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| 1 | Effect of antisense oligonucleotides targeting telomerase catalytic subunit on tumor cell proliferation in vitro显示文摘To screen specific antitumor drugs targeting telomerase catalytic subunit (hEST2), 12 different hEST2 antisense oligonucleotides were designed based on hEST2 mRNA second structure and transfected into tumor cell lines by the lipofectin-mediated method. Cell growth activity was evaluated by MTT assay. HEST212 was picked out and its specificity, antitumor tree and continuous effect were analyzed. The results showed that hEST212 had promising anti-tumor activity in vitro, hEST2 can be used as a pratical target and an antisense drug candidate for cancer. | Shengqi Wang Li Lin Zhongbin Chen Ruxian Lin Suhong Chen Wei Guan Xiaohong Wang | 2002 | Chinese Science Bulletin2002，47，12： | 10 |
| 2 | Effect of polymer solution structure on displacement efficiency显示文摘In this paper, a series of experiments, including atomic force microscope (AFM), environmental scanning electron microscope (ESEM), and core displacement tests were conducted to investigate the effect of polymer solution structure on solution properties and oil displacement efficiency. The results show that in the HPAM solution polymer coils were formed and then aggregated into a loose structure, while the HAP2010 solution formed a strong network structure, which would significantly improve the solution viscosity and flow resistance so as to upgrade the capacity of piston-like oil displacement in highly permeable porous media. Meanwhile, the retention of the HAP2010 solution at pore throats were also enhanced, which could reduce water production during subsequent water flooding and enlarge the swept volume during polymer flooding. Therefore, enhancing the interaction among polymer molecules is an effective way to improve the displacement efficiency of polymer solutions in heavy oil reservoirs with high permeability. | Shi Leiting Chen Lei Ye Zhongbin Zhou Wei Zhang Jian Yang Jie Jin Jianbo | 2012 | Petroleum Science2012，9，2： | 9 |
| 3 | PdAg bimetallic electrocatalyst for highly selective reduction of CO2 with low COOH^* formation energy and facile CO desorption显示文摘For electrocatalytic reduction of CO2 to CO,the stabilization of intermediate COOH^* and the desorption of CO^* are two key steps.Pd can easily stabilize COOH^*,whereas the strong CO^* binding to Pd surface results in severe poisoning,thus lowering catalytic activity and stability for CO2 reduction.On Ag surface,CO^* desorbs readily,while COOH^* requires a relatively high formation energy,leading to a high overpotential.In light of the above issues,we successfully designed the PdAg bimetallic catalyst to circumvent the drawbacks of sole Pd and Ag.The PdAg catalyst with Ag-terminated surface not only shows a much lower overpotential(-0.55 V with CO current density of 1 mA/cm^2)than Ag(−0.76 V),but also delivers a CO/H2 ratio 18 times as high as that for Pd at the potential of-0.75 V vs.RHE.The issue of CO poisoning is significantly alleviated on Ag-terminated PdAg surface,with the stability well retained after 4h electrolysis at-0.75 V vs.RHE.Density functional theory(DFT)calculations reveal that the Ag-terminated PdAg surface features a lowered formation energy for COOH^* and weakened adsorption for CO^*,which both contribute to the enhanced performance for CO2 reduction. | Rui Lin Xuelu Ma Weng-Chon Cheong Chao Zhang Wei Zhu Jiajing Pei Kaiyue Zhang Bin Wang Shiyou Liang Yuxi Liu Zhongbin Zhuang Rong Yu Hai Xiao Jun Li Dingsheng Wang Qing Peng Chen Chen Yadong Li | 2019 | Nano Research2019，12，11： | 7 |
