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| 1 | Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding显示文摘在 2002-2003 的 SARS 的全球爆发被新人的 coronavirus SARS-CoV 的感染引起。SARS-CoV 的感染主要通过病毒的表面 glycoproteins 被调停,它由 S1 和 S2 子单元组成并且在 virions 的信封上形成更整齐的尖铁。这里,我们报导处于单个粒子的 cryo 电子显微镜学决定的不同 conformational 状态更整齐的 SARS-CoV 表面尖铁的 ectodomain 结构。1 在 4.3 点决定了的符合构造?分辨率是三方面的对称并且有所有三受体绑定 C 终端域 1 (CTD1s ) S1 子单元在在位置下面。绑定下面到 SARS-CoV 受体 ACE2 的 CTD1s 不由于位的碰撞是可能的,建议 1 代表的符合构造受体绑定不活跃的状态。在 7.3, 5.7 和 6.8 点坚定的符合构造 2-4?决定都是不对称的,在哪个 RBD 旋转离开下面由不同角度到的位置一起来位置。起来 CTD1 为 ACE2 约会暴露受体绑定地点,建议符合构造 2-4 代表受体绑定活跃状态。这个 conformational 变化也为抵销指向 CTD1 的抗体的 SARS-CoV 的绑定被要求。这现象能被扩大到为受体绑定利用 S1 子单元的 CTD1 的另外的 betacoronaviruses,它提供新卓见进在感染期间更整齐的 coronavirus 熔化前尖铁的中间的状态。 | Miao Gui Wenfei Song Haixia Zhou Jingwei Xu Silian Chen Ye Xiang XinquanWang | 2017 | Cell Research2017，27，1： | 25 |
| 2 | Convergence of multi-block Bregman ADMM for nonconvex composite problems显示文摘The alternating direction method with multipliers(ADMM) is one of the most powerful and successful methods for solving various composite problems. The convergence of the conventional ADMM(i.e.,2-block) for convex objective functions has been stated for a long time, and its convergence for nonconvex objective functions has, however, been established very recently. The multi-block ADMM, a natural extension of ADMM, is a widely used scheme and has also been found very useful in solving various nonconvex optimization problems. It is thus expected to establish the convergence of the multi-block ADMM under nonconvex frameworks. In this paper, we first justify the convergence of 3-block Bregman ADMM. We next extend these results to the N-block case(N≥3), which underlines the feasibility of multi-block ADMM applications in nonconvex settings. Finally, we present a simulation study and a real-world application to support the correctness of the obtained theoretical assertions. | Fenghui WANG Wenfei CAO Zongben XU | 2018 | Science China(Information Sciences)2018，61，12： | 9 |
| 3 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 4 | Selective esterification of glycerol with acetic acid to diacetin using antimony pentoxide as reusable catalyst显示文摘Glycerol can be obtained as a by-product during biodiesel manufacture. It is important to convert glycerol to value-added products. Glycerol esterification with acetic acid is one of the most promising approaches for glycerol utilization. It is usually difficult to obtain diacetin with good activity and selectivity. In this work, glycerol esterification with acetic acid over different metal oxides, such as Bi2O3, Sb2O3, Sn O2, Ti O2, Nb2O5 and Sb2O5, was investigated. It was found that in the six investigated metal oxides, only Sb2O5 resulted in good activity and selectivity to diacetin. Under the optimized conditions, the glycerol conversion reached 96.8%,and the selectivity to diacetin reached 54.2%, while the selectivity to monoacetin and triacetin was 33.2% and12.6%, respectively. The catalysts were characterized with FT-IR spectra of adsorbed pyridine, which indicated that in the six investigated metal oxides, only Sb2O5 possessed Br?nsted acid sites strong enough to protonate adsorbed pyridine. The good catalytic activity and selectivity to diacetin might be mainly attributable to the Br?nsted acid sites of Sb2O5. Reusability tests showed that with Sb2O5 as catalyst, after six reaction cycles, no significant change in the glycerol conversion and the selectivity to diacetin was observed. | Wenfei Hu Yan Zhang Yizheng Huang Jiaxi Wang Jin Gao Jie Xu | 2015 | Journal of Energy Chemistry2015，24，5： | 2 |
