|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 硼污染的个人暴露剂量及其代谢的研究显示文摘以62名处于不同生活、工作环境下的人群为对象,研究了其通过空气粉尘、饭菜和饮水的日硼暴露剂量及通过尿液、粪便的代谢状况.结果表明,从事硼作业的53名工人日硼暴露均值11.8mg/d,是对照人群(1.52mg/d)的7.8倍;通过尿液代谢的硼占总代谢量的94%以上,且班后尿硼与24h全尿硼浓度的相关系数为0.952,班后尿样可代替全尿并反映硼的代谢水平;下班后尿硼浓度与日硼暴露剂量显著相关.多元线性回归可以反映不同暴露途径对尿硼水平的贡献,方程拟合度为43.0%,与实测值的平均相对偏差为23.6%. | 邢小茹 魏复盛 吴国平 荀琳 Wendie A Robbins 王春利 魏春 姜欣 葛宏斌 | 2005 | 中国环境科学2005，25，3： | 10 |
| 2 | 硼作业工人配偶妊娠结局的初步研究显示文摘目的 研究硼暴露对作业工人配偶生殖健康的影响。方法 选择硼暴露组和对照组作为研究对象,进行标准问卷调查,建立相关数据库,通过χ2 检验、多元非条件Logistic回归进行分析。结果 暴露组的自然流产率和不能顺利受孕率均高于对照组。暴露组后代子女性别比低于对照组以及全国和辽宁省出生婴儿性别比。结论 硼暴露对硼作业工人配偶的妊娠结局可能有不良影响。 | 刘平 王春利 胡俊峰 Lin Xun Wendie A Robbins 吴国平 魏复盛 | 2005 | 中国公共卫生2005，21，5： | 8 |
| 3 | Neuroimaging the brain-gut axis in patients with irritable bowel syndrome显示文摘AIM:To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome(IBS).METHODS:A database search for relevant literature was conducted using Pub Med,Scopus and Embase in February 2015.Date filters were applied from the year2009 and onward,and studies were limited to those written in the English language and those performed upon human subjects.The initial search yielded 797articles,out of which 38 were pulled for full text review and 27 were included for study analysis.Investigations were reviewed to determine study design,methodology and results,and data points were placed in tabular format to facilitate analysis of study findings across disparate investigations.RESULTS:Analysis of study data resulted in the abstraction of four key themes:Neurohormonal differences,anatomic measurements of brain structure and connectivity,differences in functional responsiveness of the brain during rectal distention,and confounding/correlating patient factors.Studies in this review noted alterations of glutamate in the left hippocampus(HIPP),commonalities across IBS subjects in terms of brain oscillation patterns,cortical thickness/gray matter volume differences,and neuroanatomical regions withincreased activation in patients with IBS:Anterio cingulate cortex,mid cingulate cortex,amygdala anterior insula,posterior insula and prefrontal cortex.A striking finding among interventions was the substantia influence that patient variables(e.g.,sex,psychologica and disease related factors)had upon the identification of neuroanatomical differences in structure and con nectivity.CONCLUSION:The field of neuroimaging can provide insight into underlying physiological differences that distinguish patients with IBS from a healthy population. | Kristen R Weaver Lee Anne B Sherwin Brian Walitt Gail D'Eramo Melkus Wendy A Henderson | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，2： | 8 |
| 4 | Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis显示文摘AIM: To investigate the vasoactive intestinal peptides(VIP) expression in irritable bowel syndrome(IBS) and trinitrobenzene sulfonic acid(TNBS) induced colitis.METHODS: The VIP gene expression and protein plasma levels were measured in adult participants(45.8% male) who met Rome Ⅲ criteria for IBS for longer than 6 mo and in a rat model of colitis as induced by TNBS.Plasma and colons were collected from naive and inflamed rats.Markers assessing inflammation(i.e.,weight changes and myeloperoxidase levels) were assessed on days 2,7,14 and 28 and compared to controls.Visceral hypersensitivity of the rats was assessed with colo-rectal distension and mechanical threshold testing on hind paws.IBS patients(n = 12) were age,gender,race,and BMI-matched with healthy controls(n = 12).Peripheral whole blood and plasma from fasting participants was collected and VIP plasma levels were assayed using a VIP peptide-enzyme immunoassay.Human gene expression of VIP was analyzed using a custom PCR array.RESULTS: TNBS induced colitis in the rats was confirmed with weight loss(13.7 ± 3.2 g) and increased myeloperoxidase activity.Visceral hypersensitivity tocolo-rectal distension was increased in TNBS treated rats up to 21 d and resolved by day 28.Somatic hypersensitivity was also increased up to 14 d