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| 1 | Post-collisional extensional and thrust-nappe structures in northern part of Dabie Mountains显示文摘Thrust-nappe structures and extensional struc-tures simultaneously occur in the northern part of the Dabie Mountains. The systematic structural study reveals that extensional structures along the Mozitan-Xiaotian fault and thrust-nappe structures that take the Jinzhai-Shucheng fault as their frontal thrust share the same shear sense, and display a transitional relationship from the ductile exten- sional structure of deep level in the south to the ductile-brit- tle and brittle thrust-nappe structure of shallow level in the north. The extensional and thrust-nappe structures in the region are explained to result from post-collisional processes by the continuous subduction of the Yangtze continental block and the extension induced by the uplifting of the core part of the Dabie Mountains, which are components of the extensional structures produced in the exhumation process of the ultrahigh pressure metamorphic rocks in the Dabie Mountains. Because of the frontal blocking in the process of the north-westward spreading, the extension and detachment of the low-grade metamorphic rocks along the Mozi-tan-Xiaotian fault was transformed into the northwestward thrusting, resulting in the thrust-nappe structures. They de-veloped in the period of 200 170 Ma, maybe last till the late Jurassic. | JIANG Laili, WU Weiping, CHU Dongru, LIU Yican & ZHANG Yong Geological Survey of Anhui Province , Hefei 230001, China Correspondence should be addressed to Jiang Laili (e-mail: lailij@mail. hf.ah.cn) | 2003 | Chinese Science Bulletin2003，48，21： | 9 |
| 2 | Low-frequency sea level variation and its correlation with climate events in the Pacific显示文摘Global mean sea level(GMSL) has not only significant secular trend and seasonal variations,but also inter-annual and decadal variations.This paper reconstructs the time series of GMSL variations between 1948 and 2007 by combining satellite altimeter measurements and tide gauge observations.Based on the time series,the acceleration of GMSL rise in the second half of 20th century is estimated to be 0.010±0.009 mm/a 2,and multi-scale low frequency sea level oscillations including decadal variations are detected,and the high-rate of GMSL rise during 1993-2003 is locate in the ascending phase of low frequency oscillation.Then,using the reconstructed GMSL time series after removing the secular trend from satellite altimetry and tide gauges measurements,it shows that low frequency signal of sea level variation has strong correlations with the index of El Ni o/Southern Oscillation(ENSO) and Pacific Decadal Oscillation(PDO).But in several time periods,they have large difference due to effects of both high frequency occurrence of El Ni o and La Ni a phenomenon and short term switch of PDO events. | JIN TaoYong LI JianCheng JIANG WeiPing CHU YongHai | 2012 | Chinese Science Bulletin2012，57，27： | 6 |
| 3 | Microstructure and Mechanical Behavior of FeNiCoCr and FeNiCoCrMn High-Entropy Alloys Fabricated by Powder Metallurgy显示文摘The present work reports a systematic investigation on phase evolution,microstructure and microstructure-property relationship of two typical face-centered cubic(FCC)structured high-entropy alloys(HEAs),FeNiCoCr and FeNiCoCrMn,prepared via mechanical alloying(MA)followed by spark plasma sintering(SPS).Following 50 h of MA,the two HEAs consisted of a mixture of FCC and body-centered cubic phases.Following SPS,the bulk FeNiCoCr alloy showed a primary FCC phase with a small amount of Cr_(23)C_(6) and Cr_(2)O_(3) contaminants,while the bulk FeNiCoCrMn alloy was composed of a primary FCC phase with some(Cr,Mn)23C6 and MnCr_(2)O_(4) contaminants.The average grain size of the primary FCC phase in the bulk FeNiCoCr alloy was~416 nm,while that of the primary FCC phase in the bulk FeNiCoCrMn alloy was~547 nm.The yield strength,compressive strength and strain-to-failure of the bulk FeNiCoCr alloy are 1525 MPa,1987 MPa and 24.4%,respectively,whereas those of the bulk FeNiCoCrMn alloy are 1329 MPa,1761 MPa and 21.9%,respectively.It suggests that the bulk FeNiCoCrMn exhibited lower strength and plasticity in comparison with the bulk FeNiCoCr alloy.Clearly,the smaller grain size of the primary FCC phase in the FeNiCoCr alloy is mainly responsible for the better mechanical performance. | Chenliang Chu Weiping Chen Zhen Chen Zhenfei Jiang Hao Wang Zhiqiang Fu | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，4： | 3 |
