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| 1 | The MOOC/SPOC Based'1+M+N'Multi-University Collaborative Teaching and Learning Mode:Practice and Experience显示文摘Since 2012, the MOOCs, the massive open online courses, have brought big influences on the higher education in the world. How to use MOOCs to help universities rather than bother them to improve their education level and quality becomes an important issue. In China, many universities have explored the new modes and approaches for MOOC/SPOC-based teaching and learning. Especially, the China MOOC Association on Computing Education(CMOOC association), established in 2014, has done a set of successful practice and achieved fruitful experiences on MOOC courses development and computer education reform. Based on the practical experiences, a MOOC/SPOC based '1+M+N' multi-university collaborative teaching and learning mode is presented, which is adapted to the real situation of Chinese university education. In the paper, the practices and experiences of CMOOC association are introduced, the MOOC/SPOC based '1+M+N' multi-university collaborative teaching and learning mode and its approaches are described. Finally, the suggestions for MOOCs development and applications are also presented. | Xiaofei Xu Dechen Zhan Ce Zhang Dianhui Chu Weihua Guo | 2018 | 计算机教育2018，，12： | 11 |
| 2 | Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis显示文摘 | Tianyu Han Weihua Zhan Mingxi Gan Fanrong Liu Bentong Yu Y. Eugene Chin Jian-Bin Wang | 2018 | Cell Research2018，28，6： | 6 |
| 3 | Wildlife conservation and management in China:achievements,challenges and perspectives显示文摘Dramatic global changes to the environment have wrought unprecedented reductions in biodiversity, with>28%species assessed by the International Union for Conservation of Nature(IUCN) under the threat of extinction[1]. China, as one of the world’s megadiverse countries, plays a critical role in global biodiversity conservation. | Guangping Huang Xiaoge Ping Weihua Xu Yibo Hu Jiang Chang Ronald R.Swaisgood Jiang Zhou Xiangjiang Zhan Zejun Zhang Yonggang Nie Jie Cui Michael Bruford Zhihe Zhang Baoguo Li Li Zhang Zhi Lv Fuwen Wei | 2021 | National Science Review2021，8，7： | 4 |
| 4 | Hetero-nanostructure of silver nanoparticles on MO_x(M=Mo,Ti and Si) and their applications显示文摘This paper reviews the recent research progress in the hetero-nanostructure of silver nanoparticles on MOx (M=Mo, Ti and Si). It describes the general synthesis of hetero-nanostructure of silver nanoparticles on MOx, and then outlines the interesting catalytic and sensing properties found in these hetero-nanostructures of silver nanoparticles on MOx. | DONG WenJun ZHAO HaiXin LI ChaoRong MEI Jie CHEN BeYong TANG WeiHua SHI Zhan FENG ShouHua | 2011 | Science China Chemistry2011，54，6： | 3 |
| 5 | How does cancer cell metabolism affect tumor migration and invasion?显示文摘 | Tianyu Han De Kang Daokun Ji Xiaoyu Wang Weihua Zhan Minggui Fu Hong-Bo Xin Jian-Bin Wang | 2013 | Cell Adhesion & Migration2013，，5： | 1 |
| 6 | Fractal property of soil particle size distribution and its application显示文摘 | Huang Guanhua Zhan Weihua | 2005 | Acta Peddogwa Sinica2005，42，4： | 1 |
| 7 | EvolutionaryMethod for Finding Communities in Bipartite Networks显示文摘 | Zhan Weihua Zhang Zhongzhi Guan Jihong | 2011 | Physical Review E:Statistical Nonlinear and Soft Matter Physics2011，83，6： | 1 |
| 8 | Effects of cytokines and chemokines on migration of mesenchymal stem cells following spinal cord injury显示文摘We investigated the effects of cytokines and chemokines and their associated signaling pathways on mesenchymal stem cell migration after spinal cord injury, to determine their roles in the curative effects of mesenchymal stem cells. This study reviewed the effects of tumor necrosis factor-α, vascular endothelial growth factor, hepatocyte growth factor, platelet-derived growth factor, basic fibroblast growth factor, insulin like growth factor-1, stromal cell-derived factor and monocyte chemoattractant protein-1, 3 during mesenchymal stem cell migration to damaged sites, and analyzed the signal transduction pathways involved in their effects on mesenchymal stem cell migration. The results confirmed that phosphatidylinositol 3-kinase/serine/threonine protein kinases and nuclear factor-κB play crucial roles in the migration of mesenchymal stem cells induced by cytokines and chemokines. | Longyun Li Maoguang Yang Chunxin Wang Qiheng Zhao Jian Liu Chuanguo Zhan Zhi Liu Xuepeng Li Weihua Wang Xiaoyu Yang | 2012 | Neural Regeneration Research2012，7，14： | 1 |
| 9 | Intestinal microbiota links to allograft stability after lung transplantation: a prospective cohort study显示文摘Whether the alternated microbiota in the gut contribute to the risk of allograft rejection(AR)and pulmonary infection(Pl)in the setting of lung transplant recipients(LTRs)remains unexplored.A prospective multicenter cohort of LTRs was identified in the four lung transplant centers.Paired fecal and serum specimens were collected and divided into AR,Pl,and event-free(EF)groups according to the diagnosis at sampling.Fecal samples were determined by metagenomic sequencing. | Junqi Wu Chongwu Li Peigen Gao Chenhong Zhang Pei Zhang Lei Zhang Chenyang Dai unpeng Zhang Bowen Shi Mengyang Liu Junmeng Zheng Bo Pan Zhan Chen Chao Zhang Wanqing Liao Weihua Pan Wenjie Fang Chang Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 10 | Development of a prognostic signature for esophageal cancer based on a novel 7-DNA damage repair genes signature显示文摘Esophageal cancer(EC)was an aggressive malignant neoplasm characterized by high morbidity and poor prognosis.Identifying the changes in DNA damage repair genes helps to better understand the mechanisms of carcinoma progression.In this study,by comparing EC samples and normal samples,we found a total of 132 DDR expression with a significant difference.Moreover,we revealed higher expression of POLN,PALB2,ATM,PER1,TOP3B and lower expression of HMGB1,UBE2B were correlated to longer OS in EC.In addition,a prognostic risk score based on 7 DDR gene expression(POLN,HMGB1,TOP3B,PER1,UBE2B,ATM,PALB2)was constructed for the prognosis of EC.Meanwhile,EC cancer samples were divided into 3 subtypes based on 132 DDR genes expressions.Clinical profile analysis showed cluster C1 and C2 showed a similar frequency of T2,which was remarked higher than that in cluster 3.Moreover,we found the immune cell inflation levels were significantly changed in different subtypes of EC.The infiltration levels of T cell CD8+,B cell and NK cells were greatly higher in cluster 2 than that in cluster 1 and cluster 3.The results showed T cell CD4+infiltration levels were dramatically higher in cluster 1 than that in cluster 2 and cluster 3.Finally,we perform bioinformatics analysis of DEGs among 3 subtypes of EC and found DDR genes may be related to multiple signaling,such as Base excision repair,Cell cycle,Hedgehog signaling pathway,and Glycolysis/Gluconeogenesis.These results showed DDR genes may serve as new target for the prognosis of EC and prediction of the potential response of immune therapy in EC. | JIAMING ZHAN WEIHUA WANG YANLEI TANG NING ZHOU DAOWEN JIANG | 2022 | BIOCELL2022，46，12： | 0 |
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