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| 1 | Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique显示文摘Many viruses can cause respiratory diseases in humans.Although great advances have been achieved in methods of diagnosis,it remains challenging to identify pathogens in unexplained pneumonia(UP) cases.In this study,we applied next-generation sequencing(NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province,China.A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS.An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples.Human rhinovirus C was the virus most frequently detected and was identified in seven samples.Human measles virus,adenovirus B 55 and coxsackievirus A10 were also identified.Metagenomic sequencing also provided virus genomic sequences,which enabled genotype characterization and phylogenetic analysis.For cases of multiple infection,metagenomic sequencing afforded information regarding the quantity of each virus in the sample,which could be used to evaluate each viruses' role in the disease.Our study highlights the potential of metagenomic sequencing for pathogen identification in UP cases. | Xiaohui Zou Guangpeng Tang Xiang Zhao Yan Huang Tao Chen Mingyu Lei Wenbing Chen Lei Yang Wenfei Zhu Li Zhuang Jing Yang Zhaomin Feng Dayan Wang Dingming Wang Yuelong Shu | 2017 | Science China(Life Sciences)2017，60，3： | 14 |
| 2 | Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents显示文摘Scavenging reactive oxygen species(ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury(CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. Among these compounds, the most active 33 not only conferred cytoprotection of H2 O2-induced oxidative damage in PC12 cells through scavenging free radicals directly and activating NRF2/ARE antioxidant pathway at the same time, but also played an important role against ischemia/reperfusion-related brain injury in animals. More importantly, in comparison with mono-antioxidant mechanism compounds, 33 exhibited higher cytoprotective and neuroprotective potential in vitro and in vivo. Overall, our findings showed compound 33 couldemerge as a promising anti-ischemic stroke drug candidate and provided novel dual-antioxidant mechanism strategies and concepts for oxidative stress-related diseases treatment. | Jiabing Wang Lili Huang Chanchan Cheng Ge Li Jingwen Xie Mengya Shen Qian Chen Wulan Li Wenfei He Peihong Qiu Jianzhang Wu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 13 |
| 3 | Religion and stock price crash risk:Evidence from China显示文摘This paper investigates whether religious traditions influence firm-specific crash risk in China.Using a sample of A-share listed firms from 2003 to 2013,we provide evidence that the more intense the religious environment,the lower the stock price crash risk,implying that religion plays an important role in Chinese corporate governance.Further,we find that(1) religion affects stock price crash risk by reducing earnings management and the management perk problem;(2) different religions have different effects,and Taoism,in particular,is unrelated to crash risk; and(3) the effects of religion are more pronounced with higher quality corporate governance and a stronger legal environment.Religion constrains the management agency problem,thus reducing stock price crash risk in China.Our paper enriches the literature on stock price crash risk and religion,and on new economic geography. | Wenfei Li Guilong Cai | 2016 | China Journal of Accounting Research2016，，3： | 7 |
