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| 1 | Segregation analysis of hepatocellular carcinoma in a moderately high-incidence area of East China显示文摘AIM: To explore the mode of inheritance of hepatocellular carcinoma (HCC) in a moderately high-incidence area of East China.METHODS: A pedigree survey was conducted in 210 families (3315 individuals) ascertained through 210 HCC probands in Haimen, Jiangsu Province. Simple segregation analysis was conducted using SEGRANB software. The probability of ascertainment (π), segregation ratio (p), and the proportion of sporadic cases (x) were estimated. Complex segregation analysis was performed using the REGTL program of S.A.G.E.Models were fitted on the data of 3212 individuals that allowed for personal HBsAg status and variable age of onset in REGTL program.RESULTS: The estimate of segregation ratio was 0.191 by SEGRANB. The probability of ascertainment was 0.0266, and the proportion of sporadic cases was 0.465. The results of complex segregation analysis showed that Mendelian autosomal recessive inheritance of a major gene that influenced the age of onset distribution of HCC, provided the best fit to the data. In the best-fitting recessive model,the frequency of the disease allele was 0.11138. HBsAg seropositive status would significantly increase the risk of developing HCC.CONCLUSION: These results suggest that at least one major gene is involved in the genetic predisposition to develop HCC at an earlier age of onset. The seropositive HBsAg status can significantly increase the risk of developing HCC, which provides strong support for the interaction between genetic and environmental risk factors. | Ru-LinCai WeiMeng Hong-YanLu Wen-YaoLin FengJiang Fu-MinShen | 2003 | World Journal of Gastroenterology2003，9，11： | 10 |
| 2 | Expression of some tumor associated factors in human carcinogenesis and development of gastric carcinoma显示文摘AIM: To study the effect of IGF-1/IGF-1R and gastrin/CCK-BR on carcinogenesis and development of human gastric carcinoma and to explore its mechanism and provide a credible theoretical foundation for early diagnosis and molecular therapy of gastric carcinoma.METHODS: mRNA expression levels of IGF-1/IGF-1R and gastrin/CCK-BR were assessed by RT-PCR method in gastric cancer tissues, adjacent mucosa, and tumor-free tissues from 56 patients with gastric carcinoma and normal gastric mucosae from 56 healthy controls. Tissue specimens were obtained by biopsy and confirmed by histological evaluation.RESULTS: The mRNA levels of IGF-1/IGF-1R were increased in gastric cancer tissues compared with normal tissues from healthy controls and successively increased in tumor-free tissues, adjacent mucosa, and gastric cancer tissues. The mRNA levels of gastrin/CCK-BR were increased in gastric cancer tissues compared with normal tissues from healthy controls. There was a significant difference between gastric cancer tissues and adjacent mucosa and tumor-free tissues, but the mRNA levels of gastrin were not significantly increased in adjacent mucosa and gastric cancer tissues compared with tumorfree tissues. The mRNA levels of CCK-BR were increased in gastric cancer tissues and adjacent mucosa compared with tumor-free tissues, but not significantly increased in adjacent mucosa and gastric cancer tissues compared with gastric cancer tissues.CONCLUSION: Overexpression of IGF-1/IGF-1R and gastrin/CCK-BR promotes the disorderly proliferation of gastric mucosa epithelia and it is of great significance in the carcinogenesis and development of gastric carcinoma. | Ming-DongZhao Xue-MeiHu Dian-JingSun QunZhang Yu-HaoZhang WeiMeng | 2005 | World Journal of Gastroenterology2005，11，21： | 8 |
| 3 | Fe3O4 Octahedral Colloidal Crystals显示文摘我们在场为没有底层的帮助的高度命令的八面的 Fe3O4 胶体的单个晶体的大规模制造的一个灵巧、可控制的方法。油的酸被用来在胶体的答案减少 nano 大楼块的溶解度并且导致一个结晶化过程。我们的胶体的晶体具有 multimicron 尺寸并且显示出典型结晶的特征。他们有很柔韧的结构并且当一篇小说与相对狭窄的毛孔尺寸分布订了磁性的 mesoporous 材料,能服务。样品基于它的好 crystallinity,以及 interparticle 在 5 K 拥有 100 K 的极其高的 Verwey 转变温度(T V ) 和 86 emu/g 的高浸透磁化(M S ) 偶极的相互作用行为从它的唯一的结构产生。电气化学的大小表明了 mesoporous 的优秀能力胶体的晶体当在锂离子电池使用了时。 | L-r Meng Weimeng Chen Yiwei Tan Lin Zou Chinping Chen Heping Zhou Qing Peng Yadong Li | 2011 | Nano Research2011，4，4： | 3 |
