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| 1 | A Kelch Motif-Containing Serine/Threonine Protein Phosphatase Determines the Large Grain QTL Trait in Rice显示文摘A thorough understanding of the genetic basis of rice grain traits is critical for the improvement of rice (Oryza sativa L.) varieties.In this study,we generated an F 2 population by crossing the large-grain japonica cultivar CW23 with Peiai 64 (PA64),an elite indica small-grain cultivar.Using QTL analysis,17 QTLs for five grain traits were detected on four different chromosomes.Eight of the QTLs were newly-identified in this study.In particular,qGL3-1,a newly-identified grain length QTL with the highest LOD value and largest phenotypic variation,was fine-mapped to the 17 kb region of chromosome 3.A serine/threonine protein phosphatase gene encoding a repeat domain containing two Kelch motifs was identified as the unique candidate gene corresponding to this QTL.A comparison of PA64 and CW23 sequences revealed a single nucleotide substitution (C→A) at position 1092 in exon 10,resulting in replacement of Asp (D) in PA64 with Glu (E) in CW23 for the 364th amino acid.This variation is located at the D position of the conserved sequence motif AVLDT of the Kelch repeat.Genetic analysis of a near-isogenic line (NIL) for qGL3-1 revealed that the allele qGL3-1 from CW23 has an additive or partly dominant effect,and is suitable for use in molecular marker-assisted selection. | Zejun Hu Haohua He Shiyong Zhang Fan Sun Xiaoyun Xin Wenxiang Wang Xi Qian Jingshui Yang Xiaojin Luo | 2012 | Journal of Integrative Plant Biology2012，54，12： | 41 |
| 2 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 3 | Experimental Study on Emission Performance of an LPP/TVC显示文摘A key issue in the commercial aircraft engine design is environmental acceptability, and designers are continually challenged to reduce emissions. In this paper, an experimental investigation is performed to evaluate the emission performance of a liquid-fueled trapped vortex combustor (TVC) under lean premixed prevaporized (LPP) mode. When operating as an LPP system, a TVC is fueled both in the cavities and in the main stream. The correlations between the emission performance and the total excess air ratio, the positions (4 positions) of the fuel injectors in the main stream, and the inlet temperature are obtained. Experi- mental results show that both the volume concentrations of unburnt hydrocarbon (UHC) and NOx (NO, NO2 usually grouped together as NOx) increase with the increase of total excess air ratio from 1.5 to 3.0; the emission performance relies heavily on the position of the main stream injector, and the best performance is achieved at Position 4 in the experiments; the increase of the inlet temperature impacts on the emission performance positively; the smallest volume concentrations of UHC and NOx obtained in the experiment are 94×10 6 and 2.3×10 6 respectively. This paper validates the feasibility of low emissions for an LPP/TVC and provides a reference for further optimization of TVCs. | JIN Yi HE Xiaomin ZHANG Jingyu JIANG Bo WU Zejun | 2012 | Chinese Journal of Aeronautics2012，25，3： | 17 |
| 4 | Initial study of biexponential model of intravoxel incoherent motion magnetic resonance imaging in evaluation of the liver fibrosis显示文摘 | Chen Cuiyun Wang Bin Shi Dapeng Fu Fangfang Zhang Jiliang Wen Zejun Zhu Shaocheng Xu Junling Lin Qing Li Jing Dou Shewei | 2014 | Chinese Medical Journal2014，，17： | 15 |
| 5 | Effect of China's rapid development on its iconic giant panda显示文摘Anthropogenic factors affect biodiversity and have led to the contraction or extinction of animal populations worldwide.Here,we use historical demographic data,spanning the past 300 years,to show that a rapid distributional contraction of giant pandas took place during the 18th and 19th centuries alongside the increase in human population.Land-use also underwent a significant change across the areas where giant pandas were found because of government agricultural policy and the introduction of new crops.The impact of social development on giant pandas includes habitat loss and fragmentation,and range reductions.Our findings would facilitate the design of effective conservation strategies that seek to conserve and increase current habitats of this iconic species,especially in areas that our analysis has identified as places where pandas have suffered from high human pressure. | ZHU LiFeng HU YiBo ZHANG ZeJun WEI FuWen | 2013 | Chinese Science Bulletin2013，58，17： | 8 |