| 4 | Atomic Co/Ni dual sites with N/P-coordination as bifunctional oxygen electrocatalyst for rechargeable zinc-air batteries显示文摘Metal-nitrogen-carbon(M-N-C)single-atom catalysts exhibit desirable electrochemical catalytic properties.However,the replacement of N atoms by heteroatoms(B,P,S,etc.)has been regarded as a useful method for regulating the coordination environment.The structure engineered M-N-C sites via doping heteroatoms play an important role to the adsorption and activation of the oxygen intermediate.Herein,we develop an efficient strategy to construct dual atomic site catalysts via the formation of a Co_(1)-PN and Ni1-PN planar configuration.The developed Co_(1)-PNC/Ni1-PNC catalyst exhibits excellent bifunctional electrocatalytic performance in alkaline solution.Both experimental and theoretical results demonstrated that the N/P coordinated Co/Ni sites moderately reduced the binding interaction of oxygen intermediates.The Co_(1)-PNC/Ni1-PNC endows a rechargeable Zn-air battery with excellent power density and cycling stability as an air-cathode,which is superior to that of the benchmark Pt/C+IrO_(2).This work paves an avenue for design of dual single-atomic sites and regulation of the atomic configuration on carbon-based materials to achieve high-performance electrocatalysts. | Botao Hu Aijian Huang Xuejiang Zhang Zheng Chen Renyong Tu Wei Zhu Zhongbin Zhuang Chen Chen Qing Peng Yadong Li | 2021 | Nano Research2021，14，10： | 6 |
| 5 | Defective Ni_(3)S_(2)nanowires as highly active electrocatalysts for ethanol oxidative upgrading显示文摘Electrochemical upgrading of biomass ethanol to value-added chemicals is promising for sustainable society.Here,we synthesize defective Ni_(3)S_(2) nanowires(NWs),which show high activity towards electrochemical oxidation of ethanol to acetate.The Ni_(3)S_(2) NWs are formed by the oriented attachment mechanism,and rich defects are introduced during the growth.A low onset potential of 1.31 V and high mass activity of 8,716 mA·mgNi^(-1) at 1.5 V are achieved using the synthesized Ni_(3)S_(2) NWs toward the ethanol electro-oxidation,which are better than the Ni(OH)2 NWs and the Ni_(3)S_(2) nanoparticles(NPs).And the selectivity for the acetate generation is ca.99%.The high activity of Ni_(3)S_(2) NWs is attributed to the easier oxidation of Ni(II)to the catalytically active Ni(III)species with the promotion from S component and rich defects.These results demonstrate that the defective NWs can be synthesized by the oriented attachment method and the defective Ni_(3)S_(2) NWs structure as the efficient nonnoble metal electrocatalysts for oxidative upgrading of ethanol. | Yufeng Zhang Wei Zhu Jinjie Fang Zhiyuan Xu Yanrong Xue Di Liu Rui Sui Qingqing Lv Xuerui Liu Yongsheng Wang Wei Chen Zhongbin Zhuang | 2022 | Nano Research2022，15，4： | 2 |
| 6 | Amorphous M0S2 confined in nitrogen-doped porous carbon for improved electrocatalytic stability toward hydrogen evolution reaction显示文摘Developing non-precious metal catalysts with high activity and stability for electrochemical hydrogen evolution reaction(HER)is of great significance in both scie nee and tech no logy.In this work,N-doped CMK-3,which was prepared with a casting method using SBA-15 as thehard template and ammonia as the nitrogen source,has been utilized to hold MoS2 and restrict its growth to form MoS2@N-CMK-3 composite.As a result,M0S2 was found to have poorly crystallized and the limited space of porous N-CMK-3 made its size much small.Then there are moreactive sites in MoS2.Accordingly,MoS2@N-CMK-3 has exhibited good electrocatalytic performance toward HER in acids with a quite small Tafelslope of 32 mV·dec^-1.And more importantly,compared to MoS2@CMK-3,its stability has been greatly improved,which can be attributedto the interaction between M0S2 and nitrogen atoms avoiding aggregation and mass loss.This work provides an idea that doping a porouscarbon support with nitrogen is an effective way to enhance the stability of the catalyst. | Shaojie Lu Wenjing Wang Shengshuang Yang Wei Chen Zhongbin Zhuang Wenjing Tang Caihong He Jiajing Qian Dekun Ma Yun Yang Shaoming Huang | 2019 | Nano Research2019，12，12： | 2 |
