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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 3 | Preparation, characterization, pharmacokinetics and anticancer effects of PEGylated β-elemene liposomes显示文摘Objective:This study aimed to develop a new polyethylene glycol(PEG)ylatedβ-elemene liposome(PEG-Lipo-β-E)and evaluate its characterization,pharmacokinetics,antitumor effects and safety in vitro and in vivo.Methods:The liposomes were prepared by ethanol injection and high-pressure micro-jet homogenization.Characterization of the liposomes was conducted,and drug content,entrapment efficiency(EE),in vitro release and stability were studied by ultra-fast liquid chromatography(UFLC)and a liquid surface method.Blood was drawn from rats to establish the pharmacokinetic parameters.The anticancer effect was evaluated in a KU-19-19 bladder cancer xenograft model.Histological analyses were performed to evaluate safety.Results:The PEG-Lipo-β-E showed good stability and was characterized as 83.31±0.181 nm in size,0.279±0.004 in polydispersity index(PDI),-21.4±1.06 mV in zeta potential,6.65±0.02 in pH,5.024±0.107 mg/mL inβ-elemene(β-E)content,and 95.53±1.712%in average EE.The Fourier transform infrared spectroscopy(FTIR)and differential scanning calorimetry(DSC)indicated the formation of PEG-Lipo-β-E.Compared to elemene injection,PEG-Lipo-β-E demonstrated a 1.75-fold decrease in clearance,a 1.62-fold increase in half-life,and a 1.76-fold increase in area under the concentration-time curves(AUCs)from 0 hour to 1.5 hours(P<0.05).PEG-Lipo-β-E also showed an enhanced anticancer effect in vivo.Histological analyses showed that there was no evidence of toxicity to the heart,kidney,liver,lung or spleen.Conclusions:The present study demonstrates PEG-Lipo-β-E as a new formulation with ease of preparation,high EE,good stability,improved bioavailability and antitumor effects. | Bingtao Zhai Qibiao Wu Wengang Wang Mingming Zhang Xuemeng Han Qiujie Li Peng Chen Xiaying Chen Xingxing Huang Guohua Li Qin Zhang Ruonan Zhang Yu Xiang Shuiping Liu Ting Duan Jianshu Lou Tian Xie Xinbing Sui | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 4 | An ATF24 peptide-functionalized β-elemene-nanostructured lipid carrier combined with cisplatin for bladder cancer treatment显示文摘Objective:In this study,we aimed to develop an amino-terminal fragment(ATF)peptide-targeted liposome carryingβ-elemene(ATF24-PEG-Lipo-β-E)for targeted delivery into urokinase plasminogen activator receptor-overexpressing bladder cancer cells combined with cisplatin(DDP)for bladder cancer treatment.Methods:The liposomes were prepared by ethanol injection and high-pressure microjet homogenization.The liposomes were characterized,and the drug content,entrapment efficiency,andin vitro release were studied.The targeting efficiency was investigated using confocal microscopy,ultra-fast liquid chromatography,and an orthotopic bladder cancer model.The effects of ATF24-PEG-Lipo-β-E combined with DDP on cell viability and proliferation were evaluated by a Cell Counting Kit-8(CCK-8)assay,a colony formation assay,and cell apoptosis and cell cycle analyses.The anticancer effects were evaluated in a KU-19-19 bladder cancer xenograft model.Results:ATF24-PEG-Lipo-β-E had small and uniform sizes(~79 nm),high drug loading capacity(~5.24 mg/mL),high entrapment efficiency(98.37±0.95%),and exhibited sustained drug release behavior.ATF24-PEG-Lipo-β-E had better targeting efficiency and higher cytotoxicity than polyethylene glycol(PEG)ylatedβ-elemene liposomes(PEG-Lipo-β-E).DDP,combined with ATF24-PEG-Lipo-β-E,exerted a synergistic effect on cellular apoptosis and cell arrest at the G2/M phase,and these effects were dependent on the caspase-dependent pathway and Cdc25C/Cdc2/cyclin B1 pathways.Furthermore,thein vivo antitumor activity showed that the targeted liposomes effectively inhibited the growth of tumors,using the combined strategy.Conclusions:The present study provided an effective strategy for the targeted delivery ofβ-elemene(β-E)to bladder cancer,and a combined strategy for bladder cancer treatment. | Bingtao Zhai Peng Chen Wengang Wang Shuiping Liu Jiao Feng Ting Duan Yu Xiang Ruonan Zhang Mingming Zhang Xuemeng Han Xiaying Chen Qiujie Li Guohua Li Ying Liu Xingxing Huang Wenzheng Zhang Ting Pan Lili Yan Ting Jin Tian Xie Xinbing Sui | 2020 | Cancer Biology & Medicine2020，17，3： | 5 |