| 6 | Recent progress in Chinese polar upper-atmospheric physics research: review of research advances supported by the Chinese Arctic and Antarctic expeditions显示文摘It has been more than 30 years since the first Chinese Antarctic Expedition took place. Polar upper atmospheric observations started at this time. First began at Great Wall Station and then at Zhongshan Station in Antarctica, and later in the Arctic at Yellow River Station, Kjell Henriksen Observatory on Svalbard, and at the China-Iceland Joint Aurora Observatory in Iceland. In this paper, we reviewed the advances in polar upper atmosphere physics(UAP) based on the Chinese national Arctic and Antarctic research over the last five years. These included newly deployed observatories and research instruments in the Arctic and Antarctic; and new research findings, from ground-based observations, about polar ionosphere dynamics, aurora and particle precipitation, polar plasma convection, geomagnetic pulsations and space plasma waves, space weather in the polar regions, simulations of the polar ionosphere-magnetosphere. In conclusion, suggestions were made for future polar upper atmosphere physics research in China. | HE Fang HU Hongqiao YANG Huigen ZHANG Beichen HUANG Dehong LIU Yonghua HU Zejun LIU Jianjun | 2016 | Advances in Polar Science2016，27，4： | 6 |
| 7 | An infectious disease of ducks caused by a newly emerged Tembusu virus strain in mainland China显示文摘 | Pixi Yan Youshu Zhao Xu Zhang Dawei Xu Xiaoguang Dai Qiaoyang Teng Liping Yan Jiewen Zhou Xiwen Ji Shumei Zhang Guangqing Liu Yanjun Zhou Yoshihiro Kawaoka Guangzhi Tong Zejun Li | 2011 | Virology2011，，1： | 5 |
| 8 | Modified Dachengqi Tang improves decreased gastrointestinal motility in postoperative esophageal cancer patients显示文摘OBJECTIVE:To investigate the clinical effects of modified Dachengqi Tang(DCQT) on promoting gastrointestinal motility in post-operative esophageal cancer patients.METHODS:Sixty postoperative esophageal cancer patients were enrolled and randomly assigned to the modified treatment group or the control group(30 patients in each group).Patients in the treatment group were given DCQT made from decocted herbs and administered via nasojejunal tube at a dosage of 150 mL.Gastrointestinal motility was assessed by recording time for recovery of bowel sounds,flatus,defecation,and the total amount of gastric drainage during the first three postoperative days.Plasma motilin(MTL) and vasoactive intestinal peptide(VIP) were measured one hour before and three days after surgery.RESULTS:Compared with the control group,the times to first bowel sound,flatus,and defecation were significantly shorter and there was less gastric drainage in the treatment group(P < 0.01,P < 0.01,P < 0.01,and P < 0.05,respectively).In the treatment group,postoperative plasma MTL was significantly higher(P < 0.01) and VIP was significantly lower than those in the control group(P < 0.05).There was no difference found in either MTL or VIP from before to after operation in the treatment group(P > 0.05).MTL was significantly lower and VIP was higher postoperatively in the control group,compared to before surgery(P < 0.01).CONCLUSION:Modified DCQT effectively improved decreased gastrointestinal motility in postoperative esophageal cancer patients by increasing MTL and reducing VIP. | Xu Zejun Xu Cuiping Ge Hongxia Li Yan Chu Liangliang Zhang Jie Cheng Kelin | 2015 | Journal of Traditional Chinese Medicine2015，35，3： | 5 |
| 9 | Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variants显示文摘Multiple new variants of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)have constantly emerged,as the delta and omicron variants,which have developed resistance to currently gained neutralizing antibodies.This highlights a critical need to discover new therapeutic agents to overcome the variants mutations.Despite the availability of vaccines against coronavirus disease 2019(COVID-19),the use of broadly neutralizing antibodies has been considered as an alternative way for the prevention or treatment of SARS-Co V-2 variants infection.Here,we show that the nasal delivery of two previously