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| 1 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 2 | Effects of dietary protein restriction on muscle fiber characteristics and m TORC1 pathway in the skeletal muscle of growing-finishing pigs显示文摘Background: To investigate the effects of dietary crude protein(CP) restriction on muscle fiber characteristics and key regulators related to protein deposition in skeletal muscle, a total of 18 growing-finishing pigs(62.30 ± 0.88 kg)were allotted to 3 groups and fed with the recommended adequate protein(AP, 16 % CP) diet, moderately restricted protein(MP, 13 % CP) diet and low protein(LP, 10 % CP) diet, respectively. The skeletal muscle of different locations in pigs, including longissimus dorsi muscle(LDM), psoas major muscle(PMM) and biceps femoris muscle(BFM) were collected and analyzed.Results: Results showed that growing-finishing pigs fed the MP or AP diet improved(P < 0.01) the average daily gain and feed: gain ratio compared with those fed the LP diet, and the MP diet tended to increase(P = 0.09) the weight of LDM. Moreover, the ATP content and energy charge value were varied among muscle samples from different locations of pigs fed the reduced protein diets. We also observed that pigs fed the MP diet up-regulated(P < 0.05) muscular m RNA expression of all the selected key genes, except that myosin heavy chain(My HC) IIb,My HC IIx, while m RNA expression of ubiquitin ligases genes was not affected by dietary CP level. Additionally, the activation of mammalian target of rapamycin complex 1(m TORC1) pathway was stimulated(P < 0.05) in skeletal muscle of the pigs fed the MP or AP diet compared with those fed the LP diet.Conclusion: The results suggest that the pigs fed the MP diet could catch up to the growth performance and the LDM weight of the pigs fed the AP diet, and the underlying mechanism may be partly due to the alteration in energy status, modulation of muscle fiber characteristics and m TORC1 activation as well as its downstream effectors in skeletal muscle of different locations in growing-finishing pigs. | Yinghui Li Fengna Li Li Wu Hongkui Wei Yingying Liu Tiejun Li Bie Tan Xiangfeng Kong Kang Yao Shuai Chen Fei Wu Yehui Duan Yulong Yin | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 13 |
| 3 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 4 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 5 | Integrated approach for optimal island partition and power dispatch显示文摘Operating in island mode when failure occurs in sure to maintain an uninterrupted power supply to significant loads. A two-stage approach that integrates optimal island partition and power dispatch is proposed in this paper, considering photovoltaics(PVs), batteries(BEs) and electric vehicles(EVs) as the power sources. In the first stage, energy indices are defined to describe the energy demand and the maximum energy that these distributed energy resources(DERs) can provide, and islands are partitioned based on an energy constraint. Considering the variability the loads and PVs, the energy constraint is a necessary but not sufficient condition for island operation,so in the second stage, a power dispatch model is proposed the active distribution network(ADN) is an effective mea-as a test for the island partition result. Sequential power flow is also simulated to guarantee a feasible and optimized island status. The situations when the tests are not passed are analyzed and classified, and corresponding modifications for the first stage model are provided. Multiple levels of constraints based on the energy index are established for the island partition model. The proposed approach has been validated through simulation using a modified IEEE 69-bus system which is divided into three districts with different load variability characteristics. | Junpeng ZHU Wei GU Ping JIANG Zhi WU Xiaodong YUAN Yinghui NIE | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，3： | 6 |
