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| 1 | Bystin-like protein is upregulated in hepatocellular carcinoma and required for nucleologenesis in cancer cell proliferation显示文摘象 bystin 一样(BYSL ) 基因以前被描绘为参予早胚胎培植的房间粘附编码附件蛋白质。它也涉及 40S ribosomal 子单元生物的续生说并且被发现在很快种胚胎和癌症房间线被表示。以便在癌症房间增长和生长探索 BYSL 的角色,我们把 hepatocellular 癌(HCC ) 用作一个模型。这里,我们报导 BYSL 在 vitro 并且在 vivo 为 HCC 房间生长是关键的。在人的 HCC 标本的 BYSL mRNA 和蛋白质的表示层次显著地与在邻近的非癌的织物看见的那些相比被增加。在 vitro,由短发卡 RNA 的 BYSL 的抑制减少了 HCC 房间增长,导致了 apoptosis 并且部分在 G2/M 阶段逮捕了房间周期。在 vivo,与 BYSL siRNA 对待的 HCC 房间没能在下的培植以后在裸体老鼠形成肿瘤。为了为 BYSL 导致 RNAi 的细胞生长决定细胞的基础,逮捕, BYSL subcellular 本地化在有丝分裂并且分裂期间 HepG2 细胞被检验。BYSL 在 nucleologenesis 期间在多重阶段是在场的,在导出核的 foci (NDF ) 包括, perichromosomal 区域和 prenucleolar 身体(PNB ) 在有丝分裂期间。BYSL 弄空显著地压制了 NDF 和 PNB 形成,并且在有丝分裂以后破坏了 nucleoli 汇编,导致增加的 apoptosis 和到浆液饥饿的 HCC 房间的减少的忍耐。一起拿,我们的研究显示那 upregulated BYSL 表情在 hepatocarcinogenesis 起一个作用。 | Hanzhi Wang Wei Xiao Qinbo Zhou Yun Chen Shuo Yang Jiansong Sheng Yanqing Yin Jia Fan Jiawei Zhou | 2009 | Cell Research2009，19，10： | 5 |
| 2 | Preparation of polymer brushes on attapulgite surfaces via a combination of CROP and click reaction显示文摘In this work,by a combination of controlled ring-opening polymerization(CROP) and click reaction,we reported a facile and useful method to synthesize linear poly(ε-caprolactone) at attapulgite nanocomposites with well-defined structures.For this,first, the chlorine terminated attapulgite was prepared by the self-assembly of 3-chloropropyltrimethoxysiIane from the surfaces of attapulgite.And then,the terminal chlorines of modified attapulgite were substituted with azido groups.As the second step,linear pr... | Chen, Jiu Cun Wang, Yun Pu Wang, Hao Dong Wei, Shuo Yun Li, Hong Jun Yan, Xiao Dong | 2010 | Chinese Chemical Letters2010，21，4： | 1 |
| 3 | A positive role for polycomb in transcriptional regulation via H4K20mel显示文摘 | Xiangdong Lv Zhijun Han Hao Chen Bo Yang Xiaofeng Yang Yuanxin Xia Chenyu Pan Lin Fu Shuo Zhang Hui Han Min Wu Zhaocai Zhou Lei Zhang Lin Li Gang Wei Yun Zhao | 2016 | Cell Research2016，26，5： | 0 |
| 4 | STUDIES ON THE CHEMICAL CONSTITUENTS OF TAXUS CUSPIDATA显示文摘From the methylene chloride extract of the leaves and stems of Taxuscuspidata Sieb et Zucc twelve taxane diterpenoids have been afforded.The structuresof two novel taxane diterpenes,named 10-deacetyltaxinine B(1)and taxacustin(2)were characterized by spectroscopic techniques and X-ray diffraction analysis. | Xiao Jie Tong Wei Shuo Fang Jin Yun Zhou Cun Heng He Wei Ming Chen Qi Cheng Fang Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050 | 1993 | Chinese Chemical Letters1993，4，10： | 0 |
| 5 | A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation显示文摘 | Xiaofeng Shi Rong Ba Haiyan You Qian Jiang Jiansong Huang Jianhua Mao Lanxiu Han Shuo Zhang Qin Zhuang Xianqiu Yu Lixia Wang Yun Wang Dongya Li Wei Zhu Yong Zhang Yan Zhu Xiaodong Xi | 2018 | Frontiers of Medicine2018，12，3： | 0 |
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