| 4 | Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival显示文摘哺乳动物的胰腺的房间通过胰岛素的生产和分泌物在开发和葡萄糖动态平衡起一个枢轴的作用。在房间数字的功能的失败或减少导致类型 2 糖尿病(T2D ) 。尽管有 -cells, 的生理的重要性,房间的生存能力经常主要由于它适应他们的变化微型环境的差的能力被质问。否定地影响房间生存能力的因素之一是象 palmitate 那样的免费的丰满的酸(船边交货) 的高集中。在这个工作,我们证明当房间与 palmitate 被对待时,那联系是的蛋白质(Yap1 ) 被激活。我们用啮齿类动物 insulinoma 房间线的 loss-of-function 和 gain-of-function 分析表明没有调整他们的增长, Yap1 在房间压制导致 palmitate 的 apoptosis。我们也发现在 palmitate 处理之上, F 肌动朊的重新整理调停 Yap1 激活。Yap1 目标基因之一的 Palmitate 处理增加表示,结缔组织生长因素(CTGF ) 。我们有 CTGF 的 gain-of-function 分析建议 CTGF 可以是在对导致船边交货的 apoptosis 的保护的机制的 Yap1 的下游的因素。 | Yaoting Deng Yurika Matsui Wenfei Pan Qiu Li Zhi-Chun Lai | 2016 | Protein & Cell2016，7，5： | 7 |
| 5 | Label-free Detection of Biotin Using Nanoporous TiO2/DNA Thin-film Coated Wavelength Interrogated Surface Plasmon Resonance Sensors显示文摘 | LI Qiushun HE Hao WANG Junnan ZHENG Hui SHI Jianguo LI Mingyu DONG Wenfei QI Zhimei | 2014 | Chemical Research in Chinese Universities2014，30，1： | 4 |
| 6 | A dendrite-free Li plating host towards high utilization of Li metal anode in Li–O_2 battery显示文摘The intense interest of Li–O_2 battery stems from its ultrahigh theoretical energy density, but its application is still hindered by the issues of Li anode. Herein, RuO_2-CNTs composite, a conventional O_2 cathode catalyst in Li–O_2 battery, is first utilized as an anode host for dendrite-free Li plating/stripping with high Coulombic efficiency. It is demonstrated that such excellent plating/stripping performance arises from the lithiophilicity characteristic of Ru nanoparticles(that is derived from the in-situ electrochemical conversion from RuO_2 to Ru/Li_2O) and buffer space provided by CNTs. Furthermore, the RuO_2-CNTs electrode pre-deposited with limited Li(RuO_2-CNTs@Li anode) is coupled with a RuO_2-CNTs catalytic cathode to form a Li–O_2 full cell, which displays an extended cycle life with dramatically improved energy density.The achieved cell shows a high stability of 200 cycles with RuO_2-CNTs@Li anode(1 mg Li) that sheds light on the efficient utilization of Li anode in Li–O_2 batteries. | Chao Li Jishi Wei Panlong Li Wenfei Tang Wuliang Feng Jingyuan Liu Yonggang Wang Yongyao Xia | 2019 | Science Bulletin2019，64，7： | 3 |
| 7 | Graph algorithms:parallelization and scalability显示文摘For computations on large-scale graphs,one often resorts to parallel algorithms.However,parallel algorithms are difficult to write,debug and analyze.Worse still,it is difficult to make algorithms parallelly scalable,such that the more machines are used,the faster the algorithms run.Indeed,it is not yet known whether any PTIME computational problems admit parallelly scalable algorithms on shared-nothing systems.Is it possible to parallelize sequential graph algorithms and guarantee convergence at the correct results as long as the sequential algorithms are correct?Moreover,does a PTIME parallelly scalable problem exist on shared-nothing systems?This position paper answers both questions in the affirmative. | Wenfei FAN Kun HE Qian LI Yue WANG | 2020 | Science China(Information Sciences)2020，63，10： | 3 |
| 8 | Efficacy of Rebixiao Chinese herbal tablets and Chinese formula granules in acute gout arthritis patients:a randomized,multicenter,double-blind,controlled trial显示文摘OBJECTIVE:To evaluate the clinical efficacy and safety of Rebixiao(RBX)Chinese herbal tablets(CHT)and Chinese formula granules(CFG)in the treatment of acute gout arthritis(AGA).METHODS:This randomized,multicenter,double-blind,controlled trial included 165 AGA patients with the damp-heat symptom pattern who were randomly divided into an RBX CHT group and an RBX CFG group and treated for 7 d at three centers.The total effective rates of the joint symptom score,Traditional Chinese Medicine(TCM)symptoms score,erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP)were used to evaluate the clinical efficacy.Safety assessments were also performed.RESULTS:Of the 165 enrolled patients,147 completed the clinical observation.There was no difference in baseline between the two groups.The