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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Environmental fate of triclosan in the River Aire Basin, UK 显示文摘 | Sabaliunas D Webb S F Hauk A | 2003 | WaterResearch2003，37，13： | 1 |
| 3 | Selective NMDA NR2B antagonists induce antinociception without motor dysfunc- tion: correlation with restricted localisation of NR2B subu- nit in dorsal horn 显示文摘 | Boyce S Wyatt A Webb JK | 1999 | Neuropharmacology1999，38，5： | 1 |
| 4 | Potent im- munogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: receptor binding is essentialand induces differential modulation of lymphocyte sub- sets显示文摘 | Nashar T O Webb S Eaglestone N A | 1996 | Proc Natl Acad Sci USA1996，9，1： | 1 |
| 5 | Rhythms in pineal immunoreactive somatostatin in the Syrian hamster, mouse and gerbil 显示文摘 | Webb S M Peinado M A Puig-Domingo M | 1988 | J Pineal Res1988，5，3： | 1 |
| 6 | Evaporation control of monomers from solventless resin composltions显示文摘 | Schroeter S H Bolon D A Webb K K | 1977 | Radiation Physics and Chemistry1977，14，36： | 1 |
| 7 | Structm and evolutionary implication of a'cysteine-rich'Campoletis sonorensis polydnavirus gene family Proc显示文摘 | Dib-Hajj S D Webb B A Summer M D | 1993 | Natl Acad Sci1993，90，： | 1 |
| 8 | Early revascularization in acute myocardial infarction complicated by cardiogenic shock显示文摘 | HOCHMAN J S SLEEPER L A WEBB J G | 1999 | N Eng J Med1999，341，： | 1 |
| 9 | The isolation and map ping of disease resistance gene analogs in maize 显示文摘 | Collins N C Webb C A Seah S etal | 1998 | Molecu- lar Plant Microbe Interact1998，11，： | 1 |
| 10 | Building Corporate Associations:Consumer Attributions for Corporate Socially Responsible Programs 显示文摘 | Ellen P S Webb D J Mohr L A | 2006 | Journal of the Academy of Marketing Science2006，34，2： | 1 |
| 11 | Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease 显示文摘 | O'Donnell D E Revill S M Webb K A | 2001 | Am J Respir Crit Care Med2001，164，5： | 1 |
| 12 | Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite 显示文摘 | Webb A J Patel N Loukogeorgakis S | 2008 | Hypertension2008，51，： | 1 |
| 13 | Displacement sensor using channelled spectrum dispersed on a linear CCD array显示文摘 | TAPLIN S PODOLEANU A GH WEBB D J | 1993 | Electronics Letters1993，29，10： | 1 |
| 14 | Resistance gene complexes: evolution and utilization显示文摘 | HULBERT S H WEBB C A SMITH S M SUN Q | 2001 | Annual Review of Phytopathology2001，39，： | 1 |
| 15 | Early goal-directed therapy of septic shock: we honestly remain skeptical显示文摘 | Peake S Webb S Delaney A | 2007 | Crit Care Med2007，35，7： | 1 |
| 16 | Shivering during epidural analgesia in women in labor显示文摘 | Webb P J James F M Wheeler A S | | 0，，06： | 1 |
| 17 | Resistance gene complexes:Evolution and utilization显示文摘 | Hulbert S H Webb C A Smith S M Sun Q | | 0，，： | 1 |
| 18 | Resistance gene complexes:evolution and utilization 显示文摘 | HULBERT S H WEBB C A SMITH S M | 2001 | Annu Rev Phyto-pathol2001，39，： | 1 |
| 19 | Arsenic localization, speciation, and with iron on rice (Oryza sativa L) roots having variable Fe coatings显示文摘 | Seyfferth A L Webb S M Andrews J C | 2010 | Environmental Science & Technology2010，44，21： | 1 |
| 20 | Development of the murine pulmonary vein and its relationship to the embryonic venous sinus显示文摘 | Webb S Brown NA Wessels A | 1998 | Anat Rec1998，250，3： | 1 |
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