| 4 | Electrolyte-mediated dense integration of graphene-MXene films for high volumetric capacitance flexible supercapacitors显示文摘High conductivity two-dimensional(2D)materials have been proved to be potential electrode materials for flexible supercapacitors because of its outstanding chemical and physical properties.However,electrodes based on 2D materials always suffer from limited electrolyte-accessible surface due to the restacking of the 2D sheets,hindering the full utilization of their surface area.In this regard,an electrolyte-mediated method is used to integrate dense structure reduced graphene oxide/MXene(RGM)-electrolyte composite films.In such composite films,reduced graphene oxide(RGO)and MXene sheets are controllable assembly in compact layered structure with electrolyte filled between the layers.The electrolyte layer between RGO and MXene sheets forms continuous ion transport channels in the composite films.Therefore,the RGM-electrolyte composite films can be used directly as self-supporting electrodes for supercapacitors without additional conductive agents and binders.As a result,the composite films demonstrate enhanced volumetric specific capacity,improved volumetric energy density and higher power density compared with both pure RGO electrode and porous composite electrode prepared by traditional methods.Specifically,when the mass ratio of MXene is 30%,the electrode delivers a volumetric specific capacity of 454.9 F·cm^(−3) with a high energy density of 39.4 Wh·L^(−1).More importantly,supercapacitors based on the composite films exhibit good flexibility electrochemical performance.The investigation provides a new approach to synthesize dense structure films based on 2D materials for application in high volumetric capacitance flexible supercapacitors. | Min Zhang Jun Cao Yi Wang Jia Song Tianci Jiang Yanyu Zhang Weimeng Si Xiaowei Li Bo Meng Guangwu Wen | 2021 | Nano Research2021，14，3： | 2 |
| 5 | Biomarker geochemistry of marine organic matter in the Hushan and Chaohu areas,Lower Yangtze region显示文摘Marine strata are widely exposed in the Hushan and Chaohu areas, Lower Yangtze region. As biomarker geochemistry of the strata has not been well documented, this paper deals with the biomarker composition of representative samples collected from the Silurian, Carboniferous and Triassic systems and their geological implications, thus providing clues to marine organic matter. On the basis of experimental results, it is shown that abundant biomarkers (e.g. n-alkanes, isoprenoids, terpanes and steranes) were detected. As organic matter in the strata is highly to over mature in general based on petrologic microobservation, some biomarkers (mainly n-alkanes) except terpanes and steranes cannot reflect the source, depositional environment and maturity of organic matter. Thus, primarily based on analyses of the terpanes and steranes, it is suggested that organic matter in the Silurian and Carboniferous strata is derived mainly from lower organisms, while higher plants are predominant in the Triassic organic matter. This further indicates that the depositional environment may have transformed from the marine to continental facies in the Late Triassic. These results provide new evidence for the study of regional depositional evolution, and have enriched the study of biological composition of organic matter. In addition, the biomarker geochemistry of organic matter at high to over maturation stage is addressed. | Chang, Chao Wang, Shaohua Zhu, Chen Ma, Weimeng Hu, Wenxuan Cao, Jian | 2011 | Chinese Journal Of Geochemistry2011，30，2： | 2 |
| 6 | The adsorption feature and photocatalytic oxidation activity of K1-2x MxTiNb05 显示文摘 | Cai Weimeng Lu Guohui He Jie | 2012 | Ceramics International2012，38，4： | 1 |
| 7 | Different enhancement of senescence induced by metabolic products of Alternaria alternata in tobacco leaves of different ages显示文摘 | Yu‐JiaoJia Dan‐DanCheng Wei‐BinWang Hui‐YuanGao Ai‐XinLiu Xin‐MinLi Qing‐WeiMeng | 2010 | Physiologia Plantarum2010，，2： | 1 |
