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| 1 | Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis显示文摘AIM: To investigate the vasoactive intestinal peptides(VIP) expression in irritable bowel syndrome(IBS) and trinitrobenzene sulfonic acid(TNBS) induced colitis.METHODS: The VIP gene expression and protein plasma levels were measured in adult participants(45.8% male) who met Rome Ⅲ criteria for IBS for longer than 6 mo and in a rat model of colitis as induced by TNBS.Plasma and colons were collected from naive and inflamed rats.Markers assessing inflammation(i.e.,weight changes and myeloperoxidase levels) were assessed on days 2,7,14 and 28 and compared to controls.Visceral hypersensitivity of the rats was assessed with colo-rectal distension and mechanical threshold testing on hind paws.IBS patients(n = 12) were age,gender,race,and BMI-matched with healthy controls(n = 12).Peripheral whole blood and plasma from fasting participants was collected and VIP plasma levels were assayed using a VIP peptide-enzyme immunoassay.Human gene expression of VIP was analyzed using a custom PCR array.RESULTS: TNBS induced colitis in the rats was confirmed with weight loss(13.7 ± 3.2 g) and increased myeloperoxidase activity.Visceral hypersensitivity tocolo-rectal distension was increased in TNBS treated rats up to 21 d and resolved by day 28.Somatic hypersensitivity was also increased up to 14 d post TNBS induction of colitis.The expression of an inflammatory marker myeloperoxidase was significantly elevated in the intracellular granules of neutrophils in rat models following TNBS treatment compared to naive rats.This confirmed the induction of inflammation in rats following TNBS treatment.VIP plasma concentration was significantly increased in rats following TNBS treatment as compared to naive animals(P < 0.05).Likewise,the VIP gene expression from peripheral whole blood was significantly upregulated by 2.91-fold in IBS patients when compared to controls(P < 0.00001; 95%CI).VIP plasma protein was not significantly different when compared with controls(P = 0.193).CONCLUSION: Alterations in VIP expression may play a role in IBS.Therefore,a better understanding of the physiology of VIP could lead to new therapeutics. | Arseima Y Del Valle-Pinero LeeAnne B Sherwin Ethan M Anderson Robert M Caudle Wendy A Henderson | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 2 | Multiple Antibiotic Resistance and Heavy Metal Resistance Profile of Bacteria Isolated from Giant Freshwater Prawn (Macrobrachium rosenbergii) Hatchery显示文摘In this article, antibiogram and heavy metal resistance profile of bacteria isolated from giant freshwater prawn (Macrobrachium rosenbergii) hatchery in Malaysia are described. Although giant freshwater prawn was introduced into Malaysia since the 1980s, there was no database information on antibiogram and heavy metal resistance profile of bacteria from giant freshwater prawn (M. rosenbergii) hatchery in Malaysia. Therefore, this study was carried out to determine the effectiveness of antibiotic and heavy metal resistance profile to control bacterial diseases in M. rosenbergii hatchery. The results can provide valuable information for local M. rosenbergii post-larval producer. Antibiotic sensitivity test was carried out by disk-diffusion method against 15 types of antibiotics as follows: oxolinic acid (2 μg), ampicillin (10 μg), erythromycin (15 μg), furazolidone (15 μg), lincomycin (15 μg), amoxicillin (25 μg), colistin sulphate (25 μg), doxycycline (30 μg), florfenicol (30 μg), flumequine (30 μg), nalidixic acid (30 μg), tetracycline (30 μg), oleandomycin (15 μg), fosfomycin (50 μg), and spiramycin (100 μg), whereas heavy metal resistance profile of the present bacterial isolates was determined by 2-fold agar dilution technique. In this study, 5 types of bacteria were successfully isolated; they were Aeromonas spp. (n = 77), Escherichia coli (n = 73), Edwardsiella spp. (n = 62), Salmonella spp. (n = 75), and Vibrio spp. (n = 43). The result showed that furazolidone was the most effective antibiotic to control the bacteria isolated in this study, approximately 89.7% of the bacterial isolates were sensitive to this antibiotic. Multiple antibiotic resistance (MAR) index indicated that the hatchery water source and M. rosenbergii post-larval and sediment tanks were at high-risk exposure to the tested antibiotic. Furthermore, all the tested heavy metals (Cd2+, Cr6+, Hg2+, and Cu2+) failed to inhibit the growth of the bacterial isolates. Therefore, it indicated that the water source of the hatchery is contaminated with both antibiotic residues and heavy metal. | S W Lee M Najiah W Wendy A Zahrol M Nadirah | 2009 | Agricultural Sciences in China2009，8，6： | 7 |
