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| 1 | Characteristics of atmospheric single particles during haze periods in a typical urban area of Beijing:A case study in October,2014显示文摘To investigate the composition and possible sources of particles, especially during heavy haze pollution, a single particle aerosol mass spectrometer(SPAMS) was deployed to measure the changes of single particle species and sizes during October of 2014, in Beijing. A total of 2,871,431 particles with both positive and negative spectra were collected and characterized in combination with the adaptive resonance theory neural network algorithm(ART-2a). Eight types of particles were classified: dust particles(dust, 8.1%), elemental carbon(EC, 29.0%), organic carbon(OC, 18.0%), EC and OC combined particles(ECOC, 9.5%),Na-K containing particles(Na K, 7.9%), K-containing particles(K, 21.8%), organic nitrogen and potassium containing particles(KCN, 2.3%), and metal-containing particles(metal,3.6%). Three haze pollution events(P1, P2, P3) and one clean period(clean) were analyzed,based on the mass and number concentration of PM_(2.5)and the back trajectory results from the hybrid single particle Lagrangian integrated trajectory model(Hysplit-4 model). Results showed that EC, OC and K were the major components of single particles during the three haze pollution periods, which showed clearly increased ratios compared with those in the clean period. Results from the mixing state of secondary species of different types of particles showed that sulfate and nitrate were more readily mixed with carbon-containing particles during haze pollution episodes than in clean periods. | Lang Liu Yanli Wang Shiyong Du Wenjie Zhang Lujian Hou Sverre Vedal Bin Han Wen Yang Mindong Chen Zhipeng Bai | 2016 | Journal of Environmental Sciences2016，28，2： | 19 |
| 2 | Advanced Space-based Solar Observatory(ASO-S):an overview显示文摘The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C. | Wei-Qun Gan Cheng Zhu Yuan-Yong Deng Hui Li Yang Su Hai-Ying Zhang Bo Chen Zhe Zhang Jian Wu Lei Deng Yu Huang Jian-Feng Yang Ji-Jun Cui Jin Chang Chi Wang Ji Wu Zeng-Shan Yin Wen Chen Cheng Fang Yi-Hua Yan Jun Lin Wei-Ming Xiong Bin Chen Hai-Chao Bao Cai-Xia Cao Yan-Ping Bai Tao Wang Bing-Long Chen Xin-Yu Li Ye Zhang Li Feng Jiang-Tao Su Ying Li Wei Chen You-Ping Li Ying-Na Su Hai-Yan Wu Mei Gu Lei Huang Xue-Jun Tang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 17 |
| 3 | Application of 3D reconstruction for surgical treatment of hepatic alveolar echinococcosis显示文摘AIM: To evaluate the reliability and accuracy of threedimensional(3D) reconstruction for liver resection in patients with hepatic alveolar echinococcosis(HAE).METHODS: One-hundred and six consecutive patients with HAE underwent hepatectomy at our hospital between May 2011 and January 2015. Fifty-nine patients underwent preoperative 3D reconstruction and 'virtual' 3D liver resection before surgery(Group A). Another 47 patients used conventional imaging methods for preoperative assessment(Group B). Outcomes of hepatectomy were compared between the two groups.RESULTS: There was no significant difference in preoperative data between the two groups. Compared with patients in Group B, those in Group A had a significantly shorter operation time(227.1 ± 51.4 vs 304.6 ± 88.1 min; P < 0.05), less intraoperative blood loss(308.1 ± 135.4 vs 458.1 ± 175.4 m L; P < 0.05), and lower requirement for intraoperative blood transfusion(186.4 ± 169.6 vs 289.4 ± 199.2 m L; P < 0.05). Estimated resection liver volumes in bothgroups had good correlation with actual graft weight(Group A: r = 0.978; Group B: r = 0.960). There was a significant higher serum level