characterized broadly neutralizing antibodies(F61 and H121)protected K18-h ACE2 mice against lethal challenge with SARS-Co V-2 variants.The broadly protective efficacy of the F61 or F61/F121 cocktail antibodies was evaluated by lethal challenge with the wild strain(WIV04)and multiple variants,including beta(B.1.351),delta(B.1.617.2),and omicron(B.1.1.529)at 200or 1000 TCID_(50),and the minimum antibody administration doses(5-1.25 mg/kg body weight)were also evaluated with delta and omicron challenge.Fully prophylactic protections were found in all challenged groups with both F61 and F61/H121 combination at the administration dose of 20 mg/kg body weight,and corresponding mice lung viral RNA showed negative,with almost all alveolar septa and cavities remaining normal.Furthermore,low-dose antibody treatment induced significant prophylactic protection against lethal challenge with delta and omicron variants,whereas the F61/H121 combination showed excellent results against omicron infection.Our findings indicated the potential use of broadly neutralizing monoclonal antibodies as prophylactic and therapeutic agent for protection of current emerged SARS-Co V-2 variants infection. | Jia Lu Qiangling Yin Rongjuan Pei Qiu Zhang Yuanyuan Qu Yongbing Pan Lina Sun Ding Gao Cuiqin Liang Jingwen Yang Wei Wu Jiandong Li Zongqiang Cui Zejun Wang Xinguo Li Dexin Li Shiwen Wang Kai Duan Wuxiang Guan Mifang Liang Xiaoming Yang | 2022 | Virologica Sinica2022，37，2： | 4 |
| 10 | Wildlife conservation and management in China:achievements,challenges and perspectives显示文摘Dramatic global changes to the environment have wrought unprecedented reductions in biodiversity, with>28%species assessed by the International Union for Conservation of Nature(IUCN) under the threat of extinction[1]. China, as one of the world’s megadiverse countries, plays a critical role in global biodiversity conservation. | Guangping Huang Xiaoge Ping Weihua Xu Yibo Hu Jiang Chang Ronald R.Swaisgood Jiang Zhou Xiangjiang Zhan Zejun Zhang Yonggang Nie Jie Cui Michael Bruford Zhihe Zhang Baoguo Li Li Zhang Zhi Lv Fuwen Wei | 2021 | National Science Review2021，8，7： | 4 |
| 11 | Grazing by wild giant pandas does not affect the regeneration of Arundinaria spanostachya显示文摘Arundinaria spanostachya is the main bamboo species on which giant pandas forage.Information on its regeneration capacity to meet the foraging demands of pandas is important to ensure the long-term survival of pandas.In 2014,2 plot types(grazed versus control)were selected in the winter habitat used by one wild giant panda.Various morphological and regeneration characteristics of the bamboo were assessed in the respective plots during 2014 and 2015.The panda avoided feeding on bamboo with a basal diameter of<6 mm,preferentially feeding on intermediate-sized bamboo.The density of new shoots and the recruitment rate of shoots were significantly higher in the grazed plots compared to the control plots.The annual recruitment rate of shoots was markedly higher than the annual mortality rate in the same plot type.After grazing,the basal diameter and height of new bamboo were similar between the 2 plots.In the grazed plots,the basal diameter of new bamboo was similar to that of the stumps.Innutrition and foraging by insects were the main factors influencing the survival of new shoots.Our results showed that grazing by giant pandas helped the clonal regeneration of A.spanostachya populations,with the basal diameter of new bamboo shoots meeting the foraging demand of pandas.However,information on the carrying capacity of A.spanostachya is necessary to ensure sufficient forage matter is available for reintroduced giant pandas.Furthermore,fertilization and insect control measures should be implemented during the shooting period to optimize A.spanostachya resources. | Longyan Zhang Xiaohong Gan Zhengyang Hou Zhisong Yang Zejun Zhang | 2019 | Journal of Forestry Research2019，30，4： | 2 |