| 5 | CNN-Based Intelligent Safety Surveillance in Green IoT Applications显示文摘Safety surveillance is considered one of the most important factors in many constructing industries for green internet of things(IoT)applications.However,traditional safety monitoring methods require a lot of labor source.In this paper,we propose intelligent safety surveillance(ISS)method using a convolutional neural network(CNN),which is an autosupervised method to detect workers whether or not wearing helmets.First,to train the CNN-based ISS model,the labeled datasets mainly come from two aspects:1)our labeled datasets with the full labeled on both helmet and pedestrian;2)public labeled datasets with the parts labeled either on the helmet or pedestrian.To fully take advantage of all datasets,we redesign CNN structure of network and loss functions based on YOLOv3.Then,we test our proposed ISS method based on the specific detection evaluation metrics.Finally,experimental results are given to show that our proposed ISS method enables the model to fully learn the labeled information from all datasets.When the threshold of intersection over union(IoU)between the predicted box and ground truth is set to 0.5,the average precision of pedestrians and helmets can reach 0.864 and 0.891,respectively. | Wengang Cao Jianing Zhang Changxin Cai Quan Chen Yu Zhao Yimo Lou Wei Jiang Guan Gui | 2021 | China Communications2021，18，1： | 4 |
| 6 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 7 | The research on method of interlayer modeling based on seismic inversion and petrophysical facies显示文摘Currently,the three-dimensional distribution of interlayer is realized by stochastic modeling.Traditionally,the three-dimensional geological modeling controlled by sedimentary facies models is built on the basis of logging interpretation parameters and geophysical information.Because of shallow gas-cap,the quality of three-dimensional seismic data vertical resolution in research area cannot meet the interlayer research that is below ten meters.Moreover,sedimentary facies cannot commendably reveal interlayer distribution and the well density is very sparse in research area.So,it is difficult for conventional technology to finely describe interlayers.In this document,it uses L1-L2 combined norm constrained inversion to enhance the recognition capability of interlayer in seismic profile and improve the signal to noise ratio,the wave group characteristics and the vertical resolution of three-dimensional data and classifies petrophysical facies of interlayer based on core,sedimentary facies and logging interpretation.The interlayer model which is based on seismic inversion model and petrophysical facies can precisely simulate the distribution of reservoir and interlayer.The results show that the simulation results of this new methodology are consistent with the dynamic production perfectly which provide a better basis for producing and mining remaining oil and a new interlayer modeling method for sparse well density. | Chao Cheng Wengang Yu Xiaojun Bai | 2016 | Petroleum2016，2，1： | 3 |
| 8 | Numerical investigation on effects of side curtain opening behavior on indoor climate of naturally ventilated dairy buildings显示文摘The side-curtain is popular in cattle buildings to regulate indoor climates and ventilation rates by adjusting the opening ratio.It normally had three different adjusting strategies relate to the position of rollers,i.e.central roller(S1),top roller(S2)and bottom roller(S3),which result in different opening behaviors to generate the same opening ratio but different opening positions in the side wall for a full-curtain house.Numerical simulations were conducted using computational fluid dynamics(CFD)to investigate the effects of the eight potential opening behaviors of side curtains on the indoor climates and airflow rates in winter for a typical naturally ventilated dairy house in China when the opening ratio were 8.5%and 17%.Airflow patterns,wind chilled temperature(WCT)and age of air were analyzed in the animal occupied zone(AOZ)by taking reference planes.Openings at the very bottom of side walls had more efficient ventilation due to the younger air age,more effective air disturbing,more uniformly distributed indicators in AOZ.However,it will result in a lower WCT in AOZ although a lower ventilation rate was observed in this case.Openings on the very top of side wall would generate a better thermal comfort in AOZ but with very poor air quality and nonuniformly distributed airflows in the dairy house.S1 was not recommended to the practical application due to the poor indoor climate and the higher cost of the mechanical structure.Based on the comprehensive evaluations of the analytic hierarchy process,the most satisfaction opening positions were at the bottom of the side curtains and the optimized adjusting strategy is S2. | Qifeng Li Chuanxia Yao Luyu Ding Ligen Yu Weihong Ma Ronghua Gao Wengang Zheng | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 2 |