of albumin in Group A(26.3 ± 5.9 vs 22.6 ± 4.3 g/L, P < 0.05). Other postoperative laboratory parameters(serum levels of aminotransferase and bilirubin; prothrombin time) and duration of postoperative hospital stay were similar. Sixteen complications occurred in Group A and 19 in Group B. All patients were followed for 3-46(mean, 17.3) mo. There was no recurrence of lesions in Group A, but two recurrences in Group B. There were three deaths: two from cerebrovascular accident, and one from car accident.CONCLUSION: 3D reconstruction provides comprehensive and precise anatomical information for the liver. It also improves the chance of success and reduces the risk of hepatectomy in HAE. | Yi-Biao He Lei Bai Tuerganaili Aji Yi Jiang Jin-Ming Zhao Jin-Hui Zhang Ying-Mei Shao Wen-Ya Liu Hao Wen | 2015 | World Journal of Gastroenterology2015，21，35： | 16 |
| 4 | Binding characteristics of perylene, phenanthrene and anthracene to different DOM fractions from lake water显示文摘Six hydrophobic and hydrophilic fractions were isolated using XAD-8 and XAD-4 resins, and were extensively characterized. Partition coefficients of perylene, phenanthrene and anthracene binding to the six fractions were determined by fluorescence quenching titration. The Kdoc values obtained for the polycyclic aromatic hydrocarbons (PAHs) binding to the hydrophobic fractions were larger than those to the hydrophilic fractions. Nonlinear Stern-Volmer plots were observed when binding phenanthrene and anthracene to some hydrophilic fraction samples, suggesting saturation of polar interaction binding sites. A significant correlation of logKdoc values with molecular weights and molar absorptivities at 280 nm was observed, while atomic ratio of C/H was found to be a poor indicator for aromaticity. Other structural descriptors such as paraffinic carbon and polarity influenced the DOM-fraction ability to bind PAHs. Different interaction mechanisms underlying binding of the different fractions to the PAHs were also discussed. | MEI Yi WU Fengchang WANG Liying BAI Yingchen LI Wen LIAO Haiqing | 2009 | Journal of Environmental Sciences2009，21，4： | 16 |
| 5 | Harvesting vibration energy by a triple-cantilever based triboelectric nanogenerator显示文摘摩擦电 nanogenerators (TENG ) ,为基于摩擦电效果收获周围的机械精力的一种唯一的技术,被证明了是为自我动力的系统的一条划算、简单、柔韧的途径。这里,我们为收获颤动精力表明讲道理地设计的三倍伸臂的基于的 TENG。与制作到金皮铜合金陪衬的表面上的 nanowire 数组的帮助,最新设计的 TENG 与 252.3 mW/m2 的山峰功率密度生产开电路的电压直到 101 V 和 55.7 A 的电线走火电流。TENG 系统地为即刻地照亮 40 根商业轻射出的二极管作为直接力量来源被调查并且示威。第一次,一台 TENG 设备为收获颤动精力被设计了,特别在低频率,打开它象一种新精力技术的申请。 | Weiqing Yang Jun Chen Guang Zhu Xiaonan Wen Peng Bai Yuanjie Su Yuan Lin Zhonglin Wang | 2013 | Nano Research2013，6，12： | 13 |
| 6 | Huge Capacity Fiber-Optic Sensing Network Based on Ultra-Weak Draw Tower Gratings显示文摘这份报纸在巨大的能力上考察工作光纤的察觉到网络基于极端弱画为纤维在国家工程实验室开发的塔栅栏眼的察觉到技术(NEL-FOST ) ,武汉工业大学,中国。一个万用的绘画塔栅栏传感器网络第一基于极端弱的纤维布拉格栅栏(FBG ) 被建议并且示威。察觉到的网络与时间部门和波长部门 multiplexing 方法被讯问,它为大规模察觉到网络是很有希望的。 | Minghong YANG Wei BAI Huiyong GUO Hongqiao WEN Haihu YU Desheng JIANG | 2016 | Photonic Sensors2016，6，1： | 13 |
| 7 | Hepatitis C virus in human B lymphocytes transformed by Epstein-Barr virus in vitro by in situ reverse transcriptase-polymerase chain reaction显示文摘AIM To study persistence and replication ofheltitis C virus (HCV) in patients' peripheralblood mononuclear cells (PBMC) cultured invitro.METHODS Epstein-Barr virus (EBV) was usedto transform the hepatitis C virus from a HCVpositive patient to permanent lymphoblastoidcell lines (LCL). Positive and negative HCV RNAstrands of the cultured cells and growth mediawere detected by reverse transcriptase-polymerase chain reaction ( RT-PCR ) eachmonth. Core and NS5 proteins of HCV werefurther tested using