total effective rates of the joint symptom score were 94.36%and 97.36%,and the total effective rates of the TCM symptoms score were 95.77%and 97.36%in the CFG group and CHT group,respectively.No statistical difference was found between the two groups(P>0.05).Additionally,ESR and CRP were similar in both groups(P>0.05).Furthermore,treatment efficacy regarding TCM and joint symptoms,the ESR,and CRP were consistent within each center and among the different centers(P>0.05).In addition,the incidence of adverse events was 4.22%and 2.63%in the CFG group and CHT group,respectively,and no difference was observed between the two groups(P>0.05).CONCLUSION:RBX CFG and CHT have significant and similar efficacy in the treatment of AGA,and CFG did not increase adverse side effects. | Wang Shasha Zhang Ying Dai Min Yang Min Leng Wenfei Peng Xiufeng Li Guojun Yang Jinbing Gan Jianping Zhu Fenglin Li Yanping Wu Bin | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 3 |
| 9 | A new hybrid method—combined heat flux method with Monte-Carlo method to analyze thermal radiation显示文摘A new hybrid method, Monte-Carlo-Heat-Flux (MCHF) method, was presented to analyze the radiative heat transfer of participating medium in a three-dimensional rectangular enclosure using combined the Monte-Carlo method with the heat flux method. Its accuracy and reliability was proved by comparing the computational results with exact results from classical 'Zone Method'. | Zengwu Zhao Daqiang Cang Wenfei Wu Yike Li Baowei Li | 2006 | Journal of University of Science and Technology Beijing2006，13，1： | 2 |
| 10 | Simultaneous Biological Removal of p-Cresol, Sulfide and Nitrate by Denitrification显示文摘Biological removal of sulfide, nitrate, and p-cresol at a loading rate of 340 gS/(m^3 · d), 340 gN/(m^3 · d) and600 gC/(m^3 · d), respectively, was achieved in an upflow anaerobic sludge blanket(UASB) reactor. The ratio of C/S could affect the elemental sulfur(S^0) accumulation, and the C/S ratio of 1.75:1 was optimal for S^0 accumulation. Strains Pseudomonas sp., Simplicispira sp., and Rhizobium sp. could likely yield heterotrophs. Strains Arcobacter sp.,Sulfurimonas sp., Sulfurovum sp., and Sulfurospirillum sp. are the autotrophics required for the proposed UASB system. At high loading rate, the autotrophic denitrification pathway declined faster than the heterotrophic pathway. | Liu Chunshuang Li Wenfei Zhao Dongfeng Li Wei Li Xuechen Zhao Chaocheng Liu Fang | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，4： | 2 |
| 11 | Fabrication and luminescence of KGdF_4:Yb^(3+)/Er^(3+) nanoplates and their improving performance for polymer solar cells显示文摘Solar energy remains the most abundant renewable energy resource available to us[1].Continuous efforts have been invested to enhance the conversion of light to electricity by the diverse range of applications[2].Especially,polymer solar cells(PSCs)have reminded extensive attention own to flexibility,light-weight | Jiqing Jiao Yao Li Wenfei Shen Shasha Gai Jianguo Tang Yao Wang Linjun Huang Jixian Liu Wei Wang Laurence A.Belfiore | 2018 | Science Bulletin2018，63，4： | 2 |
| 12 | Adding regular expressions to graph reachability and pattern queries显示文摘发现边不同类型是的在图是逐渐地普通的,显示许多关系。为如此的图,我们建议 reachability 询问的一个类和图模式,一个边与某个形式的一个正规表达式在被指定的一个类,表示经由各种各样的类型的边的一张数据图的连接。另外,我们定义图模式基于图模拟的一个修订观点匹配。在在象社会网络那样的新兴的应用的图上,我们证明这些询问能够比他们的传统的对应物发现更理智的信息。更好静止,他们的增加的富有表达力的力量不与额外的复杂性来。确实,(1 ) 我们调查他们的抑制和最小化问题,并且证明这些基本问题在 reachability 询问的二次的时间并且在模式询问的立方的时间。(2 ) 我们为回答 reachability 询问开发一个算法,在至于他们的传统的对应物的二次的时间。(3 ) 我们为评估图模式询问提供二个立方时间的算法,与图模式经由 subgraph 同晶型匹配的 NP 完全性对比。(4 ) 这些算法的有效性和效率试验性地用真实数据和合成数据被验证。 | Wenfei FAN Jianzhong LI Shuai MA Nan TANG Yinghui WU | 2012 | Frontiers of Computer Science2012，6，3： | 2 |