| 7 | Statin treatment for unruptured intracranial aneurysms study: a study protocol for a double-blind, placebocontrolled trial显示文摘background and purpose A large proportion of patients with unruptured intracranial aneurysm(IA)are not suitable for surgical clipping and endovascular treatment.For these patients,anti-inflammatory medications are worth exploring due to inflammation of aneurysmal wall being a major factor in higher risk of rupture.Statin has been proven to reduce inflammation of atherosclerosis and maybe a suitable candidate.This study aimed to evaluate whether atorvastatin will reduce inflammatory of the aneurysm wall measured by the signal index of aneurysm wall enhancement.Methods and analysis The Statin Treatment for UnruptureD Intracranial anEurysms Study is a single-centre,phase 2,randomised,controlled,double-blind clinical trial.60 patients with unruptured IAs with aneurysm wall enhancement will be enrolled in Beijing Tiantan Hospital.The patients will be randomised to receive atorvastatin 20 mg or placebo orally per day for 12 months.The primary outcome will be the change in aneurysm wall enhancement measured by the signal index during the 12 months treatment with atorvastatin.The secondary study outcomes will be the change in aneurysm wall enhancement measured by the signal index at 3 months,the changes in aneurysmal morphology and inflammation-related factors(C reactive protein,tumour necrosis factor-α,interleukin-1βand interleukin-6)at 3 and 12 months.This study is the first to explore the role of atorvastatin in reducing inflammation in unruptured IA,which could lay the groundwork for future phase III trial.Ethics and dissemination Beijing Tiantan Hospital’s Ethics committee approved the research and written informed consents would be obtained from all participant or representative included in this study. | Wenqiang Li Yisen Zhang Zhongbin Tian Wei Zhu Jian Liu Ying Zhang Xinjian Yang De-Cai Tian | 2020 | Stroke & Vascular Neurology2020，5，4： | 2 |
| 8 | Endovascular treatment of bilateral intracranial vertebral artery aneurysms: an algorithm based on a 10- year neurointerventional experience显示文摘Background The management of bilateral intracranial vertebral artery dissecting aneurysms(IVADAs)is controversial,and requires the development of endovascular treatment modalities and principles.We aim to investigate the endovascular treatment strategy and outcomes of bilateral IVADAs.Methods We identified all bilateral IVADAs at a high-volume neurointerventional centre over a 10-year period(from January 2009 to December 2018).Radiographic and clinical data were recorded,and a treatment algorithm was derived.Results Twenty-seven patients with bilateral IVADAs(54 IVADAs in total,51 unruptured,3 ruptured)were diagnosed.Four patients(14.8%)received single-stage endovascular treatment,12 patients(44.4%)with staged endovascular treatment and 11 patients(40.8%)with unilateral endovascular treatment of bilateral IVADAs.Thirty-six IVADAs(85.7%)have complete obliteration at the follow-up angiography.Two of three ruptured IVADAs with stent-assisted coiling recanalised,and had further recoiling.Three patients(11.1%)have intraprocedural or postprocedural complications(two in single-stage and one in staged).Twenty-five patients(92.6%)had a favourable clinical outcome,and two patients(7.4%,all in single-stage)showed an unfavourable clinical outcome at follow-up.For the patients with unilateral reconstructive endovascular treatment,the contralateral untreated IVADAs were stable and had no growth or ruptured during follow-up period.None of all IVADAs had rebleeding during the clinical follow-up.Conclusions Endovascular treatment can be performed in bilateral IVADAs with high technical success,high complete obliteration rates and acceptable morbidity/mortality.Contralateral IVADAs had low rates of aneurysm growth and haemorrhage when treated in a staged/delayed fashion. | Yisen Zhang Zhongbin Tian Wei Zhu Jian Liu Yang Wang Kun Wang Ying Zhang Xinjian Yang Wenqiang Li | 2020 | Stroke & Vascular Neurology2020，5，3： | 2 |