immunohistochemical SPmethod and in situ RT-PCR.RESULTS HCV RNA positive strands wereconsistently detected the cultured cells for oneyear. The negative-strand RNA in LCL cells andthe positive-strand RNA in supernatants wereobserved intermittently. Immunohistochemicalresults medicated expression of HCV NS3 and Cproteins in LCL cytoplasm mostly. The positivesignal of PCR product was dark blue and mainlylocalized to the LCL cytoplasm. The RT-PCRsignal was eliminated by overnight RNasedigestion but not DNase digestion.CONCLUSION HCV may exist and remainfunctional in a cultured cell line for a longperiod. | Ji Lin Cheng Bao Ling Liu Yi Zhang Wen Bin Tong Zheng Yan Bai Fang Feng Institute of Hepatology,Peoples Hospital,Medical Center of Beijing University,Beijing 10(X)44,China | 2001 | World Journal of Gastroenterology2001，7，3： | 11 |
| 8 | Gas-Particle Flow and Combustion Characteristics of Pulverized Coal Injection in Blast Furnace Raceway显示文摘The two-dimensional steady-state discrete phase mathematical model is developed to analyze gas-particle flow and combustion characteristics of coal particles,as well as components concentration and temperature distribution of coal gas in the process of pulverized coal injection of blast furnace raceway.The results show that a great deal of coal gas discharges on the top of raceway away from the tuyere,and the residence time of coal particles in the region of blowpipe and tuyere is 20 ms or so and 50 ms when it reaches raceway boundary.The pressure is the highest at the bottom of raceway and the maximal temperature is about 2423 K.The char combustion is mainly carried out in the raceway and the maximum of char burn-out rate attains 3×10-4 kg/s. | ZHANG Sheng-fu BAI Chen-guang WEN Liang-ying QIU Gui-bao LU Xue-wei | 2010 | Journal of Iron and Steel Research(International)2010，17，10： | 11 |
| 9 | Influence of coal blending on mineral transformation at high temperatures显示文摘Transformation of mineral matter is important for coal utilization at high temperatures.This is especially true for blended coal.XRD and FTIR were employed together to study the transformation of mineral matter at high temperature in blended coals.It was found that the concentration of catalytic minerals, namely iron oxides, increases with an increasing ratio of Shenfu coal, which could improve coal gasification.The transformation characteristics of the minerals in blended coals are not exactly predictable from the blend ratio.This was proved by comparing the iron oxide content to the blending ratio.The results from FTIR are comparable with those from XRD.FTIR is an effective method for examining variation in mineral matter. | BAI Jin LI Wen LI Chun-zhu BAI Zong-qing LI Bao-qing | 2009 | Mining Science and Technology2009，19，3： | 11 |
| 10 | Comprehensive evaluation of tolerance to alkali stress by 17 genotypes of apple rootstocks显示文摘Alkaline soils have a great influence on apple production in Northern China. Therefore, comprehensive evaluations of tolerance to such stress are important when selecting the most suitable apple rootstocks. We used hydroponics culturing to test 17 genotypes of apple rootstocks after treatment with 1:1 Na2CO3 and Na HCO3. When compared with the normally grown controls, stressed plants produced fewer new leaves, and had shorter roots and shoots and lower fresh and dry weights after 15 d of exposure to alkaline conditions. Their root/shoot ratios were also reduced, indicating that the roots had been severely damaged. For all stressed rootstocks, electrolyte leakage(EL) and the concentration of malondialdehyde(MDA) increased while levels of chlorophyll decreased. Changes in root activity(up or down), as well as the activities of