| 3 | Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders显示文摘 | E Joanna Baxter Linda M Scott Peter J Campbell Clare East Nasios Fourouclas Soheila Swanton George S Vassiliou Anthony J Bench Elaine M Boyd Natasha Curtin Mike A Scott Wendy N Erber Anthony R Green | 2005 | The Lancet . 2005 (9464)2005，，： | 2 |
| 4 | Implanted fiberoblasts genetically engineered to produce BDNF prevent MPTP toxicity to dopaminergic neurons in the rat显示文摘 | David M Tara A Wendy R | 1994 | Proc Natl Acad Sci USA1994，91，： | 1 |
| 5 | Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles显示文摘 | David Cunningham Eliza A Hawkes Andrew Jack Wendi Qian Paul Smith Paul Mouncey Christopher Pocock Kirit M Ardeshna John A Radford Andrew McMillan John Davies Deborah Turner Anton Kruger Peter Johnson Joanna Gambell David Linch | 2013 | The Lancet2013，，9880： | 1 |
| 6 | The global re-cycling of persistent organic pollutants s strongly retarded by soils 显示文摘 | Wendy A O Knut B Sandra N M | 2003 | Environ Pollution2003，121，： | 1 |
| 7 | Determination of M elamine residues in catfish tissue by triple quadrupole LC - MS - MS with HILIC chromatog - raphy 显示文摘 | Wendy C A Sherri B T Christine M K | 2007 | Laboratory Information Bulletin2007，23，： | 1 |
| 8 | Biochemical identification of citrobacteria in the clinical Laboratory显示文摘 | SHARON L A WENDY KWC | 1994 | J Clin Microbiol1994，32，： | 1 |
| 9 | Complex Business Models : Managing Strategic Paradoxes Simultaneously 显示文摘 | Wendy K S Binns A Tushrnan M L | 2010 | Long Range Planning2010，43，23： | 1 |
| 10 | Remediation of wastewater containing heavy metals using raw and modified diatomite显示文摘 | KHRAISHEH M A M AL-DEGS YS MCMINN WENDY A M | 2004 | Chemical Engineering Journal2004，99，2： | 1 |
| 11 | Nitrification of high strength ammonia wastewaters: comparative study of immobilisation media显示文摘 | Wendy M Rostronl David C Stuckey Andrew A Young | 2001 | Water Res2001，35，5： | 1 |
| 12 | Heavymetal in children's tooth enamel: related to autism anddisruptive behaviors 显示文摘 | MARYAM M A AGNES R L WENDY A G | 2012 | J Autism Dev Disord2012，42，： | 1 |
| 13 | Determination ofmelamine residues in catfish tissue by triple quadrupole LC-MS/MS with HILIC chromatography显示文摘 | Wendy C A Sherri B T Christine M K | 2007 | US Food and Drug Adminis-tration2007，23，5： | 1 |
| 14 | Determination of Melamine Residues in Catfish Tissue hy Triple Quadrupole LC-MS-MS with HILIC Chromatog-raphy 显示文摘 | Wendy C A Sherri B T Christine M K | 2007 | Laboratory Information Bulletin2007，23，： | 1 |
| 15 | Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles显示文摘 | David Cunningham Eliza A Hawkes Andrew Jack Wendi Qian Paul Smith Paul Mouncey Christopher Pocock Kirit M Ardeshna John A Radford Andrew McMillan John Davies Deborah Turner Anton Kruger Peter Johnson Joanna Gambell David Linch | 2013 | The Lancet . 2013 (9880)2013，，： | 1 |
| 16 | Regulation of auxin transport by aminopeptidases and endogenous flavonoids显示文摘 | Angus M Wendy A P Lincoln T | 2000 | Planta2000，211，3： | 1 |
| 17 | Reversible hydrogels fromself-assembling artificial proteins显示文摘 | Wendy A P James L H Kevin P M | 1998 | ProQuest Biology Journals Science1998，281，： | 1 |
| 18 | Dietary overlap between wolves and coyotes in Northwestern Montana 显示文摘 | Wendy M A Daniel H P Robert R R | 2002 | Journal of Mam- malogy2002，83，3： | 1 |
| 19 | Regulation of aux in transport by amin opeptidasesan dendogenous flavonoids显示文摘 | Angus M Wendy A P Lincoln T | 2000 | Planta2000，21，3： | 1 |
| 20 | Im- pact of Interpreter Services on Delivery of Health Care to Limited-English-Proficient Patients 显示文摘 | Jaeobs Elizabeth A Diane S Lauderdale David Mehzer Jeanette M Shorey Wendy Levinson Ronald A Thisted | 2001 | Journal of General Internal Medicine2001，16，7： | 1 |
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