| 5 | Biochar Supported Nanoscale Zero-valent Iron Composites for the Removal of Petroleum from Wastewater显示文摘Considering the need for efficiently and rapidly treating oily wastewater while preventing secondary pollution,the nanoscale zero-valent iron(nZVI)was supported on biochar prepared by using a spent mushroom substrate(SMS),to produce an iron-carbon composite(SMS-nZVI).The ability of the SMS-nZVI to treat wastewater containing high concentration of oil was then comprehensively evaluated.The morphology,structure,and other properties of the composite were characterized by using scanning electron microscopy,transmission electron microscopy,the Brunauer-Emmett-Teller nitrogen sorption analysis,and the Fourier transform infrared spectroscopy.The results show that the biochar prepared by using the SMS can effectively prevent the agglomeration of nZVI and increase the overall specific surface area,thereby enhancing the absorption of petroleum by the composite.Experiments reveal that compared with the SMS and nZVI,the SMS-nZVI composite removes petroleum faster and more efficiently from wastewater.Under optimized conditions involving an nZVI to biochar mass ratio of 1:5 and a pH value of 4,the efficiency for removal of petroleum from wastewater with an initial petroleum concentration of 1000 mg/L could reach 95%within 5 h.Based on a natural aging treatment involving exposure to air for 30 d,the SMS-nZVI composite retained an oil removal rate of higher than 62%,and this result could highlight its stability for practical applications. | Qin Feifei Xu Wenfei Hao Boyu Yin Linghao Song Jiayu Zhang Xiuxia | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，4： | 2 |
| 6 | Versatile subtypes of pericytes and their roles in spinal cord injury repair,bone development and repair显示文摘Vascular regeneration is a challenging topic in tissue repair. As one of the important components of the neurovascular unit(NVU),pericytes play an essential role in the maintenance of the vascular network of the spinal cord. To date, subtypes of pericytes have been identified by various markers, namely the PDGFR-β, Desmin, CD146, and NG2, each of which is involved with spinal cord injury(SCI) repair. In addition, pericytes may act as a stem cell source that is important for bone development and regeneration, whilst specific subtypes of pericyte could facilitate bone fracture and defect repair. One of the major challenges of pericyte biology is to determine the specific markers that would clearly distinguish the different subtypes of pericytes, and to develop efficient approaches to isolate and propagate pericytes. In this review, we discuss the biology and roles of pericytes, their markers for identification, and cell differentiation capacity with a focus on the potential application in the treatment of SCI and bone diseases in orthopedics. | Sipin Zhu Min Chen Yibo Ying Qiuji Wu Zhiyang Huang Wenfei Ni Xiangyang Wang Huazi Xu Samuel Bennett Jian Xiao Jiake Xu | 2022 | Bone Research2022，10，2： | 2 |
| 7 | Zeolite templated carbon nanodots for broadband ultrafast pulsed fiber laser generation显示文摘Carbon nanodots(C-dots) with a uniform size of about 2 nm are synthesized via in situ pyrolysis of n-propylamine that is confined in the nanochannels of zeolite Linde Type A(LTA). The as-synthesized C-dots@LTA composite shows nonlinear optical saturable absorption properties in a broad wavelength band and can be used as saturable absorber(SA) to generate ultrafast pulsed fiber lasers. By inserting a zeolite LTA single crystal hosting C-dots into the fiber laser cavity, mode-locked fiber lasers with long-term operation stability at 1.5 μm and 1 μm are achieved. These results show that the C-dots@LTA are a promising SA material for ultrafast pulsed fiber laser generation in a broad wavelength band. To the best of our knowledge, this is the first demonstration of a C-dots@LTA-based mode-locked fiber laser. | XINTONG XU JIAQI CHEN WENTAO SHI DALIN SUN SHAOWEN CHU LANG SUN WENFEI ZHANG YANPING CHEN JIANPANG ZHAI SHUANGCHEN RUAN ZIKANG TANG | 2019 | Photonics Research2019，7，10： | 2 |