peroxidase(POD), superoxide dismutase(SOD), and catalase(CAT) were rootstock-dependent, possibly reflecting their differences in alkali tolerance. Using alkali injury index(AI), adversity resistance coefficients(ARC), cluster analysis, and evaluation of their physiological responses, we classified these 17 genotypes into three groups:(1) high tolerance: Hubeihaitang, Wushanbianyehaitang, Laoshanhaitang Ls2, Xiaojinbianyehaitang, and Fupingqiuzi;(2) moderate tolerance: Pingyitiancha, Laoshanhaitang Ls3, Hubeihaitang A1, Deqinhaitang, Balenghaitang, Maoshandingzi, Shandingzi, and Xinjiangyepingguo; or(3) low tolerance: Pingdinghaitang, Hongsanyehaitang, Xiaojinhaitang, and Sanyehaitang. These results will significantly contribute to the selection of the most suitable materials for rootstocks with desired levels of tolerance to alkali stress. | ZHANG Kun-xi WEN Tian DONG Jun MA Feng-wang BAI Tuan-hui WANG Kun LI Cui-ying | 2016 | Journal of Integrative Agriculture2016，15，7： | 11 |
| 11 | Comparative study on the corrosion behavior of X52, 3Cr, and 13Cr steel in an O2–H2O–CO2 system: products, reaction kinetics, and pitting sensitivity显示文摘The corrosion behaviors of X52, 3Cr low-alloy steel, and 13Cr stainless steel were investigated in an O_2–H2O–CO_2 environment at various temperatures and O_2–CO_2 partial-pressure ratios. The results showed that the corrosion rates of X52, 3Cr, and 13Cr steels increased with increasing temperature. The corrosion rates slowly increased at temperatures less than 100°C and increased sharply when the temperature exceeded 100°C. In the absence of O_2, X52, 3Cr, and 13Cr exhibited uniform corrosion morphology and Fe CO3 was the main corrosion product. When O_2 was introduced into the system, various forms of Fe_2O_3 appeared on the surface of the samples. The Cr content strongly influenced the corrosion resistance. The 3Cr steel with a low Cr content was more sensitive to pitting than the X52 or 13Cr steel. Thus, pitting occurred on the surface of 3Cr when 1.25 MPa of O_2 was added; this phenomenon is related to the non-uniform distribution of Crin 3Cr. | Bing-wei Luo Jie Zhou Peng-peng Bai Shu-qi Zheng Teng An Xiang-li Wen | 2017 | International Journal of Minerals,Metallurgy and Materials2017，24，6： | 10 |
| 12 | Propofol vs traditional sedative agents for endoscopic retrograde cholangiopancreatography:A meta-analysis显示文摘AIM:To investigate the efficacy and safety of propofol sedation for endoscopic retrograde cholangiopancreatography(ERCP).METHODS:Databases including PubMed,Embase,and the Cochrane Central Register of Controlled Trials updated as of October 2010 were searched.Main outcome measures were ERCP procedure duration,recovery time,incidence of hypotension and hypoxia.RESULTS:Six trials with a total of 663 patients were included.The pooled mean difference in ERCP procedure duration between the propofol and traditional sedative agents was-8.05(95%CI:-16.74 to 0.63),with no significant difference between the groups.Thepooled mean difference in the recovery time was-18.69(95%CI:-25.44 to-11.93),which showed a significant reduction with use of propofol sedation.Compared with traditional sedative agents,the pooled OR with propofol sedation for ERCP causing hypotension or hypoxia was 1.69(95%CI:0.82-3.50)and 0.90(95%CI:0.55-1.49),respectively,which indicated no significant difference between the groups.CONCLUSION:Propofol sedation during ERCP leads to shorter recovery time without an increase of cardiopulmonary side effects.Propofol sedation can provide adequate sedation during ERCP. | Lu-Long Bo Yu Bai Jin-Jun Bian Ping-Shan Wen Jin-Bao Li Xiao-Ming Deng | 2011 | World Journal of Gastroenterology2011，17，30： | 9 |