| 9 | Ultrathin NiFeS nanosheets as highly active electrocatalysts for oxygen evolution reaction显示文摘The development of efficient and cost-effective oxygen evolution reaction(OER)electrocatalysts is crucial for clean energy conversion and storage devices,such as water-splitting,CO_(2) reduction,and metalair batteries.Herein,we report an efficient 2-dimensional OER catalyst of ultrathin nickel-iron sulfide nanosheets(Ni Fe S-NS).Dodecanethiol is employed in the synthesis,which prohibits the growth along the Z-axis,thus a nanosheet is obtained.The Ni Fe S-NS shows high OER catalytic activity,which only requires a small overpotential of 273 mV to achieve the OER current density of 10 mA/cm^(2) in alkaline electrolyte,and almost no decay after 150 h of chronopotentiometry test.The high performance is attributed to the 2-dimensional structure,the synergistic effect from the Ni and Fe components which promotes the formation of the high valence Ni species,and the tuning effect from the in-situ generated sulfate doping.This work demonstrates the advantages of the 2-dimensional sulfides in electrocatalysis. | Yanrong Xue Mengyuan Liu Yangyuanxiang Qin Yufeng Zhang Xuejiang Zhang Jinjie Fang Xu Zhang Wei Zhu Zhongbin Zhuang | 2022 | Chinese Chemical Letters2022，33，8： | 2 |
| 10 | Continuous dimethyl carbonate synthesis from CO_(2) and methanol over Bi_(x)Ce_(1-x)O_(δ) monoliths:Effect of bismuth doping on population of oxygen vacancies,activity,and reaction pathway显示文摘We evaluated bismuth doped cerium oxide catalysts for the continuous synthesis of dimethyl carbonate(DMC)from methanol and carbon dioxide in the absence of a dehydrating agent.Bi_(x)Ce_(1-x)O_(δ)nanocomposites of various compositions(x=0.06-0.24)were coated on a ceramic honeycomb and their structural and catalytic properties were examined.The incorporation of Bi species into the CeO_(2) lattice facilitated controlling of the surface population of oxygen vacancies,which is shown to play a crucial role in the mechanism of this reaction and is an important parameter for the design of ceria-based catalysts.The DMC production rate of the Bi_(x)Ce_(1-x)O_(δ) catalysts was found to be strongly enhanced with increasing Ov concentration.The concentration of oxygen vacancies exhibited a maximum for Bi_(0.12)Ce_(0.88)O_(δ),which afforded the highest DMC production rate.Long-term tests showed stable activity and selectivity of this catalyst over 45 h on-stream at 140°C and a gas-hourly space velocity of 2,880 mL·g_(cat)^(-1)·h^(-1).In-situ modulation excitation diffuse reflection Fourier transform infrared spectroscopy and first-principle calculations indicate that the DMC synthesis occurs through reaction of a bidentate carbonate intermediate with the activated methoxy(-OCH_(3))species.The activation of C0_(2) to form the bidentate carbonate intermediate on the oxygen vacancy sites is identified as highest energy barrier in the reaction pathway and thus is likely the rate-determining step. | Yongdong Chen Yue Li Wei Chen Wen Wu Xu Zhong-kang Han Ammara Waheed Zhongbin Ye Gao Li Alfons Baiker | 2022 | Nano Research2022，15，2： | 2 |
| 11 | Carbon-nanotube-modified glassy carbon electrode for simultaneous determination of dopamine, ascorbic acid and uric acid: The effect of functional groups显示文摘 | Huaqing Bi Yanhui Li Shufeng Liu Peizhi Guo Zhongbin Wei Chunxiao Lv Jizhen Zhang X.S. Zhao | 2012 | Sensors & Actuators: B Chemical2012，，： | 1 |
| 12 | Detection of Smell Change of Flue-Cured Tobacco Based on an Electronic Nose显示文摘 | Ding Wei Zhu Zhongbin Zhang Changhua | 2013 | Intelligent automation and Soft Computing2013，19，2： | 1 |
