|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 2 | Outcomes and possible risk factors associated with axis alignment and rotational stability after implantation of the Toric implantable collamer lens for high myopic astigmatism显示文摘·AIM:To assess the visual outcomes and possible risk factors associated with axis alignment and rotational stability after implantation of Toric implantable collamer lens (TICL) for the correction of high myopic astigmatism. ·METHODS:In this prospective, nonrandomized clinical study, 54 consecutive eyes of 29 patients with high myopic astigmatism received TICL implantation. To evaluate postoperative axis deviation from the intended axis, a digital anterior segment photograph was taken. The ultrasound biomicroscopy(UBM) was used to observe footplate-position. ·RESULTS:After mean follow-up of 8.6 months, mean manifest refractive cylinder (MRC) decreased 79.3% from (-1.88±1.49)D preoperatively to (0.39±0.61)D postoperatively. MRC within 1.00D occurred in 68.5% (37/54) of eyes, whereas 48.1% (26/54) had MRC within 0.50D. Mean manifest refraction spherical equivalent (MRSE) changed from (-12.08±4.22)D preoperatively to (-0.41±0.61)D postoperatively. Uncorrected binocular vision of 20/20 or better occurred in 72.2%(39/54) of patients compared with binocular best-corrected visual acuity (BCVA) of 20/20 or better in 44.4% (24/54) preoperatively. The mean difference between intended and achieved TICL axes was (6.96±8.37)°. Footplates of TICLs were in the ciliary sulcus in 22 eyes (46.3%), below the ciliary sulcus in 32 eyes (53.7%). The angle of TICL rotation had significant correlation with the footplates-position (t =2.127; P =0.045) and the postoperative TICL vaulting (r =-0.516; P =0.000). ·CONCLUSION:The results of our study further support the safety, efficacy and predictability of TICL for the correct high myopic astigmatism. The footplate-position of TICL and vault value should be taken into consideration as two possible risks factors for TICL rotation. | Xun-Lun Sheng, De-Jun Zhu | 2012 | International Journal of Ophthalmology(English edition)2012，5，4： | 19 |
| 3 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 4 | Acupuncture treatment of lung-spleen Qi deficiency in stable chronic obstructive pulmonary disease: a randomized, open-label, controlled trial显示文摘OBJECTIVE:To evaluate the effectiveness and safety of acupuncture that reinforces the spleen to strengthen the lung in patients with stable chronic obstructive pulmonary disease(COPD).METHODS:This was a randomized,open-controlled trial in which the acupuncturist and the participants were not blinded,but the outcome evalu-ators and data analysts were blinded.One-hundred-and-two patients with stable COPD were randomly divided into two groups in a 1∶1 ratio.The acupuncture group received 30-minute sessions of acupuncture therapy at the same acupoints three times weekly for 6 weeks in addition to routine conventional Western Medicine treatment;the control group received routine conventional Western Medicine treatment alone.The primary outcome was the Borg scale score,which was assessed immediately after the 6-minute walk test.The secondary outcomes were the 6-minute walk distance,lung function,and oxygen saturation.Measurements were obtained at baseline and after 6 weeks of treatment.RESULTS:After 6 weeks of treatment,the Borg scale score in the acupuncture group was significantly better than that in the control group(2.02±0.71 versus 5.01±0.34,P<0.05).Furthermore,the post-treatment improvements in the 6-minute walk distance,lung function,and oxygen saturation were significantly greater in the acupuncture group than in the control group,showing that the acupuncture group had better exercise tolerance.CONCLUSION:The findings suggest that acupuncture that aims to reinforce the spleen to strengthen the lung is a safe and effective adjuvant therapy that effectively improves the exercise capacity of patients with stable COPD. | Li Yu Xiong Chan Zeng Yan Wei Hua Zhuang Guangtong Zhao Lihong Li Chenyi Li Lin Qin Erqi Chen Xiaoqin Fu Juanjuan | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 13 |