| 13 | Relationship between fluorescence characteristics and molecular weight distribution of natural dissolved organic matter in Lake Hongfeng and Lake Baihua,China显示文摘Dissolved organic matter (DOM) is one of the most interesting and difficult problems in recent years due to its important functions in the ecological and environmental system and the complexity of its chemical composition and structure. It is well ac- cepted that fluorescence characteristics and mo- lecular weight distribution are two important pa- rameters in the DOM characterization. However, the relationship between them is still unknown. In this study, fluorescence and molecular weight distribution of DOM in Lake Hongfeng, Lake Baihua and their rivers, and their relationship were investigated using the combination of fluorescence spectroscopy and high-performance size exclusion chromatography (HPSEC) with on-line UV absorbance and fluores- cence detectors. The results show that there were two obvious humic-like fluorescence peaks (Peaks A and B) in DOM from lake water. But there was an- other obvious protein-like fluorescence peak (Peak C) in DOM from river water. The humic-like fluorescence material consisted of DOM fraction with smaller mo- lecular weight, ranging from 1.0 to 3.0 kDa, while the protein-like fluorescence material mainly consisted of DOM fraction with MW larger than 2.0 kDa. The cal- culation of MW using HPSEC was related to the UV absorbance wavelength chosen. | YUE Lanxiu WU Fengchang LiU Congqiang LI Wen FU Pingqing BAI Yingchen WANG Liying YIN Zuoying Lü Zhicheng | 2006 | Chinese Science Bulletin2006，51，1： | 9 |
| 14 | Suppression of acute rejective response following orthotopic liver transplantation in experimental rats infected with Echinococcus multilocularis显示文摘背景肝的牙槽的包虫病(AE ) 是在人的寄生疾病并且由包虫 multilocularis (他们) 引起。Orthotopic 肝移植(OLT ) 可以是为结束阶段的唯一的有效治疗肝的 AE。在一些 AE 病人,然而, extrahepatic 他们不能完全在 OLT 以后被消除。我们试图学习他们避免引起的免疫学的变化是否可以影响 AE 的拒绝的 response.Methods 老鼠 modles 被以后把他们暂停注入布朗挪威( BN ) rats.Three 月的腹部建立,在试验性的组,肝从路易斯( LEW )老鼠被移植到感染他们的 BN rats.In 控制组,移植从 LEW 老鼠到健康 BN 老鼠。血(PB ) 取样的肝织物和外设在天被收集 1, 3, 5,和 7 在 OLT 以后。肝织物在染色的 hematoxylin 和曙红(H&E ) 以后被分析;外部血房间上的 CD4, CD8,和 CD28 的数字被流动 cytometry 检测;并且 chemokine fractalkine (Fkn ) 的表示被反向的抄写 PCR (RT-PCR ) 检测。Interleukin-10 (IL-10 ) 被连接酶的 immunosorbent 试金(ELISA ) 在浆液测量。在每个组,八只 BN 老鼠为观察到幸存在试验性的组接受者预定的幸存 time.Results 在控制组与那些相比被延长被保留。拒绝的反应以后发生了并且在试验性的组, CD4 的百分比, CD8, CD28 T 房间和 Fkn mRNA 是更温和的表示在试验性的组是更低的。当浆液 IL-10 层次比在控制 group.Conclusions 的那些在试验性的组是更高的时,在 OLT 以后的尖锐拒绝的反应与他们感染在老鼠被稀释,并且接受者幸存时间被延长。他们可以由提高 IL-10 分泌物在这个过程起一个作用,减少受动器 T 房间,禁止 Fkn 的表示,它导致还原剂煽动性的房间渗入进肝。 | LI Tao ZHAO Jin-ming ZHANG Yan PAI Zu-la ZHANG Wei Tuxun Tuer-hongjiang BAI Lei WU Jiang WEN Hao | 2011 | Chinese Medical Journal2011，，18： | 9 |
| 15 | Effects of SLCO1 Bl and GATM gene variants on rosuvastatin-induced myopathy are unrelated to high plasma exposure of rosuvastatin and its metabolites显示文摘Myotoxicity is a sign ificant factor contributi ng to the poor adhere nee and reduced effective ness in the treatme nt of statins. Gen etic variations and high drug plasma exposure are considered as critique causes for statin-induced myopathy (SIM). This study aims to explore the sequential influences of rosuvastatin (RST) pharmacokinetic and myopathy-related single-nucleotide polymorphisms (SNPs) on the plasma exposure to RST and its metabolites: rosuvastatin lactone (RSTL) and /V-desmethyl rosuvastatin (DM-RST), and further on RST-induced myopathy. A total of 758 Chinese patients with coronary artery disease were enrolled and followed up SIM incidents for 2 years. The plasma concentrations of RST and its metabolites were determined through a validated ultra-performanee