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| 1 | Psychometric adaptation of the driving anger expression inventory in a Chinese sample显示文摘 | GE Yan QU Weina ZHANG Qian | 2015 | Transportation Research Part F :Traffic Psychology and Behaviour2015，33，： | 1 |
| 2 | Full Frame Video Stabilization with Motion Inpainting显示文摘 | Matsushita Y Ofek E Ge Weina | 2006 | IEEE Transactions on Pattern Analysis and Machine Intelligence2006，28，7： | 1 |
| 3 | Beneficial Effects of Celastrol on Immune Balance by Modulating Gut Microbiota in Experimental Ulcerative Colitis Mice显示文摘Ulcerative colitis(UC)is a chronic inflammatory bowel disease caused by many factors including colonic inflammation and microbiota dysbiosis.Previous studies have indicated that celastrol(CSR)has strong anti-inflammatory and immune-inhibitory effects.Here,we investigated the effects of CSR on colonic inflammation and mucosal immunity in an experimental colitis model,and addressed the mechanism by which CSR exerts the protective effects.We characterized the therapeutic effects and the potential mechanism of CSR on treating UC using histological staining,intestinal permeability assay,cytokine assay,flow cytometry,fecal microbiota transplantation(FMT),16S rRNA sequencing,untargeted metabolomics,and cell differentiation.CSR administration significantly ameliorated the dextran sodium sulfate(DSS)-induced colitis in mice,which was evidenced by the recovered body weight and colon length as well as the decreased disease activity index(DAI)score and intestinal permeability.Meanwhile,CSR down-regulated the production of pro-inflammatory cytokines and up-regulated the amount of anti-inflammatory mediators at both mRNA and protein levels,and improved the balances of Treg/Th1 and Treg/Th17 to maintain the colonic immune homeostasis.Notably,all the therapeutic effects were exerted in a gut microbiota-dependent manner.Furthermore,CSR treatment increased the gut microbiota diversity and changed the compositions of the gut microbiota and metabolites,which is probably associated with the gut microbiota-mediated protective effects.In conclusion,this study provides the strong evidence that CSR may be a promising therapeutic drug for UC. | Mingyue Li Weina Guo Yalan Dong Wenzhu Wang Chunxia Tian Zili Zhang Ting Yu Haifeng Zhou Yang Gui Kaming Xue Junyi Li Feng Jiang Alexey Sarapultsev Huafang Wang Ge Zhang Shanshan Luo Heng Fan Desheng Hu | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 1 |
| 4 | Lysosome-targeting red fluorescent probe for broad carboxylesterases detection in breast cancer cells显示文摘Available online The abnormal carboxylesterase(CES)expression is closely related to many diseases such as hyperlipidemia,atherosclerosis,obesity,liver cancer,type 2 diabetes mellitus and gastrointestinal stromal tumors.The detection of a single enzyme in practical samples is often constrained by the structural diversity of CESs.Thus,the development of broad-carboxylesterase responsive fluorescent probe,which can detect the presence of wide variety of CESs,may provide overall or category information from another point of view,supplementing the deficiency of single detection for CES subspecies.Organelle lysosome is involved in various cell processes,such as cell signaling,apoptosis,secretion,and energy metabolism.Up to date,lysosome-targeted fluorescent probes,especially those with red emission(over 550 nm,with relatively low biological harmfulness),for CES detection are still rare.A lysosomes-targeted red fluorescent probe CES-Lyso was designed to monitor intracellular a variety of carboxylesterases alteration with wonderful selectivity and sensitivity,which was further applied to distinguish different derived breast cancer cells and monitor carboxylesterase activity in the anticancer drug treatment. | Yanyan Sun Xiaonan Zhou Liyuan Sun Xiuxiu Zhao Yongrui He Ge Gao Weina Han Jin Zhou | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 5 | Allotetraploidization event of Coptis chinensis shared by all Ranunculales显示文摘Coptis chinensis Franch.,also named Chinese goldthread is a member of Ranunculaceae in the order Ranunculales and represents an important lineage of early eudicots with traditional medicinal value.In our study,by using syntenic analysis combined with phylogenomic analysis of C.chinensis and four other representative genomes from basal and core eudicots,we confirmed that the WGD event in C.chinensis was shared by Aquilegia coerulea and Papaver somniferum L.and quickly occurred after Ranunculales diverged from other eudicots,likely a Ranunculales common tetraploidization(RCT).The synonymous nucleotide substitutions at synonymous sites distribution of syntenic blocks across these genomes showed that the evolutionary rate of the P.somniferum genome is faster than that of the C.chinensis genome by approximately 13.7%,possibly due to Papaveraceaes having an additional special tetraploidization event(PST).After Ks correction,the RCT dated to 115—130 million years ago(MYA),which was close to the divergence of Ranunculaceaes and Papaveraceaes approximately115.45—130.51 MYA.Moreover,we identified homologous genes related to polyploidization and speciation and constructed multiple sequence alignments with different reference genomes.Notably,the event-related subgenomes in the basal genomes all showed genomic fractionation bias,suggesting a likely allopolyploid nature of the RCT,PST and T-Alpha and T-Beta events in Tetracentron sinense.In addition,we detected that the sixteen P450 subfamilies were markedly expanded in the genomes of Ranunculales,and most of them were related to the RCT and PST events.We constructed a new platform for Early Eudicot Comparative Genomic Research(http://gffzze84c5b42976d4cd7hqocnv6cfx5pn6095.ffgz.tsg.suse.edu.cn/index.html)to store more information.In summary,our findings support the WGD of C.chinensis shared by Ranunculales,which is likely an allotetraploidization event.This present effort offered new insights into the evolution of key polyploidization events and the genes related to secondary metabolites during the diversification of early eudicots. | Yan Zhang Weina Ge Jia Teng Yanmei Yang Jianyu Wang Zijian Yu Jiaqi Wang Qimeng Xiao Junxin Zhao Shaoqi Shen Yishan Feng Shoutong Bao Yu Li Yuxian Li Tianyu Lei Yuxin Pan Lan Zhang Jinpeng Wang | 2024 | Horticultural Plant Journal2024，10，1： | 0 |
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