| 9 | Extraction mechanism of rare earths from chloride acidic solution with ammonium-bifunctionalized ionic liquid extractants显示文摘A series of ammonium-bifunctionalized ionic liquid extractants(ammonium-Bif-ILEs) combined with a number of anions, including carboxylic acids and 1,3-diketonates, have been prepared and studied in this report. Their extraction behavior and properties toward rare earth ions(REs(Ⅲ)) are systematically investigated in chloride media as a function of important parameters such as aqueous phase p H, salting-out agent concentrations, and extraction temperature. The separation performance of ammonium-Bif-ILEs toward REs(Ⅲ) are systematically discussed. The results demonstrate that ammonium-Bif-ILEs have a synergistic effect between the cation and anions in separation of REs(Ⅲ). The influences of different anions on separation factor(b) values are further studied. By comparison, ammonium-Bif-ILEs containing 1,3-diketonates have more potential applications in La(Ⅲ)/RE(Ⅲ) separation than those containing carboxylic acids. | Hualing Yang Ji Chen Wei Wang Hongmin Cui Wengang Liu Yu Liu | 2016 | Science China Chemistry2016，59，5： | 2 |
| 10 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 11 | Sequence determination and anticoagulant and antithrombotic activities of a novel sulfated fucan isolated from the sea cucumber Isostichopus badionotus显示文摘 | Shiguo Chen Yaqin Hu Xinqian Ye Guoyun Li Guangli Yu Changhu Xue Wengang Chai | 2012 | BBA - General Subjects2012，，7： | 1 |
| 12 | Automatic diagnosis of strawberry water stress status based on machine vision显示文摘Water stress status of plants is very important for irrigation scheduling.However,plant water stress status monitoring has become the bottleneck of irrigation scheduling.In this study,an automatic water stress status monitoring method for strawberry plant was proposed and realized using combined RGB and infrared image information.RGB image and infrared images were obtained using RGB digital camera and infrared thermal camera,which were placed in a fixed shell in parallel.In the first experimental stage,three kinds of water stress treatments were carried out on three groups of strawberry plants,and each group includes three repetitions.Single point plant temperature,dry surface temperature,wet surface temperature were measured.In the second experimental stage,the infrared and visible light images of the canopy leaves were obtained.Meanwhile,plant temperature,dry surface temperature,wet surface temperature,and stomatal conductance were measured not only for single point but also for plant area temperature measurement.Fusion information of infrared image and visible light image was analyzed using image processing technology,to calculate the average temperature of plant areas.Based on single point temperature,area temperature,dry surface temperature and wet surface temperature of the plant,single point crop water stress index(CWSI)and area CWSI were calculated.Through analysis of variance(ANOVA),the experimental results showed that CWSI measured for plants under different treatments,were significantly different.Through correlation analysis,the experimental results showed that,determination coefficient between area CWSI and the corresponding stomatal conductance of three strawberry groups were 0.8834,0.8730 and 0.8851,respectively,which were larger than that of single-point CWSI and stomatal conductance.The results showed that area CWSI is more suitable to be used as the criteria for automatic diagnosis of plants. | Han Li Jian Yin Man Zhang Nick Sigrimis Yu Gao Wengang Zheng | 2019 | International Journal of Agricultural and Biological Engineering2019，12，1： | 1 |
| 13 | Comparison of structures and anticoagulant activities of fucosylated chondroitin sulfates from different sea cucumbers显示文摘 | Shiguo Chen Changhu Xue Li’ang Yin Qingjuan Tang Guangli Yu Wengang Chai | 2010 | Carbohydrate Polymers2010，，2： | 1 |