| 13 | A haplotype map of genomic variations and genome-wide association studies of agronomic traits in foxtail millet(Setaria italica)显示文摘 | Guanqing Jia Xuehui Huang Hui Zhi Yan Zhao QiangZhao Wenjun Li Yang Chai Lifang Yang Kunyan Liu Hengyun Lu Chuanrang Zhu Yiqi Lu Congcong Zhou Danlin Fan Qijun Weng Yunli Guo Tao Huang LeiZhang Tingting Lu Qi Feng Hangfei Hao HongkuanLiu Ping Lu Ning Zhang Yuhui Li Erhu Guo ShujunWang Suying Wang Jinrong Liu Wenfei Zhang GuoqiuChen Baojin Zhang Wei Li Yongfang Wang HaiquanLi Baohua Zhao Jiayang Li Xianmin Diao Bin HanJia | 2013 | Nature Genetics2013，45，8： | 1 |
| 14 | The S190R mutation in the hemagglutinin protein of pandemic H1N1 2009 influenza virus increased its pathogenicity in mice显示文摘Human influenza viruses preferentially bind to sialic acid-α2,6-galactose (SAα2,6Gal) receptors, which are predominant in human upper respiratory epithelia, whereas avian influenza viruses preferentially bind to SAα2,3Gal receptors. However, variants with amino acid substitutions around the receptor-binding sites of the hemagglutinin (HA) protein can be selected after several passages of human influenza viruses from patients’ respiratory samples in the allantoic cavities of embryonated chicken eggs. In this study, we detected an egg-adapted HA S190R mutation in the pandemic H1N1 virus 2009 (pdmH1N1), and evaluated the effects of this mutation on receptor binding affinity and pathogenicity in mice. Our results revealed that residue 190 is located within the pocket structure of the receptor binding site. The single mutation to arginine at position 190 slightly increased the binding affinity of the virus to the avian receptor and decreased its binding to the long human α2,6-linked sialic acid receptor. Our study demonstrated that the S190R mutation resulted in earlier death and higher weight loss in mice compared with the wild-type virus. Higher viral titers at 1 dpi (days post infection) and diffuse damage at 4 dpi were observed in the lung tissues of mice infected with the mutant virus. | Yongkun Chen Tian Bai Wenfei Zhu Rongbao Gao Zhihong Deng Yi Shi Shumei Zou Yiwei Huang Xiyan Li Fangcai Li Zhaomin Feng Tao Chen Jing Yang Dayan Wang Lidong Gao Yuelong Shu | 2018 | Science China(Life Sciences)2018，61，7： | 1 |
| 15 | Effects of UHMWPE-g- AMPS on the morphology, structure and mechanical properties of PA 1010/ UHMWPE blends显示文摘 | Li Wenfei Yao Zhanhai Li Lixia | 2013 | Polymer-Plastics Technology and Engineering2013，52，1315： | 1 |
| 16 | Discovering conditional functional dependencies 显示文摘 | Fan Wenfei Geerts F Li Jianzhong | 2011 | IEEE Trans on Knowledge and Data Engineering2011，23，5： | 1 |
| 17 | A univesal on-orbitservicing system used geostationary orbit 显示文摘 | Xu WenFei Liang Bin Li Bing | 2011 | Advances inSpace Research2011，48，： | 1 |
| 18 | Research on the performance of steel slag and blast furnace slag composite admixture显示文摘This study investigates the properties of Baosteel steel slag and blast furnace(BF)slag in order to develop high-performance steel slag and BF slag composite admixture by optimizing the composite mixing technique.Based on the investigation of the stability of steel slag powder and the performance of cement mortar in different mixing ratios and different adding amounts of steel slag and BF slag composite admixture,rational mixing ratios and the adding amount range of steel slag and BF slag composite admixture were determined. | GU Wenfei XU Li TANG Oujing | 2009 | Baosteel Technical Research2009，3，4： | 1 |
| 19 | Reasoning about record matching rules显示文摘 | FAN Wenfei JIA Xibei LI Jianzhong | | 0，，01： | 1 |
| 20 | Towards certain fixes with editing rules and master data显示文摘 | Wenfei Fan Jianzhong Li Shuai Ma Nan Tang Wenyuan Yu | 2012 | The VLDB Journal2012，，2： | 1 |
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