| 5 | The role of autophagy in sensitizing malignant glioma cells to radiation therapy显示文摘恶意的 gliomas 代表主要大脑肿瘤的多数。为恶意的 gliomas 的当前的标准处理包括外科的切除术,放射治疗,和化疗。放射疗法,标准辅助治疗,授与 glioma 房间的一些幸存优点,而是电阻到放射限制的功效处理的成功。位于 glioma 房间辐射抵抗下面的机制留下了逃犯。Autophagy 是双膜泡的突出的形成在细胞质描绘的一个蛋白质降级系统。最近的研究建议 autophagy 可能在癌症开发和前进的规定并且在决定肿瘤房间的反应到 anticancer 治疗是重要的。另外, autophagy 是到电离的 glioma 房间的新奇回答放射。Autophagic 房间死亡被考虑类型 II 规划了房间死亡,而 apoptosis 被规划房间死亡类型我。房间死亡的这二种类型是主要特殊的,但是许多研究表明在他们之间的串音。在癌症房间的 autophagy 是否引起死亡或保护房间,是争论的。autophagy 的规章的小径分享几个分子。PI3K/Akt/mTOR, DNA-PK,肿瘤 suppressor 基因, mitochondrial 损坏,和 lysosome 可以在 glioma 房间在导致放射的 autophagy 起重要作用。最近,一高度 tumorigenic glioma 肿瘤 subpopulation,称为的癌症干细胞或开始肿瘤的房间,被显示了支持治疗学的抵抗。这评论总结在恶意的 glioma 房间与导致放射的 autophagy 联系的主要调停人并且为大脑肿瘤为未来治疗的发展讨论癌症干细胞假设的含意。 | Wenzhuo Zhuang Zhenghong Qin Zhongqin Liang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 12 |
| 6 | Molecular Mapping of Three Loci Conferring Resistance to Maize (Zea mays L.) Rough Dwarf Disease显示文摘Maize rough dwarf disease (MRDD) is a viral disease that is widely distributed in the world and causes great losses in grain yield. During the past three decades, considerable progress has been made in the | F. Wang Y.S. Zhang Y.L. Zhuang G.Z. Qin J.R. Zhang | 2007 | 分子植物育种2007，5，2： | 10 |
| 7 | Effectiveness of Traditional Chinese Medicine on chemo-radiotherapy induced leukaemia in patients with lung cancer:a Meta-analysis显示文摘OBJECTIVE: To assess the curative effect of Traditional Chinese Medicine(TCM) on leukopenia induced by chemo-radiotherapy in patients with lung cancer.METHODS: A comprehensive electronic search in Medline, Embase, the Cochrane Libary database,China National Knowledge Infrastructure Database(CNKI) and Wanfang Database was conducted up to July 2017. Random-effects model was used to estimate the standardized mean differences(SMDs)with 95% confidence intervals(CIs). Eleven studies with a total of 957 patients were included in this meta-analysis.RESULTS: The effectiveness in TCM group was higher than control group [RR = 1.60, 95% CI(1.38, 1.85),P < 0.000 01]. Compare with Western Medicinegroup, the effectiveness has no significant difference [RR = 0.96, 95% CI(0.82, 1.12), P = 0.57]. The ineffective rate in test group was lower than the control group [RR = 0.30, 95% CI(0.21, 0.42), P < 0.00001].CONCLUSION: By meta-regression it was suggested that TCM has curative effect on leukopenia induced by chemo-radiotherapy in patients with lung cancer, but by the influence of number and quality of researches, publication bias, more evidence from high quality studies, and larger cohorts for observational trials are needed. | Li Yu Xiong Chan Qin Erqi Li Lin Zhuang Guangtong Yu Zheng | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 9 |
| 8 | Corrosion behavior of the friction-stir-welded joints of 2A14-T6 aluminum alloy显示文摘The corrosion behavior of friction-stir-welded 2A14-T6 aluminum alloy was investigated by immersion testing in immersion exfoliation corrosion(EXCO) solution. Electrochemical measurements(open circuit potential, potentiodynamic polarization curves, and electrochemical impedance spectroscopy), scanning electron microscopy, and energy dispersive spectroscopy were employed for analyzing the corrosion mechanism. The results show that, compared to the base material, the corrosion resistance of the friction-stir welds is greatly improved, and the weld nugget has the highest corrosion resistance. The pitting susceptibility originates from the edge of Al-Cu-Fe-Mn-Si phase particles as the cathode compared to the matrix due to their high self-corrosion potential. No corrosion activity is observed around the θ phase(Al2Cu) after 2 h of immersion in EXCO solution. | Hai-long Qin Hua Zhang Da-tong Sun Qian-yu Zhuang | 2015 | International Journal of Minerals,Metallurgy and Materials2015，22，6： | 9 |