| 6 | Experiments on the Resistance of a Large Transport Vessel Navigating in the Arctic Region in Pack Ice Conditions显示文摘In this study, we carried out model tests to investigate the ice failure process and the resistance experienced by a transport vessel navigating in the Arctic region in pack ice conditions. We tested different navigation velocities, ice plate sizes, and ice concentrations. During the tests, we closely observed several phenomena, including the modes of interaction of the ice ship and the moving and failure modes of ice. We also measured the vessel resistances under different conditions. The test results indicate that the navigation velocity is a significant determinant of the moving and failure modes of ice. Moreover, vessel resistance is remarkably dependent on the ice concentration and navigation velocity. The variances of the mean and maximum resistance are also compared and discussed in detail. | Yan Huang Wei Li Yinghui Wang Baoshan Wu | 2016 | Journal of Marine Science and Application2016，15，3： | 5 |
| 7 | Enhanced photoresponse of Ti0_(2)/MoS_(2)heterostructure phototransistors by the coupling of interface charge transfer and photogating显示文摘Two-dimensional(2D)MoS_(2)with appealing physical properties is a promising candidate for next-generation electronic and optoelectronic devices,where the ultrathin MoS_(2)is usually laid on or gated by a dielectric oxide layer.The oxide/MoS_(2)interfaces widely existing in these devices have significant impacts on the carrier transport of the MoS_(2)channel by diverse interface interactions.Artificial design of the oxide/MoS_(2)interfaces would provide an effective way to break through the performance limit of the 2D devices but has yet been well explored.Here,we report a high-performance MoS_(2)-based phototransistor with an enhanced photoresponse by interfacing few-layer MoS_(2)with an ultrathin Ti0_(2)layer.The Ti0_(2)is deposited on MoS_(2)through the oxidation of an e-beam-evaporated ultrathin Ti layer.Upon a visible-light illumination,the fabricated Ti0_(2)/MoS_(2)phototransistor exhibits a responsivity of up to 2,199 A/W at a gate voltage of 60 V and a detectivity of up to 1.67×10^(13)Jones at a zero-gate voltage under a power density of 23.2μW/mm^(2).These values are 4.0 and 4.2 times those of the pure MoS_(2)phototransistor.The significantly enhanced photoresponse of Ti0_(2)/MoS_(2)device can be attributed to both interface charge transfer and photogating effects.Our results not only provide valuable insights into the interactions at Ti0_(2)/MoS_(2)interface,but also may inspire new approach to develop other novel optoelectronic devices based on 2D layered materials. | Bingxu Liu Yinghui Sun Yonghuang Wu Kai Liu Huanyu Ye Fangtao Li Limeng Zhang Yong Jiang Rongming Wang | 2021 | Nano Research2021，14，4： | 4 |
| 8 | Four COVID-19 Cases of New Variant B.1.351 First Emerging in South Africa in Chinese Passengers on Same Flight-Shenzhen,China,January 2021显示文摘At 04∶50 on January 1,2021,a 36-year-old Chinese project manager(Case A),a 29-year-old Chinese worker(Case B),and a 53-year-old Chinese businessman(Case C)returned from Africa(Case A and B from South Africa and Case C from Lesotho)on the same flight and tested coronavirus disease 2019(COVID-19)RNA positive by real-time polymerase chain reaction(PCR)by Baoan District People’s Hospital.Shenzhen CDC received their oral nasopharyngeal swabs packages from the hospital and retested COVID-19 RNA positive at 09∶50.Meanwhile,Case D. | Cong Cheng Lei Wang Ziquan Lyu Bo Peng Yinghui Li Dongfeng Kong Le Zuo Xiaomin Zhang Chao Yang Weiwen Liu Jia Wan Yijun Tang Junjia He Ying Wen Shule Xu Weihua Wu Ying Chen Guangnan Liu Junjie Xia Xuan Zou Renli Zhang Qinghua Hu Shujiang Mei Tiejian Feng | 2021 | China CDC weekly2021，3，8： | 2 |