| 13 | Efficient X-ray luminescence imaging with ultrastable and eco-friendly copper(Ⅰ)-iodide cluster microcubes显示文摘The advancement of contemporary X-ray imaging heavily depends on discovering scintillators that possess high sensitivity,robust stability,low toxicity,and a uniform size distribution.Despite significant progress in this field,the discovery of a material that satisfies all of these criteria remains a challenge.In this study,we report the synthesis of monodisperse copper(Ⅰ)-iodide cluster microcubes as a new class of X-ray scintillators.The as-prepared microcubes exhibit remarkable sensitivity to X-rays and exceptional stability under moisture and X-ray exposure.The uniform size distribution and high scintillation performance of the copper(Ⅰ)-iodide cluster microcubes make them suitable for the fabrication of large-area,flexible scintillating films for X-ray imaging applications in both static and dynamic settings. | Yanze Wang Wenjing Zhao Yuanyuan Guo Wenbo Hu Chenxi Peng Lei Li Yuan Wei Zhongbin Wu Weidong Xu Xiyan Li Yung Doug Suh Xiaowang Liu Wei Huang | 2023 | Light(Science & Applications)2023，12，8： | 1 |
| 14 | Colloids and Surfaces A: Physicochemical and Engineering Aspects显示文摘 | Guo Peizhi Wei Zhongbin Ye Wanneng | 2012 | 295(2): 752012，295，2： | 1 |
| 15 | Design of Graphite-wall Ionization Chamber as Air-kerma Standard for γ-ray显示文摘The graphite-wall ionization chamber which is based on Bragg-Gary cavity theory is used as air-kerma primary standard for 137Cs and 60Coγ-ray reference radiation. | TENG Zhongbin SONG Mingzhe NI Ning ZHANG Xi WEI Kexin | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 16 | Temperature-insensitive KNN-based ceramics by elevating O-T phase transition temperature and crystal texture显示文摘The inferior temperature stability of piezoelectric response is the main drawback of KNN-based ceramics.Here,the Ba-doped 0.97(K0.48Na0.52)(Nb0.96Sb0.04)O3-0.03Bax(Bi0.5Ag0.5)1-xZrO3(abbreviated as KNNSBxBAZ)textured ceramics were prepared by the template grain growth(TGG)method.Excellent comprehensive properties(d33¼(406±15)pC/N,TC=274℃,strain is 0.17%)were achieved in KNNSBxBAZ textured ceramics with x=0.2.Meanwhile,its piezoelectric and strain properties also show superior temperature stability(d33 maintained within±20%change in awide temperature range from 25℃to 200℃and strain variation was less than 5%in the temperature range from room temperature to 165℃).The high O-T phase transition temperature(TO-T is 110℃)induced by incorporating Ba ions accounts for the enhanced temperature stability of piezoelectric properties.In addition,the crystal texture always maintains the contribution of piezoelectric anisotropy to the piezoelectric properties during elevated temperature,which significantly improved the temperature stability of piezoelectric properties.This work provides an effective strategy for simultaneously achieving high piezoelectric response and excellent temperature stability in KNN-based ceramics. | Shuo Gao Peng Li Jiawei Qu Mingze Sun Jigong Hao Peng Fu Zhongbin Pan Jiwei Zhai Wei Li | 2023 | Journal of Materiomics2023，9，2： | 0 |
| 17 | A general and facile calcination method to synthesize single-site catalysts for highly efficient electrochemical CO_(2) reduction显示文摘The electrochemical CO_(2) reduction reaction(CO_(2)RR)has received widespread attention as a promising method for producing sustainable chemicals and mitigating the global warming.Here,we demonstrate a general and facile synthetic route for the metal-nitrogen-carbon(M-N-C)type catalyst by simply calcinating metal acetate and urea with commercial carbon black,which have potential application in CO_(2)RR.The synthesized Ni-NC-600 catalyst has the structure of single Ni atom coordinated with one N atom and three C atoms(Ni-N_(1)C_(3)),which is suggested by X-ray absorption spectroscopy.The Ni-NC-600 catalyst exhibits high CO_(2)RR catalytic performance and a high CO Faraday efficiency above 98%in a wide potential range from-0.7 to-1.3 V(vs.reversible hydrogen electrode(RHE)),superior to most of the reported Ni-N-C catalysts.This work has developed a facile strategy to synthesize high performance CO_(2)RR catalyst. | Rui Sui Bingyan Wang Yongsheng Wang Jiajing Pei Wei Zhu Wenxing Chen Chunhui Li Ailing Sun Zhongbin Zhuang | 2024 | Nano Research2024，17，5： | 0 |