| 8 | Polymorph switching of calcium carbonate crystals by polymer-controlled crystallization 显示文摘 | Xu Anwu Dong Wenfei Antonietti M C?lfen H | 2008 | Advanced Functional Materials2008，18，8： | 1 |
| 9 | A univesal on-orbitservicing system used geostationary orbit 显示文摘 | Xu WenFei Liang Bin Li Bing | 2011 | Advances inSpace Research2011，48，： | 1 |
| 10 | Research on the performance of steel slag and blast furnace slag composite admixture显示文摘This study investigates the properties of Baosteel steel slag and blast furnace(BF)slag in order to develop high-performance steel slag and BF slag composite admixture by optimizing the composite mixing technique.Based on the investigation of the stability of steel slag powder and the performance of cement mortar in different mixing ratios and different adding amounts of steel slag and BF slag composite admixture,rational mixing ratios and the adding amount range of steel slag and BF slag composite admixture were determined. | GU Wenfei XU Li TANG Oujing | 2009 | Baosteel Technical Research2009，3，4： | 1 |
| 11 | Simultaneous bioimaging of MMP-2 and MMP-7 via Au-Se constructed fluorescence nanoprobe显示文摘Au-Se bond strategy has been applied to construct fluorescence nanoprobe that is being used to simultaneously dual-image the tumor markers matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase-7(MMP-7)in vitro.The two Se-terminating ligand peptide chains respectively labeled with fluorescein isothiocyanate(FITC)and 5-Carboxytetramethylrhodamine(5-TAMRA)dyes are attached to the surface of Au nanoparticles(NPs).The nanoprobe can be specifically cut off by MMP-2 and MMP-7 respectively to carry out significant enhanced fluorescence recovery for simultaneously imaging both markers.The nanoprobe not only displays high selectivity and sensitivity towards MMP-2 and MMP-7,but also has strong anti-interference stability against biothiols and enhanced fidelity for avoiding'false positive'results.This approach offers new perspectives in designing tumor-related early diagnosis approaches and also provides strategies for clinical applications. | Xiaonan Gao Wenfei Guo Lulu Jiang Bo Hu Xiaojun Liu Kehua Xu Bo Tang | 2020 | Science China Chemistry2020，63，1： | 1 |
| 12 | Visualization of the process:selenocysteine activates GPX4 in ferroptosis based on a nano-fluorescent probe显示文摘Developing accurate methods for visualizing the expressions of proteins during the life process is a hotspot in the biochemical research field.Glutathione peroxidase 4(GPX4),one type of selenoproteins,was previously identified as a significant ferroptosis-regulated protein.Therefore,a novel approach was established to visualize the activation process of selenocysteine(Sec)toward GPX4 via an Au–Se bonded fluorescent nanoprobe and assisted by western blot analysis.The Au–Se nanoprobe was constructed by selenol-modified peptides for monitoring the concentration changes of Sec.The fluorescence intensity of Sec in confocal fluorescence imaging positively correlates with GPX4's activation level,proved by western blot analysis in living cells.This study provides an intuitional and visual strategy for predicting the functional expression of GPX4 during the ferroptosis process and offers new directions for the future investigation of proteins'functional expressions. | Dongrui Luan Wenfei Guo Xiaonan Gao Kehua Xu Bo Tang | 2022 | Science China Chemistry2022，65，7： | 0 |
| 13 | Efficient Synthesis of Unsymmetrical Heteroaryl Ethers by a Transition Metal-Free C--O Cross-Coupling Reaction of Activated and Unactivated Heteroaryl Chlorides with Alcohols and Phenols显示文摘由经由底和溶剂的小心的屏蔽优化反应条件,我们开发了有效转变为公司 跨coupling 的没有金属的方法激活并且有主要、第二等的白酒和酚的 unactivated heteroaryl 氯化物,提供一简单,有效,并且为有用不对称的 heteroaryl 烷基和 heteroaryl 芳基醚的合成的实际方法。 | Quan Liu Zhongxiang Lu Wenfei Ren Kaibo Shen Yu Wang Qing Xu | 2013 | Chinese Journal of Chemistry2013，31，6： | 0 |
