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| 1 | nflammasomes in cancer: a double-edgecl sword显示文摘 | Ryan Kolb Guang-Hui Liu Ann M. Janowski Fayyaz S. Sutterwala Weizhou Zhang | 2014 | Protein & Cell2014，5，1： | 34 |
| 2 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘 | Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu | 2016 | Cell Research2016，26，2： | 32 |
| 3 | ROR1, an embryonic protein with an emerging role in cancer biology显示文摘(ROR1 ) 受体酷氨酸象 kinase 一样孤儿受体 1 是由 ROR1 和 ROR2 组成的 ROR 家庭的一个成员。ROR 包含二个不同细胞外的充满半胱氨酸的领域和领域 transmembrane 领域。在细胞内部的部分以内, ROR1 拥有一个酷氨酸 kinase 领域,二个 serine/threonine-rich 领域和一个充满脯氨酸的领域。ROR 通过许多相当或相同的事物在胚胎的 patterning 和神经发生的上下文被学习了。这些生理的函数基于 kinase 域的要求是两分的。成长文学为癌症作为一个标记建立了 ROR1,例如在 CLL 和另外的血恶意。另外, ROR1 极其涉及很多血和稳固的恶意的前进。ROR1 被显示了禁止 apoptosis,加强 EGFR 发信号,并且导致上皮间充质的转变(EMT ) 。重要地, ROR1 在胚胎的织物仅仅是可检测的并且通常在成年织物不在,使蛋白质成为为癌症治疗的一个理想的药目标。 | Nicholas Borcherding David Kusner Guang-Hui Liu Weizhou Zhang | 2014 | Protein & Cell2014，5，7： | 12 |
| 4 | Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding显示文摘 | Jiping Yang Jingyi Li Keiichiro Suzuki Xiaomeng Liu Jun Wu Weiqi Zhang Ruotong Ren Weizhou Zhang Piu Chan Juan Carlos Izpisua Belmonte Jing Qu Fuchou Tang Guang-Hui Liu | 2017 | Cell Research2017，27，9： | 12 |
| 5 | Vitamin C alleviates aging defects in a stem cell model for Werner syndrome显示文摘沃纳症候群(WS ) 是主要影响从中层导出的纸巾的早衰混乱。我们最近用 WRN 缺乏的人的间充质的干细胞(MSC ) 开发了一个新奇人的 WS 模型。这个模型概括 WS 的许多 phenotypic 特征。基于很多化学药品的一幅屏幕,这里,我们发现维生素 C 在出现在WRN缺乏的 MSC 的早衰为许多特征施加很有效的营救包括细胞生长拘捕,增加了反应的氧种层次, telomere 摩擦,煽动性的因素的过多的分泌物,象原子薄板和 heterochromatin 的组织的破坏一样。而且,维生素 C 在一个老鼠模型在 vivo 恢复 MSC 的生存能力。定序分析的 RNA 显示维生素 C 改变涉及染色质冷凝作用,房间周期规定, DNA 复制,和 DNA 损坏的一系列基因的表示在 WRN 缺乏的 MSC 的修理小径。我们的结果为 WS MSC 作为一个恢复因素识别维生素 C,它保持作为 WS 的处理的一种新奇类型被使用的潜力。 | Ying Li Weizhou Zhang Liang Chang Yan Han Liang Sun Xiaojun Gong Hong Tang Zunpeng Liu Huichao Deng Yanxia Ye Yu Wang Jian Li Jie Qiao Jing Qu Weiqi Zhang Guang-Hui Liu | 2016 | Protein & Cell2016，7，7： | 10 |
| 6 | Find and replace: editing human genome in pluripotent stem cells显示文摘Genetic manipulation of human pluripotent stem cells(hPSCs)provides a powerful tool for modeling diseases and developing future medicine.Recently a number of independent genome-editing techniques were developed,including plasmid,bacterial artificial chromosome,adeno-associated virus vector,zinc finger nuclease,transcription activator-like effecter nuclease,and helper-dependent adenoviral vector.Gene editing has been successfully employed in different aspects of stem cell research such as gene correction,mutation knock-in,and establishment of reporter cell lines(Raya et al.,2009;Howden et al.,2011;Li et al.,2011;Liu et al.,2011b;Papapetrou et al.,2011;Sebastiano et al.,2011;Soldner et al.,2011;Zou et al.,2011a).These techniques combined with the utility of hPSCs will significantly influence the area of regenerative medicine. | Huize Pan Weiqi Zhang Weizhou Zhang Guang-Hui Liu | 2011 | Protein & Cell2011，2，12： | 6 |
| 7 | Effects of Airflow Field on Droplets Diameter inside the Corrugated Packing of a Rotating Packed Bed显示文摘Rotating packing bed(RPB) has a better mixing performance than traditional mixers and shows potential application in the petroleum industry. However, acquisition of information about the mixing process directly through experiments is difficult because of the compact structure and complex multiphase flow pattern in RPB. To study the mixing characteristic, Fluent, the computational fluid dynamics(CFD) software, was used to explore the effect of airflow field on droplet diameter. For conducting calculations, the gas-liquid two-phase flow inside the packing was simulated with the RNG k-ε turbulence model and the Lagrange Discrete Phase Model(DPM), respectively. The numerical calculation results showed that coalescence and breakup of droplets can take place in the gas phase flow inside the packing and can be strengthened with increased rotating speed, thereby leading to the enlargement of the average diameter. | Xu Chengcheng Jiao Weizhou Liu Youzhi Guo Liang Yuan Zhiguo Zhang Qiaoling | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，4： | 4 |