liquid chromatography mass spectrometry method. Nine SNPs in six genes were genotyped by using the Sequenom MassArray iPlex platform. Results revealed that ABCG2 rs2231142 variations were highly associated with the plasma concentrations of RST, RSTL, and DM-RST (Pad)<0.01, FDR < 0.05). CYP2C9 rs1057910 significantly affected the DM-RST concentration (Padj <0.01, FDR < 0.05). SLCO1B1 rs4149056 variant allele was significantly associated with high SIM risk (OR: 1.741, 95% Cl: 1.180-2.568, P = 0.0052, FDR = 0.0468). Glycine amidinotransferase (GATM) rs9806699 was marginally associated with SIM incidents (OR: 0.617, 95% Cl: 0.406-0.939, P = 0.0240, FDR = 0.0960). The plasma concentrations of RST and its metabolites were not significantly different between the SIM (n = 51) and control groups (n=707)(all P > 0.05). In conclusion, SLCO1B1 and GATM genetic variants are potential biomarkers for predicting RST-induced myopathy, and their effects on SIM are unrelated to the high plasma exposure of RST and its metabolites. | Xue Bai Bin Zhang Ping Wang Guan-lei Wang Jia-li Li Ding-sheng Wen Xing-zhen Long Hong-shuo Sun Yi-bin Liu Min Huang Shi-Iong Zhong | 2019 | Acta Pharmacologica Sinica2019，40，4： | 9 |
| 16 | Cancer nanotechnology: Enhancing tumor cell response to chemotherapy for hepatocellular carcinoma therapy显示文摘Hepatocellular carcinoma(HCC)is one of the deadliest cancers due to its complexities,reoccurrence after surgical resection,metastasis and heterogeneity.In addition to sorafenib and lenvatinib for the treatment of HCC approved by FDA,various strategies including transarterial chemoembolization,radiotherapy,locoregional therapy and chemotherapy have been investigated in clinics.Recently,cancer nanotechnology has got great attention for the treatment of various cancers including HCC.Both passive and active targetings are progressing at a steady rate.Herein,we describe the lessons learned from pathogenesis of HCC and the understanding of targeted and non-targeted nanoparticles used for the delivery of small molecules,monoclonal antibodies,miRNAs and peptides.Exploring current efficacy is to enhance tumor cell response of chemotherapy.It highlights the opportunities and challenges faced by nanotechnologies in contemporary hepatocellular carcinoma therapy,where personalized medicine is increasingly becoming the mainstay.Overall objective of this review is to enhance our understanding in the design and development of nanotechnology for treatment of HCC. | Yongbing Sun Wen Ma Yuanyuan Yang Mengxue He Aimin Li Lei Bai Bin Yu Zhiqiang Yu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，6： | 8 |
| 17 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 18 | Experimental and analytical studies on multiple tuned mass dampers for seismic protection of porcelain electrical equipment显示文摘Porcelain electrical equipment(PEE),such as current transformers,is critical to power supply systems,but its seismic performance during past earthquakes has not been satisfactory.This paper studies the seismic performance of two typical types of PEE and proposes a damping method for PEE based on multiple tuned mass dampers(MTMD).An MTMD damping device involving three mass units,named a triple tuned mass damper(TTMD),is designed and manufactured.Through shake table tests and finite element analysis,the dynamic characteristics of the PEE are studied and the effectiveness of the MTMD damping method is verified.The adverse influence of MTMD redundant mass to damping efficiency is studied and relevant equations are derived.MTMD robustness is verified through adjusting TTMD control frequencies.The damping effectiveness of TTMD,when the peak ground acceleration far exceeds the design value,is studied.Both shake table tests and finite element analysis indicate that MTMD is effective and robust in attenuating PEE seismic responses.TTMD remains effective when the PGA far exceeds the design value and when control deviations are considered. | Bai Wen Dai Junwu Zhou Huimeng Yang Yongqiang Ning Xiaoqing | 2017 | Earthquake Engineering and Engineering Vibration2017，16，4： | 8 |