| 14 | Responses of intra-annual runoff to forest recovery patterns in subtropical China显示文摘Forest recovery plays a critical role in regulating eco-hydrological processes in forested watersheds.However,characteristics of the intra-annual runoff variation associated with different forest recovery patterns remain poorly understood.In this study,three forest change periods were identified,the baseline period(1961-1985),reforestation period(1986-2000)and fruit tree planting period(2001-2016).We selected the magnitude of seasonal runoff(wet and dry seasons)and distribution characteristics,i.e.,non-uniformity coefficient(C_(v)),complete accommodation coefficient(C_(r)),concentration ratio(C_(n)),concentration period(C_(d)),absolute variation ratio(ΔR)and relative variation ratio(C_(max)).The pair-wise approach evaluated the intra-annual runoff variation characteristics between forest change periods.Results indicate that reforestation decreased wet season runoff and increased dry season runoff.In contrast,fruit tree planting increased wet season runoff and had no significant effect on dry season runoff.For intra-annual runoff distribution characteristics,reforestation significantly reduced the C_(v),C_(r),C_(n)and C_(max).Distribution of the intra-annual runoff in the fruit tree planting period was not significantly different from the baseline.We concluded that reforestation reduced the occurance of extreme water conditions in wet and dry seasons and effectively increased the stability of the intra-annual runoff.In contrast,fruit tree planting increased instability and fluctuation of the intra-annual runoff after reforestation.The characteristics of the intra-annual runoff to fruit tree planting was similar to those of the baseline.Therefore,adopting fruit tree planting practices to regulate intra-annual runoff characteristics may not be a practical approach,and impacts of different reforestation practices should be ascertained in our study region.The implications of this study should guide regional land-water management,and this study adds to the understanding of the impacts gained in forest cover on hydrology. | Zhipeng Xu Wenfei Liu Qiang Li Jianping Wu Honglang Duan Guomin Huang Yizao Ge | 2021 | Journal of Forestry Research2021，32，4： | 0 |
| 15 | Simulation System of Internal-target Detector at HIRFL-CSRm显示文摘HIRFL-CSRm will accelerate the proton beam up to 2.8 GeV. The interesting physics, such as the hadron spectrum, di-baryon state and the rare decay mode of the neutral mesons can be investigated with such beams. The corresponding detector as introduced in Ref.[1] is an internal-target 4π detector which is composed of the forward detector (including position detector and hadron calorimeter) to detect particles emitted at forward angles, and the center detector (including tracker, plastic scintillator barrel and EM calorimeter) to measure momentum and energy loss of the charged particle, and the energy and emission angle of the high energy photon at central and backward angles. To design such a complex detector, the Monte-Carlo (MC) simulation is definitely necessary. | Li Wenfei, Xu Hushan, Sun Zhiyu, Zhan Wenlong, Duan Limin, Li SonglinXu Huagen, Chen Ruofu, Zhang Xueying, Ma Yue, Jia Fei,Li jiaxing, Xiao Guoqing and Guo Zhongyan | 2003 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2003，，1： | 0 |
| 16 | Neutron Wall at RIBLL Ⅱ显示文摘With the construction of the new Radioactive Ion Beam Line in Lanzhou (RIBLL Ⅱ) which connecting the CSRm and the CSRe, an experimental setup.The Time-of-Flight (ToF) technique was recognized as one of the best ways for neutron detection and it, is employed by the neutrons wall. Considering the high neutron multiplicity, the detector shouldal so have the ability to resolve the multiple hits. Moreover, a high detection efficiency for the neutrons with energies ranging from 100MeV to 1 GeV is also required besides the high granularity. In this case, the sampling hadronic calorimeter type of detector has been selected. In order to estimate the performance of the detector | Xu Huagen, Xu Hushan, Li Wenfei, Zhan Wenlong , Xiao Guoqing , Guo Zhongyan Sun Zhiyu, Li Chen, Chen Ruofu, Ma Yue, Zhang Xueying and Jia Fei | 2003 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2003，，1： | 0 |