| 12 | Chinese Antarctic Magnetometer Chain at the Cusp Latitude显示文摘A Chinese Antarctic Magnetometer(CAM) chain from Zhongshan Station(ZHS) to Dome-A(DMA) has been established since February 2009.A regular magnetometer is operated at ZHS,and four low power magnetometers are operated along the interior route from ZHS to DMA in the cusp latitude,extending over a distance of 1260 km.These stations fill an important void in the Antarctic magnetometer network.Furthermore,the CAM chain is magnetically conjugated with the Arctic region reaching from the Svalbard archipelago to Daneborg,on the east coast of Greenland.Conjugate measurements using the Arctic and Antarctic magnetometers provide excellent opportunities to investigate phenomena related to the coupling of the solar wind to the magnetosphere and ionosphere,such as magnetic impulse events,flux transfer events,traveling convection vortices and ultra-low frequency waves. | LIU Yonghua HU Hongqiao YANG Huigen ZHANG Beichen SUN Bo WEI Fuhai LIU Yang LIU Jianjun WANG Rui CHEN Zhuotian HU Zejun HAN Desheng SHI Guitao HU Zhengyi WANG Tao AN Chunlei Mike Rose | 2016 | Advances in Polar Science2016，27，2： | 2 |
| 13 | Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy显示文摘Chimeric antigen receptor T cell(CAR T) therapy was a milestone in the treatment of relapsed and refractory B cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implement a porous microneedle patch that accommodates CAR T cells and allows in situ penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in the post-surgical resection cavity. CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity. Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors. | Hongjun Li Zejun Wang Edikan A.Ogunnaike Qing Wu Guojun Chen Quanyin Hu Tianyuan Ci Zhaowei Chen Jinqiang Wang Di Wen Hongwei Du Jie Jiang Jie Sun Xingcai Zhang Gianpietro Dotti Zhen Gu | 2022 | National Science Review2022，9，3： | 2 |
| 14 | The mechanisms of melanogenesis inhibition by glabridin:molecular docking,PKA/MITF and MAPK/MITF pathways显示文摘Glabridin is the main ingredient of hydrophobic fraction in licorice extract and has been shown to have anti-melanogenesis activity in skins.However,the underlying mechanism(s)remain not completely understood.The aim of this study is thus to elucidate the possible mechanisms related to the melanogenesis suppression by glabridin in cultured B16 murine melanoma cells and in UVA radiation induced hyperpigmentation model of BALB/c mice as well.Molecular docking simulations revealed that between catalytic core residues and the compound.The treatment by glabridin significantly downregulated both transcriptional and/or protein expression of melanogenesis-related factors including melanocyte stimulating hormone receptor(MC1R),microphthalmia-associated transcription factor(MITF),tyrosinase(TYR),TYR-related protein-1(TRP-1)and TRP-2 in B16 cells.Both PKA/MITF and MAPK/MITF signaling pathways were found to be involved in the suppression of melanogenesis by glabridin in B16 cells.Also in vivo glabridin therapy significantly reduced hyperpigmentation,epidermal thickening,roughness and inflammation induced by frequent UVA exposure in mice skins,thus beneficial for skin healthcare.These data further look insights into the molecular mechanisms of melanogenesis suppression by glabridin,rationalizing the application of the natural compound for skin healthcare. | Chunxing Pan Xiaoying Liu Yating Zheng Zejun Zhang Yongliang Li Biao Che Guangrong Liu Lanyue Zhang Changzhi Dong Haji Akber Aisa Zhiyun Du Zhengqiang Yuan | 2023 | Food Science and Human Wellness2023，12，1： | 2 |
| 15 | Simultaneous optical and radar observations of poleward moving auroral forms under different IMF conditions显示文摘Using high temporal resolution optical data obtained from three-wavelength all-sky imagers at Chinese Yellow River Station in the Arctic, together with the EISCAT Svalbard radar (ESR) and SuperDARN radars, we investigated the dayside poleward moving auroral forms (PMAFs) and the associated plasma features in the polar ionosphere under different interplanetary magnetic field (IMF) conditions, between 0900 and 1010 UT on 22 December 2003. Simultaneous optical and ESR observations revealed that all PMAFs were clearly associated with pulsed particle precipitations. During northward IMF, particles can precipitate into lower altitudes and reach the ionospheric E-region, and there is a reverse convection cell associated with these PMAFs. This cell is one of the typical signatures of the dayside high-latitude (lobe) reconnection in the polar ionosphere. These results indicate that the PMAFs were associated with the high-latitude reconnection. During southward IMF, the PMAFs show larger latitudinal motion, indicating a longer mean lifetime, and the associated ionospheric features indicate that the PMAFs were generated by the dayside low-latitude reconnection. | XING Zanyang YANG Huigen HAN Desheng WU Zhensen LIU Junming HU Zejun ZHANG Qinghe LIU Yonghua ZHANG Beichen HU Hongqiao | 2012 | Advances in Polar Science2012，23，4： | 2 |