| 9 | Analysis of In-hospital Neonatal Death in the Tertiary Neonatal Intensive Care Unit in China: A Multicenter Retrospective Study显示文摘 | Chen-Hong Wang Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Xiao-Mei Tong Hong Liu Guo-Fang Ding Bin Yi Xin-Nian Pan Dan-Ni Zhong Ling Liu Mei Li Cui-Qing Li Shi-Wen Xia Hong-Yun Wang Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Ruo-Bing Shan De-Zhi Mu Xiao-Hong Liu Si-Qi Zhuang Jing Guo Li Liu Jia-Jun Zhu Hong Xiong | 2016 | Chinese Medical Journal2016，，22： | 8 |
| 10 | The enhanced permeability and retention effect based nanomedicine at the site of injury显示文摘The enhanced permeability retention(EPR)effect based nanomedicine has been widely used for tumor targeting during the past decades.Here we unexpectedly observed the similar'EPR effect'at the site of iniury.We found that the temporary dilated and leaky blood vessels caused by the potent vasodilator histamine in response to injury allowed the injected nanoparticles to pass through the vasculature and reached the injured tissue.Our finding shows the potential underline mechanism of'EPR effect'at the injured site.By loading with antibiotics,we further demonstrated a new strategy for prevention of infection at the site of injury. | Yingjun Liu Dongdong Sun Qin Fan Qingle Ma Ziliang Dong Weiwei Tao Huiquan Tao Zhuang Liu Chao Wang | 2020 | Nano Research2020，13，2： | 6 |
| 11 | Cobalt-catalyzed Photochemical Methoxycarbonylation of Olefins with Carbon Dioxide under Ambient Conditions显示文摘The methoxycarbonylations of cyclohexene and 1-decene with CO2 can take place under ambient conditions by catalysis of [Co]([Co]=Co(acac)2. Co(OAc)2. CoCl2 ) in the presence of ultraviolet irradiation. | Jing Mei YIN Ming GUO Rui WANG Guang Yun ZHOU Da Bin GAO Xiang Sheng WANG Xin Wen GUO Jian Qin ZHUANG | 2000 | Chinese Chemical Letters2000，11，3： | 5 |
| 12 | Geological Controls on the CBM Productivity of No.15 Coal Seam of Carboniferous–Permian Taiyuan Formation in Southern Qinshui Basin and Prediction for CBM High-yield Potential Regions显示文摘Coalbed methane(CBM) resources in No.15 coal seam of Taiyuan Formation account for 55% of the total CBM resources in southern Qinshui Basin(SQB), and have a great production potential. This study aims at investigating the CBM production in No.15 coal seam and its influence factors. Based on a series of laboratory experiments and latest exploration and development data from local coal mines and CBM companies, the spatial characteristics of gas production of No.15 coal seam were analyzed and then the influences of seven factors on the gas productivity of this coal seam were discussed, including coal thickness, burial depth, gas content, ratio of critical desorption pressure to original coal reservoir pressure(RCPOP), porosity, permeability, and hydrogeological condition. The influences of hydrological condition on CBM production were analyzed based on the discussions of four aspects: hydrogeochemistry, roof lithology and its distribution, hydrodynamic field of groundwater, and recharge rate of groundwater. Finally, a three-level analytic hierarchy process(AHP) evaluation model was proposed for predicting the CBM potentials of the No.15 coal seam in the SQB. The best prospective target area for CBM production of the No.15 coal seam is predicted to be in the districts of Panzhuang, Chengzhuang and south of Hudi. | ZHANG Zheng QIN Yong ZHUANG Xinguo LI Guoqing LIU Donghai | 2018 | Acta Geologica Sinica(English Edition)2018，92，6： | 5 |