| 4 | Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine(5hmC)显示文摘As a dioxygenase, Ten-Eleven Translocation 2(TET2) catalyzes subsequent steps of 5-methylcytosine(5 mC) oxidation. TET2 plays a critical role in the self-renewal, proliferation,and differentiation of hematopoietic stem cells, but its impact on mature hematopoietic cells is not well-characterized. Here we show that Tet2 plays an essential role in osteoclastogenesis. Deletion of Tet2 impairs the differentiation of osteoclast precursor cells(macrophages) and their maturation into bone-resorbing osteoclasts in vitro. Furthermore, Tet2^(-/-) mice exhibit mild osteopetrosis, accompanied by decreased number of osteoclasts in vivo. Tet2 loss in macrophages results in the altered expression of a set of genes implicated in osteoclast differentiation, such as Cebpa, Mafb, and Nfkbiz. Tet2 deletion also leads to a genome-wide alteration in the level of 5-hydroxymethylcytosine(5 hmC) and altered expression of a specific subset of macrophage genes associated with osteoclast differentiation. Furthermore, Tet2 interacts with Runx1 and negatively modulates its transcriptional activity. Our studies demonstrate a novel molecular mechanism controlling osteoclast differentiation and function by Tet2, that is, through interactions with Runx1 and the maintenance of genomic 5 hmC. Targeting Tet2 and its pathway could be a potential therapeutic strategy for the prevention and treatment of abnormal bone mass caused by the deregulation of osteoclast activities. | Yajing Chu Zhigang Zhao David Wayne Sant Ganqian Zhu Sarah M. Greenblatt Lin Liu Jinhuan Wang Zeng Cao Jeanette Cheng Tho Shi Chen Xiaochen Liu Peng Zhang Jaroslaw P. Maciejewski Stephen Nimer Gaofeng Wang Weiping Yuan Feng-Chun Yang Mingjiang Xu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 2 |
| 5 | The Feasibility of Total or Near-Total Bilateral Thyroidectomy for the Treatment of Bilateral Multinodular Goiter显示文摘 | Weiping Yang Tanglei Shao Jiazeng Ding Xiaotai Jin Qinyu Li Peiguo G. Chu Yun Yen Weihua Qiu | 2009 | Investigative Surgery2009，，3： | 1 |
| 6 | Microbial source tracking in a small southern California urban watershed indicates wild animals and growth as the source of fecal bacteria显示文摘 | Sunny C Jiang Weiping Chu Betty H Olson | 2007 | Appl Microbiol Biotechnol2007，10，7： | 1 |
| 7 | Adjacent acid sites cooperatively catalyze fructose to 5-hydroxymethylfurfural in a new, facile pathway显示文摘To study the effect of adjacent hydroxyl to the active sites, several acid catalysts, i.e. substituted benzoic acids with adjacent carboxyl are employed in the fructose dehydration to 5-hydroxymethylfurfural(HMF).Experimental results reveal that Br?nsted acid sites with adjacent carboxyl present higher catalytic ability than isolated ones. Computational results suggest that the adjacent sites lead to co-interaction on fructose, corresponding more stable transition state and faster HMF formation rate. Based on the enhancement from the adjacent sites, a novel ordered mesoporous carbon(OMC) full of carboxyls in surface is prepared and turns out to be an effective solid catalyst for HMF production from fructose derived from biomass. | Xia Yu Yueying Chu Lei Zhang Hui Shi Mingjiang Xie Luming Peng Xuefeng Guo Wei Li Nianhua Xue Weiping Ding | 2020 | Journal of Energy Chemistry2020，29，8： | 1 |
| 8 | Increased Mortality from Delayed Diagnosisand Treatment of Obturator Hernia in Elderly Patients显示文摘 | Seewoo Varun Jin Xiaotai Yang Weiping Wang Jiayu Chu Peiguo G Yen Christina Qiu Weihua | 2012 | EN2012，，4： | 1 |
| 9 | Energy partitioning and evapotranspiration in a black locust plantation on the Yellow River Delta,China显示文摘Plantations of woody tree species play a crucial role in ecological security along coastal zones.Understanding energy partitioning and evapotranspiration can reveal land–atmosphere interaction processes.We investigated energy fluxes,evapotranspiration,and their related biophysical factors using eddy covariance techniques in a black locust(Robinia pseudoacacia L.)plantation in 2016,2018,and 2019 on the Yellow River Delta.Downward longwave radiation offsets 84–85%of upward longwave radiation;upward shortwave radiation accounted for 12–13%of downward shortwave radiation.The ratio of net radiation to downward radiation was 18–19%over the three years.During the growing season,latent heat flux was the largest component of net radiation;during the dormant season,the sensible heat flux was the dominant component of net radiation.The seasonal variation in daily evapotranspiration was mainly controlled by net radiation,air temperature,vapor pressure deficit,and leaf area index.Black locust phenology influenced daily evapotranspiration variations,and evapotranspiration was greater under sea winds than under land winds because soil water content at 10-cm depth was greater under sea winds during the day.Seasonal patterns of daily evaporative fraction,Bowen ratio,crop coefficient,Priestley–Taylor coefficient,surface conductance,and decoupling coefficient were mainly controlled by leaf area index.The threshold value of daily surface conductance was approximately 8 mm sover the plantation. | Xiang Gao Zhenyu Du Qingshan Yang Jinsong Zhang Yongtao Li Xiaojie Wang Fengxue Gu Weiping Hao Zekun Yang Dexi Liu Jianmin Chu | 2022 | Journal of Forestry Research2022，33，4： | 1 |