| 18 | Chiral cation promoted interfacial charge extraction for efficient tin-based perovskite solar cells显示文摘Pb-free Sn-based perovskite solar cells(PSCs) have recently made inspiring progress, and power conversion efficiency(PCE) of 14.8% has been achieved. However, due to the energy-level mismatch and poor interfacial contact between commonly used hole transport layer(i.e., poly(3,4-ethylenedioxythio phene):poly(styrene sulfonate), PEDOT:PSS) and FASnI_(3) film, it is still challenging to effectively extract holes at the interface. Owing to the p-type nature of Sn-based perovskites, the efficient hole extraction is of particular significance to improve the PCE of their solar cells. In this work, for the first time, the role of chiral cations, a-methylbenzylamine(S-/R-/rac-MBA), in promoting hole transportation of FASnI_(3)-based PSCs is demonstrated. The introduction of MBAs is found to form 2D/3D film with lowdimensional structures locating at PEDOT:PSS/FASnI_(3) interface, which facilitates the energy level alignment and efficient charge transfer at the interface. Importantly, chiral-induced spin selectivity(CISS)effect of R-MBA_(2)SnI_(4)induced by chiral R-MBA cation is found to further assist the specific interfacial transport of accumulated holes. As a result, R-MBA-based PSCs achieve decent PCE of 10.73% with much suppressed hysteresis and enhanced device stability. This work opens up a new strategy to efficiently promote the interfacial extraction of accumulated charges in working PSCs. | Weiyin Gao He Dong Nan Sun Lingfeng Chao Wei Hui Qi Wei Hai Li Yingdong Xia Xingyu Gao Guichuan Xing Zhongbin Wu Lin Song Peter Müller-Buschbaum Chenxin Ran Yonghua Chen | 2022 | Journal of Energy Chemistry2022，31，5： | 0 |
| 19 | Calculation of Spencer-Attix Cavity Theory Correction Factor of Different Cavity Volumes显示文摘For purpose of obtaining a lower absolute measurement limit ofγ-ray air kerma,a larger graphite-walled cavity ionization chamber is usually expected.Although this method is feasible,it is necessary to consider the effect of the actual cavity on the results calculated by cavity theory.In order to investigate the accuracy of the results calculated by Spencer-Attix cavity theory,the Spencer-Attix cavity correction factor kSAof the spherical graphite cavity ionization chamber with different volumes were calculated by EGSnrc code.The physical quantities used in kSAcalculation are calculated by the user codes in EGSnrc code,and the kSAcalculation results are shown in Fig.1. | TENG Zhongbin SONG Mingzhe NI Ning ZHANG Xi GAO Fei WEI Kexin | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 20 | Electrochemical converting ethanol to hydrogen and acetic acid for large scale green hydrogen production显示文摘Electrochemical coupling hydrogen evolution with biomass reforming reaction(named electrochemical hydrogen and chemical cogeneration(EHCC)),which realizes green hydrogen production and chemical upgrading simultaneously,is a promising method to build a carbon-neutral society.Herein,we analyze the EHCC process by considering the market assessment.The ethanol to acetic acid and hydrogen approach is the most feasible for large-scale hydrogen production.We develop AuCu nanocatalysts,which can selectively oxidize ethanol to acetic acid(>97%)with high long-term activity.The isotopic and in-situ infrared experiments reveal that the promoted water dissociation step by alloying contributes to the enhanced activity of the partial oxidation reaction path.A flow-cell electrolyzer equipped with the AuCu anodic catalyst achieves the steady production of hydrogen and acetic acid simultaneously in both high selectivity(>90%),demonstrating the potential scalable application for green hydrogen production with low energy consumption and high profitability. | Yufeng Zhang Wei Zhu Jinjie Fang Zhiyuan Xu Yanrong Xue Jiajing Pei Rui Sui Xingdong Wang Xuejiang Zhang Zhongbin Zhuang | 2024 | Nano Research2024，17，3： | 0 |
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