the Toyoshima Endoscopy Clinic were enrolled.Polyps sized≥5 mm suspected of adenomas or clinically significant serrated polyps were included in the study.We defined the surface structures of colorectal polyps,which were brown curves inside and along the tubular glands identified using a combination of a new X1 system(Olympus Corporation)and a conventional magnifying colonoscope with non-staining narrow band imaging(NBI),as brown slits.The brown slits corresponded to slit-like lumens on endocytoscopy and histological crypt openings of an adenoma.We evaluated the diagnostic performance of brown slits for adenoma.RESULTS A total of 108 Lesions from 62 patients were eligible.The average age was 60.4 years and 41.9%were male.The mean polyp size was 7.45±2.83 mm.Fifty-seven lesions were positive for brown slits.Histopathological diagnosis comprised 59 low-grade tubular adenomas,16 sessile serrated lesions,and 33 hyperplastic polyps.Among 59 adenomas,56(94.9%)were positive for brown slits.Among 16 sessile serrated lesions,0(0%)was positive for brown slits.Among 33 hyperplastic polyps,1(3.0%)was positive for brown slits.The sensitivity,specificity,and accuracy of brown slits for adenoma were 94.9%,98.0%,and 96.3%,respectively.The positive predictive value and negative predictive value of brown slits for adenoma were also excellent for 98.2%,and 94.1%,respectively.CONCLUSION Brown slits on conventional magnifying endoscopy with non-staining NBI using the X1 system were useful for diagnosing colorectal adenoma.The new endoscopy system could be examined using new standards. | Osamu Toyoshima Toshihiro Nishizawa Shuntaro Yoshida Hidenobu Watanabe Nariaki Odawara Kosuke Sakitani Toru Arano Hirotoshi Takiyama Hideyuki Kobayashi Hirofumi Kogure Mitsuhiro Fujishiro | 2022 | World Journal of Gastroenterology2022，28，24： | 1 |
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