| 8 | Effect of Panaxtriol Saponins on synaptophysin and postsynaptic density-95 expression at different periods of cerebral infarction显示文摘BACKGROUND:The change in expression of synaptophysin (Syp) and postsynaptic density-95 (PSD-95) alters after cerebral infarction,and the plasticity of synapses contributes greatly to nerve function recovery. Chinese medicinal substances may play an important role in the expression of Syp and PSD-95. OBJECTIVE: To observe the effect of Panaxtriol Saponins (PTS),an active component in Sanqi tongshu capsules,on the expression of Syp and PSD-95 after cerebral infarction at different time points in rats,so as to examine the cerebral function remodeling mechanism. DESIGN,TIME AND SETTING: A randomized and controlled observation which was performed in Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine from January to March,2007. MATERIALS: Twenty-six healthy male Sprague Dawley rats were used to establish middle cerebral artery occlusion based on the Longa method. Sanqi tongshu capsules (containing 100 mg PTS per tablet) were provided by the Chengdu Huashen Group and nimodipine tablets (30 mg) by Tianjin Zhongyang Pharmaceutical Co.,Ltd. METHODS: Twenty-six rats were randomly divided into an operation group (n=21) and a control group (n=5). The operation group underwent the EZ Longa procedure to make the middle cerebral artery occlusion model. After surgery rats were randomly divided into a model group,a PTS group and a nimodipine group,with seven rats in each group. Rats were intragastrically administrated with saline (2 mL/d) in the model group,with Sanqi tongshu capsule (5.4 mg/100 g/d) in the PTS group,and with nimodipine (1.73 mg/100 g/d) in the nimodipine group. Rats in the control group did not undergo model establishment and drug administration. MAIN OUTCOME MEASURES: The expressions of Syp and PSD-95 were measured by immunohistochemical and image analysis at days 3,7 and 28 after the operation. RESULTS: The expression of Syp and PSD-95 in the operation group was significantly lower than in the control group at days 3,7,28 postoperatively (P<0.05). The expression of Syp and PSD-95 in the PTS group and nimodipine group was significantly higher than in the model group at day 28 postoperatively (P< 0.05-0.01). Additionally,after PTS and nimodipine treatment at different intervals,the expression of Syp and PSD-95 at day 28 postoperatively was significantly higher than those at days 3 and 7 postoperatively,respectively (P<0.01). CONCLUSION: PTS can promote the expression of Syp and PSD-95,i.e. the remodeling process of synapses,after cerebral infarction at different time points in rats,which contributes to cerebral function remodeling. | Fangyuan Cui Jiangying Zhai Weimeng Zou Xiling Wang Yihuai Zou Linggqun Zhu | 2008 | Neural Regeneration Research2008，3，11： | 1 |
| 9 | 显示文摘 | Si Weimeng Lei Wu Han Zhen | 2014 | Sensors and Actua- tors B: Chemical2014，193，： | 1 |
| 10 | 3-D solid finite element modeling and rotor dynamics of large rotating machines: application to an industrial turbo engine显示文摘 | MA Weimeng WANG Jianjun | 2012 | Advanced Ma- terials Research2012，，： | 1 |
| 11 | 显示文摘 | Si Weimeng Han Zhen Lei Wu | 2014 | Journal of the Elec trochemical Society2014，161，1： | 1 |
| 12 | 显示文摘 | Lei Wu Wu Qiuju Si Weimeng | 2013 | Sensors and Actua- tors2013，183，13： | 1 |
| 13 | Selective sensing of catechol and hydroquinone based on poly(3,4-ethylenedioxythiophene)/nitrogen-doped graphene composites显示文摘 | Si Weimeng Lei Wu Han Zhen | 2014 | Sensors and Actuators B:Chemical2014，199，4： | 1 |
| 14 | LOCAL A PRIORI AND A POSTERIORI ERROR ESTIMATE OF TQC9 ELEMENT FOR THE BIHARMONIC EQUATION显示文摘在这篇论文,本地先验的、本地后验和全球后验错误估计为双性人泛音方程为 TQC9 元素被获得。一个适应算法基于后验错误估计被给。 | Ming Wang Weimeng Zhang | 2008 | Journal of Computational Mathematics2008，26，2： | 0 |
| 15 | Functions of Nitrogen,Phosphorus and Potassium in Energy Status and Their Influences on Rice Growth and Development显示文摘Nitrogen(N),phosphorus(P)and potassium(K)are important essential nutrients for plant growth and development,but their functions in energy status remains unclear.Here,we grew Nipponbare rice seedlings in a growth chamber for 20 d at 30℃/24℃day/night)under natural sunlight conditions with different nutrient regimes.The results showed that N had the strongest influence on the plant growth and development,followed by P and K.The highest nonstructural carbohydrate content,dry matter weight,net photosynthetic rate(Pn),ATP content,as well as NADH dehydrogenase,cytochrome oxidase and ATPase activities were found in the plants that received sufficient N,P and K.The lowest values of these parameters were detected in the N-deficient plants.Higher dry matter accumulation was observed in the K-deficient than in the P-deficient treatments,but there was no significant difference in the ratio of respiration rate to Pn between these two treatments,suggesting that differences in energy production efficiency may have accounted for this result.This hypothesis was confirmed by higher ATP contents and activities of NADH dehydrogenase,cytochrome oxidase and ATPase in the K-deficient plants than in the P-deficient plants.We therefore inferred different abilities in energy production efficiency among N,P and K in rice seedlings,which determined rice plant growth and development. | MA Jiaying CHEN Tingting LIN Jie FU Weimeng FENG Baohua LI Guangyan LI Hubo LI Juncai WU Zhihai TAO Longxing FU Guanfu | 2022 | Rice science2022，29，2： | 0 |