post TNBS induction of colitis.The expression of an inflammatory marker myeloperoxidase was significantly elevated in the intracellular granules of neutrophils in rat models following TNBS treatment compared to naive rats.This confirmed the induction of inflammation in rats following TNBS treatment.VIP plasma concentration was significantly increased in rats following TNBS treatment as compared to naive animals(P < 0.05).Likewise,the VIP gene expression from peripheral whole blood was significantly upregulated by 2.91-fold in IBS patients when compared to controls(P < 0.00001; 95%CI).VIP plasma protein was not significantly different when compared with controls(P = 0.193).CONCLUSION: Alterations in VIP expression may play a role in IBS.Therefore,a better understanding of the physiology of VIP could lead to new therapeutics. | Arseima Y Del Valle-Pinero LeeAnne B Sherwin Ethan M Anderson Robert M Caudle Wendy A Henderson | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 5 | Multiple Antibiotic Resistance and Heavy Metal Resistance Profile of Bacteria Isolated from Giant Freshwater Prawn (Macrobrachium rosenbergii) Hatchery显示文摘In this article, antibiogram and heavy metal resistance profile of bacteria isolated from giant freshwater prawn (Macrobrachium rosenbergii) hatchery in Malaysia are described. Although giant freshwater prawn was introduced into Malaysia since the 1980s, there was no database information on antibiogram and heavy metal resistance profile of bacteria from giant freshwater prawn (M. rosenbergii) hatchery in Malaysia. Therefore, this study was carried out to determine the effectiveness of antibiotic and heavy metal resistance profile to control bacterial diseases in M. rosenbergii hatchery. The results can provide valuable information for local M. rosenbergii post-larval producer. Antibiotic sensitivity test was carried out by disk-diffusion method against 15 types of antibiotics as follows: oxolinic acid (2 μg), ampicillin (10 μg), erythromycin (15 μg), furazolidone (15 μg), lincomycin (15 μg), amoxicillin (25 μg), colistin sulphate (25 μg), doxycycline (30 μg), florfenicol (30 μg), flumequine (30 μg), nalidixic acid (30 μg), tetracycline (30 μg), oleandomycin (15 μg), fosfomycin (50 μg), and spiramycin (100 μg), whereas heavy metal resistance profile of the present bacterial isolates was determined by 2-fold agar dilution technique. In this study, 5 types of bacteria were successfully isolated; they were Aeromonas spp. (n = 77), Escherichia coli (n = 73), Edwardsiella spp. (n = 62), Salmonella spp. (n = 75), and Vibrio spp. (n = 43). The result showed that furazolidone was the most effective antibiotic to control the bacteria isolated in this study, approximately 89.7% of the bacterial isolates were sensitive to this antibiotic. Multiple antibiotic resistance (MAR) index indicated that the hatchery water source and M. rosenbergii post-larval and sediment tanks were at high-risk exposure to the tested antibiotic. Furthermore, all the tested heavy metals (Cd2+, Cr6+, Hg2+, and Cu2+) failed to inhibit the growth of the bacterial isolates. Therefore, it indicated that the water source of the hatchery is contaminated with both antibiotic residues and heavy metal. | S W Lee M Najiah W Wendy A Zahrol M Nadirah | 2009 | Agricultural Sciences in China2009，8，6： | 7 |
| 6 | Surgical treatment of Lenke 5 adolescent idiopathic scoliosis: Comparison of anterior vs posterior approach显示文摘AIM To compare the posterior vs anterior approaches for fusion of Lenke 5 adolescent idiopathic scoliosis curves,matched for curve magnitude and for the distal level of fixation(dLOF) standardized to the third lumbar vertebrae(L3).METHODS A prospectively collected multicenter database was used for this retrospective comparative study. Our dependent variables included sagittal and coronal radiographic measurements, number of fused vertebrae, estimated blood loss, length of hospitalization and SRS total and individual domain scores at the two-year follow-up. Subject