| 17 | Isotopic Trends of Fusion Probability in Reactions with Zn Isotopes Bombarding ^(208)Pb显示文摘where σc is the effective capture cross section for the transition of the colliding nuclei over the entrance Coulomob arrier, Wsur is the survival probability of the compound nucleus. In the DNS model, the compound nucleus is reached by a series of transfers of nuclcons from the light nucleus to the heavy one. Thc dynamics of the DNS is considered as a diffusion process in the mass asymmetry degree of freedom η=(A1 - A2)/(A1 + A2) (A1 and A2 are the mass numbers of the DNS nuclei), PCN is the complete fusion probability, here it is calculated by solving the Master equation numcrically[2]. The fusion barrier Bfus in η supplies a hindrance for fusion. | Li Wenfei, Xu Hushan, Zuo Wei, Jia Fei and Li Junqing | 2003 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2003，，1： | 0 |
| 18 | Analyzing Affect of Image Charge in Space Charge Effect显示文摘There is an increasing requirement of high injection current and highly charged ion beams for accelerators at many laboratories, such as CERN, GSI, GANIL and IMP, with the development of super-conducting ECR source in recent.years. In this case, the space charge effect becomes a major concern when the beam current is as high as tens of mA. In fact, the faradic field induced by the image charges will be come into the metallic surfaces while the beams are transported in a vacuum tube or in between two plates. In order to ensure studying the space charge effect in reason, it is necessary to investigate the effect from such a field. | Zhang Xueying, Xu Hushan, Jia Fei and Li Wenfei | 2003 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2003，，1： | 0 |
| 19 | Conceptual Design of a Branch Beam Line at HIRFL显示文摘In the case of matching the parameters between the SFC and the SSC, a stripper was installed in between the beam transport line connecting the two accelerators. The singly charged beam from SFC will turn into multi-charged one when it goes through the stripper and only the most intensive charged beam particles will be transported to SSC. In order to collect the surplus beam particles with other charge states for experiment as well, a new branch beam line is designed behind the exit of the original BL1-B2 dipole. Fig.l shows the layout of the newly designed beam line (with the dashed components in the figure). | Zhang Xueying, Tang Jingyu, Yin Quanming, Xu Hushan, Li Wenfei and Mao Ruishi | 2003 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2003，，1： | 0 |
| 20 | Investigation on Properties of BGO Rectangular Detector Units for PET显示文摘Bi4Ge3O12 (BGO) is a commonly used scintillating crystal for Positron Emission Tomography detector (PET) due to its relatively high Z and high density. In order to finalize the crystal size of BGO block unit for our PET system, the detection efficiency, energy resolution and the linearity have been studied for three types of BGO rectangular detector units with the dimension of 20×20×10mm^3, 20×20×20mm^3 and 20×20×30mm^3 respectively. The light from the BGO is readout by the photomultiplier of HAMAMATSU R1213 of which, peak sensitivity matches well with wavelength of the maximal emission of the crystal. | Qi Huirong, Xiao Guoqing, Wang Jinchuan, Zhan Wenlong, Guo Zhongyan, Xu HushanSun Zhiyu, Li Jiaxing, Wang Meng, Mao Ruishi, Li Chen, Chen ZhiqiangChen Lixin, Li Wenfei, Zhao Tiecheng, Wu Lijie and Xu Zhiguo | 2003 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2003，，1： | 0 |
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