| 14 | Sequence determination and anticoagulant and antithrombotic activities of a novel sulfated fucan isolated from the sea cucumber Isostichopus badionotus显示文摘 | Shiguo Chen Yaqin Hu Xinqian Ye Guoyun Li Guangli Yu Changhu Xue Wengang Chai | 2012 | BBA - General Subjects2012，，7： | 1 |
| 15 | Establishment of an orthotopic perirenal space xenograft mousemodel of retroperitoneal sarcoma显示文摘Dear Editor,Soft tissue sarcomas are a heterogeneous group of rare malignancies with mesenchymal origin that can arise at any anatomic site.They account for almost 1.5% of all malignancies in humans,with an increased incidence in young adults[1,2].The retroperitoneum is the primary site of 15%-20% of soft tissue sarcomas[3,4]. | Fu’an Xie Dongmei Qin Lanlan Lian Ming Li Xu Kong Xiaogang Xia Chundong Yu Chenghua Luo Wengang Li | 2021 | Cancer Communications2021，41，7： | 1 |
| 16 | Sequence determination of a non-sulfated glycosaminoglycan-like polysaccharide from melanin-free ink of the squid Ommastrephes bartrami by negative-ion electrospray tandem mass spectrometry and NMR spectroscopy显示文摘 | Shiguo Chen Jie Xu Changhu Xue Ping Dong Wenjing Sheng Guangli Yu Wengang Chai | 2008 | Glycoconjugate Journal2008，，5： | 1 |
| 17 | Damage Mechanism and Countermeasures of Carbon Bonded Refractories for Continuous Casting显示文摘The long nozzle,stopper,and submerged entry nozzle play an important role in continuous casting. They are of the similar composition and are mainly damaged by liquid steel thermal shock which leads to immediate cracks or fracture in their combined area because of the thermal mechanical properties mismatch,or damaged by corrosion on their interface. The failure mechanisms are the thermal shock damage and continuous reaction corrosion. High efficiency and long life of the long nozzle,stopper,and submerged entry nozzle can be realized by optimizing the thermal mechanical properties,the key erosion step,and the combination match. | QIAN Fan LI Hongxia LIU Guoqi YANG Wengang YU Jianbin MA Weikui | 2016 | China's Refractories2016，25，3： | 0 |
| 18 | Design of Composite Ladle Shroud for Improving Thermal Shock Resistance显示文摘A ladle shroud is one of the functional refractories for continuous casting,which undergoes severe thermal shock by molten steel when used without pre-heating.The composite ladle shroud with an insulating liner presents excellent thermal shock resistance.Finite element simulation is an effective method to explore the maximum thermal stress for predicting the thermal shock resistance of ladle shrouds.In this paper,the influence of the lining materials and the structure of ladle shrouds on the thermal stress distribution is systematically researched.The working mechanism of the lining material on the body material is also presented.Lining materials with low thermal expansion,elastic modulus and thermal conductivity are helpful to improve the thermal shock resistance and an optimum lining thickness is suggested.The lining material can both serve as thermal resistance for the body material to buffer the thermal stress,and apply a strain load to the body material by the thermal strain to increase the stress. | LIU Guoqi LI Hongxia YANG Wengang QIAN Fan YU Jianbin MA Weikui | 2021 | China's Refractories2021，30，1： | 0 |
| 19 | Reconstruction of facial through-and-through defect显示文摘 | Wengang Li Dongsheng Zhang Dianshen Yu Shizhou Zhang | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
| 20 | Influence of Glass Dust on Properties of Alumina-carbon Refractories显示文摘In order to improve the properties of alumina-carbon refractories,specimens were prepared using white fused corundum,zirconia-mullite and flake graphite as the raw materials,phenolic resin as the binder,adding different mass fractions(1.5%,2.0%,and 2.5%,respectively)of glass dust,cold isostatic pressing by 120 MPa,drying and firing at 900℃for 3 h.Effects of the glass dust addition on the apparent porosity,bulk density,cold modulus of rupture,hot modulus of rupture and thermal shock resistance were studied.The results show that the cold modulus of rupture of the specimens is improved significantly as the results of glass dust accelerating sintering.However,the hot modulus of rupture decreases.As the glass phase buffers the strain produced by thermal shock,the thermal shock resistance of alumina-carbon specimens is improved,especially for low carbon alumina-carbon materials. | MA Weikui LIU Guoqi YU Jianbin QIAN Fan YANG Wengang | 2019 | China's Refractories2019，28，4： | 0 |
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