| 13 | Immune checkpoint inhibitor for hepatocellular carcinoma recurrence after liver transplantation显示文摘To the Editor:Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-related death globally.Hepatocellular carcinoma(HCC)accounts for 90%of primary liver cancers with the highest incidence in China(more than 50%of all cases worldwide)[1].Liver transplantation(LT)is regarded as an optimal therapy for selected HCC patients.The Milan criteria are the benchmark for candidate selection that ensure excellent prognosis for patients with HCC[2].The Hangzhou criteria expand 51.5%more of Milan criteria for LT candidates with comparable posttransplant survivals[3].However,LT recipients fulfilling Milan criteria or Hangzhou criteria are at the risk of up to 13%−18%HCC recurrence rate within five years[4].Only 25%−50%of recurrent HCC patients post-LT are eligible for surgical treatment which have consistently presented favored survival benefit than systemic therapy[5]. | Li Zhuang Hai-Bo Mou Lan-Fang Yu Heng-Kai Zhu Zhe Yang Qin Liao Shu-Sen Zheng | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 4 |
| 14 | Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia(2021 Edition)显示文摘Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Transurethral plasmakinetic resection of prostate (TUPKP) is one of the foremost surgical procedures for the treatment of BPH. It has become well established in clinical practice with good efficacy and safety. In 2018, we issued the guideline “2018 Standard Edition”. However much new direct evidence has now emerged and this may change some of previous recommendations. The time is ripe to develop new evidence-based guidelines, so we formed a working group of clinical experts and methodologists. The steering group members posed 31 questions relevant to the management of TUPKP for BPH covering the following areas: questions relevant to the perioperative period (preoperative, intraoperative, and postoperative) of TUPKP in the treatment of BPH, postoperative complications and the level of surgeons’ surgical skill. We searched the literature for direct evidence on the management of TUPKP for BPH, and assessed its certainty generated recommendations using the grade criteria by the European Association of Urology. Recommendations were either strong or weak, or in the form of an ungraded consensus-based statement. Finally, we issued 36 statements. Among them, 23 carried strong recommendations, and 13 carried weak recommendations for the stated procedure. They covered questions relevant to the aforementioned three areas. The preoperative period for TUPKP in the treatment of BPH included indications and contraindications for TUPKP, precautions for preoperative preparation in patients with renal impairment and urinary tract infection due to urinary retention, and preoperative prophylactic use of antibiotics. Questions relevant to the intraoperative period incorporated surgical operation techniques and prevention and management of bladder explosion. The application to different populations incorporating the efficacy and safety of TUPKP in the treatment of normal volume (< 80 ml) and large-volume (≥ 80 ml) BPH compared with transurethral urethral resection prostate, transurethral plasmakinetic enucleation of prostate and open prostatectomy;the efficacy and safety of TUPKP in high-risk populations and among people taking anticoagulant (antithrombotic) drugs. Questions relevant to the postoperative period incorporated the time and speed of flushing, the time indwelling catheters are