| 19 | Recent advances in nanoporous graphene membrane for gas separation and water purification显示文摘Graphene is a one-atom-thick sheet of graphite comprising sp2-hybridized carbon atoms arranged in the hexagonal honeycomb lattices. By removing the honeycomb lattices and forming nanopores with specific geometry and size, nanoporous graphene has been demonstrated as a very high-efficiency separation membrane, due to the ultrafast molecular permeation rate for its one-atom thickness. This review focuses on the recent advances in nanoporous graphene membrane for the applications of gas separation and water purification, with a major emphasis on the molecular permeation mechanisms and the advanced fabrication methods of this state-of-the-art membrane. We highlight the advanced theoretical and experimental works and discuss the gas/water molecular transport mechanisms through the graphene nanopores accompanied with theoretical models. In addition, we summarize some representative membrane fabrication methods, covering the graphene transfer to porous substrates and the pore generation. We anticipate that this review can provide a platform for understanding the current challenges to make the conceptual membrane a reality and attracting more and more attentions from scientists and engineers. | Chengzhen Sun Boyao Wen Bofeng Bai | 2015 | Science Bulletin2015，60，21： | 8 |
| 20 | Emission factors, ozone and secondary organic aerosol formation potential of volatile organic compounds emitted from industrial biomass boilers显示文摘To evaluate the potential benefits of biomass use for air pollution control, this paper identified and quantified the emissions of major reactive organic compounds anticipated from biomass-fired industrial boilers. Wood pellets(WP) and straw pellets(SP) were burned to determine the volatile organic compound emission profiles for each biomass-boiler combination. More than 100 types of volatile organic compounds(VOCs) were measured from the two biomass boilers. The measured VOC species included alkanes, alkenes and acetylenes, aromatics, halocarbons and carbonyls. A single coal-fired boiler(CB) was also studied to provide a basis for comparison. Biomass boiler 1(BB1) emitted relatively high proportions of alkanes(28.9%–38.1% by mass) and alkenes and acetylenes(23.4%–40.8%),while biomass boiler 2(BB2) emitted relatively high proportions of aromatics(27.9%–29.2%)and oxygenated VOCs(33.0%–44.8%). The total VOC(TVOC) emission factors from BB1(128.59–146.16 mg/kg) were higher than those from BB2(41.26–85.29 mg/kg). The total ozone formation potential(OFP) ranged from 6.26 to 81.75 mg/m^3 with an average of 33.66 mg/m^3 for the two biomass boilers. The total secondary organic aerosol potential(SOAP) ranged from 61.56 to 211.67 mg/m^3 with an average of 142.27 mg/m^3 for the two biomass boilers.The emission factors(EFs) of TVOCs from biomass boilers in this study were similar to those for industrial coal-fired boilers with the same thermal power. These data can supplement existing VOC emission factors for biomass combustion and thus enrich the VOC emission inventory. | Chunmei Geng Wen Yang Xuesong Sun Xinhu Wang Zhipeng Bai Xia Zhang | 2019 | Journal of Environmental Sciences2019，31，9： | 8 |
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