| 8 | Visualization of aging-associated chromatin alterations with an engineered TALE system显示文摘在实时房间的特定的 genomic loci 的可视化在多样的生物过程期间是为在染色质建筑学的动态变化的调查的一个前提,例如细胞的老化。然而,当前的精确 genomic 成像方法被缺乏妨碍荧光灯有高特性和 signal-to-noise 的探针形成对照。我们发现那常规抄写像使活跃之物的受动器(故事) 趋于形成蛋白质总数,从而在成像应用程序损害他们的性能。通过屏蔽,我们发现有故事的那熔化 thioredoxin 阻止了总数形成,开基于故事的 genomic 成像的完整的力量。用熔化 thioredoxin 的故事(TTALE ) ,我们在各种各样的 genomic loci 完成了高质量的成像并且观察联系老化(epi ) 在在人和老鼠早衰模型的 telomeres 和着丝点的 genomic 改变。重要地,我们鉴别 ribosomal DNA 的摩擦为人的老化作为一个分子的标记重复。我们的学习为精确在 vitro 并且在 vivo 监视染色质动力学建立一个简单、柔韧的成像方法。 | Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu | 2017 | Cell Research2017，27，4： | 4 |
| 9 | Sm-Nd isotopic compositions of Cambrian-Ordovician strata at the Jinggangshan area in Jiangxi Province: Tectonic implications显示文摘Whole-rock Sm-Nd isotopes were investigated for Cambrian-Ordovician strata from the Jinggangshan area between the Yangtze Block and Cathysia Block in South China. These strata were deposited as a greatly thick unit of muddy-sandy laminas with intercalated carbonate and organic carbon-bearing layers. They have low εNd(t) values of –13.9 to –7.9 and old Nd model ages of 1842 to 2375 Ma. In tDM-tStr diagram, they are far away from the concordant line but fall within the evolution zone of the Proterozoic crust of South China. This indicates that the Cambrian-Ordovician strata are mainly composed of mat- ters eroded from ancient Paleoproterozoic crust that may mainly consist of continental-derived detrital sediments with high maturity in the Cathysia Block. However, the Ordovician Jueshangou Formation and Dui’ershi Formation have εNd(t) values of –10.5 and –7.9 at the higher end of the above range and Nd model ages of 1842 to 2059 Ma at the lower end of the above range. This suggests involvement of more detritus that were eroded from the relatively juvenile crust from Late Paleoproterozoic to the Early Neoproterozoic. All the Nd model ages for the Cambrian-Ordovician sedimentary rocks in the Cathysia Block and the southeastern margin of the Yangtze Block are older than 1800 Ma, suggesting that no material from the Early Paleozoic depleted mantle-derived magmas was involved in these regions. | SHEN WeiZhou LING HongFei SHU LiangShu ZHANG FangRong XIANG Lei | 2009 | Chinese Science Bulletin2009，54，10： | 4 |
| 10 | Efficacy and safety of drug-eluting stent implantation for the treatment of in-stent restenosis occurring within bare-metal stent and drug-eluting stent显示文摘Objective:Although drug-eluting stent(DES) implantation is the primary treatment modality for bare-metal stent(BMS) in-stent restenosis(ISR),little is known about the efficacy and safety profile of DES in the treatment of DES-ISR.The goal of this study was to compare the clinical outcomes following DES treatment for BMS-ISR and DES-ISR.Methods:Rates of major adverse cardiac events(MACE) were compared in 97 consecutive patients who underwent DES implantation for the treatment of ISR(56 BMS-ISR and 41 DES-ISR) from January 2004 to December 2008.Results:Baseline clinical and procedural characteristics were comparable,except that the DES used in the BMS-ISR group was longer and had a larger diameter.The length of follow-up was(28.60±1.96) and(20.34±1.54) months for the BMS-ISR and DES-ISR groups,respectively.One patient(1.8%) experienced non-cardiac mortality and one(1.8%) had target-vessel revascularization(TVR) in the BMS-ISR group.In the DES-ISR group,three patients(7.3%) died of sudden death with a documented acute ST-segment