| 9 | Interval Type-2 Fuzzy Hierarchical Adaptive Cruise Following-Control for Intelligent Vehicles显示文摘Intelligent vehicles can effectively improve traffic congestion and road traffic safety.Adaptive cruise followingcontrol(ACFC)is a vital part of intelligent vehicles.In this paper,a new hierarchical vehicle-following control strategy is presented by synthesizing the variable time headway model,type-2 fuzzy control,feedforward+fuzzy proportion integration(PI)feedback(F+FPIF)control,and inverse longitudinal dynamics model of vehicles.Firstly,a traditional variable time headway model is improved considering the acceleration of the lead car.Secondly,an interval type-2 fuzzy logic controller(IT2 FLC)is designed for the upper structure of the ACFC system to simulate the driver's operating habits.To reduce the nonlinear influence and improve the tracking accuracy for the desired acceleration,the control strategy of F+FPIF is given for the lower control structure.Thirdly,the lower control method proposed in this paper is compared with the fuzzy PI control and the traditional method(no lower controller for tracking desired acceleration)separately.Meanwhile,the proportion integration differentiation(PID),linear quadratic regulator(LQR),subsection function control(SFC)and type-1 fuzzy logic control(T1 FLC)are respectively compared with the IT2 FLC in control performance under different scenes.Finally,the simulation results show the effectiveness of IT2 FLC for the upper structure and F+FPIF control for the lower structure. | Hong Mo Yinghui Meng Fei-Yue Wang Dongrui Wu | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，9： | 2 |
| 10 | Adding regular expressions to graph reachability and pattern queries显示文摘发现边不同类型是的在图是逐渐地普通的,显示许多关系。为如此的图,我们建议 reachability 询问的一个类和图模式,一个边与某个形式的一个正规表达式在被指定的一个类,表示经由各种各样的类型的边的一张数据图的连接。另外,我们定义图模式基于图模拟的一个修订观点匹配。在在象社会网络那样的新兴的应用的图上,我们证明这些询问能够比他们的传统的对应物发现更理智的信息。更好静止,他们的增加的富有表达力的力量不与额外的复杂性来。确实,(1 ) 我们调查他们的抑制和最小化问题,并且证明这些基本问题在 reachability 询问的二次的时间并且在模式询问的立方的时间。(2 ) 我们为回答 reachability 询问开发一个算法,在至于他们的传统的对应物的二次的时间。(3 ) 我们为评估图模式询问提供二个立方时间的算法,与图模式经由 subgraph 同晶型匹配的 NP 完全性对比。(4 ) 这些算法的有效性和效率试验性地用真实数据和合成数据被验证。 | Wenfei FAN Jianzhong LI Shuai MA Nan TANG Yinghui WU | 2012 | Frontiers of Computer Science2012，6，3： | 2 |
| 11 | Isolation and Characterization of Melanin Pigment from Yesso Scallop Patinopecten yessoensis显示文摘Melanin is one of the essential compounds in the pigments of molluscan shells.However,the effects of melanin on color variations in molluscs are largely unknown.Our previous study suggests that Yesso scallop Patinopecten yessoensis might contain melanin pigment in the dark brown shell.We therefore isolated melanin from the pigmented shells using hydrochloric acid method,and characterized the types of melanin pigments by spectrophotometry.The purified melanin,which was verified by spectrophotometry scanning and HPLC analysis,showed the typical characteristics of melanin absorption spectra and HPLC chromatograms.The contents of pheomelanin and eumelanin in pigmented shells,which were determined by the linear standard curve of melanin at 405 nm and 350 nm absorbance,were 48.23 ? 1.350 and 157.65 ? 5.905 mg,respectively.The present results indicate that the brown-pigmented shells of scallops comprise approximately 76.6% of eumelanin and 23.4% of pheomelanin,which supports the presence of eumelanin-rich pigment in scallop shells.Therefore,the combination of hydrochloric acid extraction and spectrophotometric quantification is a rapid and efficient method to isolate and quantify melanin in shells.This will facilitate the melanin studies related to shell color polymorphism and the selective breeding of bivalves with different shell colors. | SUN Xiujun WU Biao ZHOU Liqing LIU Zhihong DONG Yinghui YANG Aiguo | 2017 | Journal of Ocean University of China2017，16，2： | 2 |
| 12 | Envelope protection for aircraft encountering upset condition based on dynamic envelope enlargement显示文摘Upset condition encountered by an aircraft in flight could pose great threat to flight safety, which is of chief importance in civil aviation. The causal factors have the nonlinear and multiple characteristics, and as a result the conventional envelope protection system cannot successfully do with the condition. So dynamic envelope based on differential manifold theory, which can take more coupling factors into account, is proposed as a basis to design a novel envelope protection system. Then the relationship between the dynamic envelope and the control coefficient or pilot command is obtained, and the result shows that the dynamic envelope can be enlarged with the change of control coefficient. Furthermore, quantification of flight security is realized via defining relative