| 10 | Colony-stimulating factor 3 receptor (CSF3R) M696T mutation does not impact on clinical outcomes of a Ph+ acute lymphoblastic leukemia patient显示文摘Colony-stimulating factor 3 receptor(CSF3R)mutations have been identified in a variety of myeloid disorders.Although CSF3R point mutations(eg,T618I)are emerging as key players in chronic neutrophilic leukemia/atypical chronic myelogenous leukemia,the significance of rarer CSF3R mutations is unknown.Here,we report a 32-year-old female who was diagnosed as Philadelphia chromosome-positive acute lymphoblastic leukemia(Ph^(+)ALL)with the CSF3R M696T mutation and was undergone unrelated donor hematopoietic stem cell transplantation.The patient achieved complete remission with chemotherapy in combination with tyrosine kinase inhibitor(TKI)and long-term survival by unrelated donor transplantation.Meanwhile,we performed a series of experiments using murine interleukin 3(IL-3)-dependent Ba/F3 cell line to evaluate the transforming capacity of the CSF3R M696T mutation.We confirmed the presence of a CSF3R M696T germline mutation in this patient which was inherited from her mother.The in vitro experiment results showed that the CSF3R M696T mutation contributes marginally to the tumor transformation of Ba/F3 cells,indicating that CSF3R M696T mutation was neutral in tumor transformation ability.We concluded that TKI is effective in patients with the CSF3R M696T mutation in Ph+ALL and donors with CSF3R M696T mutation might still be selected as the candidate for transplantation. | Xin Chen Bichen Wang Aiming Pang Weiping Yuan Erlie Jiang Yajing Chu Sizhou Feng Mingzhe Han | 2021 | Blood Science2021，3，3： | 0 |
| 11 | Mathematical modelling study for water uptake of steadily growing plant root显示文摘The root system of plant is a vitally important organ for living plant. One of the major functions of the root system is uptaking water and nutrients from the soil. The present paper analyzes the whole process of water uptake from soil by a steadily growing plant with a single slender root. We start from the basic principles of physics and fluid-dynamics, consider the structure characteristics of the water transport channel formed by the tiny xylems tubes inside plant, and establish a simplified coherent mathematical model to describe the water transport in the complete system consisting of soil, individual plant, including root, stem and leaves-atmosphere, on the basis of the plant physiology. Moreover, we resolve the proposed mathematical model for a simple artificial plant model under a variety of conditions, in terms of the numerical approach as well as analytical approach. It is shown that the results obtained by both approaches are in very good agreement; the theoretical predictions are qualitatively consistent with the practical experi-ences very well. The simplified mathematical model established in the present pa-per may provide a basis for the further investigations on the more sophisticated mathematical model. | CHU JiaQiang JIAO WeiPing XU JianJun | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，2： | 0 |
| 12 | Reply to: Parker A. Comment on “Low-frequency sea level variation and its correlation with climate events in the Pacific”显示文摘First, we would like to thank Parker for his discussion and comments on our work. Parker’s main concern [1] is that the sea level is oscillating with important multi-decadal periodicities but absolutely not positively accelerating. He also argued that the global mean sea level (GMSL) acceleration computed by Jin et al. [2] seemed too large. His | JIN TaoYong LI JianCheng JIANG WeiPing CHU YongHai | 2013 | Chinese Science Bulletin2013，58，14： | 0 |
| 13 | Loss of Tet2 affects platelet function but not coagulation in mice显示文摘Ten-eleven translocation 2(TET2)functions as a methylcytosine dioxygenase that catalyzes the iterative oxidation of 5-methylcytosine to 5-hydroxymethylcytosine,5-formylcytosine and 5-carboxylcytosine.TET2 has been shown to be crucial for the maintenance and differentiation of hematopoietic stem cells,and its deletion and/or mutations results in the expansion of HSPCs,and leads to hematological malignancies.TET2 mutations were found in a variety of hematological disorders such as CMML(60%),MDS(30%),MPN(13%)and AML(20%).Interestingly,it was shown that CMML patients with TET2 mutation exhibited fewer platelets than CMML patients without TET2 mutation.However,the role and function of TET2 in platelet hemostasis and thrombogenesis is not well defined.Here in this study,using a genetically engineered Tet2 deletion mouse model,we found that the absence of Tet2 caused a decrease in the proportion of MEP cells and hyperploid megakaryocytes.Additionally,Tet2-deficient mice displayed impaired platelet activation and aggregation under stimulation of ADP and low concentrations of thrombin,although the modestly compromised platelet function and MEP differentiation in Tet2-deficient mice could be compensated without affecting blood coagulation function.Our study indicate that Tet2 deficiency leads to mild impairment of platelet function and thrombopoiesis in mice. | Bichen Wang Meijuan Xia Ting Chen Mengke Li Deyang Shi Xiaomin Wang Aiming Pang Jiaxi Zhou Weiping Yuan Yajing Chu | 2020 | Blood Science2020，2，4： | 0 |
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