elevation myocardial infarction,and three suffered TVR(7.3%).Kaplan-Meier analysis indicated that cumulative survival probability and MACE-free probability were both significantly lower for the DES-ISR group(log rank test P=0.047 and P=0.005,respectively).In Cox regression analysis,DES-ISR remained an independent predictor for future MACE occurrence after adjustment for other factors(compared with BMS-ISR,risk ratio(RR)=8.743,95% confidence interval(CI) 1.54-49.54,P=0.014).Switching to a different type of DES to treat DES-ISR did not improve the prognosis.Conclusion:DES-ISR patients had a poorer prognosis than BMS-ISR patients after DES therapy. | Heng GE Qing ZHANG WeiZHOU Qing HE Zhi-hua HAN Ben HE | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，8： | 3 |
| 11 | Dispersion Performance of Methanol-Diesel Emulsified Fuel Prepared by High Gravity Technology显示文摘A new continuous process for preparing methanol-diesel emulsified fuel with an Impinging Stream-Rotating Packed Bed is proposed. The droplet size of dispersed phase(methanol) of the emulsified fuel has a significant effect on the combustion of methanol-diesel emulsified fuel. In this paper, the methanol-diesel emulsified fuel uses diesel as the continuous phase and methanol as the dispersed phase. The Sauter mean diameter of the dispersed phase of methanol-diesel emulsified fuel was characterized with microphotography and arithmetic method. The experimental result showed that the Sauter mean diameter of the dispersed phase, which was decreased with the augmentation of the high gravity factor, liquid flow rate and emulsifier dosage, was inversely proportional to the methanol content. The Sauter mean diameter of the dispersed phase can be controlled and adjusted in the range of 12—40 μm through the change of operating conditions. The correlative expressions of the Sauter mean diameter of emulsified fuel were obtained and the calculated values agreed well with the experimental values. | Jiao Weizhou Li Jing Liu Youzhi Zhang Qiaoling Liu Wenli Xu Chengcheng Guo Liang | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，1： | 2 |
| 12 | Effect of phosphate-based sealing treatment on the corrosion performance of a PEO coated AZ91D mg alloy显示文摘This study investigated the effect of sealing treatment on the corrosion performance of plasma electrolytic oxidation(PEO)coated AZ91D Mg alloy with and without addition of corrosion inhibitor.The microstructure,phase composition and corrosion property of the sealed and unsealed coatings were evaluated by using scanning electron microscopy(SEM),energy dispersion spectroscopy(EDS),x-ray diffraction(XRD),x-ray photoelectron spectroscopy(XPS),polarization,and electrochemical impedance spectroscopy(EIS)tests.Electrochemical experiments and salt spray tests showed that,after sealing in phosphate solution containing corrosion inhibitor,the corrosion current density of PEO-coated AZ91D decreased more than 10-fold and the anti-corrosion time in a salt spray environment increased more than three-fold.The corrosion rate of the PEO coating slowed down due to the releasing and adsorbing of the corrosion inhibitors in the pores and cracks of the coating during the corrosion process. | Kun Qian Weizhou Li Xiaopeng Lu Xinxin Han Yong Jin Tao Zhang Fuhui Wang | 2020 | Journal of Magnesium and Alloys2020，8，4： | 2 |