distance between flight state and dynamic envelope, which can detect whether there is a risk for an aircraft in flight. Finally, an envelope protection system based on dynamic envelope enlargement is proposed on the basis. NASA's Generic Transport Model encountering hazard gust wind in climbing phase is taken as an example to verify the system's feasibility. The result shows that the system can give a better operation encountering upset condition and to a certain extent reduce the number of accidents or incidents. | Wuji ZHENG Yinghui LI Dengcheng ZHANG Chi ZHOU Pengwei WU | 2018 | Chinese Journal of Aeronautics2018，31，7： | 1 |
| 13 | Hybrid composites of conductive polyaniline and nanocrystalline titanium oxide prepared Via self-assembling and graft polymerization 显示文摘 | LI Jing ZHU Lihua WU Yinghui | 2006 | Polymer2006，47，： | 1 |
| 14 | Efficient expression and secretion of recombinant hirudin III in E. coli using the l -asparaginase II signal sequence显示文摘 | Shuhua Tan Wutong Wu Jingjing Liu Yi Kong Yinghui Pu Riying Yuan | 2002 | Protein Expression and Purification2002，，3： | 1 |
| 15 | Polypeptide N-acetylgalactosaminyltransferase 2 regulates cellular metastasis-associatedbehavior in gastric cancer显示文摘 | Dong Hua Li Shen Lan Xu Zhi Jiang Yinghui Zhou Aihuan Yue Shitao Zou Zhihong Cheng Shiliang Wu | 2012 | International Journal of Molecular Medicine2012，，6： | 1 |
| 16 | Gravity affects the responsiveness of Runx2 to 1, 25-dihydroxyvitamin D3 (VD3)显示文摘 | Feima Guo Zhongquan Dai Feng Wu Zhaoxia Liu Yingjun Tan Yumin Wan Peng Shang Yinghui Li | 2013 | Acta Astronautica2013，，： | 1 |
| 17 | Depressed mitochondrial biogenesis and dynamic remodeling in mouse tibialis anterior and gastrocnemius induced by 4‐week hindlimb unloading显示文摘 | Jing Liu Yunhua Peng Zhiwei Cui Zhiming Wu Airong Qian Peng Shang Lina Qu Yinghui Li Jiankang Liu Jiangang Long | 2012 | IUBMB Life2012，，11： | 1 |
| 18 | In-situ formed NiS/Ni coupled interface for efficient oxygen evolution and hydrogen evolution显示文摘High-performance electrocatalysts for water splitting are desired due to the urgent requirement of clean and sustainable hydrogen production.To reduce the energy barrier,herein,we adopt a facile in-situ surface modification strategy to develop a low-cost and efficient electrocatalyst for water splitting.The synthesized mulberry-like NiS/Ni nanoparticles exhibit excellent catalytic performance for water splitting.Small overpotentials of 301 and 161 mV are needed to drive the current density of 10 mA cm^-2 accompanying with remarkably low Tafel slopes of 46 and 74 mV dec^-1 for oxygen evolution reaction(OER)and hydrogen evolution reaction(HER),respectively.Meanwhile,a robust electrochemical stability is demonstrated.Further high-resolution X-ray photoelectron spectroscopy analyses reveal that the intrinsic HER activity improvement is attributed to the electron-enriched S on the strongly coupled NiS and Ni interface,which simultaneously facilitates the important electron transfer,consistent with the electrochemical impedance results.The post characterizations demonstrate that surface reconstructed oxyhydroxide contributes to the OER activity and NiS/Ni is an OER precatalyst.This structure construction with in-situ formation of active interface provides an effective way to design efficient electrocatalysts for energy conversion. | Chaoyi Yan Jianwen Huang Chunyang Wu Yaoyao Li Yuchuan Tan Luying Zhang Yinghui Sun Xiaona Huang Jie Xiong | 2020 | Journal of Materials Science & Technology2020，42，7： | 1 |
| 19 | Prokaryotic Expression, Purification, and Production of Polyclonal Antibody Against Novel Human Serum Inhibited Related Protein I (SI1)显示文摘 | Mingxing Ma Jie Ma Yinghui Shi Hong Wu Wenxiu Zhao Weiwei Huang Yang Jiao Deyong Tan | 2010 | The Protein Journal2010，，2： | 1 |
| 20 | A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development显示文摘 | Juan Lin Hanjie Li Min Yang Junming Ren Zhe Huang Felicia Han Jian Huang Jianhui Ma Duanwu Zhang Zhirong Zhang Jianfeng Wu Deli Huang Muzhen Qiao Guanghui Jin Qiao Wu Yinghui Huang Jie Du Jiahuai Han | 2013 | Cell Reports2013，，1： | 1 |
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