| 16 | MXene-based electrochemical (bio) sensors for sustainable applications: Roadmap for future advanced materials显示文摘MXenes are emerging transition metal carbides and nitrides-based 2D conductive materials.They have found wide applications in sensors due to their excellent valuable properties.This paper reviews the recent research status of MXene-based electrochemical(bio)sensors for detecting biomarkers,pesticides,and other aspects.The first part of this paper introduced the synthesis strategy and the effect of surface modification on various prop-erties of MXenes.The second part of this paper discussed the application of MXenes as electrode modifiers for detecting pesticides,environmental pollutants,and biomarkers such as glucose,hydrogen peroxide,etc.Hope this review will inspire more efforts toward research on MXene-based sensors to meet the growing requirements. | Qing Wang Ning Han Zhangfeng Shen Xue Li Zhijie Chen Yue Cao Weimeng Si Fagang Wang Bing-Jie Ni Vijay Kumar Thakur | 2023 | Nano Materials Science2023，5，1： | 0 |
| 17 | Animal Safety Test of Bacillus thuringiensis BT Protein显示文摘[Objectives]To determine the biological safety of BT protein from Bacillus thuringiensis(Bt)fermentation broth to mammals at high doses.[Methods]Healthy mice were randomly divided into 4 groups with 10 mice in each group.The experimental groups were fed with Bt fermentation supernatant at 0.2,0.6 and 1.0 mL/kg,respectively,once a day for 7 consecutive days.The blank control group was fed normally without intragastric administration.[Results]There was no significant difference in blood routine and blood biochemical analysis between the experimental group and the control group.After intragastric administration,the mice were dissected,and no obvious pathological changes were found;the heart,liver,spleen,lung and kidney were taken to make tissue sections,and no pathological changes were found by microscopic observation.[Conclusions]Mice can tolerate high doses of BT protein from B.thuringiensis fermentation broth. | Weimeng NING Dingkuo LIU Fang LIU Yuan LI Xiaowei YANG Zhenguo GUAN Guijun YANG Bo ZHANG Pengcheng HU | 2024 | Asian Agricultural Research2024，16，2： | 0 |
| 18 | A UV cross-linked gel polymer electrolyte enabling high-rate and high voltage window for quasi-solid-state supercapacitors显示文摘Serving as a promising alternative to liquid electrolyte in the application of portable and wearable devices,gel polymer electrolytes(GPEs)are expected to obtain more preferable properties rather than just be satisfied with the merits of high safety and deformability.Here,an easy-operated method is employed to fabricate cross-linked composite polymer membranes used for GPEs assisted by UV irradiation,in which N-doped carbon quantum dots(N-CQDs)and TiO2are introduced as photocatalysts and additives to improve the performances of GPEs.Specifically,N-CQDs participate as a cross-linker to construct the inner porous structure,and TiO2nanoparticles serve as a stabilizer to improve the electrochemical stability of GPEs under high voltage(3.5 V).The excellent thermal and mechanical stability of the membrane fabricated in this work guarantee the safety of the supercapacitors(SCs).This GPE based SC not only exhibits prominent rate performance(105%capacitance retention at the current density of 40A g^(-1))and cyclic stability(85%at 1 A g^(-1)under 3.5 V after 20,000 cycles),but also displays remarkable energy density(42.88 Wh kg^(-1))with high power density(19.3 k W kg^(-1)).Moreover,the superior rate and cycling performances of the as-prepared GPE based flexible SCs under flat and bending state confirm the feasibility of its application in flexible energy storage devices. | Yuge Bai Chao Yang Boheng Yuan Hongjie Li Weimeng Chen Haosen Yin Bin Zhao Fei Shen Xiaogang Han | 2023 | Journal of Energy Chemistry2023，，1： | 0 |
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