| 13 | Converted neural cells: induced to a cure?显示文摘Many neurodegenerative disorders such as Parkinson’s disease(PD),amyotrophic lateral sclerosis(ALS)and others often occur as a result of progressive loss of structure or function of neurons.Recently,many groups were able to generate neural cells,either differentiated from induced pluripotent stem cells(iPSCs)or converted from somatic cells.Advances in converted neural cells have opened a new era to ease applications for modeling diseases and screening drugs.In addition,the converted neural cells also hold the promise for cell replacement therapy(Kikuchi et al.,2011;Krencik et al.,2011;Kriks et al.,2011;Nori et al.,2011;Rhee et al.,2011;Schwartz et al.,2012).Here we will mainly discuss most recent progress on using converted functional neural cells to treat neurological diseases and highlight potential clinical challenges and future perspectives. | Weiqi Zhang Shunlei Duan Ying Li Xiuling Xu Jing Qu Weizhou Zhang Guang-Hui Liu | 2012 | Protein & Cell2012，3，2： | 2 |
| 14 | Multi-scale finite element simulation on large deformation behavior of wood under axial and transverse compression conditions显示文摘Multi-scale finite element method is adopted to simulate wood compression behavior under axial and transverse loading. Representative volume elements (RVE) of wood microfibril and cell are proposed to analyze orthotropic mechanical behavior. Lignin, hemicellulose and crystalline-amorphous cellulose core of spruce are concerned in spruce nanoscale model. The equivalent elastic modulus and yield strength of the microfibril are gained by the RVE simulation. The anisotropism of the crystalline-amorphous cellulose core brings the microfibril buckling deformation during compression loading. The failure mechanism of the cell-wall under axial compression is related to the distribution of amorphous cellulose and crystalline cellulose. According to the spruce cell observation by scanning electron microscope, numerical model of spruce cell is established using simplified circular hole and regular hexagon arrangement respectively. Axial and transverse compression loadings are taken into account in the numerical simulations. It indicates that the compression stress-strain curves of the numerical simulation are consistent with the experimental results. The wood microstructure arrangement has an important effect on the stress plateau during compression process. Cell-wall buckling in axial compression induces the stress value drops rapidly. The wide stress plateau duration means wood is with large energy dissipation under a low stress level. The numerical results show that loading velocity affects greatly wood microstructure failure modes in axial loading. For low velocity axial compression, shear sliding is the main failure mode. For high velocity axial compression, wood occur fold and collapse. In transverse compression, wood deformation is gradual and uniform, which brings stable stress plateau. | Weizhou Zhong Zexiong Zhang Xiaowei Chen Qiang Wei Gang Chen Xicheng Huang | 2021 | Acta Mechanica Sinica2021，37，7： | 2 |
| 15 | "TET-on" pluripotency显示文摘 | Ping Wang Jing Qu Mm-Zu Wu Weizhou Zhang Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2013 | Cell Research2013，23，7： | 1 |
| 16 | Processing and Thermal Behaviors of Poly (Butylene Succinate) Blends with Highly-Filled Starch and Glycerol显示文摘 | Wei Wang Guixin Zhang Weizhou Zhang Weihong Guo Jikui Wang | 2013 | Journal of Polymers and the Environment2013，，1： | 1 |
| 17 | Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signaling显示文摘 | Wei Tan Weizhou Zhang Amy Strasner | 2011 | Nature2011，470，： | 1 |
| 18 | The analysis of driving factor,regional difference and trend of carbon intensity in China显示文摘 | ZHONG Weizhou ZHANG Jincan NAN Shijing | 2014 | Science&Technology Progress and Policy2014，31，21： | 1 |
| 19 | Reprogramming based gene therapy for inherited red blood cell disorders显示文摘 | Xiuling Xu Jing Qu Keiichiro Suzuki Mo Li Weizhou Zhang Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2012 | Cell Research2012，22，6： | 1 |
| 20 | Properties of nuclear matter with two- body correlations显示文摘 | ZHANG XIURONG JIANG WEIZHOU ZHU ZHIYUAN | 1996 | Nuclear Physics1996，18，： | 1 |
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