| 16 | Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism显示文摘 | Lu Wang Zejun Wang Xiaoming Li Yi Zhang Min Yin Jiang Li Haiyun Song Jiye Shi Daishun Ling Lihua Wang Nan Chen Chunhai Fan | 2018 | Nano Research2018，11，5： | 2 |
| 17 | Dayside poleward moving auroral forms and ionospheric convection under stable interplanetary magnetic field (IMF) conditions显示文摘Using high temporal resolution optical data obtained from three-wavelength all-sky imagers over six winters continuously at Yellow River Station (78.92°N,11.93°E) in Arctic,we statistically investigated the dependence of location of poleward moving auroral forms (PMAFs) on the interplanetary magnetic field (IMF) B z and B y components as a function of MLT and MLAT under stable IMF conditions.It is found that more PMAFs occurred in lower latitude for Bz<0 and there was less evident IMF B y-related prenoon-postnoon asymmetry for Bz<0 than for Bz>0.We found that the PMAFs were distributed over a wide range of MLT when Bz<0,which indicates that the reconnection X-line might spread like an 'S' shape.However,during northward IMF,PMAFs were observed predominantly prenoon for IMF By>0 and postnoon for IMF By<0 associating with the effect of the high-latitude reconnection,which is largely consistent with the theoretical model of the convection flow. | XING ZanYang YANG HuiGen HAN DeSheng WU ZhenSen LIU JunMing HU ZeJun ZHANG QingHe HU HongQiao LIU YongHua | 2013 | Science China(Technological Sciences)2013，56，4： | 2 |
| 18 | Ectopic overexpression of tomato JERF3 in tobacco activates downstream gene expression and enhances salt tolerance显示文摘 | Hui Wang Zejun Huang Qi Chen Zhijin Zhang Hongbo Zhang Yanming Wu Dafang Huang Rongfeng Huang | 2004 | Plant Molecular Biology2004，，2： | 1 |
| 19 | Fault tolerant attitude control of under-actuated spacecraft:Theory and experiment显示文摘This paper investigates fault tolerant attitude control theory and experiment for underactuated spacecraft with one reaction wheel completely broken and two others suffering actuator faults of partial loss of effectiveness or bias.A non-smooth robust adaptive fault tolerant control law is proposed under the zero-momentum and input saturation conditions.It shows that the available reaction wheels need to produce sufficient control torque for the fault tolerance.Such a new control method is implemented in a semi-physical simulation system of an air-bearing platform.Experimental results show the effectiveness of the proposed method in spacecraft practical engineering. | Zejun ZHANG Hao YANG Bin JIANG | 2023 | Chinese Journal of Aeronautics2023，36，5： | 1 |
| 20 | Dynamic Response Solution of Multi-Layered Pavement Structure Under FWD Load Appling the Precise Integration Algorithm显示文摘The pavement layered structures are composed of surface layer,road base and multi-layered soil foundation.They can be undermined over time by repeated vehicle loads.In this study,a hybrid numerical method which can evaluate the displacement responses of pavement structures under dynamic falling weight deflectometer(FWD)loads.The proposed method consists of two parts:(a)the dynamic stiffness matrices of the points at the surface in the frequency domain which is based on the domain-transformation and dual vector form equation,and(b)interpolates the dynamic stiffness matrices by a continues rational function of frequency.The mixed variables formulation(MVF)can treat multiple degree of freedom systems with considering the coupling term between degree of freedoms.The accuracy of the developed method has been demonstrated by comparison between the proposed method and published results from the other method.Then the proposed method can be applied as a forward calculation technique to emulate the falling weight deflectometer test for multi-layered pavement structures. | Zejun Han Hongyuan Fang Juan Zhang Fuming Wang | 2019 | Computers, Materials & Continua2019，，6： | 1 |
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