demographics were similar for all group comparisons.Independent t-test was used to compare groups for all analyses at P < 0.01.RESULTS For all matched cases of Lenke 5 curves, a selective approach was used only 50% of the time in cases undergoing a posterior fusion. When comparing a posterior selective approach to an anterior selective approach,surgeons utilizing a posterior approach fused significantly more levels than surgeons using an anterior approach with no other significant differences in radiographic or SRS outcomes(Ant = 4.8 ± 1.0 levels vs post = 6.1 ± 1.0 levels, P < 0.0001). When the dLOF was standardized to L3, the anterior approached provided significantly greater lumbar Cobb percent correction than the posterior approach(Ant = 69.1% ± 12.6% vs post =54.6% ± 16.4%, P = 0.004), with no other significant radiographic or SRS score differences between approaches.CONCLUSION Surgeons treating Lenke 5c curves with a posterior instrumentation and fusion vs an anterior approach include more motion segments, even with a selective fusion. When controlled for the distal level of fixation,the anterior approach provides greater correction of the thoracolumbar curve. | Mark F Abel Anuj Singla Mark A Feger Lindsay D Sauer Wendy Novicoff | 2016 | World Journal of Orthopedics2016，7，9： | 6 |
| 7 | Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders显示文摘 | E Joanna Baxter Linda M Scott Peter J Campbell Clare East Nasios Fourouclas Soheila Swanton George S Vassiliou Anthony J Bench Elaine M Boyd Natasha Curtin Mike A Scott Wendy N Erber Anthony R Green | 2005 | The Lancet . 2005 (9464)2005，，： | 2 |
| 8 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 9 | Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion显示文摘 | Philip N Newsome Ingolfur Johannessen Shelagh Boyle Evangelos Dalakas Karen A Mcaulay Kay Samuel Frances Rae Lesley Forrester Marc L Turner Peter C Hayes David J Harrison Wendy A Bickmore John N Plevris | 2003 | Gastroenterology2003，，7： | 2 |
| 10 | Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya显示文摘 | Wendy P O'Meara Phillip Bejon Tabitha W Mwangi Emelda A Okiro Norbert Peshu Robert W Snow Charles RJC Newton Kevin Marsh | 2008 | The Lancet2008，，9649： | 2 |
| 11 | Auxin transport显示文摘 | JOSHUAJ BLAKESLEE WENDY A PEER | 2005 | Current Opinion in Plant Biology2005，，8： | 1 |
| 12 | Implanted fiberoblasts genetically engineered to produce BDNF prevent MPTP toxicity to dopaminergic neurons in the rat显示文摘 | David M Tara A Wendy R | 1994 | Proc Natl Acad Sci USA1994，91，： | 1 |
| 13 | Wavelet entropy for subband segmentation of EEG during in- jury and recover显示文摘 | Hasan A A Joseph S P Wendy C Z | 2003 | Annals of Biomedical Engineer- ing2003，31，6： | 1 |
| 14 | Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles显示文摘 | David Cunningham Eliza A Hawkes Andrew Jack Wendi Qian Paul Smith Paul Mouncey Christopher Pocock Kirit M Ardeshna John A Radford Andrew McMillan John Davies Deborah Turner Anton Kruger Peter Johnson Joanna Gambell David Linch | 2013 | The Lancet2013，，9880： | 1 |
| 15 | Biosorption of cadmium and copper contaminated water by Scenedesmus abundans 显示文摘 | Patricia T A Wendy S | 2002 | Chemosphere2002，47，3： | 1 |
| 16 | The global re-cycling of persistent organic pollutants s strongly retarded by soils 显示文摘 | Wendy A O Knut B Sandra N M | 2003 | Environ Pollution2003，121，： | 1 |
| 17 | Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function显示文摘 | Wendy A Esther E Michelle C | 2008 | Mol Cell Biol2008，28，18： | 1 |
| 18 | Combined screening with ultrasound and mammography compared to mammography alone in women at elevated risk of bread cancer:results of the first-year screen in ACRIN 6666显示文摘 | Wendie A Berg MD Jeffrey D | 2008 | JAMA2008，299，18： | 1 |
| 19 | Learner Strategies显示文摘 | Wendy A | | 0，，19： | 1 |
| 20 | Pregnancy outcome when both members of a couple have balanced translocations 显示文摘 | Stephanie A C Wendy R U Debra D | 1995 | Obstet Gynecol1995，85，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员