needed, principles of postoperative therapeutic use of antibiotics, follow-up time and follow-up content. Questions related to complications incorporated types of complications and their incidence, postoperative leukocyturia, the treatment measures for the perforation and extravasation of the capsule, transurethral resection syndrome, postoperative bleeding, urinary catheter blockage, bladder spasm, overactive bladder, urinary incontinence, urethral stricture, rectal injury during surgery, postoperative erectile dysfunction and retrograde ejaculation. Final questions were related to surgeons’ skills when performing TUPKP for the treatment of BPH. We hope these recommendations can help support healthcare workers caring for patients having TUPKP for the treatment of BPH. | Xian-Tao Zeng Ying-Hui Jin Tong-Zu Liu Fang-Ming Chen De-Gang Ding Meng Fu Xin-Quan Gu Bang-Min Han Xing Huang Zhi Hou Wan-Li Hu Xin-Li Kang Gong-Hui Li Jian-Xing Li Pei-Jun Li Chao-Zhao Liang Xiu-Heng Liu Zhi-Yu Liu Chun-Xiao Liu Jiu-Min Liu Guang-Heng Luo Yi Luo Wei-Jun Qin Jian-Hong Qiu Jian-Xin Qiu Xue-Jun Shang Ben-Kang Shi Fa Sun Guo-Xiang Tian Ye Tian Feng Wang Feng Wang Yin-Huai Wang Yu-Jie Wang Zhi-Ping Wang Zhong Wang Qiang Wei Min-Hui Xiao Wan-Hai Xu Fa-Xian Yi Chao-Yang Zhu Qian-Yuan Zhuang Li-Qun Zhou Xiao-Feng Zou Nian-Zeng Xing Da-Lin He Xing-Huan Wang 无 | 2022 | Military Medical Research2022，9，5： | 4 |
| 15 | Expression of serum Dickkopf-1 in gastric cancer patients显示文摘Objective:To explore the expression and clinical significance of DKK-1 protein in patients with gastric cancers.Methods:Enzyme linked imtnuno sorbent assay was used to detect expressions of serum DKK-1 protein in 90 cases of gastric cancers,50 cases of gastric benign disease and 40 healthy cases.The dynamic change in serum DKK-1 protein of gastric cancer patients who accepted radical operation for a month was also observed.Results:The expression of serum DKK-1 protein in gastric cancer groups was significantly higher than that in gastric benign group's(P<0.01) and in health control(P<0.01).Serum DKK 1 level was increased gradually along with the progress of the disease.Serum DKK 1 levels were significantly higher in patients at TNM staging Ⅲ and Ⅳ than patients at TNM staging Ⅰ andⅡ.Level of serum DKK-1 was related to microvascular invasion,differentiation degree and infiltration depth.Level of serum DKK-1 was significantly reduced in patients after radical surgery(P<0.01).Conclusions:The expression of serum DKK-1 protein in gastric cancer patients is increased.Level of serum DKK-1 is related to TNM staging,microvascular invasion,differentiation degree and infiltration depth.DKK-1 detection can be used as a reference index in monitoring gastric cancer progress and biological behavior. | Gui-Feng Zhuang Yan Tan Jun-Tao Zeng Jie-Wei Zhang Jing Tang Shi-Ping Zeng Xi Qin | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，10： | 4 |
| 16 | Chimeric Newcastle Disease Virus-like Particles Containing DC-Binding Peptide-Fused Haemagglutinin Protect Chickens from Virulent Newcastle Disease Virus and H9N2 Avian Influenza Virus Challenge显示文摘Newcastle disease virus(NDV)and H9N2 subtype Avian influenza virus(AIV)are two notorious avian respiratory pathogens that cause great losses in the poultry industry.Current inactivated commercial vaccines against NDV and AIV have the disadvantages of inadequate mucosal responses,while an attenuated live vaccine bears the risk of mutation.Dendritic cell(DC)targeting strategies are attractive for their potent mucosal and adaptive immune-stimulating ability against respiratory pathogens.In this study,DC-binding peptide(DCpep)-decorated chimeric virus-like particles(cVLPs),containing NDV haemagglutinin–neuraminidase(HN)and AIV haemagglutinin(HA),were developed as a DC-targeting mucosal vaccine candidate.DCpep-decorated cVLPs activated DCs in vitro,and induced potent immune stimulation in chickens,with enhanced secretory immunoglobulin A(sIgA)secretion and splenic T cell differentiation.40μg cVLPs can provide full protection against the challenge with homologous,heterologous NDV strains,and AIV H9N2.In addition,DCpep-decorated cVLPs could induce a better immune response when administered intranasally than intramuscularly,as indicated by robust s IgA secretion and a reduced virus shedding period.Taken together,this chimericVLPs are a promising vaccine candidate to control NDV and AIV H9N2 and a useful platform bearing multivalent antigens. | Xiaohong Xu Jing Qian Lingsong Qin Jindou Li Cong Xue Jiaxin Ding Weiqi Wang Wei Ding Renfu Yin Ningyi Jin Zhuang Ding | 2020 | Virologica Sinica2020，35，4： | 4 |
| 17 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 3 |
| 18 | Arsenic biotransformation and an arsenite Sadenosylmethionine methyltransferase in plankton显示文摘Arsenic(As)is a well-recognized toxicant and carcinogen.Chronic exposure to inorganic arsenic causes a range of human cancers(e.g.,skin,bladder,and lung)and increases the risk of developing diabetes,hypertension,and cardiovascular and neurological diseases.The prevalence of arsenic species and the severity of their health effects continue to drive and demand for extensive research(Carlin et al.,2016). | Jagdeesh S.Uppal Qin Shuai Zhuang Li X.Chris Le | 2017 | Journal of Environmental Sciences2017，29，11： | 3 |
| 19 | Natural variations of ZmSRO1d modulate the trade-off between drought resistance and yield by affecting ZmRBOHC-mediated stomatal ROS production in maize显示文摘While crop yields have historically increased,drought resistance has become a major concern in the context of global climate change.The trade-off between crop yield and drought resistance is a common phenomenon;however,the underlying molecular modulators remain undetermined.Through genome-wide association study,we revealed that three non-synonymous variants in a drought-resistant allele of ZmSRO1d-R resulted in plasma membrane localization and enhanced mono-ADP-ribosyltransferase activity of ZmSRO1d toward ZmRBOHC,which increased reactive oxygen species(ROS)levels in guard cells and promoted stomatal closure.ZmSRO1d-R enhanced plant drought resilience and protected grain yields under drought conditions,but it led to yield drag under favorable conditions.In contrast,loss-of-function mutants of ZmRBOHC showed remarkably increased yields under well-watered conditions,whereas they showed compromised drought resistance.Interestingly,by analyzing 189 teosinte accessions,we found that the ZmSRO1d-R allele was present in teosinte but was selected against during maize domestication and modern breeding.Collectively,our work suggests that the allele frequency reduction of ZmSRO1d-R in breeding programs may have compromised maize drought resistance while increased yields.Therefore,introduction of the ZmSRO1d-R allele into modern maize cultivars would contribute to food security under drought stress caused by global climate change. | Huajian Gao Junjun Cui Shengxue Liu Shuhui Wang Yongyan Lian Yunting Bai Tengfei Zhu Haohao Wu Yijie Wang Shiping Yang Xuefeng Li Junhong Zhuang Limei Chen Zhizhong Gong Feng Qin | 2022 | Molecular Plant2022，15，10： | 2 |
| 20 | Minimally invasive perventricular device closure of perimembranous ventricular septal defect without cardiopulmonary bypass: Multicenter experience and mid-term follow-up显示文摘 | Quansheng Xing Silin Pan Qi An Zewei Zhang Jianhua Li Feng Li Qin Wu Zhongyun Zhuang | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，6： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员